|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Optimization approach of background value and initial item for improving prediction precision of GM(1,1) model显示文摘A combination method of optimization of the background value and optimization of the initial item is proposed. The sequences of the unbiased exponential distribution are simulated and predicted through the optimization of the background value in grey differential equations. The principle of the new information priority in the grey system theory and the rationality of the initial item in the original GM(1,1) model are fully expressed through the improvement of the initial item in the proposed time response function. A numerical example is employed to illustrate that the proposed method is able to simulate and predict sequences of raw data with the unbiased exponential distribution and has better simulation performance and prediction precision than the original GM(1,1) model relatively. | Yuhong Wang Qin Liu Jianrong Tang Wenbin Cao Xiaozhong Li | 2014 | Journal of Systems Engineering and Electronics2014，25，1： | 32 |
| 2 | Distribution and assessment of heavy metals in the surface sediment of Yellow River, China显示文摘Large amounts of heavy metals discharged by industrial cities that are located along the middle reach of Yellow River, China have detrimental impacts on both the ecological environment and human health. In this study, fourteen surface sediment samples were taken in the middle reach of the Yellow River. Contents of Zn, Pb, Ni, Cu, Cr, Cd, As were measured, and the pollution status was assessed using three widely used pollution assessment methods, including the single factor index method, Nemerow pollution index method and potential ecological risk index. The concentrations of the studied heavy metals followed the order: Zn > Cr > Cu > Ni > Pb > As > Cd. Nearly 50% of sites had Cu and Cr accumulation. The concentration of Cu at the Yiluo River exceeded the secondary standard value of the Environmental quality standard for soils. Comparison of heavy metal concentrations between this study and other selected rivers indicated that Cu and Cr may be the major pollutants in our case. The single factor index indicated that many samples were at high levels of pollution for Cu and Cd; the Nemerow pollution index indicated that the Yihe River, Luohe River, Yiluo River and Huayuankou were polluted. According to the results of potential ecological risk assessment, Cd in the tributaries of Luo River, Yihe River,and Yiluo River showed high risk toward the ecosystem and human health, Cd in Huanyuankou and Cu in Yiluo River showed a middle level of risk and other samples were at a low level of risk. | Nan Yan Wenbin Liu Huiting Xie Lirong Gao Ying Han Mengjing Wang Haifeng Li | 2016 | Journal of Environmental Sciences2016，28，1： | 33 |
| 3 | Correction of β-thalassemia mutant by base editor in human embryos显示文摘 | Puping Liang Chenhui Ding Hongwei Sun Xiaowei Xie Yanwen Xu Xiya Zhang Ying Sun Yuanyan Xiong Wenbin Ma Yongxiang Liu Yali Wang Jianpei Fang Dan Liu Zhou Songyang Canquan Zhou Junjiu Huang | 2017 | Protein & Cell2017，8，11： | 34 |
| 4 | 外商直接投资对中国经济高质量发展的影响——基于Index DEA和面板分位回归的分析显示文摘改革开放40多年来,我国引进了大量外商直接投资(FDI),不仅增加了资本供给和劳动力需要,还促进了我国经济增长与发展。十九大报告指出我国经济已由高速增长阶段转向高质量发展阶段。为了探究FDI是否会对我国经济高质量发展产生影响,本文基于2003-2016年的省级面板数据,从经济基本面、社会发展以及生态环境成果三个维度出发,首先采用Index DEA模型,构建了经济高质量发展指标,进而运用面板分位数回归探究了FDI对经济高质量发展的影响。我们发现,FDI对中西部地区的经济高质量发展会带来显著的积极作用,能促进当地经济高质量发展,然而对于东部地区而言却有相反的作用。分析结果表明,在10%-30%分位点下,FDI对区域经济高质量发展影响不确定,但在40%-80%分位点下,FDI对区域经济高质量发展有显著正向影响。这将为研究中国区域经济高质量发展提供参考,并为地方政府合理引进外商直接投资、实现由经济增长阶段向经济高质量发展阶段的转型提供启示。 | 周忠宝 邓莉 肖和录 吴士健 LIU Wenbin | 2022 | 中国管理科学2022，30，5： | 34 |
| 5 | G-CSF is a key modulator of MDSC and could be a potential therapeutic target in colitis-associated colorectal cancers显示文摘Granulocyte 刺激殖民地的因素(G-CSF ) 是嗜中性的 trafficking 的一个必要管理者并且高度在多重肿瘤被表示。Myeloid 导出 suppressor 房间(MDSC ) 由有免疫力的抑制通过多重机制支持肿瘤的前进。尽管有在结肠癌前进的 G-CSF 功能的调查结果, MDSC 规定上的 G-CSF 和它肿瘤生长上的封锁效果的精确机制仍然是调查的一个相称的区域。在这研究,我们在一只老鼠观察了 G-CSF 的 overexpression 联系大肠炎的癌症(CAC ) 当模特儿,它与在老鼠结肠纸巾的 MDSC 的累积一致。进一步,在 vitro,研究证明 G-CSF 能通过信号变换器和表明小径的抄写 3 的使活跃之物(STAT3 ) 支持 MDSC 幸存和激活。而且与适应于不同地区生活的动物控制相比, anti-G-CSF mAb 治疗表明了减少的 MDSC 累积,它在鼠标在瘤尺寸和数字导致了显著减少。我们的结果显示 G-CSF 是在迁居,增长和 MDSC 的功能维护的一个批评调整分子,它能是为联系大肠炎的癌症的一个潜在的治疗学的目标。 | Wenbin Li Xinghua Zhang Yongkang Chen Yibin Xie Jiancheng Liu Qiang Feng Yi Wang Wei Yuan Jie Ma | 2016 | Protein & Cell2016，7，2： | 29 |
| 6 | The crustal structures of the central Longmenshan along and its margins as related to the seismotectonics of the 2008 Wenchuan Earthquake显示文摘In 2010,a 500-km-long wide-angle reflection/refraction seismic profile was completed,running northwest from the central Sichuan Basin.This profile orthogonally crosses the meizoseismal area of great Wenchuan earthquake of 12 May 2008,which occurred in the central part of the Longmenshan.The profile also passes through the northwestern Sichuan Plateau,along which a new deep seismic sounding observation system was set up that was much improved over previous datasets and enabled abundant observations to be recorded.Seismic wave phase records that reflect the structural characteristics of different tectonic blocks,especially the complicated phase features associated with the Wenchuan earthquake,were calculated and analyzed in detail.A 2D crustal P-wave velocity model for the orogenic belt in the central Longmenshan and its margins was determined,and crustal structure differences between the stable Sichuan Basin and the thickened northwestern Sichuan Plateau were characterized.Lithological variations within the upper and lower crust in the interior of the plateau,especially a great velocity decrease and plastic rheological properties associated with strong lithologic weakening in lower crust,were detected.From west to east in the lower crust beneath the orogenic belt lying between the Sichuan Basin and the northwestern Sichuan Plateau,a giant shovel-like upwelling is observed that dips gently in the lower part and at higher angles in the upper part;this is inferred to be related to the fault systems in the central Longmenshan.An upwelling in the upper-middle crust along the eastern margin of the orogenic belt is associated with steeply dipping thrusts that strongly uplift the upper crust and crystalline basement beneath a central fault system in the Longmenshan.The data,combined with an understanding of the regional tectonic stress field and previous geological results,enable a discussion of basin-and-range coupling,orogenic tectonics,the crustal fault system,and the seismogenic tectonic environment of the central Longmenshan along the eastern margin of the Qinghai-Tibet Plateau. | JIA ShiXu LIU BaoJin XU ZhaoFan LIU Zhi FENG ShaoYing ZHANG JianShi LIN JieYan TIAN XiaoFeng LIU QiaoXia GUO WenBin | 2014 | Science China Earth Sciences2014，57，4： | 26 |
| 7 | Three-dimensional crustal velocity structure model of the middle-eastern north China Craton (HBCrust1.0)显示文摘Lithosphere thinning and destruction in the middle-eastern North China Craton(NCC), a region susceptible to strong earthquakes, is one of the research hotspots in solid earth science. All 42 seismic wide-angle reflection/refraction profiles have been completed in the middle-eastern NCC. We collect all the 2-D profiling results and perform gridding of the velocity and interface depth data, building a 3-D crustal velocity structure model for the middle-eastern NCC, named HBCrust1.0, by using the Kriging interpolation method. Our result shows that the first-arrival times calculated by HBCust1.0 fit well with the observations. The result demonstrates that the upper crust is the main seismogenic layer, and the brittle-ductile transition occurs at depths near interface C(the interface between upper and lower crust). The depth of interface Moho varies beneath the source area of the Tangshan earthquake, and a low-velocity structure is found to extend from the source area to the lower crust. Based on these observations, it can be inferred that stress accumulation responsible for the Tangshan earthquake may have been closely related to the migration and deformation of the mantle materials. Comparisons of the average velocities of the whole crust, the upper and the lower crust show that the average velocity of the lower crust under the central part of the North China Basin(NCB) in the east of the craton is obviously higher than the regional average. This high-velocity probably results from long-term underplating of the mantle magma. | DUAN YongHong WANG FuYun ZHANG XianKang LIN JiYan LIU Zhi LIU BaoFeng YANG ZhuoXin GUO WenBin WEI YunHao | 2016 | Science China Earth Sciences2016，59，7： | 24 |
| 8 | Quality Markers of Traditional Chinese Medicine:Concept,Progress,and Perspective显示文摘As the most important complementary medication against a variety of diseases,traditional Chinese medicines(TCMs)have been extensively applied over thousands of years.Current quality control of herbal medicines,however,is in great dispute.Unlike chemical drugs,which have clear and validated quality standards,the content of only one(or a few)compounds of many herbs and preparations is currently assessed as an indicator of quality,even though the assessed compound(s)is neither closely associated with the efficacy nor representative of the medicine as a whole.Based on the clinical use,compatibility of multiple component prescriptions,and manufacturing process of TCM,the new concept of a TCM quality marker that was proposed in previous work is discussed further here.In addition,practical technological approaches are described for the qualitative analysis and quantification of TCMs including herbs,processed products,and preparations,which lead to the discovery and identification of specific chemicals as quality markers and new quality control patterns.The progress that has been made in TCM quality control is also addressed.This work provides useful information for the quality control of herbal medicines in the future. | Yazhuo Li Ying Xie Yufei He Wenbin Hou Maoliang Liao Changxiao Liu | 2019 | Engineering2019，5，5： | 22 |
| 9 | Trends in cancer mortality in China from 2004 to 2018:A nationwide longitudinal study显示文摘Background:The long-term trend in cancer death in a rapidly developing country provides information for cancer prophylaxis.Here,we aimed to identify the trends in cancer mortality in China during the 2004-2018 period.Methods:Using raw data from the national mortality surveillance system of China,we assessed the mortalities of all cancer and site-specific cancers during the 2004-2018 period.The participants were divided into three age groups:≥65 years,40-64 years,and≤39 years.Changing trends in cancer death by gender,residency,and tumor location were estimated using fitting joinpoint models to log-transformed crude mortality rates(CMRs)and age-standardizedmortality rates(ASMRs).Results:Cancer death accounted for 24% of all-cause of death in China during 2014-2018.The CMR of all cancer was 150.0 per 100,000 persons.Cancer was the leading cause of death in the population<65 years.The six major cancer types(lung/bronchus cancer,liver cancer,stomach cancer,esophagus cancer,colorectal cancer,and pancreas cancer)accounted for 75.85% of all cancer deaths.The CMR of all cancer increased while the ASMR decreased during 2014-2018(P<0.001).Lung/bronchus cancer and liver cancer were the leading causes of cancer death in the population<65 years,accounting for 45.31%(CMR)and 44.35%(ASMR)of all cancer death,respectively.The ASMR of liver cancer was higher in the 40-64 years population than in the≥65 years population,in contrast to the other five major cancers.The ASMRs of liver cancer,stomach cancer,and esophagus cancer decreased although they were higher in rural residents than in urban residents;the ASMRs of lung/bronchus cancer,colorectal cancer,and pancreas cancer increased in rural residents although they were higher in urban residents than in rural residents during 2014-2018.Conclusion:Although the ASMR of all cancer decreased in China during 2004-2018,lung/bronchus cancer and liver cancer remained the leading causes of cancer-related premature death.Lung/bronchus cancer,colorectal cancer,and pancreas cancer increased in rural residents. | Dongming Jiang Lijuan Zhang Wenbin Liu Yibo Ding Jianhua Yin Rongbing Ren Qi Li Yifan Chen Jiaying Shen Xiaojie Tan Hongwei Zhang Guangwen Cao | 2021 | Cancer Communications2021，41，10： | 23 |
| 10 | Fegeneration of functional alveoli by adult human SOX9^+ airway basal cell transplantation显示文摘 | Qiwang Ma Yu Ma Xiaotian Dai Tao Ren Yingjie Fu Wenbin Liu Yufei Han Yingchuan Wu Yu Cheng Ting Zhang Wei Zuo | 2018 | Protein & Cell2018，9，3： | 20 |
| 11 | Effective gene editing by high-fidelity base editor 2 in mouse zygotes显示文摘通过相应再结合的指向的点 mutagenesis 广泛地在基因研究被使用了并且为在病人修理引起疾病的变化保持可观的诺言。然而,象 mosaicism 那样的问题和低 mutagenesis 效率继续提出挑战到如此的途径的临床的申请。最近,一个基础编辑器() 在 cytidine (C) 脱氨基酶上造的系统和 CRISPR/Cas9 技术在植物,酵母,和人的房间为指向的点 mutagenesis 作为一个其他的方法被开发。然而,基础编辑器高效地在 deamination 窗口中把 C 变换成 thymidine (T) 是否指向了在鼠标胚胎的基础编辑,仍然保持不清楚是可行的。在这份报告,我们产生了基础编辑的一个修改高保真版本 2 (HF2-BE2 ) ,并且调查了它在老鼠胚胎编辑功效的底。我们发现 HF2-BE2 能高效地把 C 变换成 T,与直到在老鼠胚胎的 100% biallelic 变化效率。不同于 BE3, HF2-BE2 能在目标和非目标海滨上把 C 变换成 T,扩展基础编辑器的编辑范围。令人惊讶地,我们发现 HF2-BE2 能也使脱去氨基对 gRNA 有约束力的区域近似的 C。一起拿,我们的工作表明由基础编辑,和下划线在鼠标产生点变化的可行性小心地优化编辑系统以便消除近似地点的 deamination 的底的需要。 | Puping Liang Hongwei Sun Ying Sun Xiya Zhang Xiaowei Xie Jinran Zhang zhen Zhang Yuxi Chen Chenhui Ding Yuanyan Xiong Wenbin Ma Dan Liu Junjiu Huang Zhou Songyang | 2017 | Protein & Cell2017，8，8： | 17 |
| 12 | Vulnerability of premyelinating oligodendrocytes to white-matter damage in neonatal brain injury显示文摘Premature birth is a significant economic and public health burden, and its incidence is rising. Periventricular leukomalacia (PVL) is the predominant form of brain injury in premature infants and the leading cause of cerebral palsy. PVL is characterized by selective white-matter damage with prominent oligodendroglial injury. The maturation-dependent vulnerability of developing and premyelinating oligodendrocytes to excitotoxic, oxidative, and inflammatory forms of injury is a major factor in the pathogenesis of PVL. Recent studies using mouse models of PVL reveal that synapses between axons and developing oligodendrocytes are quickly and profoundly damaged in immature white matter. Axon-glia synapses are highly vulnerable to white-matter injury in the developing brain, and the loss of synapses between axons and premyelinating oligodendrocytes occurs before any cellular loss in the immature white matter. Microglial activation and astrogliosis play important roles in triggering white-matter injury. Impairment of white-matter development and function in the neonatal period contributes critically to functional and behavioral deficits. Preservation of the integrity of the white matter is likely key in the treatment of PVL and subsequent neurological consequences and disabilities. | Xiao-Bo Liu Yan Shen Jennifer M.Plane Wenbin Deng | 2013 | Neuroscience Bulletin2013，29，2： | 17 |
| 13 | Blocking FSH inhibits hepatic cholesterol biosynthesis and reduces serum cholesterol显示文摘Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease.The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen.In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH)levels become elevated at menopause.In this study,we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis.First,epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels,even after adjustment by considering the effects of serum estrogen,in addition,the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in premenopausal women.Furthermore,we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX)mice,in which a normal level of estrogen (E2)was maintained by exogenous supplementation. Consistently,the results indicate that FSH,independent of estrogen,increases the serum cholesterol level in this mouse model. Moreover,blocking FSH signaling by anti-FSHβ antibody or ablating the FSH receptor (FSHR)gene could effectively prevent hypercholesterolemia induced by FSH injection or high-cholesterol diet feeding.Mechanistically,FSH,via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter,thus preventing FoxO1 from repressing SREBP-2 gene transcription.This effect,in turn,results in the upregulation of SREBP-2,which drives HMGCR nascent transcription and de novo cholesterol biosynthesis,leading to the increase of cholesterol accumulation.This study uncovers that blocking FSH signaling might be a new strategy for treating hypercholesterolemia during menopause, particularly for women in peri-menopause characterized by FSH elevation only. | Yanjing Guo Meng Zhao Tao Bo Shizhan Ma Zhongshang Yuan Wenbin Chen Zhao He Xu Hou Jun Liu Zhenhai Zhang Qiang Zhu Qiangxiu Wang Xiaoyan Lin Zhongli Yang Min Cui Lu Liu Yujie Li Chunxiao Yu Xiaoyi Qi Qian Wang Haiqing Zhang Qingbo Guan Lifang Zhao Shimeng Xuan Huili Yan Yanliang Lin Li Wang Qihang Li Yongfeng Song Ling Gao Jiajun Zhao | 2019 | Cell Research2019，29，2： | 16 |
| 14 | Change analysis of rice area and production in China during the past three decades显示文摘米饭空间时间的分布,它批评为农业,环境并且食物安全研究,被自然条件以及社会经济的开发影响。把数据基于多来源,一个有效模型说出集成可耕地分发,庄稼数据的行政单位统计,农业灌溉数据和庄稼的空间生产分配模型(垃圾)适用性数据,被用来在国家规模与 10-km 象素得到米饭区域和生产的一系列空间分布它向前从1980年代初被使用并且过去常分析空间、时间的变化的模式。结果证明重要变化在 19802010 期间在中国发生在米饭。总的来说,超过 50% 米饭区域减少了,当将近 70% 米饭生产在 19802010 期间在变化区域增加了时。空间地,特别,大多数增加的区域和生产在吉林和 Heilongjiang 在东北中国;特别,大多数减少的区域和生产在区域位于东南中国很快在广东,福建和浙江的都市化。因此,米饭区域的矩心是自从 1980,向东北移动了约 230 km,并且米饭生产大约 320 km,它移动的工具米饭生产向东北比米饭区域快因为东北中国的重要米饭收益增加。结果也证明那个米饭区域变化在米饭生产变化上有明确的影响。米饭生产的大约 54.5% 增加由于播种区域的扩大,当在在米饭的 83.2% 减少附近生产由于米饭区域的收缩时。这暗示米饭生产增加可能由于区域扩大和另外的非区域因素,但是减少米饭生产能大部分被归因于米饭区域减少。 | LIU Zhenhuan LI Zhengguo TANG Pengqin LI Zhipeng WU Wenbin YANG Peng YOU Liangzhi TANG Huajun | 2013 | Journal of Geographical Sciences2013，23，6： | 15 |
| 15 | 2-D P-wave velocity structure of lithosphere in the North China tectonic zone: Constraints from the Yancheng-Baotou deep seismic profile显示文摘We obtained the 2-D P-wave velocity structure of the lithosphere in the eastern North China Craton, Shanxi fault subsidence zone, and Yinchuan-Hetao fault subsidence zone by ray tracking technology based on six groups of clearly identified crustal phases and one group of lithospheric interface reflection phases from seismic recording sections of 21 shots along the 1300-km-long Yancheng-Baotou deep seismic wide-angle reflection/refraction profile. The results indicate significant differences between the lithospheric structure east and west of the Taihang Mountains, which is a gravity-gradient zone as well as a zone of abrupt change in lithospheric thickness and a separation zone of different rock components. East of the Taihang Mountains, the Mesozoic and Cenozoic lithospheric structure of the North China Craton has undergone strong reformation and destruction, resulting in the lithosphere thickness decreasing to 70–80 km. The North China Basin has a very thick Cenozoic sedimentary cover and the deepest point of crystalline basement is about 7.0 km, with the crustal thickness decreasing to about 31.0 km. The crystalline basement of the Luxi uplift zone is relatively shallow with a depth of 1.0–2.0 km and crustal thickness of 33.0–35.0 km. The Subei Basin has a thicker Cenozoic sedimentary cover and the bottom of its crystalline basement is at about 5.0–6.0 km with a crustal thickness of 31.0–32.0 km. The Tanlu fault is a deep fracture which cuts the lithosphere with a significant velocity structure difference on either side of the fault. The Tanlu fault plays an important role in the lithospheric destruction in the eastern part of the North China Craton. West of the Taihang Mountains, the crustal thickness increases significantly. The crust thickness beneath the Shanxi fault depression zone is about 46 km, and there is a low-velocity structure with a velocity of less than 6.1 km s?? in the upper part of the middle crust. Combined with other geophysical study results, our data shows that the lithospheric destruction at the Shaanxi-Shanxi fault depression zone and the Yinchuan-Hetao rift surrounding the Ordos block is non-uniform. The lithosphere thickness is about 80–90 km in the Datong-Baotou area, 75–137 km at the Dingxiang-Shenmu region, and about 80–120 km in the Anyang-Yichuan area. The non-uniform lithospheric destruction may be related to the ancient tectonic zone surrounding the Ordos block. This zone experienced multi-period tectonic events in the long-term process of its tectonic evolution and was repeatedly transformed and weakened. The weakening level is related to the interactions with the Ordos block. The continental collision between the Cenozoic India and Eurasia plates and N-E thrusting by the Qinghai Tibet Plateau block is causing further reformation and reduction of the lithosphere. | DUAN YongHong LIU BaoJin ZHAO JinRen LIU BaoFeng ZHANG ChengKe PAN SuZhen LIN JiYan GUO WenBin | 2015 | Science China Earth Sciences2015，58，9： | 14 |
| 16 | Cropland redistribution to marginal lands undermines environmental sustainability显示文摘Cropland redistribution to marginal land has been reported worldwide;however,the resulting impacts on environmental sustainability have not been investigated sufficiently.Here we investigated the environmental impacts of cropland redistribution in China.As a result of urbanization-induced loss of high-quality croplands in south China(~8.5 t ha^(-1)),croplands expanded to marginal lands in northeast(~4.5 t ha^(-1)) and northwest China(~2.9 t ha^(-1)) during 1990-2015 to pursue food security.However,the reclamation in these low-yield and ecologically vulnerable zones considerably undermined local environmental sustainability,for example increasing wind erosion(+3.47%),irrigation water consumption(+34.42%),fertilizer use(+20.02%) and decreasing natural habitats(-3.11%).Forecasts show that further reclamation in marginal lands per current policies would exacerbate environmental costs by 2050.The future cropland security risk will be remarkably intensified because of the conflict between food production and environmental sustainability.Our research suggests that globally emerging reclamation of marginal lands should be restricted and crop yield boost should be encouraged for both food security and environmental benefits. | Wenhui Kuang Jiyuan Liu Hanqin Tian Hao Shi Jinwei Dong Changqing Song Xiaoyong Li Guoming Du Yali Hou Dengsheng Lu Wenfeng Chi Tao Pan Shuwen Zhang Rafiq Hamdi Zherui Yin Huimin Yan Changzhen Yan Shixin Wu Rendong Li Jiuchun Yang Yinyin Dou Wenbin Wu Liqiao Liang Bao Xiang Shiqi Yang | 2022 | National Science Review2022，9，1： | 13 |
| 17 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 18 | Effects of minor Sc on the microstructure and mechanical properties of Al-Zn-Mg-Cu-Zr based alloys显示文摘Five kinds of Al-Zn-Mg-Cu-Zr based alloys with different Sc additions were prepared by ingot metallurgy. The effects of minor Sc on the microstructure and mechanical properties of Al-Zn-Mg-Cu-Zr based alloys were investigated using tensile tests, optical microscopy (OM), and transmission electron microscopy (TEM). The results show that the ultimate tensile strength and yield strength are improved by 94 and 110 MPa, respectively, and the elongation to failure remains at a reasonable extent (11.1%) in the Al-Zn-Mg-Cu-Zr based alloy with 0.21 wt.% Sc addition after solution heat treatment at 475°C for 40 min and then aged at 120°C for 24 h. The addition of minor Sc induces the formation of Al3(Sc,Zr) particles, which are highly effective in refining the cast microstructures, retarding recrystallization, and pinning dislocations. The increment of strength is attributed mainly to fine grain strengthening, precipitation strengthening of Al3(Sc,Zr) particles, and substructure strengthening. | LI Wenbin PAN Qinglin ZOU Liang LIANG Wenjie HE Yunbin LIU Junsheng | 2009 | Rare Metals2009，28，1： | 12 |
| 19 | A PRIORI ERROR ESTIMATE AND SUPERCONVERGENCE ANALYSIS FOR AN OPTIMAL CONTROL PROBLEM OF BILINEAR TYPE显示文摘在这篇论文,我们为一个模型调查先验的错误估计和超级集中性质最佳的控制问题双线性打申请,它包括某参数评价。州、有肋骨是由片的 discretized 明智的线性功能和控制被片接近明智的经常的功能。我们为控制和州的近似导出先验的错误估计和超级集中分析。我们也在状态附近给最佳的 L2 标准错误估计和几乎最佳的 L<sup>∞</sup>-norm 估计并且有肋骨。结果能乐意地被使用在如此的最佳的控制问题的适应有限元素近似构造后验错误评估者。 | Danping Yang Yanzhen Chang Wenbin Liu | 2008 | Journal of Computational Mathematics2008，26，4： | 12 |
| 20 | Spatio-temporal dynamics of maize cropping system in Northeast China between 1980 and 2010 by using spatial production allocation model显示文摘在地区性的规模上理解庄稼模式和他们的变化是为投射 agro 生态系统动力学的一个批评要求。然而,为印射庄稼区域和产量的分发的工具和方法仍然正在缺乏。基于跨熵的理论,一个空间生产分配模型(垃圾) 为介绍在 19802010 期间在东北中国收割系统的玉米的空间与时间的动力学被开发了。模仿的结果显示了那(1 ) 播种区域向北扩展了到 48 獥的玉米吗? | TAN Jieyang YANG Peng LIU Zhenhuan WU Wenbin ZHANG Li LI Zhipeng YOU Liangzhi TANG Huajun LI Zhengguo | 2014 | Journal of Geographical Sciences2014，24，3： | 12 |
您所在的机构暂未开通此部分的功能，请联系管理员