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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Mediation ofbenthic -pelagic coupling by microphytobenthos ; an energy- andmaterial-based model for initiation of blooms of Aureococcusanophagefferens 显示文摘 | MACINTYRE H L LOMAS M W Cornwell J | 2004 | Harmful Algae2004，3，40： | 1 |
| 3 | Protecting poorly chosen secrets from guessing attacks显示文摘 | Gong L Lomas M Needham R | 1993 | IEEE J Selected Areas Commun1993，11，5： | 1 |
| 4 | Protecting Poorly Chosen Secrets from Guessing Attacks显示文摘 | Gong L Lomas M Needham R | 1993 | IEEE Journal on Selected Areas in Communications1993，11，5： | 1 |
| 5 | Leuko- cyte apoptosis and its signifieance in sepsis and shock 显示文摘 | Wesche D E Lomas - Neira J L Perl M | 2005 | J Leukoe Bioc2005，78，2： | 1 |
| 6 | Protecting Poorly Cho-sen Secrets from Guessing Attacks显示文摘 | Gong L Lomas M Needham R | 1993 | IEEE Journal on Se-lected Areas in Communications1993，11，： | 1 |
| 7 | Leukocyte apoptosis and its significance in sepsis and shock 显示文摘 | WESCHE D E LOMAS NEIRA J L PERL M | 2005 | J Leukoc Biol2005，78，2： | 1 |
| 8 | Inter annual variability of Aureococcus anophage ffens in Qantuck Bay, Long Island:natural test of the DON hy- pothesis显示文摘 | Lomas M W Kana T M Maclntyre H L | 2004 | Harmful Algae2004，3，4： | 1 |
| 9 | Sex differences in NMDA antagonist enhancement of morphine antihyperalgesia in a eapsaicin model of persistent pain:comparisons to two models of acute pain 显示文摘 | LOMAS L M TERNER J M PICKER M J | 2008 | Pharmacol Biochem Behavior2008，89，2： | 1 |
| 10 | Proteomic analysis of hu- man blood serum using peptide library beads 显示文摘 | Sennels L Salek M Lomas L | 2007 | J Proteome Res2007，6，10： | 1 |
| 11 | Environmental genome shotgun sequencing of the Sargasso sea显示文摘 | Venter J C Remington K Heidelberg J F Halpern A L Rusch D Eisen J A Wu D Paulsen I Nelson K E Nelson W Fouts D E Levy S Knap A H Lomas M W Nealson K White O Peterson J Hoffman J Parsons R Baden-Tillson H Pfannkoch C Rogers Y H Smith H O | 2004 | Science2004，304，5667： | 1 |
| 12 | Proteomic analysis of human blood serum using peptide library beads显示文摘 | SENNELS L SALEK M LOMAS L | 2007 | Journal of Proteome Research2007，6，10： | 1 |
| 13 | Interannual vari- ability of Aureococcus anophagefferens in Quantuck Bay, Long Island: natural test of the IX)N hypothesis显示文摘 | Lomas M W Kana T M MacIntyre H L | 2004 | Harmful Algae2004，3，4： | 1 |
| 14 | Mediation of benthic-pelagic coupling by microphytobenthos:an energy-and material-based model for initiation of blooms of Aureococcus anophagefferens显示文摘 | MacIntyre H L Lomas M W Cornwell J | 2004 | Harmful Algae2004，3，4： | 1 |
| 15 | Stimulation of the brown tide organism ,Aureococcus anophagefferens, by selective nutrient additions to in situ mesocosms显示文摘 | KANA T M LOMAS M W MACINTYRE H L | 2004 | Harmful Algae2004，3，4： | 1 |
| 16 | Proteomic analysis of human blood serum using peptide library, beads 显示文摘 | Sennels L Salek M Lomas L | 2007 | J Proteome Res2007，6，10： | 1 |
| 17 | Src kinase activi- ty is required for integrin ct V 3-mediated activation of nuclear factor-KB 显示文摘 | Courter DL Lomas L Scatena M | 2005 | J Biol Chem2005，280，12： | 1 |
| 18 | Harmful algal blooms in the Chesapeake and coastal bays of Maryland,USA:Comparison of 1997,1998,and 1999 events显示文摘 | Glibert P M Magnien R Lomas M W Alexander J Tan C L Haramoto E Trice M Kana T M | 2001 | Estuaries2001，24，： | 1 |
| 19 | Protecting poorly chosen secrets from guessing attacks显示文摘 | GONG L LOMAS M NEEDHAM R | 1993 | IEEE J Sel Areas Commun1993，11，5： | 1 |
| 20 | Stimulationof the brown tide organism, Aureococcus anophagefferens, by se-lective nutrient additions to in situ mesocosms 显示文摘 | KANA T M LOMAS M W MACINTYRE H L | 2004 | Harmful Al-gae2004，3，4： | 1 |
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