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| 1 | Antioxidant role of heme oxygenase-1 in prehepatic portal hypertensive rats显示文摘瞄准:在氧化的肝地位和这项活动和表示上学习胆红素的效果他我在老鼠肝损伤的 oxygenase-1 (HO-1 ) 由 prehepatic 门静脉高血压导致了。方法:Wistar 雄的老鼠,称 200-250 g,在随机被划分成二个组:有调整 prehepatic 门静脉结扎(PPVL ) 导致的 prehepatic 门静脉高血压(PH ) 的一个组和另外的组对应于假冒的操作老鼠。门压力,氧化压力参数,抗氧化剂酶, HO-1 活动和表示和肝的正弦曲线血管舒张被测量。结果:在 PPVL 老鼠,氧化应力被在减少的谷胱甘肽(GSH ) 的反应物质(TBARS ) 内容和减少铺平的 thiobarbituric 酸的显著增加证实。当 HO-1 的活动和表示被提高时,肝抗氧化剂酶,超级氧化物歧化酶(草皮) ,过氧化氢酶(猫) 和谷胱甘肽过氧化物酶(GSH-Px ) 的活动也被减少。胆红素(5 mumol/kg 体重) 的管理在实验的结束前的 24 h 完全阻止了所有这些效果。有 Sn-protoporphyrin IX (Sn-PPIX ) 的预告的处理(100 mug/kg 体重, i.p ) ,一个有势力禁止者惊讶,完全废除了氧化压力并且每氧化象类脂化合物的增加一样在肝 GSH 层次挑起了细微减少。而且,一氧化碳,另一他我分解代谢的产品,在在 PPVL 的肝的区域组织的正弦曲线导致了重要增加。有 Sn-PPIX 的 PPVL 老鼠的预告的处理完全阻止了这效果。结论:这些结果在 prehepatic 门 hypertensive 老鼠在表示上建议 HO-1 的一个有益的角色。 | Soledad Gonzales María Julia Pérez Juan C Perazzo María Luján Tomaro | 2006 | World Journal of Gastroenterology2006，12，26： | 6 |
| 2 | Management of primary achalasia: The role of endoscopy显示文摘Achalasia is an oesophageal motor disorder which leads to the functional obstruction of the lower oesophageal sphincter(LES) and is currently incurable. The main objective of all existing therapies is to achieve a reduction in the obstruction of the distal oesophagus in order to improve oesophageal transit, relieve the symptomatology, and prevent long-term complications. The most common treatments used are pneumatic dilation(PD) and laparoscopic Heller myotomy, which involves partial fundoplication with comparable shortterm success rates. The most economic non-surgical therapy is PD, with botulinum toxin injections reserved for patients with a higher surgical risk for whom the former treatment option is unsuitable. A new technology is peroral endoscopic myotomy, postulated as a possible non-invasive alternative to surgical myotomy. Other endoluminal treatments subject to research more recently include injecting ethanolamine into the LES and using a temporary self-expanding metallic stent. At present, there is not enough evidence permitting a routine recommendation of any of these three novel methods. Patients must undergo follow-up after treatment to guarantee that their symptoms are under control and to prevent complications. Most experts are in favour of some form of endoscopic follow-up, however no established guidelines exist in this respect. The prognosis for patients with achalasia is good, although a recurrence after treatment using any method requires new treatment. | Marisol Luján-Sanchis Patricia Suárez-Callol Ana Monzá-Gallego Inmaculada Bort-Pérez Lydia Plana-Campos Luis Ferrer-Barceló Laura Sanchis-Artero María Llinares-Lloret Juan Antonio Tuset-Ruiz Javier Sempere-Garcia-Argüelles Pilar Canelles-Gamir Enrique Medina-Chuliá | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 5 |
| 3 | PrevalenceofdiabetesamongmenandwomeninChina[J]显示文摘 | YangW LuJ WengJ etal | | NEnglJMed0，，： | 2 |
| 4 | Synthesis of a malaria candidate glycosylphosphatidylinositol (GPI) structure: A strategy for fully inositol acylated and phosphorylated GPIs显示文摘A congener of the glycosylpbosphatidylinositol (GPI) membrane anchor present on the cell surface of the malaria pathogen Plasmodium, falciparum has been synthesized. This GPI is an example of a small number of such membrane anchors that carry a fatty acyl group at 0-2 of the inositol. Although the acyl group plays crucial roles in GPI biosynthesis, it rarely persits in mature molecules.Other notable examples are the mammalian GPIs CD52 and AchE. The presence of bulky functionalities at three contiguous positions of the inositol moiety creates a very crowded environment that poses difficulties for carrying out selective chemical manipulations.Thus installations of the axial long-chain acyl group and neighboring pbosphoglyceryl complex were fraught with obstacles. The key solution to these obstacles in the successful synthesis of the malarial candidate and prototype structures involved stereoelectronically controlled opening of a cyclic ortho ester. The reaction proceeds in very good yields, the desired axial diastereomer being formed predominantly, even more so in the case of long-chain acyl derivatives. The myoinositol precursor was prepared from methyl alpha-D-glu-copyranoside by the biornimetic procedure of Bender and Budhu. For the glycan array, advantage was taken of the fact that (a) n-pentenyl ortho ester donors are rapidly and chemospecifically activated upon treatment with ytterbium triflate and N-iedosueeinimide and (b) coupling to an aeeeptor affords alpha-coupled product exclusively. A strategy for obtaining the GPI's alpha-glucosaminide component from the corresponding a-mannoside employed Deshong's novel azide displacement procedure. Thus all units of the glycan array were obtained from a beta-D-manno-n-pentenyl ortho ester, this being readily prepared from D-mannose in three easy, high-yielding steps. The 'crowded environment' at positions 1 and 2, noted above, could conceivably be relieved by migration of the acyl group to the neighboring cis-O-3-hydroxyl in the natural product. However, study of our synthetic intermediates and prototypes indicate that the 0-2 acyl group is quite stable, and that such migration does not occur readily. | LuJ JayaprakashKN SchlueterU Fraser-ReidB | 2004 | 天然产物研究与开发2004，16，4： | 2 |
| 5 | Detection of non-alcoholic steatohepatitis in patients with morbid obesity before bariatric surgery: preliminary evaluation with acoustic radiation force impulse imaging显示文摘 | F. Guzmán-Aroca M. D. Frutos-Bernal A. Bas J. A. Luján-Mompeán M. Reus Juan Dios Berná-Serna P. Parrilla | 2012 | European Radiology2012，，11： | 2 |
| 6 | Prognostic role of P27Kip1 and apoptosis in human breast cancer 显示文摘 | Wu J ShenZZ LuJS etal | 1999 | Br J Cancer1999，79，： | 1 |
| 7 | 罗国安(LuoGA),刘清飞(LiuQF),王义明(WangYM)显示文摘 | 路娟(LuJ) | | 有机化学0，，： | 1 |
| 8 | Property Rights Protection and Access to Bank Loans:Evidence from Private Enterprisesin China显示文摘 | Bai C E LuJ Y Tao Z G | | 0，，04： | 1 |
| 9 | prevalence of diabetes among men and women in china显示文摘 | Yang W Luj el al | 2010 | N Engl j med2010，362，12： | 1 |
| 10 | Prevalence of diabetes among men and women in China显示文摘 | Yang W LuJ WengJ | 2010 | N EnglJ Med2010，362，12： | 1 |
| 11 | Effect of a carbohydrate-containing late-eveningsnack on energy metabolism and fasting substrate utilization in adultswith acute-on-chronic liver failure due to Hepatitis B显示文摘 | Hou LiJ LuJ | 2013 | EurJ ClinNutr2013，67，12： | 1 |
| 12 | 调强放射治疗局部晚期鼻咽癌过程中解剖和剂量的变化[J]显示文摘 | Wangx LuJ XiongX 等 | | 医疗放射剂量测定0，，： | 1 |
| 13 | Therapeuticeffectsofepinericglycyrrhizicacidsonhepaticinjuryinrats[J]显示文摘 | WUXM LUJ LIBR | | 中国药理学报0，，： | 1 |
| 14 | Combustion simulation of turbocharger HSDI Diesel engines during transient operation using neural networks显示文摘 | J. Galindo J.M. Luján J.R. Serrano L. Hernández | 2004 | Applied Thermal Engineering2004，，5： | 1 |
| 15 | Monomethyl selenium--specific inhibition of MMP-2 and VEGF expression: implications for angiogenic switch regulation显示文摘 | Ganther H LuJ | 2000 | Mol Carcinog2000，29，4： | 1 |
| 16 | Advanced applications of ionic liquids in polymer science显示文摘 | LuJ Van F Texte | 2009 | Prog Polym Sci2009，34，： | 1 |
| 17 | DeterminantsofAccepting Wireless Mobile Data Services in China显示文摘 | LuJ LiuC YuCS etal | 2008 | Infor-mation&Management2008，45，1： | 1 |
| 18 | Pelvic radiation with concurrent chemotherapy compared with pelvic and paraaortic radiation for high-risk cervical cancer显示文摘 | Morris M Eifel PJ LuJ | 1999 | N Eng[J Med1999，340，15： | 1 |
| 19 | Face recognition with radial basis function (RBF) neural networks显示文摘 | Er MJ Wu S LuJ | 2002 | Neural Networks IEEE Transactions on2002，13，3： | 1 |
| 20 | Model of the expansion process for R245fa in an Organic Rankine Cycle (ORC)显示文摘 | J.M. Luján J.R. Serrano V. Dolz J. Sánchez | 2012 | Applied Thermal Engineering2012，，： | 1 |
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