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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Eucaglobulin, A New Complex of Gallotannin and Monoterpene from Eucalyptus globulus显示文摘Eucaglobulin 1, a new complex of gallotannin and monoterpene, was isolated from theleaves of Eucalyptus globulus. Its structure was determined by spectral methods. | Hou, AJ Liu, YZ Lin, ZW Sun, HD | 1998 | Chinese Chemical Letters1998，9，6： | 2 |
| 3 | Temporal relationship between apparent diffusion coefficient and absolute measurements of cerebral blood flow in acute stroke patients显示文摘 | Lin WL Lee JM Lee YZ | 2003 | Stroke2003，34，： | 1 |
| 4 | Rhein lysinate in- duced S- phase arrest and increased the anti- tumor activity of 5 - FU in Hela cells显示文摘 | Lin YJ Zhen YZ Zhao YF | 2011 | Am J Chin Med2011，39，4： | 1 |
| 5 | Effect of time factors on the mortality in brittle hip fracture 显示文摘 | Li YZ Lin JK Wang PW | 2014 | J Orthop Surg Res2014，9，： | 1 |
| 6 | Efficacy of nebulized budes- onide in hospitalized infants and children younger than 24 months with bronchiolitis显示文摘 | Chao LC Lin YZ Wn WF | 2003 | Acta Paediatr Taiwan2003，44，6： | 1 |
| 7 | Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence显示文摘 | Yao SY Veach RA | 1995 | J Biol Chem1995，270，14： | 1 |
| 8 | Analytical and clinical evaluation of CYFRA 21-1 by electrochemiluminescent immunoassay in head and neck squamous cell carcinoma显示文摘 | Chen P Lin YZ | 2003 | J Laryngol Otol2003，117，3： | 1 |
| 9 | Genetic diversity of Chinese rabies viruses:evidence for the presence of two distinct clades in China显示文摘 | Zhang YZ Xiong CL Lin XD | 2009 | Infect Genet Evol2009，9，1： | 1 |
| 10 | IL-35: a potential target for the treatment of atherosclerosis显示文摘 | Huang Y Lin YZ Shi Y | 2013 | Pharmazie2013，68，10： | 1 |
| 11 | Intractable occipital lobe epilepsy:clinical characteristics,surgical treatment,and a systematic review of the literature显示文摘 | Yang PF Jia YZ Lin Q | 2015 | Acta Neurochir(Wien)2015，157，1： | 1 |
| 12 | Torsional mode versus conventional ultrasound mode phacoemulsification randomized comparative clinical study显示文摘 | Liu YZ Zeng MB Lin XL | 2007 | J Cataract Refract Surg2007，33，2： | 1 |
| 13 | Singnificance of vascular endothelial growth factor messenger RNA expression in gastric cancer显示文摘 | Lin YZ | 1998 | World J Gastroentero1998，410，： | 1 |
| 14 | Sensitive detection of micrometastases in bone marrow from patients with breast cancer using immunomagnetic isolation of tumor cells in combinaion with reverse transcriptase polymerase chain reaction for cytokeratin显示文摘 | Xiao YZ Sepp Kaul Lin YS | 2002 | J Cancer Res Clin Oncol2002，126，4： | 1 |
| 15 | The PTEN/MMACI/TEP tumor suppressor gene decrease cell growth and in duces apoptosis and anoikis in breast cancer cells显示文摘 | Lu YL Lin YZ Lapushin R | 1999 | Oncogene1999，18，5： | 1 |
| 16 | Genetic diversity ofChinese rabies viruses:evidence for the presence of two distinctclades in China显示文摘 | Zhang YZ Xiong CL Lin XD | 2009 | Infect Genet Evol2009，9，1： | 1 |
| 17 | Molecular mecha- nisms responsible for microglia - derived protection of Sprague - Dawley rat brain cells during in vitro ischemia 显示文摘 | Lu YZ Lin CH Cheng FC | 2005 | Neurosci Lett2005，373，： | 1 |
| 18 | Detection and Recognition of Steel Ball Surface Defect Based on MATLAB显示文摘 | LIN YZ LIU XL HAN HY | 2009 | Key Engineering Materials2009，416，： | 1 |
| 19 | Infantile wheezing and bronchodilator treatment显示文摘 | Lin YZ Huang FY | 2005 | Acta Paediatr Taiwan2005，46，1： | 1 |
| 20 | Rhein lysinate induced S-phase arrest and increased the anti-tumor activity of 5-FU in HeLa cells 显示文摘 | Lin Y J Zhen YZ Zhao YF | 2011 | Am J Chin Med2011，39，： | 1 |
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