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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Community structure of ammonia-oxidizing bacteria under long-term application of mineral fertilizer and organic manure in a sandy loam soil显示文摘 | Chu HY Fujii T Morimoto S Lin XG Yagi K Hu JL Zhang JB | 2007 | 中国生物学文摘2007，21，6： | 77 |
| 3 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 4 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 5 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 6 | The Responsivity of the Bacteriorhodopsin Langmuir-Blodgett Film Intermittent Light显示文摘TheResponsivityoftheBacteriorhodopsinLangmuir-BlodgettFilmIntermittentLight￥GuangYuWANG;JianHuaYANG;ZhiGuangZHANG;ShuHuangLIN... | Wang, GY Yang, JH Zhang, ZG Lin, SH Lu, T Li, BF Jiang, L | 1996 | Chinese Chemical Letters1996，7，12： | 12 |
| 7 | Immune checkpoint inhibitors for treatment of advanced gastric or gastroesophageal junction cancer:Current evidence and future perspectives显示文摘Despite the application of conventional therapies,the prognosis of advanced gastric cancer(GC)or gastroesophageal junction cancer(GEJC)is still poor.In recent years,immune checkpoint inhibitors(ICIs)have reshaped the paradigm of cancer therapy.Emerging evidence support the feasibility of programmed cell death-1(PD-1)and its ligand(PD-L1)inhibition in chemo-refractory GC/GEJC.Nivolumab and pembrolizumab have initially been approved in Japan and United States,respectively for the third-line treatment of progressive GC or GEJC.In March 2020,nivolumab has also been licensed in China for treating advanced GC/GEJC who received≥2 lines of systemic therapies.Current studies are moving forward to the first-line application or focusing on combination strategies,though data are insufficient and disputable.In this review,we summarize the recently reported and ongoing clinical trials in ICIs for advanced GC/GEJC.Molecular characteristics and clinical implications of different tumor subtypes are also reviewed.We further discuss the safety profile and biomarkers for predicting the response of ICIs,which has guiding values in clinical practice. | Zhening Zhang T ong Xie Xiaotian Zhang Changsong Qi Lin Shen Zhi Peng | 2020 | Chinese Journal of Cancer Research2020，32，3： | 10 |
| 8 | 施万细胞在阴茎和外周神经再生中的作用显示文摘施万细胞(SCs)是外周神经系统中主要的胶质细胞。施万细胞最终发育为形成髓鞘的细胞和不形成髓鞘的细胞,前者包绕直径较大的神经,后者则包绕直径较小的神经。他们在神经损伤后的再生中发挥重要作用,包括海绵体神经损伤导致的勃起功能障碍(ED)。尽管前列腺癌根治术手术技术有所提高,但是仍有相当一部分患者术后出现ED。这是由于术中牵拉损伤或局部炎症反应改变了自主神经的微环境,最终导致终末器官-阴茎的病理生理改变。该综述目的是总结现有的如下方面相关文献:(1)外周神经特别是阴茎神经中施万细胞的起源和发育;(2)外周神经特别是阴茎神经损伤后的Wallerian变性和施万细胞的可塑性;(3)施万细胞如何通过分泌神经生长因子促进神经再生;(4)以施万细胞作为治疗靶点促进神经再生的技术。我们搜索了Pubmed,发现了为数众多的与上述主题相关的动物实验和人体研究,这提示施万细胞有望成为神经源性ED治疗的新靶点。 | Lin Wang Melissa T Sanford Zhongcheng Xin Guiting Lin Tom F Lue | 2015 | Asian Journal of Andrology2015，17，5： | 7 |
| 9 | Portal vein thrombosis in cirrhotic patients-it is always the small pieces that make the big picture显示文摘Portal vein thrombosis(PVT) is a frequent and serious complication in patients with liver cirrhosis(LC). Recently, a new classification of PVT was proposed, although the functional component was not completed included. The status of liver disease(compensated/decompensated) should be added to this classification. Reduced portal flow velocity and the acquired hypercoagulable status associated with LC are the main risk factors for PVT development, although endothelial dysfunction may play an important role that needs to be further evaluated. The European Association for the Study of the Liver and the American Association for the Study of Liver Disease recommend that the anticoagulant treatment should be consider in cirrhotic patients with PVT. Low molecular weight heparin and vitamin K antagonists proved their efficacy and relatively safety in PVT treatment, although in addition to recanalization rates, more complex endpoints such as mortality and decompensation rate should be evaluated. The new oral anticoagulant therapies offers the advantage of oral administration in the absence of laboratory monitoring, however, there are a few reports regarding their use in cirrhotic patients, most of them referring to compensated isolated cases. Transjugular intrahepatic portosystemic shunt could be an alternative if thrombosis progresses despite anticoagulatant therapy and/or when PVT is associated with portal hypertension complications. The aim of this editorial is to discuss the different aspects of pathophysiology, clinical relevance, diagnosis and management of PVT in patients with LC. | Irina Girleanu Anca Trifan Carol Stanciu Cǎtǎlin Sfarti | 2018 | World Journal of Gastroenterology2018，24，39： | 6 |
| 10 | Expression and release of IL-29 by mast cells and modulation of mast cell behavior by IL-29显示文摘 | He, S Zhang, H Chen, H Yang, H Huang, T Chen, Y Lin, J Wang, F Chen, X Li, TL Yang, P | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 6 |
| 11 | 夹层电缆引发火灾的实验研究显示文摘模拟现代建筑夹层中贮藏大量未加金属导管防护的电线电缆所引发的火灾效应。在一个全尺寸燃烧套房模型中进行了起火室和顶棚夹层空间电缆火灾的实验研究 ,并采用大涡模拟的方法对实验中烟气速度场进行了数值模拟。结果表明 ,加明火源可以加强电缆的火灾功率 ;通风状况对夹层电缆火灾的温度场、烟气遮光度和火灾功率有明显影响。电缆燃烧产物中主要毒性气体为 CO。电缆在夹层燃烧时 ,CO和 CO2 浓度均高于目标室和起火室中的浓度。而夹层毒气最为集中 ,其 CO浓度远远超出 OSHA和 IDL H标准。 | 尤飞 Lin John Z 周建军 Chow T T 邹样辉 厉培德 | 2002 | 安全与环境学报2002，2，6： | 5 |
| 12 | 新辅助放化疗联合全直肠系膜切除术后接受辅助化疗不能改善Ⅱ/Ⅲ期直肠癌患者的无复发生存率显示文摘目的:目前,NCCN指南建议对局部进展期Ⅱ/Ⅲ期直肠癌先行新辅助放化疗(nCRT),然后行全直肠系膜切除术(TME)和辅助化疗。辅助化疗的肿瘤学获益尚未得到进一步证实。本研究的目的是评估nCRT+TME手术后接受辅助化疗的直肠癌患者肿瘤复发和生存情况。方法:本研究是在南加州的14家医院和相关诊所完成的回顾性研究,研究对象为2005年1月1日至2016年12月31日接受手术治疗的862例Ⅱ/Ⅲ期直肠癌患者,无论是否行辅助化疗,纳入研究的患者均接受了新辅助化疗以及全直肠系膜切除术。主要终点是无复发生存率。 | 李来元 VOSS R K LIN J C ROPER M T | 2020 | 结直肠肛门外科2020，26，2： | 5 |
| 13 | Four New Compounds from Isodon Eriocalyx显示文摘Four new diterpenoids named maoecrystal Q-T (1-4) were isolated from the dried leaves of Isodon eriocalyx. Their sturctures were established by spectroscopic methods. | Wang, J Lin, ZW Shingu, T Sun, HD | 1997 | Chinese Chemical Letters1997，8，7： | 4 |
| 14 | Microstructure and Wear Behaviour of Laser-Induced Thermite Reaction Al_2O_3 Ceramic Coatings on Pure Aluminum and AA7075 Aluminum Alloy显示文摘Wear-resistant laser-induced thermite reaction Al_2O_3 ceramic coatings can be fabricated on pure Al and AA7075 aluminum alloy by laser cladding(one-step method)and laser cladding followed by laser re-melting(two-step method)using mixed powders CuO-Al-SiO_2 in order to improve the wear properties of aluminum and aluminum alloy,respectively.The microstructure of the coatings was characterized by scanning electron microscopy(SEM)and X-ray diffraction(XRD).The wear resistance of the coatings was evaluated under dry sliding wear test condition at room temperature.Owing to the presence of hardα-Al_2O_3 andγ-Al_2O_3 phases,the coatings exhibited excellent wear resistance.In addition,the wear resistance of the coatings fabricated by two-step method is superior to that of the coatings fabricated by one-step method. | 黄开金 LIN Xin XIE Changsheng T M Yue | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，1： | 4 |
| 15 | 肝内胆管细胞癌和转移性胰腺导管腺癌的免疫组化鉴别显示文摘在肝脏活检标本中,原发性肝内胆管细胞癌(ICC)和转移性胰腺导管腺癌(PDA)组织学上难以区分,但二者的鉴别具有重要的临床意义。本组实验对41例ICCs和60例PDAs分别进行SLOOP、pVHL、IMP3、肿瘤抑制基因蛋白maspin、MUC5AC及CKl7蛋白的免疫表型评估,以了解这些标志物在两种疾病鉴别诊断中的价值。结果显示:29例(71%)ICCs表达pVHL,PDAs中仅3例(5%)出现pVHL表达。S100P、MUC5AC和CKl7在PDAs中阳性率较高,分别为57例(95%)、40例(67%)和36例(60%),ICCs中S100P、MUC5AC和CK17分别为11例(27%)、5例(12%)及5例(12%)表达。IMP3在ICCs和PDAs中阳性率均为90%。60例(100%)PDA和30例(73%)ICC患者存在maspin的阳性表达。作者对上述标志物表达情况进行归纳后发现,当免疫组化染色结果呈SLOOP-/pVHL+/MUC5AC-/CK17-时提示ICC,呈SLOOP+/pVHL-/MUC5AC+/CK17+和S100P+/pVHL-/MUC5AC-/CK17+时则提示PDA。据此可有效将ICC和PDA鉴别开来。 | Lok T Chen L Lin F 王慧 余英豪 | 2014 | 临床与实验病理学杂志2014，30，10： | 3 |
| 16 | Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers显示文摘 | Shigematsu H Lin L Takahashi T | | 0，，05： | 3 |
| 17 | Remifentanil Induces Systemic Arterial Vasodilation which is Not Associated with Alterations in Concentrations of Histamine, Nitric Oxide and Prostacyclin in Patients undergoing Cardiopulmonary Bypass显示文摘 | Lin P T Zhang B.J Wei W Li J Liu J | 2010 | 麻醉与监护论坛2010，17，4： | 3 |
| 18 | Vitamin D levels do not predict the stage of hepatic fibrosis in patients with non-alcoholic fatty liver disease: A PRISMA compliant systematic review and meta-analysis of pooled data显示文摘AIM To investigate the relationship between 25-hydroxyvitamin D [25(OH)D] levels and fibrosis stage in patients with non-alcoholic fatty liver disease(NAFLD).METHODS Two individual reviewers identified relevant studies using the Pub Med, EMBASE, Cochrane, and Scopus databases. Inclusion criteria were as follows:(1) Studies that evaluated adults with NAFLD and serum or plasma 25(OH)D levels; and(2) assessed fibrosis stage using liver biopsy. A rigorous analysis yielded six articles as having sufficient data to employ in evaluating the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. To meta-analyze vitamin D levels in F0-F2 vs F3-F4 fibrosis, a random-effects meta-analysis fit using restricted maximum likelihood was applied. To examine trends across each stage of fibrosis with respect to vitamin D levels, a meta-regression was performed. P < 0.05 was considered statistically significant. RESULTS A total of 937 subjects from six studies were included in the final analysis to evaluate the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. First, the investigators performed a meta-analysis to compare serum vitamin D levels in patients with NAFLD with stage F0-F2 compared to F3-F4, which did not show significance [meta-estimate of the pooled mean difference =-0.86, P = 0.08(-4.17, 2.46)]. A metaregression evaluation of serum vitamin 25(OH)D levels across the individual stages(F0-F4) of fibrosis did not show an association for the six included studies.CONCLUSION Low vitamin D status is not associated with higher stages of liver fibrosis in patients with NAFLD. | Behnam Saberi Alia S Dadabhai Julie Nanavati Lin Wang Russell T Shinohara Gerard E Mullin | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 19 | Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway显示文摘BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually.Fibrosis develops from recurrent liver injury but the molecular mechanisms are not fully understood.Recently,the TLR4-MyD88 signaling pathway has been reported to contribute to fibrosis.Extracellular histones are ligands of TLR4 but their roles in liver fibrosis have not been investigated.AIM To investigate the roles and potential mechanisms of extracellular histones in liver fibrosis.METHODS In vitro,LX2 human hepatic stellate cells(HSCs)were treated with histones in the presence or absence of non-anticoagulant heparin(NAHP)for neutralizing histones or TLR4-blocking antibody.The resultant cellular expression of collagen I was detected using western blotting and immunofluorescent staining.In vivo,the CCl4-induced liver fibrosis model was generated in male 6-week-old ICR mice and in TLR4 or MyD88 knockout and parental mice.Circulating histones were detected and the effect of NAHP was evaluated.RESULTS Extracellular histones strongly stimulated LX2 cells to produce collagen I.Histone-enhanced collagen expression was significantly reduced by NAHP and TLR4-blocking antibody.In CCl4-treated wild type mice,circulating histones were dramatically increased and maintained high levels during the duration of fibrosisinduction.Injection of NAHP not only reduced alanine aminotransferase and liver injury scores,but also significantly reduced fibrogenesis.Since the TLR4-blocking antibody reduced histone-enhanced collagen I production in HSC,the CCl4 model with TLR4 and MyD88 knockout mice was used to demonstrate the roles of the TLR4-MyD88 signaling pathway in CCl4-induced liver fibrosis.The levels of liver fibrosis were indeed significantly reduced in knockout mice compared to wild type parental mice.CONCLUSION Extracellular histones potentially enhance fibrogenesis via the TLR4–MyD88 signaling pathway and NAHP has therapeutic potential by detoxifying extracellular histones. | Zhi Wang Zhen-Xing Cheng Simon T Abrams Zi-Qi Lin ED Yates Qian Yu Wei-Ping Yu Ping-Sheng Chen Cheng-Hock Toh Guo-Zheng Wang | 2020 | World Journal of Gastroenterology2020，26，47： | 3 |
| 20 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
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