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| 1 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 2 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 3 | The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells 显示文摘 | Liu BY Mcdermott SP Khwaja SS | 2004 | Proc Natl Acad Sci USA2004，101，12： | 1 |
| 4 | The effects of low frequency electrical stimulation on satellite cell activity in rat skeletal muscle during hindlimb suspension显示文摘 | Zhang BT Yeung SS Liu Y | | 0，，： | 1 |
| 5 | Cadmium-induced apoptosis in mouse liver显示文摘 | Habeebu SS Liu J Klaassen CD | 1998 | Toxicol Appl Pharmacol1998，149，： | 1 |
| 6 | Acute CdMT injection is not a good model to study chronic Cd nephropathy: comparison of chronic CdCl2 and CdMT exposure with acute CdMT injection in rats 显示文摘 | Liu J Liu YP Habeebu SS | 1998 | Toxicol Appl Pharm1998，153，： | 1 |
| 7 | Epigenetic silencing of microRNA-199b-Sp is associated with acquired chemore- sistance via activation of JAG1-Notchl signaling in ovarian cancer 显示文摘 | Liu MX Siu MK Liu SS | 2013 | Oncotarget2013，5，： | 1 |
| 8 | Rapamycin protects heart from ischemia/reperfusion injury independent of autophagy by activating PI3 kinase-Akt pathway and mitochondria K ( ATP ) channel 显示文摘 | Yang SS Liu YB Yu JB | 2010 | Pharmazie2010，65，10： | 1 |
| 9 | Identification of urotensin Ⅱas the endogenous ligand for the orphan G-protein-coupled receptor GPR14显示文摘 | Liu Q Pong SS Zeng Z | 1999 | Biochem Biophys Res Commun1999，266，： | 1 |
| 10 | Abnormal expression of pan-ras,c-myc and tp53 in squamous cell carcinoma of cervix: correlation with HPV and prognosis 显示文摘 | Ngan HY Cheung AN Liu SS | 2001 | OncolRep2001，8，： | 1 |
| 11 | Molecular characterization of de- letional forms of - thalassemia in Taiwan 显示文摘 | Peng CT Liu SC Chiou SS | 2003 | Ann Hematol2003，82，1： | 1 |
| 12 | Multifunctional nanoparticles of biodegrada= blo ~opolymor blend for ~an~~r diagnosi~ and treatment 显示文摘 | I Pan J Liu Y Feng SS | 2010 | Nanom- edicine (Lond)2010，5，3： | 1 |
| 13 | Preparation of the stable core - shell latex particles containing organic -si- loxane in the shell 显示文摘 | Liu B L Zhang BT Cao SS | 2008 | Progress in Organic Coatings2008，61，： | 1 |
| 14 | Crucial roles of NGF in dorsal hom plasticity in partially deafferentated cats 显示文摘 | Liu J Chen SS Dan QQ | 2011 | Growth Fac- tors2011，29，23： | 1 |
| 15 | Beta-cypermethrin impairs reproductive function in male mice by inducing oxidative stress显示文摘 | Wang XZ Liu SS Sun Y | | 0，，： | 1 |
| 16 | The role of implant constraint in revision total knee arthroplasty:Not too little, not too much显示文摘 | Callaghan JJ O' Rourke MR Liu SS | 2005 | J Arthroplasty2005，20，1： | 1 |
| 17 | Polymeric micelles anchored with TAT for delivery of antibiotics across the blood–brain barrier显示文摘 | Liu L Venkatraman SS Yang YY | 2008 | Biopolymers2008，90，5： | 1 |
| 18 | Daphnodorin dimers from Edgeworth- ia ehrysantha with a - glueosidase inhibitory aetivit 显示文摘 | Zhou T Zhang SW Liu SS | 2010 | Phytoehem Lett2010，3，4： | 1 |
| 19 | Effects of inflammatory fac- tors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer显示文摘 | Liu Y Han ZP Zhang SS | 2011 | J Biol Chem2011，286，25： | 1 |
| 20 | Prevalence and risk factors of urinary incontinence among Chinese women in Shanghai显示文摘 | Liu B Wang L Huang SS | 2014 | Int J Clin Exp Med2014，7，3： | 1 |
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