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| 1 | Seasonal variation in surface ozone and its regional characteristics at global atmosphere watch stations in China显示文摘We investigated the seasonal and spatial ozone variations in China by using three-year surface ozone observation data from the six Chinese Global Atmosphere Watch(GAW)stations and tropospheric column ozone data from satellite retrieval over the period2010–2012. It is shown that the seasonal ozone variations at these GAW stations are rather different, particularly between the western and eastern locations. Compared with western China, eastern China has lower background ozone levels. However, the Asian summer monsoon(ASM) can transport photochemical pollutants from the southern to the northern areas in eastern China, leading to a northward gradual enhancement of background ozone levels at the eastern GAW stations. Over China, the tropospheric column ozone densities peak during spring and summer in the areas that are directly and/or indirectly affected by the ASM, and the peak time lags from the south to the north in eastern China. We also investigated the regional representativeness of seasonal variations of ozone at the six Chinese GAW stations using the yearly maximum tropospheric column month as indicator.The results show that the seasonal variation characteristics of ozone revealed by the Chinese GAW stations are typical, with each station having a considerable large surrounding area with the ozone maximum occurring at the same month. Ozone variations at the GAW stations are influenced by many complex factors and their regional representativeness needs to be investigated further in a broader sense. | Ningwei Liu Weili Lin Jianzhong Ma Wanyun Xu Xiaobin Xu | 2019 | Journal of Environmental Sciences2019，31，3： | 23 |
| 2 | Neuroprotective effect of ethyl acetate extract from gastrodia elata against transient focal cerebral ischemia in rats induced by middle cerebral artery occlusion显示文摘OBJECTIVE: To investigate the protective effect of neuroprotection against transient focal cerebral ischemia of the extract from Tianma(Rhizoma Gastrodiae) and the possible mechanisms underlying the action.METHODS: Cerebral ischemia-reperfusion injury was induced through middle cerebral artery occlusion(MCAO). Adult male Sprague-Dawley rats were randomly divided into four groups: sham-operated,ischemia-reperfusion model, 102.6 mg/kg extract treated and 11.4 mg/kg extract treated groups. The extract was prepared from gastrodia elata with ethyl acetate. The effect of the extract tested on rat neurological de fi cits and Cerebral index, cerebral infarct volume, brain injury, terminal dexynucleotidyl transferase-mediated d UTP nick end labeling(TUNEL) and B-cell lymphoma-2(Bcl-2) positive cells.RESULTS: The extract was able to reduce neurological scores, cerebral index and cerebral infarction rate. The brain injury was also relieved by the extract. The results of immunofluorescence staining analysis indicated that the extract increased the expression of Bcl-2 and reduced TUNEL-positive cells significantly in the extract treated groups.CONCLUSION: These results suggested that the extract relieved ischemic injury induced by transient focal cerebral ischemia in rats, and this neuroprotective effect might be partially due to the attenuated apoptosis pathway. | Duan Xiaohua Wang Weili Liu Xiaoqing Yan Hanwen Dai Rong Lin Qing | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 18 |
| 3 | Characteristics and recent trends of sulfur dioxide at urban,rural,and background sites in North China:Effectiveness of control measures显示文摘SO 2 measurements made in recent years at sites in Beijing and its surrounding areas are performed to study the variations and trends of surface SO 2 at different types of sites in Northern China.The overall average concentrations of SO 2 are (16.8±13.1) ppb,(14.8±9.4) ppb,and (7.5±4.0) ppb at China Meteorological Administration (CMA,Beijing urban area),Gucheng (GCH,relatively polluted rural area,110 km to the southwest of Beijing urban area),and Shangdianzi (SDZ,clean background area,100 km to the northeast of Beijing urban area),respectively.The SO 2 levels in winter (heating season) are 4-6 folds higher than those in summer.There are highly significant correlations among the daily means of SO 2 at different sites,indicating regional characteristics of SO 2 pollution.Diurnal patterns of surface SO 2 at all sites have a common feature with a daytime peak,which is probably caused by the downward mixing and/or the advection transport of SO 2 -richer air over the North China Plain.The concentrations of SO 2 at CMA and GCH show highly significant downward trends (-4.4 ppb/yr for CMA and -2.4 ppb/yr for GCH),while a less significant trend (-0.3 ppb/yr) is identified in the data from SDZ,reflecting the character of SDZ as a regional atmospheric background site in North China.The SO 2 concentrations of all three sites show a significant decrease from period before to after the control measures for the 2008 Olympic Games,suggesting that the SO 2 pollution control has long-term effectiveness and benefits.In the post-Olympics period,the mean concentrations of SO 2 at CMA,GCH,and SDZ are (14.3±11.0) ppb,(12.1±7.7) ppb,and (7.5±4.0) ppb,respectively,with reductions of 26%,36%,and 13%,respectively,compared to the levels before.Detailed analysis shows that the differences of temperature,relative humidity,wind speed,and wind direction were not the dominant factors for the significant differences of SO 2 between the pre-Olympics and post-Olympics periods.By extracting the data being more representative of local or regional characteristics,a reduction of up to 40% for SO 2 in polluted areas and a reduction of 20% for regional SO 2 are obtained for the effect of control measures implemented for the Olympic Games. | Weili Lin Xiaobin XU Zhiqiang Ma Huarong Zhao Xiwen Liu Ying Wang | 2012 | Journal of Environmental Sciences2012，24，1： | 15 |
| 4 | Wintertime peroxyacetyl nitrate(PAN) in the megacity Beijing: Role of photochemical and meteorological processes显示文摘Previous measurements of peroxyacetyl nitrate(PAN) in Asian megacities were scarce and mainly conducted for relative short periods in summer. Here, we present and analyze the measurements of PAN, O3, NOx, etc., made at an urban site(CMA) in Beijing from 25 January to 22 March 2010. The hourly concentration of PAN averaged 0.70 × 10 9mol/mol(0.23 × 10 9–3.51 × 10 9mol/mol) and was well correlated with that of NO2but not O3, indicating that the variations of the winter concentrations of PAN and O3in urban Beijing are decoupled with each other. Wind conditions and transport of air masses exert very significant impacts on O3, PAN, and other species. Air masses arriving at the site originated either from the boundary layer over the highly polluted N-S-W sector or from the free troposphere over the W-N sector. The descending free-tropospheric air was rich in O3, with an average PAN/O3ratio smaller than 0.031, while the boundary layer air over the polluted sector contained higher levels of PAN and primary pollutants, with an average PAN/O3ratio of 0.11. These facts related with transport conditions can well explain the observed PAN-O3decoupling. Photochemical production is important to PAN in the winter over Beijing. The concentration of the peroxyacetyl(PA) radical was estimated to be in the range of 0.0014 × 10 12–0.0042 × 10 12 mol/mol. The contributions of the formation reaction and thermal decomposition to PAN's variation were calculated and found to be significant even in the colder period in air over Beijing, with the production exceeding the decomposition. | Hualong Zhang Xiaobin Xu Weili Lin Ying Wang | 2014 | Journal of Environmental Sciences2014，26，1： | 11 |
| 5 | Background concentrations of reactive gases and the impacts of long-range transport at the Jinsha regional atmospheric background station显示文摘Lorentz curve fittings are applied to frequency distributions of the concentrations of O 3 , CO, NO x and SO 2 recorded at the Jinsha regional atmospheric background station (JSH) from June 2006 to July 2007, and the peak concentrations of these species for the different seasons are obtained. The peak concentrations are considered to be representative of different background levels for certain processes. The peak concentrations are compared with the corresponding mean (median) concentrations, and the suitability and limitations of the mean (median) values as the background levels are discussed. The mean (median) values might represent the background concentrations in the region under some circumstances, but in other cases these values often underestimate or overestimate the true background concentrations owing to the transport of pollutants and other factors. The effects of air masses transported from different regions on the pollutant background concentrations are obtained by analyzing the 72-hour backward trajectories of air masses 100 m above the ground at JSH. These trajectories are estimated using the HYSPLIT model and then clustered for the measurement period. The spatial distribution and seasonal variations of trajectories and the corresponding mean concentrations of O 3 , SO 2 , NO x and CO for different clusters are analyzed. After filtering the seasonal changes in pollutant concentrations, the relative influences of air masses from different regions are obtained. The results show that JSH can be used to obtain the atmospheric background information of different air masses originating from or passing over the Yangtze River Delta, Central South China and the Jianghan Plain. Air masses from Central China, South China, and the western Yangtze River Delta contribute significantly to O 3 at JSH. Air masses from the north and northeast of JSH (i.e., the Jianghan Plain, Huang-Huai Plain and North China Plain) and the south (Central South China) contribute significantly to SO 2 , CO and NO x concentrations. Air masses originating from the ocean often bring clean air. Air masses originating from high altitudes over northwestern regions often have lower CO and NO x concentrations, lower relative humidity, and higher concentrations of O 3 and SO 2 . | LIN WeiLi XU XiaoBin SUN JunYing LIUXiWen WANG Ying | 2011 | Science China Earth Sciences2011，54，10： | 8 |
| 6 | Variability of SO_2 in an intensive fog in North China Plain:Evidence of high solubility of SO_2显示文摘一个地实验在在 11 月 5 日和 2009 年 11 月 8 日之间的一个集中的雾事件被进行,在在诺思中国平原(NCP ) 的一个重重地弄脏 SO2 的区域,到措施 SO2 和其它空气污染物质,雾微滴的液体水内容(LWC ) ,和另外的基本气象学的参数。在雾时期期间, SO2 的集中在雾微滴与 LWC 有关仔细显示出大可变性,它是。, SO2 的平均集中在雾时期期间在非雾时期期间是大约 25 ppbv,它很快归结为大约 47 ppbv。SO2 的如此的大减小建议由于 SO2 的高溶解度, SO2 (大约 70%80%) 的一个多数在雾微滴在水里从气体回复了到水的阶段。然而,到水的阶段变换的计算气体被仅仅使用亨利 SO2 的法律常数大部分低估,因此在雾微滴建议 SO2 的那水的反应可能在提高 SO2 的溶解度起某重要作用。简化现象,一个有效溶解度系数在这研究被建议。SO2 测量的这可变性在 NCP 在雾微滴,为在云的酸味的更好的理解的因此提供的重要含意,猛冲,和雾在广泛的雾事件期间提供 SO2 的氧化的直接证据,现在在中国的一个中央环境焦点由于它的快速的经济发展。 | Qiang Zhang Xuexi Tie Weili Lin Junji Cao Jiannong Quan Liang Ran Wanyun Xu | 2013 | Particuology2013，11，1： | 8 |
| 7 | Significant downward trend of SO_2 observed from 2005 to 2010 at a background station in the Yangtze Delta region,China显示文摘SO2 is an important gas in atmosphere with great environmental and climate implications.SO2 emission in China has been receiving great attention as the economy grows and the amount of coal consumption has increased in the past few decades.SO2 has been observed from July 2005 to June 2010 at Linan WMO GAW regional station(30.3 °N,119.73 °E,138 m a.s.l.) located in the Yangtze Delta region in eastern China.These observation data are analyzed to understand the trend of regional SO2 background concentration.Strict quality controls are conducted to ensure the temporal comparability of the data.Significant downward trend with ?2.4 ppb/yr(P < 0.0001) of surface SO2 is observed from 2005 to 2010,especially after 2008.The average concentration of SO2 from July 2005 to June 2008 is 14.2±3.1 ppb,which is slightly higher than the mean values of 13.5±5.1 ppb during 1999?2000 and is two folds of the average value(7.1±3.1 ppb) from July 2008 to June 2010.More than 50% of the SO2 has been cut down after 2008 in the Yangtze Delta region due to the implementation of stricter emission control measures.The peak SO2 concentration appears around 10 o'clock in the morning after 2009 while appears at night before 2009.These diurnal variations of SO2 might indicate that after 2009,more SO2 is from the vertical exchange process than from the local accumulation. | QI HuangXiong LIN WeiLi XU XiaoBin YU XiangMing MA QianLi | 2012 | Science China Chemistry2012，55，7： | 7 |
| 8 | Emission inventory evaluation using observations of regional atmospheric background stations of China显示文摘Any accurate simulation of regional air quality by numerical models entails accurate and up-to-date emissions data for that region.The INTEX-B2006 (I06),one of the newest emission inventories recently popularly used in China and East Asia,has been assessed using the Community Multiscale Air Quality model and observations from regional atmospheric background stations of China.Comparisons of the model results with the observations for the species SO2,NO 2,O 3 and CO from the three regional atmospheric background stations of Shangdianzi,Longfengshan and Linan show that the model can basically capture the temporal characteristics of observations such as the monthly,seasonal and diurnal variance trends.Compared to the other three species,the simulated CO values were grossly underestimated by about two-third or one-half of the observed values,related to the uncertainty in CO emissions.Compared to the other two stations,Shangdianzi had poorer simulations,especially for SO2 and CO,which partly resulted from the site location close to local emission sources from the Beijing area;and the regional inventory used was not capable of capturing the influencing factors of strong regional sources on stations.Generally,the fact that summer gave poor simulation,especially for SO2 and O 3,might partly relate to poor simulations of meteorological fields such as temperature and wind. | Xingqin An Zhaobin Sun Weili Lin Min Jin Nan Li | 2013 | Journal of Environmental Sciences2013，25，3： | 7 |
| 9 | Clinical effectiveness of cognitive behavioural therapy on alcoholdependent patients:an observation with the WeChat platform显示文摘Background With the continuous improvement of people's material living standards,the consumption of alcoholic beverages is increasing.Alcohol dependence caused by alcohol addiction has become a widespread concern in society.As the brand-new medical and health model created by the modern biomedical technology revolution and the information technology revolution,mobile health has been used more and more widely in the field of medical health with the characteristics of convenience,rapidity and generalisability.With the general use of the social software WeChat,it is feasible to implement mobile health on the WeChat platform.Aim We aimed to explore the clinical effect of WeChat platform used in the cognitive behavioural therapy(CBT)on the maintenance period of alcohol dependence and addiction.Methods Seventy alcohol-dependent patients in the withdrawal maintenance stage admitted into our hospital were randomly divided into the CBT on WeChat platform group(the experiment group,n=35)and the general clinical treatment using sertraline group(the control group,n=35)with block randomisation grouping.They were evaluated with the Severity of Alcohol Dependence Questionnaire(SADQ-C)before the treatment,at the end of the fourth week,at the end of the eighth week and at the end of the twelfth week of treatment.In addition,Zung's Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)were employed to evaluate the degree of anxiety and depression of the two groups.Results The SADQ-C,SAS and SDS scores of the two groups after treatment decreased markedly compared with those before treatments,and the differences were statistically significant.Between-group comparison:the SADQ-C scores of the experiment group at the end of the fourth,eighth and twelfth weeks were lower than those of the control group,and the difference was statistically significant,which indicated that the score reduction in the experiment group was larger than that in the control group.The SAS and SDS scores of the experiment group at these time points were not significantly different from those of the control group,which indicated that these two treatment methods were comparable in treating patients1 anxiety and depression.Conclusion The CBT in tervention using WeChat may improve the subjectively reported severity of alcohol dependence of patients who had completed detoxification.It is conducive to prevention of relapse,and is convenient for patients.It is worthy of clinical application and further study. | Jing Chen Mincai Qian Conghao Sun Min Lin Weili fang | 2019 | General Psychiatry2019，32，5： | 6 |
| 10 | Risks Associated with Misuse of Ketamine as a Rapid-Acting Antidepressant显示文摘Major depression is a serious psychiatric disorder and remains a leading cause of disability worldwide.Conventional antidepressants take at least several weeks to achieve a therapeutic response and this lag period has hindered their ability to attain beneficial effects in depressed individuals at high risk of suicide.The non-competitive Nmethyl-D-aspartate glutamate receptor antagonist ketamine has been shown to have rapid antidepressant effects in both rodents and humans.The emergence of ketamine as a fastacting antidepressant provides promising new insights into the development of a rapid treatment response in patients with clinical depression.However,its safety and toxicity remain a concern.In this review,we focus on the limitations of ketamine,including neurotoxicity,cognitive dysfunction,adverse events associated with mental status,psychotomimetic effects,cardiovascular events,and uropathic effects.Studies have shown that its safety and tolerability profiles are generally good at low doses and with short-term treatment in depressed patients.The adverse events associated with ketamine usually occur with very high doses that are administered for prolonged periods of time and can be relieved by cessation.The antidepressant actions of its two enantiomers,S-ketamine(esketamine) and R-ketamine,are also discussed.R-ketamine has greater antidepressant actions than S-ketamine,without ketamine-related sideeffects.Future treatment strategies should consider using Rketamine for the treatment of depressed patients to decrease the risk of adverse events associated with long-term ketamine use. | Weili Zhu Zengbo Ding Yinan Zhang Jie Shi Kenji Hashimoto Lin Lu | 2016 | Neuroscience Bulletin2016，32，6： | 5 |
| 11 | Estimation on organic carbon content of source rocks by logging evaluation method as exemplified by those of the 4^(th) and 3^(rd) members of the Shahejie Formation in western sag of the Liaohe Oilfield显示文摘One of the most important tasks of evaluating natural resources of petroliferous basins is to determine the organic matter abundance of source rocks in the basin.The usual method for assessing the organic carbon content of source rocks is based on laboratory analyses.There is a deviation in calculating organic carbon content due to the heterogeneous distribution of organic matter and the artificial factors when sampling.According to the continuous characteristics of information logging,the conventional logging curves(mainly acoustics and resistivity,etc.) were calibrated with the organic carbon experimental data of cores,cuttings or sidewall cores.The organic carbon content of source rocks of the 4 th(Es 4) and 3 rd(Es 3) members of the Shahejie Formation in western sag in the Liaohe depression was estimated directly by a great amount of continuous data including resistivity and acoustic logging,etc.Comparison between the results from computer processing and lab analysis of logging data shows that the organic carbon contents derived from the computer processing of logging data have the same reliability and accuracy as the lab analysis results.The present data show that this method is suitable to evaluate the source rocks of western sag in the Liaohe depression and has great potential in evaluating natural resources of sedimentary basins in the future.On the basis of logging data of source rocks,experimental data and existing geochemical analyses of the Liaohe Oilfield,the corresponding total organic carbon(TOC) isograms of source rocks were plotted.The source rocks of Es 4 and Es 3 of the Shahejie Formation are thought to be beneficial to hydrocarbon accumulation due to the high TOC. | LIU Luofu SHANG Xiaoqing WANG Ping GUO Yongqiang WANG Weili WU Lin | 2012 | Chinese Journal Of Geochemistry2012，31，4： | 3 |
| 12 | Efficacy and Safety of Yanggan Jian in Hepatitis B Virusrelated Decompensated Cirrhosis:A Randomized,Doubleblind,Controlled Trial显示文摘Background and Aims:The aim was to evaluate the efficacy and safety of Yanggan Jian(YGJ)in HBV-infected patients with decompensated cirrhosis.Methods:This randomized,double-blind controlled trial enrolled 160 patients with HBV-related decompensated cirrhosis who were already receiving or about to start antiviral therapy.Patients were randomly assigned to receive YGJ or placebo for 24 weeks,and were followed-up to 36 weeks.The primary outcome was the proportion of patients with a≥2 point reduction in Child-Turcotte-Pugh(CTP)score from baseline at week 24.Secondary outcomes were CTP class and score,serum liver function indices,mortality,incidence of hepatocellular carcinoma and variceal bleeding.Results:The proportion of patients with a CTP score reduction≥2 was significantly greater in the YGJ than in the placebo group(p=0.009);the percentage of patients with CTP class C was significantly less than that in the placebo group(p<0.05),and the YGJ group had a significantly greater mean change from baseline in CTP score at week 24(p=0.034).The improvement in measured values and change from baseline of prothrombin time,serum albumin,platelets,cholinesterase,international normalized ratio,and activated partial thromboplastin time were significantly better with YGJ than with placebo.Between-group differences in cumulative rates of variceal bleeding,hepatocellular carcinoma,death,or the frequency of any adverse event(AE),AEs related to treatment,or discontinuation because of AEs were not significant.Conclusions:YGJ significantly improved CTP scores and hepatic synthetic and reserve function in patients with HBV-related decompensated cirrhosis,and was safe and well tolerated. | Long Chen Chaoqun Zhao Weili Yao Wei Liu Hua Zhang Yongping Mu Hong Cai Dongying Xue Chengbao Wang Wan’e Wang Yuehong Lin Jiamei Chen Ping Liu | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 3 |
| 13 | A study of peroxyacetyl nitrate at a rural site in Beijing based on continuous observations from 2015 to 2019 and the WRFChem model显示文摘Peroxyacetyl nitrate(PA N)is one of the most important photochemical pollutants and has aroused much concern in China in recent decades.However,few studies described the long-term variations in PAN in China.In this study,we continuously monitored the PAN,03 and NOx concentrations at a regional background site near Beijing from August 2015 to February 2019.Based on the observed concentrations and climate data,w e analyzed the seasonal PAN variations.The results revealed that the monthly mean PAN concentration ranged from 0.33-2.41 ppb,with an average value of 0.94 ppb.The PAN concentration exhibited a distinct seasonal variation,with high values in spring and low values in winter.After analyzing the corresponding meteorological data,we found that stronger ultraviolet(UV)radiation,a relatively longer lifetime and a higher background PAN concentration contributed to the high PAN concentrations in spring.In addition,with the utilization of the WRF-Chem(Weather Research and Forecasting with Chemistry)model,the cause of the extremely high PAN concentration in spring 2018 wa s determined.The model results demonstrated that an anomalously low pressure and the southwesterly winds in northern China might be the main causes of the increased PAN concentration in Beijing and its surrounding area in spring 2018. | Yulu Qiu Zhiqiang Ma Weili Lin Weijun Quan Weiwei Pu Yingruo Li Liyan Zhou Qingfeng Shi | 2020 | Frontiers of Environmental Science & Engineering2020，14，4： | 3 |
| 14 | Generation of sp3111 transgenic RNAi mice via permanent integration of small hairpin RNAs in repopulating spermatogonial cells in vivo显示文摘spermatid 特定的基因, sp3111,是 four-transmembrane 基因家庭的一个新成员。然而,它的繁殖生物功能留下逃犯。这研究的目的是为进一步在它的繁殖功能上学习 sp3111 基因表示的抑制的效果建立一个 sp3111 击倒的雄的老鼠模型。pSUPER-sp3111-shRNA 的 Recombinant 向量,对老鼠 sp3111 mRNA 的不同区域包含抄录功能的小发卡 RNA 顺序,被构造并且识别。然后,线性化的 recombinant 向量被 electroporation 注入成熟老鼠睾丸和 transfected 到 spermatogonial 房间产生 sp3111 转基因的 RNAi 老鼠。这些 electroporated 男性老鼠与野类型的女性一起被交配在 electroporation 和他们的子孙以后的 30 天被荧光显微镜学和 PCR 两个都检验。在 vivo 的 sp3111 mRNA 的睾丸表达式上的 RNAi 的抑制效率是超过30%并且能稳定地被传给 F3 产生,这被发现,并且与野类型的雄的鼠标相比,吗 sp3111 RNAi 雄的鼠标的后代的吝啬的数字从 11 被减少???????????????????????栠吗?? | Weili Shi Tingyan Shi Zheyu Chen Jufang Lin Xiaofeng Jia Jian Wang Huijuan Shi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，2： | 2 |
| 15 | The abuse of anesthetic propofol: associated with cognitive impairment显示文摘Propofol (2,6-diisopropylphenol)is a widely used intravenous anesthetic for the fast induction of anesthesia and rapid recovery from general anaesthesia.As a γ-aminobu-tyric acid(GABA)receptor agonist,propofol exerts the anesthetic effects through potentiation of the inhibitory neurotransmitter GABA. | Weili Zhu Wen Zhang Jiali Li Zengbo Ding Yingjie Huang Lin Lu | 2018 | Science China(Life Sciences)2018，61，11： | 2 |
| 16 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hvknokkkppvqb6o05.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 17 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 18 | Effects of friction stir processing on the microstructure and superplasticity of in situ nano-ZrB_2/2024Al composite显示文摘In this study, in situ nano-ZrB_2/2024 Al composites fabricated from 2024Al–K_2ZrF_6–KBF_4 system were processed by friction stir processing(FSP) to achieve superplasticity of the composites. And the effects of particle contents(1 wt%, 3 wt%, 5 wt%), matrix grain size(micron or submicron), strain rates(5×10^(-3)s^(-1), 1×10^(-2)s^(-1), 2×10^(-2)s^(-1) and deformation temperatures(400 K, 480 K, 600 K, 700 K, 750 K) on the superplasticity of the composites were investigated. After the friction stir processing, the coarse grains of the cast composites with matrix grain size of about 80–100 μm and nano-Zr B2 reinforcement size of 30–100 nm were crushed into small grains about 1 μm in size, and the uniformity of the nano-Zr B_2 reinforcements was also improved. And under the same superplastic tensile testing condition at the temperature of 750 K and strain rate of 5×10^(-3)s^(-1), the FSP nano 3 wt%Zr B_2/2024 Al composite exhibited an superplastic elongation of 292.5%, while the elongation of the corresponding cast composite was only less than 100%. Meanwhile, the m values of the FSP composites were always higher than the cast composites, especially the FSP composites with 3 wt% particles has the m value of 0.5321 i.e., the FSP composites should had better superplastic properties than cast ones. Furthermore, the FSP composites had higher apparent deformation activation energy(Q) than that of the lattice diffusion of pure aluminium, indicating that the deformation mechanisms of the FSP composites should be grain boundary sliding mechanisms. | Yutao Zhao Xizhou Kai Gang Chen Weili Lin Chunmei Wang | 2016 | Progress in Natural Science:Materials International2016，26，1： | 2 |
| 19 | Two-year measurements of surface ozone at Dangxiong,a remote highland site in the Tibetan Plateau显示文摘Measurements of surface O3 and carbon monoxide(CO) were made from September 2009 to August 2011 at Dangxiong(30.48°N, 91.10°E, 4187 m a.s.l.), a remote highland site in a southern valley of the Nyainqêntanglha Mountains in the Tibetan Plateau, China. The monthly mean O3 mixing ratio ranged from 29.1 to 51.4 ppb, with an average of 38.5 ppb, and the maximum value was observed in May. The average diurnal cycle of O3 concentration showed a minimum in early morning and a maximum in the afternoon, with a broader 'high platform' from the late morning to the late afternoon, and resembled that of surface wind speed. The concentration of surface O3 was highly significantly correlated with tropospheric column O3 over the regions surrounding Dangxiong and with that of surface O3 observed at a site north of the Nyainqêntanglha Mountains, suggesting a good regional representativeness of surface O3 at Dangxiong. In the afternoon when stronger winds blew, surface air showed distinct features of free-atmospheric air, with higher O3, lower CO, and lower relative humidity(RH). The negative O3–CO and O3–RH correlations in most months indicate a significant influence of air masses from the free troposphere. Trajectory analysis suggests that air masses originating from the south of the site make a negative net contribution to surface O3 and a positive contribution to CO and humidity, and those from the northwest sector contribute conversely to the respective quantities. | Weili Lin Xiaobin Xu Xiangdong Zheng Jaxi Dawa Ciren Baima Jin Ma | 2015 | Journal of Environmental Sciences2015，27，5： | 1 |
| 20 | Observed levels and trends of gaseous SO_2 and HNO_3 at Mt.Waliguan,China:Results from 1997 to 2009显示文摘Long-term measurements of SO2 and HNO3,particularly those from the background sites,are rarely reported.We present for the first time the long-term measurements of SO2 and HNO3 at Waliguan(WLG),the only global baseline station in the back-land of the Eurasian Continent.The concentrations of SO2 and HNO3 were observed at WLG from 1997 to 2009.The observed annual mean concentrations of SO2 and HNO3 at WLG were 1.28±0.41 and 0.22±0.19μg/m3,respectively.The HNO3 concentrations were much higher in warmer seasons than in colder seasons,while the SO2 concentrations showed a nearly reversed seasonal pattern.In most months,the concentration of HNO3 was significantly correlated with that of SO2,suggesting that some common factors influence the variations of both gases and the precursors of HNO3 may partially be from the SO2-emitting sources.The SO2 concentration had a very significant(P < 0.0001) decreasing trend(-0.2μg/(m3·yr)) in 1997-2002,but a significant(P < 0.05) increasing trend(+0.06 μg/(m 3 ·yr)) in 2003-2009.The HNO3 concentration showed no statistically significant trend during 1997-2009.While the decrease of SO2 in 1997-2002 agrees with the trend of global SO2 emissions,the increase in 2003-2009 is not consistent with the decreasing trends in many other regions over the world.Trajectory analysis suggests that the airmasses from the northern Qinghai-Tibetan Plateau and the Takla Makan Desert regions contributed significantly to the increasing trends of SO2 and HNO3 at WLG in 2003-2009,with a rate of +0.13μg/(m3·yr) and +0.007μg/(m3·yr),respectively. | Weili Lin Xiaobin Xu Xiaolan Yu Xiaochun Zhang Jianqing Huang | 2013 | Journal of Environmental Sciences2013，25，4： | 1 |
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