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| 1 | Neuroprotective and neuroregenerative potential of pharmacologically-induced hypothermia with D-alanine D-leucine enkephalin in brain injury显示文摘Neurovascular disorders, such as traumatic brain injury and stroke, persist as leading causes of death and disability – thus, the search for novel therapeutic approaches for these disorders continues. Many hurdles have hindered the translation of effective therapies for traumatic brain injury and stroke primarily because of the inherent complexity of neuropathologies and an inability of current treatment approaches to adapt to the unique cell death pathways that accompany the disorder symptoms. Indeed, developing potent treatments for brain injury that incorporate dynamic and multiple disorder-engaging therapeutic targets are likely to produce more effective outcomes than traditional drugs. The therapeutic use of hypothermia presents a promising option which may fit these criteria. While regulated temperature reduction has displayed great promise in preclinical studies of brain injury, clinical trials have been far less consistent and associated with adverse effects, especially when hypothermia is pursued via systemic cooling. Accordingly, devising better methods of inducing hypothermia may facilitate the entry of this treatment modality into the clinic. The use of the delta opioid peptide D-alanine D-leucine enkephalin(DADLE) to pharmacologically induce temperature reduction may offer a potent alternative, as DADLE displays both the ability to cause temperature reduction and to confer a broad profile of other neuroprotective and neuroregenerative processes. This review explores the prospect of DADLE-mediated hypothermia to treat neurovascular brain injuries, emphasizing the translational steps necessary for its clinical translation. | M.Grant Liska Marci G.Crowley Julian P.Tuazon Cesar V.Borlongan | 2018 | Neural Regeneration Research2018，13，12： | 4 |
| 2 | Enforcing the Discrete Maximum Principle for Linear Finite Element Solutions of Second-Order Elliptic Problems显示文摘The maximum principle is a basic qualitative property of the solution of second-order elliptic boundary value problems.The preservation of the qualitative characteristics,such as the maximum principle,in discrete model is one of the key requirements.It is well known that standard linear finite element solution does not satisfy maximum principle on general triangular meshes in 2D.In this paper we consider how to enforce discrete maximum principle for linear finite element solutions for the linear second-order self-adjoint elliptic equation.First approach is based on repair technique,which is a posteriori correction of the discrete solution.Second method is based on constrained optimization.Numerical tests that include anisotropic cases demonstrate how our method works for problems for which the standard finite element methods produce numerical solutions that violate the discrete maximum principle. | Richard Liska Mikhail Shashkov | 2008 | Communications in Computational Physics2008，3，4： | 2 |
| 3 | Relevance of miR-21 and miR-143 expression in tissue samples of colorectal carcinoma and its liver metastases显示文摘 | Vlastimil Kulda Martin Pesta Ondrej Topolcan Vaclav Liska Vladislav Treska Alan Sutnar Karel Rupert Marie Ludvikova Vaclav Babuska Lubos Holubec Radim Cerny | 2010 | Cancer Genetics and Cytogenetics2010，，： | 2 |
| 4 | CiS-X2Bis (2,2-bipyridyl-4,4-dicarboxylate)-ruthenium(Ⅱ) charge-transfer sensitizes (X=Cl-,Br-,I-,CN-and SCN-) on nanocrystalline TiO2 electrodes显示文摘 | GRATZEL M LISKA P VLACHOPOULOS N | 1993 | J Am Chem Soc1993，115，： | 1 |
| 5 | The ripple effect: Biofuels, food security, and the environment显示文摘 | Naylor R L Liska A J Burke M B | 2007 | Environment: Science and Policy for Sustainable Development2007，49，9： | 1 |
| 6 | Viremia and AIDS in rhesus macaques after intramuscular inoculation of plasmid DNA encoding full-length SIVmac239显示文摘 | Liska V Khimani A H Hofmann-Lehmann R | 1999 | AIDS Res Human Retroviruses1999，15，5： | 1 |
| 7 | Thin lubricating fihns behavior at very high contact pressure显示文摘 | Krupka I ttartl M Liska M | 2006 | Tribol Int2006，39，： | 1 |
| 8 | Cytokeratin serum biomarke- rs in patients with colorectat cancer 显示文摘 | Holdenricder S Stieber P Liska V | 2012 | Anticancer Res2012，32，5： | 1 |
| 9 | Clinical relevance of the expression of mRNA of MMP-7, MMP-9, TIMP-1 ,TIMP-2 and CEA tissue samples from col- oreetal liver metastases 显示文摘 | Sutnaf A Pesta M Liska V | 2007 | Tumor Biol2007，28，5： | 1 |
| 10 | Volar fixed- angle plate os- teosynthesis of unstable distal radius fractures: 12 months results 显示文摘 | Figl M Weninger P Liska M et at | 2009 | Arch Orthop Trauma Surg2009，129，5： | 1 |
| 11 | Recent results from experimental studies on laser–plasma coupling in a shock ignition relevant regime显示文摘 | P Koester L Antonelli S Atzeni J Badziak F Baffigi D Batani C A Cecchetti T Chodukowski F Consoli G Cristoforetti R De Angelis G Folpini L A Gizzi Z Kalinowska E Krousky M Kucharik L Labate T Levato R Liska G Malka Y Maheut A Marocchino P Nicolai T O’Dell | 2013 | Plasma Physics and Controlled Fusion2013，，12： | 1 |
| 12 | Evaluation of an IgM/IgG Sensitive Enzyme Immunoassay and the Utility of Index Values for the Screening of Syphilis Infection in a High-Risk Population显示文摘 | Ernest H. Wong Jeffrey D. Klausner Gloria Caguin-Grygiel Carmela Madayag Kim O. Barber Julia S. Qiu Sally Liska Mark W. Pandori | 2011 | Sexually Transmitted Diseases2011，，6： | 1 |
| 13 | Fifty years of solid-phase extraction in water analysishistorical development and overview显示文摘 | Liska I | 2000 | Journal of Chromatography A2000，885，12： | 1 |
| 14 | The role of sensitivity analysis in ecological modelling显示文摘 | Cariboni J Gatelli D Liska R | 2007 | Ecological Model2007，203，： | 1 |
| 15 | Cis-X2bis(2,2-bipyridyl-4,4-dicarboxylate)-ruthe-nium(Ⅱ)charge-transfer sensitizes(x=c1-,Br-,I-,CN-and SCN-)on nanecrystalline TiO2 Electrodes显示文摘 | Gratzel M Liska P Vlachopoulos N | 1993 | Am Chem Soc1993，115，： | 1 |
| 16 | Pyogenie abscesses of the liver 显示文摘 | Treska V Skalick T Liska V | 2007 | Rozhl Chir2007，86，6： | 1 |
| 17 | Research resource:transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells显示文摘 | Széles L Póliska S Nagy G | 2010 | Molecular Endocrinology2010，24，11： | 1 |
| 18 | Ultra-green construction: Reactive MgO masonry products 显示文摘 | LISKA M AL-TABBAA A | 2009 | Proc Inst Civil Eng-Waste Res Manage2009，162，： | 1 |
| 19 | Tumor markers as useful predictors of survival rate after exploratory laparotomy for liver malignancies 显示文摘 | Liska V Holubec L Treska V | 2007 | Anticancer Res2007，27，4： | 1 |
| 20 | Fifty years of solid-phase extraction in water analysis -historical development and overview显示文摘 | LISKA I | 2000 | Journal of Chromatography A2000，885，： | 1 |
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