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| 1 | 世界胃肠病学组织(WGO-OMGE)临床指南——发展中国家幽门螺杆菌感染显示文摘我非常高兴向大家推荐这份发展中国家幽门螺杆菌(H.priori)临床指南。该指南的编译是由数位在该领域具有丰富临床经验的世界知名专家共同完成的。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F Van der Merwe S vaz Coelho LG Fock KM Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BC Krabshuis JH 杜颖 丛衍群 戴宁 | 2007 | 胃肠病学2007，12，1： | 85 |
| 2 | 温度对美拉德反应的研究(英文)显示文摘本文报道了反应温度对以d-葡萄糖和l-甘氨酸水溶液模式体系美拉德反应的影响。研究了在不同反应温度(80、100、120℃)和不同反应时间下,体系中糖和氨基酸的降解程度,反应中间体:阿利德诺和有机酸的累积程度,类黑素的形成及pH变化程度。研究结果表明:随着反应温度和反应时间的增加,反应速率加快。 | 吴少雄 M A J S van Boeke S I F S Martins 郭祀远 李琳 | 2005 | 食品科学2005，26，7： | 54 |
| 3 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 4 | How the Bcl-2 family of proteins interact to regulate apoptosis显示文摘到 apoptosis 的房间的承诺主要被在 Bcl-2 蛋白质家庭的成员之间的蛋白质蛋白质相互作用管理。它的三个亚科有不同角色:BH3 仅仅,蛋白质经由他们的 BH3 领域由绑定触发 apoptosis 到支持幸存的亲戚,当 pro-apoptotic Bax 和 Bak 有一个必要下游的角色包含 organellar 膜和 caspase 激活的正式就职的混乱时。BH3 仅仅,蛋白质充当损坏传感器,由压力信号保持惰性直到他们的激活。一旦激活,他们被认为杂乱地绑在支持幸存的蛋白质目标,但是意外选择最近从他们的相互作用的分析出现了。BH3 仅仅,蛋白质也绑在 Bax 和 Bak 的一些。Bax 和 Bak 是否被这些 BH3 仅仅直接激活蛋白质,或间接地作为后果 BH3 仅仅蛋白质抵销他们的支持幸存的目标是强烈争论的题目。不管这,在家庭成员之间的相互作用的详细理解,经常选择,为设计反癌症药指向 Bcl-2 家庭有著名含意。 | Mark F van Delft David CS Huang | 2006 | Cell Research2006，16，2： | 38 |
| 5 | 世界胃肠病学组织全球指南——发展中国家幽门螺杆菌感染显示文摘世界上有一半人口感染幽门螺杆菌(H.pylori),其感染率因地理位置、种族、年龄和社会经济状况不同而存在很大差异.在发展中国家较高.发达国家较低。但总体而言,近年世界许多地区的H.pylori感染率均呈下降趋势。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F van der Merwe S Vaz Coelho LG Fock M Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BCY Krabshuis J Le Mair A 杜颖 戴宁 | 2011 | 胃肠病学2011，16，7： | 27 |
| 6 | Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets显示文摘Hepatocellular 癌(HCC ) 每年是为 500 000 死亡负责的世界范围的一个主要健康问题。很多个风险因素与也被联系疾病或它的前进的正式就职;这些与肝炎 B 或 C 病毒,白酒消费,非酒精的 steatohepatitis 和某些先天的混乱包括感染。在约 80% 盒子, HCC 与肝硬化或先进纤维变性并且与发炎和氧化应力被联系。在这评论,我们为 HCC 第一集中于不同风险因素并且总结由哪个各被认为贡献 HCC 的机制。在第二部分,我们看涉及癌症前进的分子的过程。HCC 开发作为 multistep 进程被认出通常在许多年发展。在几个变化在房间和那积累的这个时期上刺激诽谤转变,生长,和变形行为。在最近的年,不仅肿瘤房间本身而且肿瘤 microenviroment 在一个肿瘤的发展起一个主要作用,变得明显。与这 microenviroment 在发炎和肝硬化的角色之间有一个直接连接。在 vitro 并且在 vivo,它被看了那肿瘤形成,变形性质被连接到上皮间充质的转变(EMT ) ,由 facillitates,肿瘤房间是尝试移居到更赞成的 microenviroment 的一个过程。几个组由 microarray 在 HCC 和它的包围织物分析了基因表示,这导致了分子的分类进班的一个不同数字。这里,我们也发现为组织缺氧的一个角色导致了基因表示导致一临床上在 HCC 的更好攻击的基因表示。分子的分析也帮助识别重要细胞的小径和可能的治疗学的目标。这样为肝癌症显示出临床的申请的第一个分子是 multikinase 禁止者 sorafenib,其它当前在象 mTOR 禁止者 everolimus 一样的临床的研究的不同阶段。 | Tamara SEVERI Hannah van MALENSTEIN Chris VERSLYPE Jos F van PELT | 2010 | Acta Pharmacologica Sinica2010，31，11： | 23 |
| 7 | Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial显示文摘 | Martijn HGM van der Pas Eva Haglind Miguel A Cuesta Alois Fürst Antonio M Lacy Wim CJ Hop Hendrik Jaap Bonjer | 2013 | Lancet Oncology2013，，： | 17 |
| 8 | 生物质燃烧颗粒物的定量分析和化学形态显示文摘用电子探针技术开展单个含钾颗粒物的分析表征 .第一种方法用蒙特卡洛方法模拟电子束与样品复杂的相互作用 ,对于KCl晶粒取得的计算结果与理论值一致 .K/Cl比的均值为 0 996 ,标准偏差为 0 0 1 2 .由于晶形不规则和热稳定性差 ,K2 SO4 和KHSO4 的结果没有达到KCl的准确度 .其K/S比的均值和标准偏差分别为 1 90 5±0 0 1 3和 1 0 1 4± 0 0 72 .第二种方法用回归分析方法处理了同一种类若干数目的颗粒物分析数据 .直接用同种类标准颗粒物的分析结果校准 ,进行定量分析和化学形态识别 .研究结果表明 ,非洲草原大火燃烧排放时 ,含钾颗粒经历了逐步酸化的过程 .在排放时主要以KCl形态存在 ,少量是K2 SO4 和复盐 .在大气传输过程中逐渐酸化 ,主要转变成KHSO4 .少量停空时间长的颗粒则继续酸化 ,成为高度富硫的颗粒 . | 刘咸德 李玉武 董树屏 Van EspenP Adams F Maenhaut W | 2002 | 环境化学2002，21，3： | 13 |
| 9 | New insights in the treatment of acromioclavicular separation显示文摘A direct force on the superior aspect of the shoulder may cause acromioclavicular(AC) dislocation or separation. Severe dislocations can lead to chronic impairment, especially in the athlete and high-demand manual laborer. The dislocation is classified according to Rockwood. Types Ⅰ?and Ⅱ are treated nonoperatively, while types Ⅳ, Ⅴ and Ⅵ are generally treated operatively. Controversy exists regarding the optimal treatment of type Ⅲ dislocations in the high-demand patient. Recent evidence suggests that these should be treated nonoperatively initially. Classic surgical techniques were associated with high complication rates, including recurrent dislocations and hardware breakage. In recent years, many new techniques have been introduced in order to improve the outcomes. Arthroscopic reconstruction or repair techniques have promising short-term results. This article aims to provide a current concepts review on the treatment of AC dislocations with emphasis on recent developments. | Christiaan J A van Bergen Annelies F van Bemmel Tjarco D W Alta Arthur van Noort | 2017 | World Journal of Orthopedics2017，8，12： | 12 |
| 10 | Treatment of acute periprosthetic infections with prosthesis retention: Review of current concepts显示文摘Periprosthetic joint infection(PJI) is a devastating complication after total joint arthroplasty, occurring in approximately 1%-2% of all cases. With growing populations and increasing age, PJI will have a growing effect on health care costs. Many risk factors have been identified that increase the risk of developing PJI, including obesity, immune system deficiencies, malignancy, previous surgery of the same joint and longer operating time. Acute PJI occurs either postoperatively(4 wk to 3 mo after initial arthroplasty, depending on the classification system), or via hematogenous spreading after a period in which the prosthesis had functioned properly. Diagnosis and the choice of treatment are the cornerstones to success. Although different definitions for PJI have been used in the past, most are more or less similar and include the presence of a sinus tract, blood infection values, synovial white blood cell count, signs of infection on histopathological analysis and one ormore positive culture results. Debridement, antibiotics and implant retention(DAIR) is the primary treatment for acute PJI, and should be performed as soon as possible after the development of symptoms. Success rates differ, but most studies report success rates of around 60%-80%. Whether single or multiple debridement procedures are more successful remains unclear. The use of local antibiotics in addition to the administration of systemic antibiotic agents is also subject to debate, and its pro's and con's should be carefully considered. Systemic treatment, based on culture results, is of importance for all PJI treatments. Additionally, rifampin should be given in Staphylococcal PJIs, unless all foreign material is removed. The most important factors contributing to treatment failure are longer duration of symptoms, a longer time after initial arthroplasty, the need for more debridement procedures, the retention of exchangeable components, and PJI caused by Staphylococcus(aureus or coagulase negative). If DAIR treatment is unsuccessful, the following treatment option should be based on the patient health status and his or her expectations. For the best functional outcome, one- or two-stage revision should be performed after DAIR failure. In conclusion, DAIR is the obvious choice for treatment of acute PJI, with good success rates in selected patients. | Jesse WP Kuiper Robin Tjeenk Willink Dirk Jan F Moojen Michel PJ van den Bekerom Sascha Colen | 2014 | World Journal of Orthopedics2014，5，5： | 12 |
| 11 | Current concepts in the management of radial head fractures显示文摘Fracture of the radial head is a common injury. Over the last decades, the radial head is increasingly recognized as an important stabilizer of the elbow. In order to maintain stability of the injured elbow, goals of treatment of radial head fractures have become more and more towards restoring function and stability of the elbow. As treatment strategies have changed over the years, with an increasing amount of literature on this subject, the purpose of this article was to provide an overview of current concepts of the management of radial head fractures. | Iza?k F Kodde Laurens Kaas Mark Flipsen Michel PJ van den Bekerom Denise Eygendaal | 2015 | World Journal of Orthopedics2015，6，11： | 9 |
| 12 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 13 | Cerebral processing of auditory stimuli in patients with irritable bowel syndrome显示文摘瞄准:用大脑决定功能的磁性的回声成像(fMRI ) 非内脏的刺激的服的处理是否在急躁的肠症候群(IBS ) 被改变病人与健康题目相比。围绕针的内脏躯体集中机制,并且识别心理因素的可能的影响,我们使用了听觉的刺激刺激在他们的感情的质量不同。方法:在 8 个 IBS 病人和 8 控制, fMRI 大小用不同感情的质量(钟声,讨厌的偷看(2000 Hz ) ,中立的词,和感情的词的愉快的声音) 的 4 听觉的刺激的一个块图案被执行。坡度回响 T2 * 加权的顺序被用于功能的扫描。统计地图用一般线性模型被构造。结果:到感情的听觉的刺激,,相对控制的 IBS 病人在感情的处理区域的一个更大的变化与更强壮的释放反应了反应模式,在控制不同,没在令人烦恼或愉快的声音之间区分。到中立听觉的刺激,由对比,仅仅 IBS 病人与大重要激活反应了。结论:到在感情的处理刺激的区域的听觉的刺激的改变的服的反应模式建议在 IBS 的改变的感觉处理不能为内脏的感觉是特定的,但是可能在感情的敏感和感情方面的反应反映概括变化,可能与经常在 IBS 病人发现的心理 comorbidity 联系了。 | Viola Andresen Alexander Poellinger Chedwa Tsrouya Dominik Bach Albrecht Stroh Annette Foerschler Petra Georgiewa Marco Schmidtmann Ivo R van der Voort Peter Kobelt Claus Zimmer Bertram Wiedenmann Burghard F Klapp Hubert Monnikes | 2006 | World Journal of Gastroenterology2006，12，11： | 8 |
| 14 | How to Make Capsules Containing Rejuvenators for Their Use in Asphalt Concrete显示文摘Rejuvenators are products designed to restore original properties to oxidized asphalt binders by restoring the original ratio of asphaltenes to maltenes. But,for a rejuvenator to be successful,it must penetrate the pavement surface. Besides,application of a rejuvenator will also reduce the skid resistance of the pavement. To solve this,these rejuvenators can be encapsulated and mixed in asphalt concrete. Once the stress in the capsules reaches a certain threshold,the particles break and the rejuvenator is released,giving back the original properties of the pavement. The objective of this paper is to show how these capsules behave and define the most appropriate testing methods to find their effect on asphalt concrete. For this,two different types of rejuvenators will be encapsulated and their effect on the properties of the capsules investigated. Besides,the release mechanisms of the capsules will be unravelled. | GARCIA A SCHLANGEN E VAN DE VEN M F C | 2010 | 武汉理工大学学报2010，32，17： | 7 |
| 15 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 16 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 17 | Isolation and proteomic analysis of the SYP61 compartment reveal its role in exocytic trafficking in Arabidopsis显示文摘endomembrane 系统是建筑群和动态细胞内部的 trafficking 网络。它很正在质问在实时追踪单个泡和他们的货物;然而,亲密关系纯化允许泡处于他们的自然状态被孤立以便他们的成分蛋白质能被识别。在植物开创这条途径,我们孤立 SYP61 trans-Golgi 网络分隔空间并且与从另外的细胞器的仅仅最小的干扰执行了它的内容的全面 proteomic 分析。SYP61 的 proteome 揭示了以前没被归功于到这分隔空间的未知功能的蛋白质的协会。我们识别了完全的 SYP61 圈套建筑群,包括规章的蛋白质并且由显示出在 planta 与 SYP61 联系的几这些蛋白质验证了 proteome 数据。我们进一步识别了 SYP121 复杂并且纤维素 synthases,建议那 SYP61 在 exocytic trafficking 和房间墙部件的运输起一个作用到血浆膜。在包括针鼹鼠的 SYP61 proteome 的未知功能的蛋白质的存在提供机会识别新奇 trafficking 部件和货物。处于他们的自然状态的植物泡的亲密关系纯化为复杂 endomembrane 网络的进一步的分析和解剖提供一个基础。途径是广泛地适用的并且能在植物负担得起几张泡人口的学习,它能与 SYP61 泡 proteome 相比。 | Georgia Drakakaki Wilhelmina van de Ven Songqin Pan Yansong Miao Junqi Wang Nana F Keinath Brent Weatherly Liwen Jiang Karin Schumacher Glenn Hicks Natasha Raikhel | 2012 | Cell Research2012，22，2： | 4 |
| 18 | Adherence to surveillance guidelines for dysplasia and colorectal carcinoma in ulcerative and Crohn's colitis patients in the Netherlands显示文摘AIM: To study adherence to the widely accepted surveillance guidelines for patients with long-standing colitis in the Netherlands. METHODS: A questionnaire was sent to all 244 gastroenterologists in the Netherlands. RESULTS: The response rate was 63%. Of all gastroenterologists, 95% performed endoscopic surveillance in ulcerative colitis (UC) patients and 65% in patients with Crohn's colitis. The American Gastroenterological Association (AGA) guidelines were followed by 27%, while 27% and 46% followed their local hospital protocol or no specific protocol, respectively. The surveillance was correctly initiated in cases of pancolitis by 53%, and in cases of left-sided colitis by 44% of the gastroenterologists. Although guidelines recommend 4 biopsies every 10 cm, less than 30 biopsies per colonoscopy were taken by 73% of the responders. Only 31%, 68% and 58% of the gastroenterologists referred patients for colectomy when low-grade dysplasia, high-grade dysplasia (HGD) or Dysplasia Associated Lesion or Mass (DALM) was present, respectively. CONCLUSION: Most Dutch gastroenterologists performendoscopic surveillance without following international recommended guidelines. This practice potentially leads to a decreased sensitivity for dysplasia, rendering screening for colorectal cancer in this population highly ineffective. | Anne F van Rijn Paul Fockens Peter D Siersema Bas Oldenburg | 2009 | World Journal of Gastroenterology2009，15，2： | 4 |
| 19 | A numerical model of gas-fluidized beds显示文摘 | Kuipers J A M Van Duin K J Van Beckum F P H | 1992 | Chem Eng Sci1992，47，5： | 4 |
| 20 | 颈总动脉内径与心血管事件及死亡风险研究:4项队列研究的汇总分析显示文摘颈动脉内径增加是动脉重构的表现,且可能是心血管病的危险因素。研究者评估颈动脉内径与脑卒中、冠状动脉性心脏病、心血管病及全因死亡的关系,并探讨与血压有关的中膜增厚、动脉僵硬、动脉壁应力及动脉硬化等动脉重构过程能否解释此关系。 | Sedaghat S van Sloten TT Laurent S London GM Pannier Kavousi M Mattace-Raso F Franco OH Boutouyrie P Ikram MA Stehouwer CDA 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，7： | 4 |
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