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| 1 | CT arterial portography and CT hepatic arteriography in detection of micro liver cancer显示文摘AIM To recognize the characteristic findings of micrQliver cancer (MLC) and to evaluate the effect of CT arterial portography (CTAP) and CT hepatic arteriography (CTHA) in diagnosis of MLC. METHODS Between April 1996 to December 1998, CTAP and CTHA were performed in 12patients with MLC, which were not detect ed byconventional CT examinations. After CTHA, 3 mL-- 5 mL mixture of lipiodol, doxorubic in andmitomycin C were injected into hepatic arterythrough the catheter, and then followed up by CTthree or four weeks later (Lipiodol CT LP-CT).RESULTS A total of 22 micro--tumors (0 .2 cm 0.6 cm in diameter ) were detected in 12patients, which manifested as small perfusiondefects in CTAP and small round enhancement inCTHA. The rate of detectability of CTAP andCTHA was 68.2% (15/ 22) and 77.3% (17/ 22)respectively, and the rate of the simultaneoususe of both procedures reached 86. 4% (19/ 22 ).All micro--tumors were demonstrated as punctatelipiodol deposit fool in LP--CT. After LP--CT, theelevated serum level of Q-fetoprotein (AFP)dropped to the normal level in all patients.CONCLUSION The CTAP and CTHA are the mostsensitive imaging methods for detecting microIiver cancer. Confirmed by the change of theelevated serum AFP level and lipiodol depositfool in LP-CT, small perfusion defects in CTAPand punctate enhancement in CTHA may suggestmicro--liver cancer. | Li L Wu PH Mo YX Lin HG Zheng L Li JQ Lu LX Ruan CM Chen L | 1999 | World Journal of Gastroenterology1999，5，3： | 16 |
| 2 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 3 | Transactivation of the TIEG1 confers growth inhibition of transforming growth factor-β-susceptible hepatocellular carcinoma cells显示文摘AIM:To investigate the role of transforming growth factor(TGF)-β-inducible early gene 1(TIEG1) in TGF-β-induced growth inhibition in hepatocellular carcinoma(HCC) cells.METHODS:Human hepatocyte and HCC cell lines with varied susceptibilities to TGF-β1 were tested by methylthiazoletetrazolium(MTT) assay.The expression changes of Smad2,Smad3,Smad4,Smad7,TIEG1 and TIEG2 gene following treatment with TGF-β1 in a TGF-β-sensitive hepatocyte cell line(MIHA),a TGF-β-sensitive hepatoma cell line(Hep3B) and two TGF-β-insensitive hepatoma cell lines(HepG2 and Bel7404) were examined.SiRNA targeting TIEG1 was transfected into Hep3B cells and the sensitivity of cells to TGF-β1 was examined.Overexpression of TIEG1 was induced by lentiviral-mediated transduction in TGF-β1-resistant hepatoma cell lines(Bel7404 and HepG2).MTT assay and 4',6-Diamidino-2-phenylindole staining were used to identify cell viability and apoptosis,respectively.The expression level of stathmin was measured by reverse transcriptase polymerase chain reaction and Western-blotting analysis,and stathmin promoter activity by TIEG1 was monitored by a luciferase reporter gene system.RESULTS:TIEG1 was significantly upregulated by TGF-β1 in the TGF-β1-sensitive HCC cell line,Hep3B,but not in the resistant cell lines.The suppression of TIEG1 by siRNAs decreased the sensitivity of Hep3B cells to TGF-β1,whereas the overexpression of TIEG1 mediated growth inhibition and apoptosis in TGF-β1-resistant HCC cell lines,which resembled those of TGF-β1-sensitive HCC cells treated with TGF-β1.Our data further suggested that stathmin was a direct target of TIEG1,as stathmin was signif icantly downregulated by TIEG1 overexpression,and stathmin promoter activity was inhibited by TIEG1 in a dose-dependent manner.CONCLUSION:Our data suggest that transactivation of TIEG1 conferred growth inhibition of TGF-β-susceptible human HCC cells. | Lei Jiang Yiu-Kay Lai Jin-Fang Zhang Chu-Yan Chan Gang Lu Marie CM Lin Ming-Liang He Ji-Cheng Li Hsiang-Fu Kung | 2012 | World Journal of Gastroenterology2012，18，17： | 13 |
| 4 | Type Ⅱ Vanilloid Receptor Signaling System:One of the Possible Mechanisms for the Rise in Asthma Cases显示文摘 | Li CM Qiao Y | 2005 | Frontiers in Bioscimce2005，10，： | 1 |
| 5 | How to simplify the diagnostic criteria of hypertension in adolescents显示文摘 | LU Q MA CM YIN FZ | 2011 | J Hum Hypertens2011，25，3： | 1 |
| 6 | Fascaplysin, an unusual antimicrobial pigment from the marine sponge Fascaplysinopsis sp 显示文摘 | Roll DM Ireland CM Lu HSM | 1988 | J Org Chem1988，53，： | 1 |
| 7 | Peptide biomarker discovery for iden- tification of methicillin-resistant and vancomycin-intermediate Staphylococcus anreus strains by MALDI-TOF 显示文摘 | Lu JJ Tsai FJ Ho CM | 2012 | Anal Chem2012，84，13： | 1 |
| 8 | Durability of lamivudine-induced HBeAg seroconversion for chronic hepatitis B patients with acute exacerbation显示文摘 | Lee CM Ong GY Lu SN | 2002 | Hepatol2002，37，： | 1 |
| 9 | Molecular epldemiological and clinical aspects of hepatitis D virus in a unique triple hepatitis viruses (B, C, D) endemic community in Taiwan显示文摘 | Lu SN Chen TM Lee CM | 2003 | J Med Virol2003，70，1： | 1 |
| 10 | Educational diagnosis of self- management behaviors of parents with asthmatic children by tri- angulation based on PRECEDE-PROCEED model in Taiwan 显示文摘 | Chiang LC Huang JL Lu CM | 2003 | Patient Education and Counseling2003，49，1： | 1 |
| 11 | PPARregulates hy-poxia-induced Nox4 expression in human pulmonary artery smoothmuscle cells through NF-κB显示文摘 | Lu XH Murphy TC Nanes MS Hart CM | 2010 | Am J Physiol Lung Cell Mol-Physiol2010，299，4： | 1 |
| 12 | A nearly vision based snake model for ultrasound image segmentation显示文摘 | Chen CM Lu HHS Lin YC | 2000 | Ultrasound in Med&Biol2000，26，2： | 1 |
| 13 | How to simplify the diagnostic criteria of hypertension in adolescents显示文摘 | Lu Q Ma CM Yin FZ | 2011 | J Hum Hyper- tens2011，25，3： | 1 |
| 14 | Guidelines for prevention and control of overweight and obesity in Chinese adults 显示文摘 | Chen CM Lu FC | 2004 | Biomed Environ Sci2004，17，1： | 1 |
| 15 | The Effects of Music asTherapy on the Overall Well - Being of Elderly Patients onMaintenance Hemodialysis显示文摘 | Lin YJ Lu KC Chen CM | 2012 | Biological research for nurs-ing2012，14，3： | 1 |
| 16 | Homocysteine inhibits ar- terial endothelial cell growth through transcriptional downregulation of fibroblast growth factor-2 involving G protein and DNA methylation显示文摘 | Chang PY Lu SC Lee CM | 2008 | Circ Res2008，102，： | 1 |
| 17 | Outcome of palliative total gas- trectomy for stage IV proximal gastric cancer显示文摘 | Zhang JZ Lu HS Huang CM | 2011 | Am J Surg2011，202，1： | 1 |
| 18 | Up-regulation of Bax and endonuclease G,and down-modulation of Bcl-XL in-volved in cardiotoxin m-induced apoptosis in K562 cells 显示文摘 | Yang SH Chien CM Lu MC | 2006 | Exp Mol Med2006，38，4： | 1 |
| 19 | Fifteen cases of penicilliosis in Guangdong,China显示文摘 | Xi LY Lu CM Zhou XY | 2004 | Mycopathologia2004，158，2： | 1 |
| 20 | Learning curve of la- paroscopy spleen-preserving splenic hilar lymph node dissection for advanced upper gastric cancer显示文摘 | Lu J Huang CM Zheng CH | 2012 | Hepato- gastroenterology2012，60，122： | 1 |
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