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| 1 | Aquathermolysis of conventional heavy oil with superheated steam显示文摘This paper presents a new aquathermolysis study of conventional heavy oil in superheated steam.A new high temperature autoclave was designed,where volume and pressure could be adjusted. Aquathermolysis was studied on two different conventional heavy oil samples under different reaction times and temperatures.Experimental results show that aquathermolysis does take place for conventional heavy oil.As reaction time increases,the oil viscosity reduces.However,the reaction will reach equilibrium after a certain period of time and won’t be sensitive to any further reaction time any more. Analysis shows that,while resin and asphaltenes decrease,saturated hydrocarbons and the H/C ratio increase after reaction.The main mechanism of aquathermolysis includes hydrogenization,desulfuration reaction of resin and asphaltenes,etc. | Song Guangshou Zhou Tiyao Cheng Linsong Wang Yunxian Tian Guoqing Pi Jian Zhang Zheng | 2009 | Petroleum Science2009，6，3： | 6 |
| 2 | A model for coupling reservoir inflow and wellbore flow in fishbone wells显示文摘A coupling model is proposed in this paper by using the Green Function and Newman's product principle, and the solution method is provided here as well. This model can be used to describe the reservoir inflow and wellbore flow for fishbone wells in an unsteady flow or pseudo-steady flow state. A case study indicates that the bottom hole pressure declines quickly in the unsteady flow period which is very short. The pressure drop per unit time remains unchanged under the pseudo-steady flow conditions. The distribution of flow rate along the main wellbore shows a wave shape under the unsteady flow condition, and the flow rate distribution in each branch is similar. The flow rate distribution along the main wellbore is irregular 'U' shaped under the pseudo-steady flow condition, and the space-symmetrical branches have the same flow distribution pattern. In the initial production period, the flow rate increases significantly as the length of branches and the angle between branches and the main wellbore increase. As the production continues, the length and angle of branches have only a slight effect on the flow in fishbone wells. | Lian Peiqing Cheng Linsong Tan Xuequn Li Linlin | 2012 | Petroleum Science2012，9，3： | 4 |
| 3 | Enhancing DNA vaccine potency against hantavirus by co-administration of interleukin-12 expression vector as a genetic adjuvant显示文摘Background The heavy incidence and mortality of hemorrhagic fever with renal syndrome, as well as no specific drugs in curing the disease,clearly indicate the need for development of the more effective hantavirus vaccine. Refining the DNA vaccination strategy to elicit more clinically efficacious immune responses is now under intensive investigation. In the present study, we examined the effects of using an interleukin-12 expression plasmid as a genetic adjuvant to enhance the immune responses induced by a DNA vaccine based on the S gene encoding nucleocapsid protein against hantavirus.Methods BALB/c mice were immunized three times by intramuscular inoculations of DNA vaccine encoding of hantanvirus nucleocapsid protein alone or in combination with a plasmid expressing murine interleukin-12 (pcIL-12). Booster immunizations were employed 2 times at 2-week interval. To evaluate the humoral and cellular immune responses, antigen-specific lymphocyte proliferation and antibody production were assayed by MTT method and ELISA respectively. The level of interleukin-4 and interferon-γ in the splenic lymphocytic cultured supernatant were detected with ELISA kit at day 5, 10, 17, 35 and 42 after primary immunization.Results Antigen-specific IgG antibodies was increased markedly at day 17 in the experiment groups and reached a plateau after day 35. As pcIL-12 co-injected, a significant inhibition of antigen-specific IgG levels was displayed over the period and the antibody mean titre was decreased to only about 1∶50 at day 42 after primary immunization, significantly lower than the group immunized with pcDNA3.1+S alone, in which the mean titre was about 1∶70. Interferon-γ was increased remarkably by the co-injection of pcIL-12 compared with the injection of pcDNA3.1+S alone. However, the production of interleukin-4 was inhibited by pcIL-12 co-injection. Furthermore, pcIL-12 co-injection efficiently enhanced antigen-specific lymphocyte proliferation.Conclusion Humoral and cytokine responses elicited by pcDNA3.1+S inoculation can be modulated by co-inoculation with pcIL-12 and efficiently induced Th1-dominant immune responses. | ZHENGLan-yan MOULing LINSong LURun-ming LUOEn-jie | 2005 | Chinese Medical Journal2005，，4： | 4 |
| 4 | EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation显示文摘Dear Editor,oll-like receptor 4(TLR4)is a key receptor sensing bacterial lipopolysaccharide(LPS),and is the most investigated member of the Tol-like receptor family(Kawai and Akira,2007;Kayagaki et al,2013;Klein et al.,2015).Cell surface TLR4 expression is determined by the balance between receptor trafficking from the Golgi apparatus to the cell membrane,and internalization of the cell surface receptor into endosomal compartments(Saltoh,2009).In bone mar-row-derived macrophages(BMDM),we observed LPS-in-duced EGFR phosphorylation on the surface of BMDM,and this was inhibited by pretreatment with PD168393 or TAPI-1(Fig.S1).Next,we measured dynamic changes in cell sur-face TLR4 expression after LPS treatment.At6,12,and 24 h after LPS treatment,TLR4 expression on the surface of BMDM was increased^2-,~6-,and^9-fold,respectively,as compared with controls. | Jing Tang Bowei Zhou Melanie JScott Linsong Chen Dengming Lai Erica KFan Yuehua Li Qiang Wu Timothy RBilliar Mark AWilson Ping Wang Jie Fan | 2020 | Protein & Cell2020，11，2： | 2 |
| 5 | Self-adaptive phosphor coating technology for white LED packaging显示文摘变换黄磷的轻射出的二极管(pclead ) 它与黄黄磷采用蓝 LEDs 产生白色点亮照明,是点亮来源的广泛地使用的 solidstate。以便在带的薄片上与高质量进行黄磷层涂层,一种自我适应的涂层技术在这份报纸被介绍。与自我暴露方法相结合的一种泥浆涂层技术被使用并且发展了表明自我适应的涂层层的好处。为自我暴露,泥浆涂层暴露于除到以外的带的本身的蓝排放紫外(紫外) 做光致抗蚀剂 crosslinking 的轻外面。测量的结果显示有自我适应的涂层的白 LEDs 与常规涂层和另外的保角的涂层比那些显示出自我适应性到蓝轻、执行的更高空间的颜色一致性的紧张的尖分发。 | Haibo RAO Kun DING Jirong SONG Likun XIE Wei WANG Xianlong WAN Linsong ZHOU Junyuan LIAO | 2012 | Frontiers of Optoelectronics2012，5，2： | 2 |
| 6 | Effects of Fenvalerate on Steroidogenesis in Cultured Rat Granulosa Cells显示文摘Objective This study was designed to examine the in vitro effects of fenvalerate on steroid production and steroidogenic enzymes mRNA expression level in rat granulosa cells. Methods Using primary cultured rat granulosa cells (rGCs) as model, fenvalerate of various concentrations (0, 1, 5, 25, 125, 625 μmol/L) was added to the medium for 24 h. In some cases, optimal concentrations of 22(R)-hydroxycholesterol (25 μmol/L), Follicle stimulating hormone (FSH, 2 mg/L), or 8-Bromo-cAMP (1 mmol/L) were provided. Concentrations of 17β-estradiol(E2) and progesterone (P4) in the medium from the same culture wells were measured by RIA and the steroidogenic enzyme mRNA level was quantified by semi-quantitative RT-PCR. Results Fenvalerate decreased both P4 and E2 production in a dose-dependent manner while it could significantly stimulate rGCs proliferation. This inhibition was stronger in the presence of FSH. Furthermore, it could not be reversed by 22(R)-hydroxycholesterol or 8-Bromo-cAMP. RT-PCR revealed that fenvalerate had no significant effect on 3β-HSD, but could increase the P450scc mRNA level. In addition, 17β-HSD mRNA level was dramatically reduced with the increase of fenvalerate dose after 24 h treatment. Conclusion Fenvalerate inhibits both P4 and E2 production in rGCs. These results support the view that fenvalerate is considered as a kind of endocrine-disrupting chemicals. The mechanism of its disruption may involve the effects on steroidogenesis signaling cascades and/or steroidogenic enzyme’s activity. | JIAN-FENGCHEN HAI-YANCHEN RULIU JUNHE LINSONG QIANBIAN LI-CHUNXU JIAN-WEIZHOU HANGXIAO GUI-DONGDAI XIN-RUWANG | 2005 | Biomedical and Environmental Sciences2005，18，2： | 2 |
| 7 | Multiple Solutions to />-Laplacian Problems with Concave Nonlinearities 显示文摘 | SHI Linsong CHANG Xiaojun | 2010 | J Math Anal Appl2010，363，1： | 1 |
| 8 | Multiple Solutions to p-Laplacian Problems with Concave Nonlinearities显示文摘 | SHI Linsong CHANG Xiaojun | 2010 | J Math Anal Appl2010，363，1： | 1 |
| 9 | A Predictive Model of Enhanced Oil Recovery by Infill Drilling and Its Application显示文摘Infill drilling is now recognized as a viable improved recovery process. However, the reliable prediction of incremental recovery by infill drilling cannot be readily and accurately determined by present techniques. This paper proposes a hybrid predictive model of stream tube simulation and numerical simulation by using the contemporary theory of fluid flow in porous media. The model calculates the geometries of stream tubes, remaining oil distribution and water cut at different development stages in the near future, and uses a three-dimensional simulation to track fluid movement in each stream tube slice. This will help reservoir engineers to determine the feasibility of infill drilling. This predictive model is used to forecast the degree of control of well pattern, the ultimate incremental recovery of infill wells within an inverted 5-spot case in an oilfield and the economic benefit is also analyzed. | Xu Jianhong Cheng Linsong Ma Lili | 2007 | Petroleum Science2007，4，3： | 1 |
| 10 | The influence of so-dium ion on the solid polymer electrolyte water electrolysis 显示文摘 | Zhang Linsong Jie Xiao Shao ZhiGang | 2012 | International Journal of Hydrogen Energy2012，37，： | 1 |
| 11 | Identification and Functional Analysis of Candidate Genes Regulating Mesenchymal Stem Cell Self‐Renewal and Multipotency显示文摘 | LinSong Nicole E.Webb YingjieSong Rocky S.Tuan | 2009 | STEM CELLS2009，，7： | 1 |
| 12 | Agricultural machinery safety alert system using ultrasonic sensors显示文摘 | Guo Linsong Zhang Qin Han Shufeng | 2002 | Journal of Agricultural Safety and Health2002，8，4： | 1 |
| 13 | High quality ZnSe and ZnS nanocrystals formed by activating zinc carboxylate precurs ors显示文摘 | Li Linsong Narayan Pradhan Wang Yunjun | 2004 | Nano Letters2004，4，11： | 1 |
| 14 | Effect of Ni content on crack- ing susceptibility and microstructure of laser-clad Fe-Cr-Ni-B-Si alloy 显示文摘 | Wu Linsong Zhu Peidi Cui Kun | 1996 | Surface and Coatings Technology1996，80，： | 1 |
| 15 | Genesis of Kaolinite Deposits in the Jungar Coalfield,North China:Petrological,Mineralogical and Geochemical Evidence显示文摘Petrological,mineralogical and geochemical studies carried out on kaolinite deposits in Haerwusu surface mine,Jungar Coalfield,northern Ordos Basin,North China,define their characteristics,ore genesis and economic interest.Based on the crystalline size,two different types of kaolinite rocks,cryptocrystalline and grainy,were identified under the microscope.XRD data show that kaolinite is the predominant mineral,associated with boehmite,magnesite,anatase,pyrite,diaspore and calcite.However,high boehmite content(mean 70%)shows up in the middle layers.Kaolinite minerals present homogeneous shape and a good crystallinity(HI=0.96–1.26).Geochemical studies show that the SiO_(2)/Al_(2)O_(3)molar ratio of kaolinite is close to the theoretical value,and the contents of Na_(2)O,K_(2)O,CaO,Mg O are less,suggesting a strong chemical weathering environment.The REE and Eu anomalies show a close relationship between kaolinite and the Yinshan Oldland granite.A Ce anomaly reflects a continental sedimentary environment with shallow water.A temperature range of 26.7–34℃was calculated on the basis of the isotopic signatures(δ18O,δD)of the kaolinite rocks.All these data indicate that the formation of the kaolinite is caused mainly by the dissolution,coagulation,precipitation and recrystallization of aluminosilicate clastics in acidic conditions.The formation of boehmite in the middle layers indicates that the source rocks have changed.Boehmite is mainly formed by dehydration and compaction of an aluminum-rich colloid which transported into peat swamp during diagenesis.In addition,it formed by desiliconization of kaolinite under acidic conditions.Due to its high kaolinite content(up to 90%)and low iron mineral content(less than 1%),and good crystallinity,kaolinite deposits occurred at Haerwusu surface mine probably have great economical value in the future. | LIU Linsong ZHANG Tongjun LIU Jianping LIU Qinfu LI Kuo LIU Di LIU Wanyue | 2021 | Acta Geologica Sinica(English Edition)2021，95，2： | 1 |
| 16 | The calculation model of on-wayparameters in the overheated steam injection wellbore显示文摘 | ZHOU Tiyao CHENG Linsong | 2009 | Journal ofSouthwest Petroleum University(Science & Technology Edition)2009，31，1： | 1 |
| 17 | The characteristics of relative permeability curves in naturally fractured car bonate reservoirs显示文摘 | Lian Peiqing Cheng Linsong Ma CY | 2012 | Journal of Canadian Petroleum Tech nology2012，51，13： | 1 |
| 18 | Lowvelocity non-linear flow in ultra-low permeabilityreservoir 显示文摘 | ZENG Baoquan CHENG Linsong LI Chunlan | 2011 | Journal of Petroleum Science andEngineering2011，80，1： | 1 |
| 19 | Kinematic analysis of a rice transplanting mechanism with eccentric planetary gear trains显示文摘 | GUO Linsong ZHANG W J | 2001 | Mechanism and Machine Theory2001，36，1112： | 1 |
| 20 | High quality ZnSe and ZnS nanocrystals formed by activating zinc carboxylate precursors 显示文摘 | Li Linsong Narayan Pradhan Wang Yunjun | 2004 | Nano Letters2004，4，11： | 1 |
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