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| 1 | Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients.显示文摘A substantial proportion of patients with irritable bowel syndrome(IBS) associate their symptoms with the ingestion of specific foods. Therefore, in recent years, scientific research has increasingly focused on the role of diet in IBS and dietary management is now considered an important tool in IBS treatment. This article reviews the main dietary approaches in IBS emphasizing evidence from experimental and observational studies and summarizing the main diet and lifestyle recommendations provided by dietary guidelines and scientific literature. Despite the limited evidence for a beneficial role, general advice on healthy eating and lifestyle is recommended as the first-line approach in the dietary management of IBS. Standard recommendations include adhering to a regular meal pattern, reducing intake of insoluble fibers, alcohol, caffeine, spicy foods, and fat, as well as performing regular physical activity and ensuring a good hydration. Second-line dietary approach should be considered where IBS symptoms persist and recommendations include following a low FODMAP diet, to be delivered only by a healthcare professional with expertise in dietary management. The efficacy of this diet is supported by a growing body of evidence. In contrast, the role of lactose or gluten dietary restriction in the treatment of IBS remains subject to ongoing research with a lack of high-quality evidence. Likewise, further clinical trials are needed to conclude the efficacy of probiotics on IBS symptoms. | Anamaria Cozma-Petrut Felicia Loghin Doina Miere Dan Lucian Dumitrascu | 2017 | World Journal of Gastroenterology2017，23，21： | 16 |
| 2 | Influence of Genista Tinctoria L or Methylparaben on Subchronic Toxicity of Bisphenol A in Rats显示文摘Objective To evaluate the influence of an extract of Genista tinctoria L. herba(GT) or methylparaben(MP) on histopathological changes and 2 biomarkers of oxidative stress in rats subchronicly exposed to bisphenol A(BPA). Methods Adult female Wistar rats were orally exposed for 90 d to BPA(50 mg/kg), BPA+GT(35 mg isoflavones/kg) or BPA+MP(250 mg/kg). Plasma and tissue samples were taken from liver, kidney, thyroid, uterus, ovary, and mammary gland after 30, 60, and 90 d of exposure respectively. Lipid peroxidation and in vivo hydroxyl radical production were evaluated by histological analysis along with malondialdehyde and 2,3-dihydroxybenzoic acid detection. Results The severity of histopathological changes in liver and kidneys was lower after GT treatment than after BPA or BPA+MP treatment. A minimal thyroid receptor antagonist effect was only observed after BPA+MP treatment. The abnormal folliculogenesis increased in a time-dependent manner, and the number of corpus luteum decreased. No significant histological alterations were found in the uterus. The mammary gland displayed specific estrogen stimulation changes at all periods. Both MP and GT revealed antioxidant properties reducing lipid peroxidation and BPA-induced hydroxyl radical generation. Conclusion GT L. extract ameliorates the toxic effects of BPA and is proved to have antioxidant potential and antitoxic effect. MP has antioxidant properties, but has either no effect or exacerbates the BPA-induced histopathological changes. | Daniela-Saveta POPA Pompei BOLFA Bela KISS Laurian VLASE Ramona PLTINEAN Anca POP Cornel CTOI Gianina CRISAN Felicia LOGHIN | 2014 | Biomedical and Environmental Sciences2014，27，2： | 2 |
| 3 | Outeome of pulmonary vein isolation ablation for paroxysmal atrial fibrillation: predictive role of left atrial mechanical dyssynehrony by speckle tracking echocardiography显示文摘 | Loghin C Karimzadehnajar K Ekeruo IA | 2014 | J Interv Card Electrophysiol2014，39，1： | 1 |
| 4 | Efficient sorptionof Cu2+ by composite chelating sorbents based on potato starch-gra/i-polyamidoxime embedded in chitosan beads 显示文摘 | Dragan E S Apopei Loghin D F Cocarta A I | 2014 | ACSApplied Materials & Interfaces2014，6，16： | 1 |
| 5 | A pre-conditioner for the steady-state Navier-Stokes equations显示文摘 | Kay D Loghin D Wathen A | 2002 | SIAM Journal on Scientific Computing2002，24，1： | 1 |
| 6 | The treatment of malignant gliomas显示文摘 | Gilbert M R Loghin M | 2005 | Curr Treat Options Neurol2005，7，： | 1 |
| 7 | Outcome of pulmona- ry vein isolation ablation for paroxysmal atrial fibrillation:predictive role of left atrial mechanical dyssynchrony by speckle tracking echo- cardiography显示文摘 | Loghin C Karimzadehnajar K Ekeruo IA | 2014 | J Interv Card Electrophysiol2014，39，1： | 1 |
| 8 | The cracked tooth: histopathologic and histobacteriologic aspects 显示文摘 | Ricucci D Siqueira JF Jr Loghin S | 2015 | J Endod2015，41，3： | 1 |
| 9 | The use of brachytherapy to treat renal artery in-stent restenosis显示文摘 | Ellis K Murtagla B Loghin C | 2005 | J Interv Cardiol2005，18，： | 1 |
| 10 | Is hard tissue formation in the dental pulp after the death of the primary odontoblasts a regenerative or a reparative process?显示文摘 | Rieueci D Loghin S Lin LM | 2014 | J Dent2014，42，9： | 1 |
| 11 | The treatment of malignant gliomas显示文摘 | Gilbert M R Loghin M | 2005 | Curr Treat Options Neurol2005，7，： | 1 |
| 12 | Oxidative Metabolism of Estrone Modified by Genistein and Bisphenol A in Rat Liver Microsomes显示文摘Genistein, the main isoflavone from soy, and bisphenol A(BPA), a food contaminant, are considered ubiquitous xenoestrogens. Here we investigated the influence of genistein and BPA on estrone(E1) metabolism in rat liver microsomes. Both substances inhibited the 2-hydroxylation and 16α-hydroxylation of E1, but in different degrees, thereby reducing the 2-OH-E1/16α-OH-E1 ratio, a biomarker for the risk of breast cancer. Although the 2-OH-E1/16α-OH-E1 ratio was lower under BPA treatment than under the control condition, the difference was not statistically significant. The 2-OH-E1/16α-OH-E1 ratio was significantly reduced by genistein treatment(P<0.05), and this effect was more pronounced when using a combination of BPA and genistein(P<0.01). Our findings suggest that a synergistic inhibition effect of genistein and BPA on E1 metabolism is associated with an increased risk of breast cancer. | GHELDIU Ana-Maria POPA Daniela-Saveta LOGHIN Felicia VLASE Laurian | 2015 | Biomedical and Environmental Sciences2015，28，11： | 1 |
| 13 | Exuberant biofilm infection in a lateral canal as the cause of short-term endodontic treat- ment failure: report of a case 显示文摘 | Ricucci D Loghin S Siqueira JF Jr | 2013 | J Endod2013，39，5： | 1 |
| 14 | The study of codeine - gluthetim- ide pharmacokinetic interaction in rats 显示文摘 | Popa D Loghin F Imre S | 2003 | J Pharm Biomed Anal2003，32，： | 1 |
| 15 | Experimental research on the sewability of ferromagnetic micro-wires显示文摘 | LOGHIN C URSACHE M IONESCU I | | 0，，04： | 1 |
| 16 | Cyclooxygenase-2 and matrix metal!o-proteinase-9 expressions correlate with tissue inflammation degree in peri- odontal disease显示文摘 | Lazfir L Loghin A Bud ES | 2015 | Rom J Morphol Embryol2015，56，4： | 1 |
| 17 | Enhanced sorption of methylene blue from aqueous solutions by semi-IPN composite cryogels with anionically modified potato starch entrapped in PAAm matrix显示文摘 | Dragan E S Loghin D F A | 2013 | Chemical Engineering Journal2013，234，： | 1 |
| 18 | Common artifacts in PET myo- cardial perfusion images due to attenuation-emission misregistration: clinical significance, causes, and solutions显示文摘 | Loghin C Sdringola S Gould KL | 2004 | J Nucl Med2004，45，： | 1 |
| 19 | Diagnostic value of HBME-1,CD56,Galectin-3 and cytokeratin-19 in papillary thyroid carcinomas and thyroid tumors of uncertain malignant potential显示文摘 | Nechifor-Boil A Cǎtanǎ R Loghin A | 2014 | Rom J Morphol Embryol2014，55，1： | 1 |
| 20 | The use of brachytherapy to treat renal artery in-- stent restenosis显示文摘 | Ellis K Murtagh B Loghin C | 2005 | J Interv Cardiol2005，18，： | 1 |
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