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| 1 | Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis显示文摘AIM: To evaluate insulin resistance, cytolysis and nonalcoholic steatohepatitis (NASH) score (NAS) using the Kleiner and Brunt criteria in 54 patients with NASH and mild-to-moderate hypertension, treated with telmisartan vs valsartan for 20 mo. METHODS: All patients met the NCEP-ATP TM(standard dose 20 mg o.d., n = 28). Treatment had to be taken daily at the same hour with no concomitant medication or alcohol consumption allowed. Neither the patient nor the medical staff was aware of treatment group allocation. Paired liver biopsies obtained at inclusion (visit 1) and end of treatment (EOT) were assessed by a single blinded pathologist, not aware of patient or treatment group. Blood pressure, BMI, ALT, AST, HOMA-IR, plasma triglycerides (TG) and total cholesterol (TC) were evaluated at inclusion and every 4 mo until EOT (visit 6). RESULTS: At EOT we noticed a significant decrease in ALT levels vs inclusion in all patients and this decrease did not differ significantly in group T vs group V. HOMA-IR significantly decreased at EOT vs inclusion in all patients but in group T, the mean HOMA-IR decrease per month was higher than in group V. NAS significantly diminished at EOT in all patients with a higher decrease in group T vs group V. CONCLUSION: Angiotensin receptor blockers seem to be efficient in hypertension-associated NASH. Telmisartan showed a higher efficacy regarding insulin resistance and histology, perhaps because of its specific PPAR-gamma ligand effect. | Eugen Florin Georgescu Reanina Ionescu Mihaela Niculescu Laurentiu Mogoanta Liliana Vancica | 2009 | World Journal of Gastroenterology2009，15，8： | 15 |
| 2 | Contrast-enhanced ultrasonography parameters in neural network diagnosis of liver tumors显示文摘AIM:To study the role of time-intensity curve(TIC) analysis parameters in a complex system of neural networks designed to classify liver tumors.METHODS:We prospectively included 112 patients with hepatocellular carcinoma(HCC)(n = 41),hypervascular(n = 20) and hypovascular(n = 12) liver metastases,hepatic hemangiomas(n = 16) or focal fatty changes(n = 23) who underwent contrast-enhanced ultrasonography in the Research Center of Gastroenterology and Hepatology,Craiova,Romania.We recorded full length movies of all contrast uptake phases and post-processed them offline by selecting two areas of interest(one for the tumor and one for the healthy surrounding parenchyma) and consecutive TIC analysis.The difference in maximum intensities,the time to reaching them and the aspect of the late/portal phase,as quantified by the neural network and a ratio between median intensities of the central and peripheral areas were analyzed by a feed forward back propagation multi-layer neural network which was trained to classify data into five distinct classes,corresponding to each type of liver lesion.RESULTS:The neural network had 94.45% training accuracy(95% CI:89.31%-97.21%) and 87.12% testing accuracy(95% CI:86.83%-93.17%).The automatic classification process registered 93.2% sensitivity,89.7% specificity,94.42% positive predictive value and 87.57% negative predictive value.The artificial neural networks(ANN) incorrectly classified as hemangyomas three HCC cases and two hypervascular metastases,while in turn misclassifying four liver hemangyomas as HCC(one case) and hypervascular metastases(three cases).Comparatively,human interpretation of TICs showed 94.1% sensitivity,90.7% specificity,95.11% positive predictive value and 88.89% negative predictive value.The accuracy and specificity of the ANN diagnosis system was similar to that of human interpretation of the TICs(P = 0.225 and P = 0.451,respectively).Hepatocellular carcinoma cases showed contrast uptake during the arterial phase followed by wash-out in the portal and first seconds of the late phases.For the hypovascular metastases did not show significant contrast uptake during the arterial phase,which resulted in negative differences between the maximum intensities.We registered wash-out in the late phase for most of the hypervascular metastases.Liver hemangiomas had contrast uptake in the arterial phase without agent wash-out in the portallate phases.The focal fatty changes did not show any differences from surrounding liver parenchyma,resulting in similar TIC patterns and extracted parameters.CONCLUSION:Neural network analysis of contrastenhanced ultrasonography-obtained TICs seems a promising field of development for future techniques,providing fast and reliable diagnostic aid for the clinician. | Costin Teodor Streba Mihaela Ionescu Dan Ionut Gheonea Larisa Sandulescu Tudorel Ciurea Adrian Saftoiu Cristin Constantin Vere Ion Rogoveanu | 2012 | World Journal of Gastroenterology2012，18，32： | 11 |
| 3 | Issues and controversies in esophageal inlet patch显示文摘The proximal esophagus is rarely examined,and its inspection is often inadequate.Optical chromoendoscopy techniques such as narrow band imaging improve the detection rate of inlet patches in the proximal esophagus,a region in which their prevalence is likely underestimated.Various studies have reported correlations between these esophageal marks with different issues such as Barrett’s esophagus,but these findings remain controversial.Conflicting reports complicate the process of interpreting the clinical features of esophageal inlet patches and underestimate their importance.Unfortunately,the limited clinical data and statistical analyses make reaching any conclusions difficult.It is hypothesized that inlet patches are correlated with various esophageal and extraesophageal symptoms,diagnoses and the personalized therapeutic management of patients with inlet patches as well as the differential diagnosis for premalignant lesions or early cancers.Due to its potential underdiagnosis,there are no consensus guidelines for the management and follow up of inlet patches.This review focuses on questions that were raised from published literature on esophageal inlet patches in adults. | Adriana Ciocalteu Petrica Popa Mircea Ionescu Dan Ionut Gheonea | 2019 | World Journal of Gastroenterology2019，25，30： | 8 |
| 4 | Psychosocial stress and liver disease status显示文摘'Psychosocial stress' is an increasingly common concept in the challenging and highly-demanding modern society of today. Organic response to stress implicates two major components of the stress system, namely the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Stress is anamnestically reported by patients during the course of disease, usually accompanied by a decline in their overall health status. As the mechanisms involving glucocorticoids and catecholamines have been deciphered, and their actions on immune cell function deeper understood, it has become clear that stress has an impact on hepatic inflam-matory response. An increasing number of articles have approached the link between psychosocial stress and the negative evolution of hepatic diseases. This article reviews a number of studies on both human populations and animal models performed in recent years, all linking stress, mainly of psychosocial nature, and the evolution of three important liver-related pathological entities: viral hepatitis, cirrhosis and hepatocellular carcinoma. | Cristin Constantin Vere Costin Teodor Streba Letitia Maria Streba Alin Gabriel Ionescu Felix Sima | 2009 | World Journal of Gastroenterology2009，15，24： | 7 |
| 5 | Effect of niobium alloying level on the oxidation behavior of titanium aluminides at 850°C显示文摘This work addresses the alloying of titanium aluminides used in aircraft engine applications and automobiles. The oxidation resistance behavior of two titanium aluminides of α_2 + γ(Ti_3Al + TiA l) and orthorhombic Ti_2NbAl, recognized as candidates for high-temperature applications, was investigated by exposure of the alloys for 100 h in air. Thus, oxidation resistance was expressed as the mass gain rate, whereas surface aspects were analyzed using scanning electron microscopy in conjunction with energy-dispersive X-ray spectroscopy, and the type of oxidation products was analyzed by X-ray diffraction and Raman spectroscopy. The orthorhombic Ti_2NbAl alloy was embrittled, and pores and microcracks were formed as a result of oxygen diffusion through the external oxide layer formed during thermal oxidation for 100 h. | Alexandra Banu Maria Marcu Simona Petrescu Nicolae Ionescu Alexandru Paraschiv | 2016 | International Journal of Minerals,Metallurgy and Materials2016，23，12： | 2 |
| 6 | Thermodynamics of protein unfolding:questions pertinent to testing the validity of the two - state model 显示文摘 | Eftink M R Ionescu R | 1997 | Biophysical Chemistry1997，64，13： | 1 |
| 7 | Enhenced cleavage of type Ⅱ collagenases in osteoarthritic cartilage显示文摘 | Billinghurst RC Dahlberg L Ionescu M | 1997 | J Clin Invest1997，99，7： | 1 |
| 8 | Ligands for natural killer cell-acticating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias显示文摘 | Nowbakht P Ionescu M C Rohner A | 2005 | Blood2005，105，9： | 1 |
| 9 | Hyperprolactinemia and pregnancy显示文摘 | Ionescu O Vulpoi C Cristea C | 2002 | Rev Med Chir Soc Med Nat Lasi2002，106，1： | 1 |
| 10 | Initial/final state selection of the spin polarization in electron tunneling across an epitaxial Fe/GaA(OOI) interface显示文摘 | KUREBAYASHI H STEINMULLER S J LALOE J B TRYPINIOTIS T EASTON S IONESCU A YATES J R BLAND J A C | 2007 | Appl Phys Lett2007，91，10： | 1 |
| 11 | Double-gate tunnel FET with high-k gate dielectric显示文摘 | BOUCART K IONESCU A M | 2007 | IEEE Transactions on Electron Devices2007，54，7： | 1 |
| 12 | Differential diagno- sis of abdominal wall defects-omphalocele versus gas- troschisis显示文摘 | Ionescu S Mocanu M Andrei B | 2014 | Chirurgia(Bucur)2014，109，1： | 1 |
| 13 | Defining anxious depression: a review of the literature显示文摘 | Dawn F. Ionescu Mark J. Niciu Ioline D. Henter Carlos A. Zarate | 2013 | CNS Spectrums2013，，5： | 1 |
| 14 | A new method for prepar- ing electrospinning-derived carbon nanofiber webs with electro- deposited'Sn-Sb alloy as an anode material of lithium ion batter- ies显示文摘 | Chandra T Ionescu M Mantovani D | 2012 | Materials Science Forum2012，706，1： | 1 |
| 15 | Oral citrus seed extract显示文摘 | IONESCU G KIEHL R WICHMANN K F | 1991 | Journal of Orthomolecular Medicine1991，5，： | 1 |
| 16 | Using NDIS intermediate drivers for extending the protocol stack:A case study显示文摘 | Floroiu J W Ionescu T C Ruppeltr R Henckel B Mateescu M | 2001 | Computer Communications2001，，24： | 1 |
| 17 | Shear behavior ofrailway ballast based on large-scale triaxial tests显示文摘 | lndraratna B Ionescu D Christie H D | 1998 | Journal of Geotechnical & Geoenviromental Engineering1998，124，5： | 1 |
| 18 | Studies on pathogenicity of Yersinia enterocolitica in mice with diabetes mellitus显示文摘 | Dima VF Ionescu MD Popa C | 1999 | Roum Arch Microbiol Immunol1999，58，： | 1 |
| 19 | Neutrophils induce sequential focal changes in endothelial adherens junction components:role of elastase显示文摘 | Ionescu CV Cepinskas G Savickiene J | 2003 | Microcirculation2003，10，： | 1 |
| 20 | Shear behavior of railway ballast based on large- scale triaxial tests 显示文摘 | Indraratna B Ionescu D Christie H D | 1998 | Journal of Geotechnical & Geoenvironmental Engineering1998，124，5： | 1 |
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