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| 1 | Type 2 diabetes mellitus and CA 19-9 levels显示文摘AIM:To prospectively investigate serum CA 19-9 levels in type 2 diabetic patients in comparison with age-and gender-matched control subjects. METHODS:We recorded duration of diabetes and examined fasting glucose levels,HbA1c levels and serum CA 19-9 levels in 76 type 2 diabetic patients and 76 controls.Abdominal CT was performed in order to eliminate abdominal malignancy in the diabetic and control groups. RESULTS:The average CA 19-9 level was 46.0±22.4 U/mL for diabetic patients whereas it was 9.97±7.1 U/mL for the control group(P<0.001).Regression analysis showed a positive correlation between diabetes and CA 19-9 independent from age,gender,glucose level and HbA1c level(t=8.8,P<001).Two of the diabetic patients were excluded from the study because of abdominal malignancy shown by CT at the initial evaluation.For all patients,abdominal CT showed no pancreatic abnormalities. CONCLUSION:CA 19-9 is a tumor-associated antigen, which is elevated in pancreatic,upper gastrointestinal tract,ovarian hepatocellular,and colorectal cancers,as well as in inflammatory conditions of the hepatobiliary system,biliary obstruction and in thyroid diseases. Diabetes has been claimed to be a risk factor for pancreatic cancer,which is increasing its incidence and has one of the lowest survival rates of all cancers.CA 19-9 is used in the diagnosis of pancreatic cancer but is also a marker of pancreatic tissue damage that might be caused by diabetes.We propose that a higher cut- off value of CA 19-9 should be used in diabetics to differentiate benign and malignant pancreatic disease, and subtle elevations of CA 19-9 in diabetics should be considered as the indication of exocrine pancreatic dysfunction. | Oya Uygur-Bayramicli Resat Dabak Ekrem Orbay Can Dolapclo■lu Mehmet Sargin Gamze Kilico■lu Yüksel Güleryüzlü Alpaslan Mayada■li | 2007 | World Journal of Gastroenterology2007，13，40： | 63 |
| 2 | Vasculogenic mimicry is a prognostic factor for postoperative survival in patients with glioblastoma显示文摘A previous report has confirmed the existence and clinical significance of vasculogenic mimicry(VM)in glioma.However,its conclusions about the negative clinical significance of VM in glioblastoma are based on a small group of patients and,thus,might be unconvincing.The aim of the present study was to reevaluate the clinical significance of VM in glioblastoma.Patients were classified as VM-positive or | Wang SY Ke YQ Lu GH Song ZH Yu L Xiao S Sun XL Jiang XD Yang ZL Hu CC | 2013 | 中国神经肿瘤杂志2013，11，3： | 22 |
| 3 | The effect of retinoic acid on Ito cell proliferation and content of DNA and RNA显示文摘 | Gao ZL Li DG Lu HM Gu XH | 1999 | World Journal of Gastroenterology1999，5，5： | 13 |
| 4 | Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles显示文摘 | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 4 |
| 5 | Toll-like receptors and cytokines/ cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine显示文摘 | ChenJ Liang ZL Lu F | 2011 | Vaccine2011，29，4： | 1 |
| 6 | Partial liquid ventilation confers protection against acute lung injury induced by endotoxin in juvenile piglets显示文摘 | Guo ZL Lu GP Ren T | | 0，，3： | 1 |
| 7 | hTERT-based therapy: a Universal anticancer approach (review) 显示文摘 | Lu MH Liao ZL Zhao XY | 2012 | Oncology Reports2012，28，： | 1 |
| 8 | Xuezhikang,an extract of cholestin,reduces cardiovascular events in type 2 diabetes patients with coronary heart disease:subgroup analysis of patients with type 2 diabetes from China coronary secondary prevention study (CCSPS)显示文摘 | Zhao SP Lu ZL Du BM | 2007 | J Cardiovasc Pharmacol2007，49，2： | 1 |
| 9 | Category and perceptual learningin subjects with treated Wilson’s disease 显示文摘 | Xu P Lu ZL Wang XP | 2010 | PLoS One2010，5，3： | 1 |
| 10 | Metabonomic study on Kidney-Yang Deficiency syndrome' and intervention effects of Rhizoma Drynariae extracts in rats using ultra performance liquid chromatography coupled with mass spectrometry 显示文摘 | Lu XM Xiong ZL Li J J | 2011 | Talanta2011，83，3： | 1 |
| 11 | Effects of D-cycloserine on extinction and reinstatement of morphine-induced conditionedplace preference显示文摘 | Lu GY Wu N Zhang ZL | 2011 | Neurosci Lett2011，503，3： | 1 |
| 12 | 2013, Reproductive parameters of fe- male Macaca mulatta tcheliensis in the temperate forest of Mount Taihangshan, Jiyuan, China显示文摘 | Tian JD Wang ZL Lu JQ | 2013 | American Journal of Primatology2013，75，60： | 1 |
| 13 | Calcium-sensing receptors regu- late cardiomyocyte Ca2 signaling via the sarcoplasmic reticulum-mi- tochondrion interface during hypoxia/reoxygenation 显示文摘 | Lu FH Tian ZL Zhang WH | 2010 | J Biomed Sci2010，17，： | 1 |
| 14 | Generating high gray-level resolution monochrome displays with conventional computer graphics cards and color monitors显示文摘 | Li X Lu ZL Xu P | 2003 | J Neurosci Methods2003，130，1： | 1 |
| 15 | Gonadotropin-releasing hormone analog structural determinants of selectivity for inhibition of cell growth : support for the concept of ligand-induced selective signaling显示文摘 | Lopez de Maturana R Pawson AJ Lu ZL | 2008 | Mol Endocrinol2008，，： | 1 |
| 16 | Arsenic trioxide induce gallbladder carcinoma cell apoptosis via downregulation of Bcl-2显示文摘 | Ai ZL Lu WQ Qin XY | 2006 | BBRC2006，8，348： | 1 |
| 17 | RCesaealrcchium-sensing receptors regulate cardiomyocyte Ca2+ signaling via the sarcoplasmic reticulum-mitochondrion interface during hypoxia/reoxygenation显示文摘 | Lu FH Tian ZL Zhang WH | 2010 | J Biomed Sci2010，17，： | 1 |
| 18 | Impact of long-term Xuezhikang therapy on cardiovascular events in high-risk patients with nonspecific,preexisting kiver tests:a post-hoc analysis from Chinese Coronary Secondary Prevention Study (CCSPS)显示文摘 | Li JJ Lu ZL kou WR | | 0，，： | 1 |
| 19 | Processes and factors controlling N2O production in an intensively managed low carbon calcareous soil under sub-humid monsoon conditions显示文摘 | Ju XT Lu X Gao ZL | 2011 | Environmental Pollution2011，159，4： | 1 |
| 20 | Baicalein reduces lipopolysac- charide-induced inflammation via suppressing JAK/ STATs activation and ROS production显示文摘 | Qi ZL Yin F Lu LA | 2013 | Inflamm Res2013，62，9： | 1 |
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