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| 1 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 2 | PHOTOELECTROCHEMICAL STUDY OF PASSIVE LAYERS ON COPPER ELECTRODES IN SOME ALKALINE MEDIA显示文摘PHOTOELECTROCHEMICALSTUDYOFPASSIVELAYERSONCOPPERELECTRODESINSOMEALKALINEMEDIA①A.Kamkina,1,ZhouGuodinga,XuQunjiebandB.H.cLooaE... | A. Kamkina,1, Zhou Guodinga, Xu Qunjieb and B. H.c Loo a Electrochemical Research Group, Shanghai Institute of Electric Power, Shanghai 200090, P. R. China b Corrosion Prevention Center, East China University of | 1998 | 中国有色金属学会会刊:英文版1998，8，2： | 2 |
| 3 | Preparation and molecular structure of polyvinyl alcohol by low temperature bulk polymerization of vinyl acetate and saponification显示文摘 | Loo W S Lee C J | 2000 | Int J PolymerMater2000，46，12： | 1 |
| 4 | Computer Models for Fading Channels with Applications to Digital Transmission显示文摘 | Loo C Second N | 1991 | IEEE Transactions on VT1991，40，4： | 1 |
| 5 | Multi-objective simulation-based evolutionary algorithm for an aircraft spare parts allocation problem显示文摘 | Loo H L Ek P C Suyan T | 2008 | European Journal of Operational Research2008，189，： | 1 |
| 6 | High(15 Hz)and low(1 Hz) frequency transcranial magnetic stimulation have different acute ef- fects on regional cerebral blood flow in depressed patients显示文摘 | Loo C K Sachdev P S Haindl W | 2003 | Psy chol Med2003，33，99： | 1 |
| 7 | Cubic AgPb, SbTez+,, : bulk thermoelectric materials with high figure of merit 显示文摘 | Hsu K F Loo S Guo F Chen W Dyck J S Uher C Hogan T Polychroniadis E K Kanatzidis M G | 2004 | Science2004，303，： | 1 |
| 8 | Airway inflammation and IgE production induced by dust mite allergen-specific memory/effector Th2cell line can be effectively attenuated by IL-35显示文摘 | HUANG C H LOO E X KUO I C | 2011 | J Immunol2011，187，： | 1 |
| 9 | Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation显示文摘 | Onno J de Boer Floris Hirsch Allard C van der Wal Chris M van der Loos Pranab K Das Anton E Becker | 1997 | Atherosclerosis1997，，2： | 1 |
| 10 | Immunotargeted nanoshells for Integrated cancer imaging and therapy 显示文摘 | Loo C Lowery A Halas N J | 2005 | Nano Lett2005，5，： | 1 |
| 11 | Physical treatments for bipolar disorder:a review of electroconvulsive therapy,stereotactic surgery and other brain stimulation techniques显示文摘 | Loo C Katalinic N Mitchell PB et al | 2011 | Journal Of Affective Disorders2011，132，12： | 1 |
| 12 | Relevant anatomy for botulinum toxin fa- cial rejuvenation显示文摘 | LOOS B M MAAS C S | 2003 | Facial Plastic Surgery Clinics of North Ameri- ca2003，11，4： | 1 |
| 13 | Curing of epoxy matrix composites 显示文摘 | LOOS A C SPRINGER G S | 1983 | Journal of Composite Materials1983，17，2： | 1 |
| 14 | A novel approach for unit commitment problem via an effective hybrid particle swarm optimization 显示文摘 | TING T O RAO M V C LOO C K | 2006 | IEEE Trans on Power Systems2006，21，1： | 1 |
| 15 | Streptococcus gordonii biofilm formation: identification of genes that code for biofilm phenotypes显示文摘 | LOO C Y CORLISS D A GANESHKUMAR N | 2000 | Journal of Bacteriology2000，182，5： | 1 |
| 16 | A Statistical Model for a Land Mobile Satellite Link显示文摘 | Loo C | 1985 | IEEE Transactions on VT1985，34，3： | 1 |
| 17 | Curing of Epoxy Matrix Composites显示文摘 | Loos A C Springer G S | 1983 | Journal of Composite Materials1983，17，2： | 1 |
| 18 | Recent advances in radio resource management for heterogeneous LTE/LTE-A networks 显示文摘 | Ying L L Chuah T C Loo J | 2014 | IEEE Communications Surveys & Tutorials2014，16，4： | 1 |
| 19 | Static and Repeated Load Tests on Precast Concrete Beam-to-Column Connections 显示文摘 | Loo Y C Yao B Z | 1995 | PCI Journal1995，，2： | 1 |
| 20 | Multi-objective simulation-based evolutionary algorithm for an aircraft spare parts allocation problem 显示文摘 | Loo H L Ek P C Suyan T | | European Journal of Operational Research0，200，189： | 1 |
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