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| 1 | Dynamic changes in blood cytokine levels as clinical indicators in severe acute respiratory syndrome显示文摘Objective To investigate the dynamic changes observed in serum levels of interleukins (ILs), tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) in severe acute respiratory syndrome (SARS) patients.Methods Sixty-one cases of SARS with positive antibodies to SARS coronavirus (SARS-CoV) were classified into the following categories: initial stage (3-7 days), peak stage (8-14 days), and remission and recovery stage (15-27 days). Forty-four healthy individuals were used as controls. Serum levels of ILs, TNF-α and TGF-β1 were measured in all subjects. Serum antibodies to SARS-CoV were detected only in SARS cases. Results The mean concentration of serum IL-6 in SARS patients did not differ from that in the control group in initial and peak stages, but became significantly higher in remission and recovery stage compared with the control group, initial and peak stages (P<0.01). The mean concentration of serum IL-8 in SARS patients did not differ from that of the control group in initial stage, but was significantly higher than control group in peak stage and remission and recovery stage (P<0.05). And it was more significantly higher in remission and recovery stage than in peak stage (P<0.01). The mean concentrations of IL-16 and TNF-α in SARS patients were higher than those of the control group for every length of the clinical courses investigated, and were especially high in remission and recovery stage (P<0.01). SARS patients experienced higher concentration of serum IL-13 compared with the controls in initial stage (P<0.01), but returned to normal levels in peak stage and in remission and recovery stage. The mean concentration of serum IL-18 in SARS patients was significantly lower than that of the control group during all clinical courses (P<0.05). The mean concentration of serum TGF-β1 in SARS patients was higher than that of the control group during all clinical courses. Although TGF-β1 in serum decreased in remission and recovery stage in SARS patients, the average was still higher than that of the control group (P<0.01).Conclusions Most proinflammatory cytokines and TGF-β1 were elevated during the early phase of SARS, which may be associated with lung infiltration and proliferation. Concurrently, the mean concentration of serum IL-13 decreased gradually, and the mean concentration of serum IL-18 level in SARS patients was lower than that of the control group during all the courses of SARS, suggesting that the immune state of the patients with SARS was obviously abnormal. Observing the dynamic changes in blood cytokine levels can provide a scientific basis to assess pathogenesis and efficacy of clinical treatment of SARS. | PangBS WangZ ZhangLM TongZH XuLL HuangXX GuoWJ ZhuM WangC LiXW HeZP LiHX ZhaoFJ | 2003 | Chinese Medical Journal2003，，9： | 12 |
| 2 | Anovelicesiurry producing system: Producing ice by utilizing inner waste heat 显示文摘 | LiXW ZhangXS CaoRQ FuXZ | 2009 | Energy Conversion and Management2009，50，： | 1 |
| 3 | FloristicstudyofYunnanprovince[J]显示文摘 | LiXW(李锡文) | | 云南植物研究0，，： | 1 |
| 4 | Materiaeadfloramlabiatarumsinensium(1)[J]显示文摘 | WuCY(吴征镒) LiXW(李锡文) XuanSJ(宣淑洁)etal | | 植物分类学报0，，： | 1 |
| 5 | Emulsifier-freeemulsioncopolymerizationofstyrenewithsodiumstryenesulfonate[J]显示文摘 | LiXW YanCH ZhouCD etal | | 功能高分子学报0，，： | 1 |
| 6 | The potential for palaeo botany in the explanation of Chinas plant geography[J]显示文摘 | LIXW(李锡文) SUNXJ(孙湘君) WALKERD | 1984 | 云南植物研究1984，6，2： | 1 |
| 7 | Developmentandcontrolofcottonredleafdisease(inChinese)显示文摘 | LiXW | 2002 | 中国棉花2002，29，3： | 1 |
| 8 | AfloristicstudyontheseedplantsfromtheregionofYunnanPlateau显示文摘 | LiXW(李锡文) | | 云南植物研究0，，： | 1 |
| 9 | AfloristicstudyontheseedplantsfromtropicalYunnan显示文摘 | LiXW(李锡文) | | 云南植物研究0，，： | 1 |
| 10 | MateriaeadfloramLabiatarumSinensium(1)(中国唇形科植物志资料(一))[J]显示文摘 | WuZY(吴征镒) LiXW(李锡文) XuanSJ(宣淑洁) etal | | 植物分类学报0，，： | 1 |
| 11 | On the boundness of some solutions of the LYU system显示文摘 | ZHANGFC MUCL LIXW | 2012 | Interna- tional Journal of Bifurcation and Chaos2012，22，1： | 1 |
| 12 | Peach genetic resources: diversity, population structure and linkage disequilibrium显示文摘 | LIXW MENGXQ JIAHJ YUML MAR J WANGLR CAO K SHEN Z J NIU L TIAN J B CHEN M J XIE M ARUS P GAO Z S ARANZANA M J | 2013 | BMC Genetics2013，14，： | 1 |
| 13 | Changes in monocyte counts and expression of mCD_( 14)and HLA-DR in the peripheral blood of patients with severe acute respiratory syndrome显示文摘 | WangC XiaCQ XuLL WangZ QinZQ TongZH HuangKW XiaoB QiM JiangBZ LiL WangLH YangX HeSD FengL LiYJ LiAD WangS LiXW HeZP LiuSA ZhaoCH WuH HuangC ZhaoLZ LiJR YangDL LuSF AnYQ | 2004 | Chinese Medical Journal2004，，4： | 0 |
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