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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Tissue-specific microdissec- tion coupled with protein chip array technologies: applications in re- seach 显示文摘 | Von Eggeling F Davies H Lomas L | 2002 | Biotechniques2002，29，5： | 1 |
| 3 | Two novel non-cationic defensin-like antimicrobial peptides from haemolymph of the female tick, Amblyomma hebraeum显示文摘 | Lai R Lomas L O Jonczy J | 2004 | Biochem J2004，379，： | 1 |
| 4 | Tissue-specific microdissection coupled with proteinChip array technologies:applications in cancer research显示文摘 | Von Eggeling F Davies H Lomas L | 2000 | Biotechniques2000，29，5： | 1 |
| 5 | Mediation ofbenthic -pelagic coupling by microphytobenthos ; an energy- andmaterial-based model for initiation of blooms of Aureococcusanophagefferens 显示文摘 | MACINTYRE H L LOMAS M W Cornwell J | 2004 | Harmful Algae2004，3，40： | 1 |
| 6 | Evaluation of serum CC-16 as a biomarker for COPD in the ECLIPSE cohort 显示文摘 | Lomas D A Silverman E K Edwards L D etal | 2008 | Thorax2008，63，10： | 1 |
| 7 | The mechanism of Z alpha 1-antitrypsin accumulation in the liver显示文摘 | LOMAS D A EVANS D L FINCH J T | 1992 | Nature1992，357，6379： | 1 |
| 8 | Tissue-specific microdissection coupled with protein chip array technologies:applications in cancer research显示文摘 | Eggeling F Davies H Lomas L | 2000 | Biotechniques2000，29，5： | 1 |
| 9 | Effects of spatial and temporal scales on cultural services valu- ation显示文摘 | Martin-Lopez B Gamez-Baggethun E Lomas P L | 2009 | Journal of Environmental Management2009，90，2： | 1 |
| 10 | Tissue-specific microdissection coupled with protein chip array technologies:applications in cancer research显示文摘 | Von Eggeling F Davies H Lomas L | 2000 | Biotechniques2000，29，： | 1 |
| 11 | Tissue-specific microdissection coupled with ProteinChip array technologies: applications in cancer research 显示文摘 | Von Eggeling F V Davies H Lomas L | 2000 | Biotechniques2000，29，5： | 1 |
| 12 | The history of ecosystem services in economic theory and practice: from early notions to markets and payment schemes 显示文摘 | GOMEZ-BAGGETHUN E GROOT R D LOMAS P L | 2010 | Ecological economics2010，69，6： | 1 |
| 13 | Protecting poorly chosen secrets from guessing attacks显示文摘 | Gong L Lomas M Needham R | 1993 | IEEE J Selected Areas Commun1993，11，5： | 1 |
| 14 | Tissue-sypecific microdissection coupled with proteinec hip arrary technologies applicationsin cancer research显示文摘 | yon Eggeling F Davies H Lomas L | 2000 | Biotechniques2000，29，5： | 1 |
| 15 | Descriptors of dyspnea by patients with chronic obstructive pulmonary dis ease versus congestive heart failure显示文摘 | Adelaide SC Suzanne CL Loma L | 2004 | Heart Lung2004，33，2： | 1 |
| 16 | The History of Ecosys- tem Services in Economic Theory and Practice : From Early Notions to Mar- kets and Payment Schemes显示文摘 | Gomez - Baggenthun E De Grot R Lomas P L | 2010 | Ecological Economics2010，，69： | 1 |
| 17 | Tissue-specific microdissecrion coupled with Proteinchip array technologies:applications in cancer research显示文摘 | Von-Eggeling F Davies H Lomas L | 2000 | Biotechniques2000，29，5： | 1 |
| 18 | Protecting Poorly Chosen Secrets from Guessing Attacks显示文摘 | Gong L Lomas M Needham R | 1993 | IEEE Journal on Selected Areas in Communications1993，11，5： | 1 |
| 19 | Leuko- cyte apoptosis and its signifieance in sepsis and shock 显示文摘 | Wesche D E Lomas - Neira J L Perl M | 2005 | J Leukoe Bioc2005，78，2： | 1 |
| 20 | Tissue-specific microdissection coupled with proteinchip array technologies: applications in cancer research显示文摘 | Von Eggeling F Davies H Lomas L | 2000 | Biotechniques2000，29，： | 1 |
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