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| 1 | Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with, firsthand examples显示文摘纳米技术在药交货广泛地被使用了改进各种各样的疾病的治疗学的结果。巨大的努力在与他们的生物命运和函数的关系集中于 nanoparticles 的物理化学的性质的新奇 nanoparticles 和描述的开发。然而在这些基于纳米技术的药交货系统的设计和评估,交付的药的药理学并且(patho-) 主人的生理学收到了更少的注意。在这评论,我们讨论集成于使纳米技术能的药交货系统和治疗的设计的重要药理学机制,生理的特征,和病理学的因素。第一手的例子被举由利用 1 为癌症治疗说明如此的综合设计策略的原则和优点)到克服的multidrug抵抗的癌症的药药和 drug-nanomaterial 联合的细胞内部的 synergistic 相互作用, 2 )循环系统到的血流动方向为肺转移最大化药交货到肿瘤 neovasculature 和房间 overexpressing integrin 受体, 3 )装饰 nanocarriers 和 t 的内长的脂蛋白关于在糖尿病管理的申请,一个使纳米技术能的靠近环的胰岛素交货系统被设计在生理地相关的时间规模和葡萄糖层次提供动态胰岛素版本。和另外的研究结果,这些例子建议药理学的相互影响的那利用,(patho-) 生理学和纳米技术是一条灵巧的途径与高效率和翻译潜力开发创新的药交货系统和治疗。 | Rui Xue ZHANG Jason LI Tian ZHANG Mohammad A AMINI Chunsheng HE Brian LU Taksim AHMED HoYin LIP Andrew M RAUTH Xiao Yu WU | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 2 | Single-port laparoscopic cholecystectomy vs standard laparoscopic cholecystectomy:A non-randomized,agematched single center trial显示文摘AIM: To compare the safety of single-port laparoscopic cholecystectomies with standard four-port cholecystectomies.METHODS: Between January 2011 and December 2012 datas were gathered from 100 consecutive patients who received a single-port cholecystectomy. Patient baseline characteristics of all 100 single-port cholecystectomies were collected(body mass index, age, etc.) in a database. This group was compared with 100 age-matched patients who underwent a conventional laparoscopic cholecystectomy in the same period. Retrospectively, per- and postoperative data were added. The two groups were compared to each other using independent t-tests and χ2-tests, P values below 0.05 were considered significantly different.RESULTS: No differences were found between both groups regarding baseline characteristics. Operating time was significantly shorter in the total single-port group(42 min vs 62 min, P < 0.05); in procedures performed by surgeons the same trend was seen(45 min vs 59 min, P < 0.05). Peroperative complications between both groups were equal(3 in the single-port group vs 5 in the multiport group; P = 0.42). Although not significant less postoperative complications were seen in the single-port group compared with the multiport group(3 vs 9; P = 0.07). No statistically significant differences were found between both groupswith regard to length of hospital stay, readmissions and mortality. CONCLUSION: Single-port laparoscopic cholecystectomy has the potential to be a safe technique with a low complication rate, short in-hospital stay and comparable operating time. Single-port cholecystectomy provides the patient an almost non-visible scar while preserving optimal quality of surgery. Further prospective studies are needed to prove the safety of the single-port technique. | Yoen TK van der Linden Koop Bosscha Hubert A Prins Daniel J Lips | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 2 |
| 3 | 高血压和心房颤动:流行病学、病理生理学与临床结局的关系显示文摘心房颤动是临床实践中最常见的持续性心律失常。单纯的心房颤动并不多见,更多的是作为心血管病临床表现的一部分,与左心房结构和电信号重构有关。由于在心房颤动人群的患病率高,动脉性高血压在心房颤动及其并发症的发病机制中起重要作用。 | Dzeshka MS Shahid F Shantsila A Lip GYH 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，4： | 2 |
| 4 | Atrial fibrillation显示文摘 | Gregory YH Lip Hung Fat Tse Deirdre A Lane | 2012 | The Lancet . 2012 (9816)2012，，： | 2 |
| 5 | Guidelines for the man- agement of atrial fibrillation The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology ( ESC ) 显示文摘 | Camm A J Kirchhof P Lip G Y H | 2010 | European heart journal2010，31，19： | 1 |
| 6 | Characterization of a transcription terminator of the procyclin PARP A unit of Trypanosoma brucei显示文摘 | Berberof M Pays A Lips S | | 0，，03： | 1 |
| 7 | 显示文摘 | Lip GYH Blann A | 1997 | Cardiovasc Res1997，34，2： | 1 |
| 8 | Comparison of entropy and complexity measures for the assessment of depth of sedation显示文摘 | FERENETS R LIPPING T ANIER A | 2006 | IEEE Trans Biomed Eng2006，，53： | 1 |
| 9 | Management of atrial fibrillation显示文摘 | Lip G Y Tello-Montoliu A | 2006 | Heart2006，92，8： | 1 |
| 10 | Von willebrand factor: a marker of endothelial dysfunction in vascular disorders? 显示文摘 | Lip GYH Blann A | 1997 | Cardiovasc Res1997，34，2： | 1 |
| 11 | Guidelines for the man- agement of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology ( ESC ) 显示文摘 | CAMM A J KIRCHHOF P LIP G Y | 2010 | Eur Heart J2010，31，19： | 1 |
| 12 | Guide- lines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)显示文摘 | CAMM A J KIRCHHOF P LIP G Y | 2010 | Eur Heart J2010，31，： | 1 |
| 13 | Effects of fixed low-dose warfarin, aspirin-warfarin combination therapy, and dose-adjusted warfarin on thrombogenesis in chronic atrial fibrillation 显示文摘 | LI-SAW-HEE F L BLANN A D LIP G Y | 2000 | Stroke2000，31，： | 1 |
| 14 | Guidelines for the man- agement of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the Europeean Society of Cardiology(ESC) 显示文摘 | Camm A J Kirchhof P Lip G Y | 2010 | Eur Heart J2010，31，19： | 1 |
| 15 | Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European So- ciety of Cardiology (ESC) 显示文摘 | Camm A J Kirchhof P Lip G Y | 2010 | Eur Heart J2010，31，19： | 1 |
| 16 | cAMP-Dependent protein kinase (PKA) subunit mRNA levels in postmortem brain from patients with bipolar affective disorder (BD)显示文摘 | CHANG A LIP P WARSH J | 2003 | Brain Res Mol Brain Res2003，116，12： | 1 |
| 17 | Nitrate uptake by roots as regulated by nitrate reduction products of the shoot显示文摘 | Ben-Zioni A Vaadia Y Lips S H | 1971 | Physiol Plant1971，24，： | 1 |
| 18 | Nitrate uptake by roots as regulated by nitrate reduction products of the shoot显示文摘 | Ben-Zioni A Vaadia Y Lips S H | 1971 | Physiol Plant1971，24，： | 1 |
| 19 | Acute kidney iniury global health alert显示文摘 | LIP K BURDMANN E A MEHTA R L | 2013 | Kidney Int2013，83，3： | 1 |
| 20 | von Willebrand factor: a marker of endothelial dysfunction in vascular disorders显示文摘 | Lip GYH Blann A | 1997 | Cardiovasc Res1997，34，2： | 1 |
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