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| 1 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | GIBBS: isothermal-isobaric thermodynamics of solids from energy curves using a quasiharmonic Debye model显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Commun2004，158，1： | 1 |
| 4 | GIBBS:Isothermal-isobaric Thermodynamics of Solids from Energy Curves Using a Quasiharmonic Debye Model显示文摘 | BLANCO M A FRANCISCO E LUANA V | | 0，，01： | 1 |
| 5 | A rice high-afinity potassium transporter (HTK) conceals a calcium-permeable cation 显示文摘 | Lan W Z Wang W Wang S M Li L G Buchanan B B Lin H X Gao J P Luana S | 2010 | Proceedings of the National Academy of Sciences of the United States of America2010，107，15： | 1 |
| 6 | Influence of norbixin on plasma cholesteroassociated lipoproteins,plasma arylesterase/paraoxonase activity and hepatic lipid peroxidation of Swiss mice on a high fat diet显示文摘 | Andressa A A Santos Márcia V G Silva Luana T A Guerreiro | 2002 | Food Chemistry2002，77，： | 1 |
| 7 | GIBBS:Isothermal-isobaric thermodynamics of solids from energy curves using a quasi-harmonic Debye model显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Commun2004，158，1： | 1 |
| 8 | GIBBS:isothermal-isobaric thermodynamics of solids from energy curves using a quasi-harmonic Debye model显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Commun2004，158，： | 1 |
| 9 | GIBBS: isothermalisobaric thermodynamics of solids from energy curves using a quasi - harmonic Dybcy model显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Commun2004，158，： | 1 |
| 10 | GIBBS: isothermal-isobaric thermodynamics of solids from energy curves using a quasi-harmonic Debye model显示文摘 | BLANCO M A FRANCISCO E LUANA V | 2004 | Computer Physics Communications2004，158，1： | 1 |
| 11 | GIBBS: Isothermal-Isobaric Thermodynamics of Solids from Energy Curves Using a Quasi-harmonic Debye Model 显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Comm2004，158，1： | 1 |
| 12 | Antimicrobial activity ofrhamnolipids against Listeria monocytogenes andtheir synergistic interaction with nisin显示文摘 | LUANA M MARCIA N | 2013 | FoodControl2013，29，： | 1 |
| 13 | GIBBS: isothermal-isobaric thermodynamics of solids from energy curves using a quasi-harmonic Debye model显示文摘 | Blanco M A Francisco E Luana V | 2004 | ComputPhys Commun2004，158，1： | 1 |
| 14 | GIBBS: Isothermal-i-sobaric thermodynamics of solids from energy curves using aquasi-harmonic Debye model 显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Commun2004，158，1： | 1 |
| 15 | Gibbs:isother- mal-isobaric thermodynamics of solids from energy curves using a quasi-harmonic Debye model显示文摘 | Blaneo M A Francisco E Luana V | 2004 | Comp Phys Commun2004，158，： | 1 |
| 16 | GIBBS : i- sothermal-isobaric thermodynamics of solids from energy curves using a quasiharmonic Debye model显示文摘 | BLANCO M A FRANCISCO E LUANA V | 2004 | Computer Physics Communications2004，158，1： | 1 |
| 17 | GIBBS: Isothermal-isobaric thermodynamics of solids from energy curves using a quasiharmonic Debye model显示文摘 | Blanco M A Francisco E Luana V | 2004 | Comput Phys Commun2004，158，1： | 1 |
| 18 | Optimizationof J3-glucosidase, |3-xylosidase and xylanase produc-tion by colletotrichum graminicoLa under solid-statefermentation and application in raw sugarcane trashsaccharification 显示文摘 | Ana L R L Z Cesar S?Luana P M | 2013 | Int J Mol Sci2013，14，2： | 1 |
| 19 | GIBBS: isothermal-isobaric thermodynamics of solids from energy curves using a quasi-harmonic De- bye model显示文摘 | Blanco M A Francisco E Luana V | 2004 | ComputPhys Commun2004，158，1： | 1 |
| 20 | GIBBS: Isothermal-isobaric thermodynamics of solids from ener- gy curves using a quasiharmonic Debye model 显示文摘 | BLANCO M A FRANCISCO E LUANA V | 2004 | Computer Physics Communications2004，158，1： | 1 |
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