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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Early Impacts of Limited-stakes Casino Gambling on Rural Community Life显示文摘 | Long P T | 1996 | Tourism Management1996，17，5： | 1 |
| 3 | Effect of laparoscopic hysterectomy on bladder neck and urinary symptoms显示文摘 | Long C Y Hsu S C Wu T P | 2003 | Aust N Z J Obstet Gynaecol2003，43，1： | 1 |
| 4 | Regulation of exoprotease production by temperature and oxygen in Vibrio algirmlyticus 显示文摘 | HARE P LONG S ROBB F T | 1981 | Arch Microbiol1981，130，： | 1 |
| 5 | Rural Resident's Attitudes Toward Recreation and Tourism Development显示文摘 | ALLEN L R H R HAFER P T LONG | 1993 | Ournal of Travel Research1993，21，4： | 1 |
| 6 | Graph-based active learningbased on label propagation显示文摘 | Long J Yin J P Zhao W T | 2008 | Lecture Notes in Computer Sci-ence2008，5285，： | 1 |
| 7 | Resident Attitudes Toward Legal Gambling显示文摘 | Kang Y P T Long R R Perdue | 1996 | Annals of Tourism Research1996，23，1： | 1 |
| 8 | Biomechanics of the double rocker sole shoe: Gait kinematics and kinetics 显示文摘 | Long J T Klein J P Sirota N M | 2007 | J Biomech2007，40，13： | 1 |
| 9 | Hydrogen production for fuel cells via steam reforming of dimethyl ether over commercial Cu/ZnO/AI2O3 and zeolite显示文摘 | LI J ZIIANG Q J LONG X QI P LIU Z T LIU ZW | 2012 | Chem Eng J2012，187，： | 1 |
| 10 | Electrospinning of linear homopolymers of poly(methyl methacrylate):Exploring relationships between fiber formation,viscosity,molecular weight and concentration in a good solvent显示文摘 | GUPTA P ELKINS C LONG T E | 2005 | Polymer2005，46，13： | 1 |
| 11 | Electrospinning of linear homopolymers of poly(methylmethacrylate):exploring relationships between fiberformation,viscosity,molecularweight and concentrationin good solvent显示文摘 | GUPTA P ELKINSET C LONG T E | 2005 | Polymer2005，46，13： | 1 |
| 12 | Integration of methanogensis with simultaneous nitrification and denitrification in a membrane bioreactor显示文摘 | ZHANG D J LU P L LONG T R | | 0，，02： | 1 |
| 13 | Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro 显示文摘 | LONG T C TAJUBA J SAMA P | 2007 | Environ Health Perspect2007，115，11： | 1 |
| 14 | Cellular microcystin con- tent in N-limited Microeystis aeruginosa can be predicted from growth rate显示文摘 | Long B M Jones G J Orr P T | 2001 | Applied and Environmental Microbi- ology2001，67，1： | 1 |
| 15 | A modification of the injury severity score that both improves accuracy and simplifies scoring显示文摘 | Osier T Baker S P Long W | | 0，，6： | 1 |
| 16 | Robust non-homogeneity detec- tion algorithm based on prolate spheroidal wave functions for space-time adaptive processing 显示文摘 | Yang X P Liu Y X Long T | 2013 | IET Radar Sonar and Navigation2013，7，1： | 1 |
| 17 | Influence of counteranion on the thermal and solution behavior of poly(2-(dimethylamino)ethyl methacrylate)-based polyelectrolytes显示文摘 | HUNLEY M T ENGLAND J P LONG T E | 2010 | Macromolecules2010，43，10： | 1 |
| 18 | A quantitative review comparing the yields of two candidate C4 perennial biomass crops in relation to nitrogen,temperature and water 显示文摘 | Heaton E Voigt T Long S P | 2004 | Biomass and Bioenergy2004，27，： | 1 |
| 19 | Adsorbents for dioxins: a new technique for sorbent screening for low-volatile organics 显示文摘 | Yang R T Long R Joel P Akria T | 1999 | Industrial & Eng Chem Res1999，38，7： | 1 |
| 20 | Decreased expression of FENDRR is associated with poor prognosis in gastric cancer and FENDRR regulates gastric cancer cell metastasis by affecting fibroneetinl expression显示文摘 | Xu T P Huang M D Xia the long non-coding RNA R | 2014 | J Hematol Oncol2014，7，： | 1 |
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