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| 1 | 产脂肪酶黑曲霉摇瓶发酵条件优化研究显示文摘黑曲霉Aspergillus niger G62s是一株具有遗传稳定的高产脂肪酶菌株。针对于G62s摇瓶发酵条件进行统计学优化研究,以提高该菌株的产脂肪酶能力。首先,采用单因素方法对发酵接种量、摇瓶装量、培养温度、培养时间等因素进行考查,在此基础上进行4因素3水平的响应面分析(Response surface methodology,RSM)的统计学优化。得到的优化发酵条件是接种量1.9%,摇瓶装量56 m L(500 m L摇瓶),培养温度30 oC,培养时间75 h。在该优化条件下,脂肪酶活性达到(212 9±39.9)U/m L,相比初始的发酵条件提高16.7%。针对于影响G62s菌株产脂肪酶的4个发酵条件,在单因素实验的基础上通过RSM方法优化,显著提高了目标菌株脂肪酶产量。 | 张谦 贾佳 林智 杨晓锋 郭宏涛 王剑英 CarolSze Ki Lin | 2015 | 生物技术通报2015，31，12： | 12 |
| 2 | Effectiveness and safety of traditional Chinese herbs in children with cough variant asthma: a systematic review and Meta-analysis显示文摘OBJECTIVE:To systematically investigate the clinical effectiveness and safety of traditional Chinese herbs(TCHs)as an alternative to conventional medicine(CM)in children with cough variant asthma(CVA).METHODS:Randomized controlled trial(RCT)studies that were published from their inceptions to March 31,2020,were identified from the electronic databases of China National Knowledge Infrastructure,Wangfang,Pub Med,and Cochrane Central Library.The primary outcome of the review was the total effective rate(TER),and the secondary outcomes were immunoglobulin E(Ig E),peak expiratory flow(PEF),adverse drug reactions,and relapse rates of interventions.RESULTS:For the Meta-analysis,13 studies involving 992 children with CVA were included.In terms of TER and Ig E,the experimental interventions of TCH,when compared with the control interventions of CM,on pediatric CVA were found to be significantly effective(P<0.0001),whereas for spirometry,PEF was not significantly improved in the TCH group(P=0.48).The incident rates of adverse drug reaction and relapse were found to be significantly lower in the TCH group than those in the CM group(P=0.02 and P<0.0001,respectively).CONCLUSION:Compared with CM therapy,the effects of TCH therapy on pediatric CVA were significantly beneficial in terms of TER and Ig E,but not for PEF,and the methodological quality of included studies was poor.Therefore,the results should be interpreted with caution.More randomized controlled trials with rigorous experimental methodologies are required for objectivity in the future. | Kyou-Hwan Han Ki Haeng Cho CUI Shanqin Lily Lin Jaejong Kim | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 6 |
| 3 | Antifungal and antiviral products of marine organisms显示文摘 | Randy Chi Fai Cheung Jack Ho Wong Wen Liang Pan Yau Sang Chan Cui Ming Yin Xiu Li Dan He Xiang Wang Evandro Fei Fang Sze Kwan Lam Patrick Hung Kui Ngai Li Xin Xia Fang Liu Xiu Yun Ye Guo Qing Zhang Qing Hong Liu Ou Sha Peng Lin Chan Ki Adnan A Bekhit Alaa | 2014 | Applied Microbiology and Biotechnology2014，，8： | 2 |
| 4 | Down‐regulation of ING4 is associated with initiation and progression of lung cancer显示文摘 | Qiu‐shiWang MingLi Lin‐youZhang YanJin Dan‐danTong YangYu JingBai QiHuang Fang‐LiLiu AnLiu Ki‐YoungLee Song‐binFu | 2010 | Histopathology2010，，2： | 2 |
| 5 | Evaporator models for operation with dry,wet and frosted finned surfaces显示文摘 | Oskarsson SP Krakow KI Lin S | 1990 | ASHRAE Transactions1990，96，1： | 1 |
| 6 | Optical Detection of Human Papil- lomavirus Type 16 and Type 18 by Sequence Sandwich Hybridiza- tion With Oligonucleotide-Functionalized Au Nanopartieles 显示文摘 | Chen SH Lin KI Tang CY | 2009 | Ieee T Nanobiosic2009，8，2： | 1 |
| 7 | The role of cytogenetic abnormalities as a prognostic marker in primary myelofibrosis:applicability at the time of diagnosis and later during disease course显示文摘 | TamCS Abruzzo LV Lin KI | 2009 | {H}Blood2009，，18： | 1 |
| 8 | Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program 显示文摘 | Shaffer AL Lin KI Kuo TC | 2002 | Immunity2002，17，： | 1 |
| 9 | An idealized model of re- versed-cycle hot gas defrosting of evaporators, Part 2: Experimental analysis and validation 显示文摘 | Krakow KI Yan L Lin S | 1993 | ASHRAE Transactions1993，99，2： | 1 |
| 10 | Thiol-ene hydrogels as desmoplasia- mimetic matrices for modeling pancreatic cancer cell growih, invasion, and drug resistance显示文摘 | Ki CS Lin TY Korc M | 2014 | Biomaterials2014，35，36： | 1 |
| 11 | Microstructure and segregation behavior of pal adium in silver-copper-pal adium al oys显示文摘 | Chen KI Lin JH Ju CP | | 0，，07： | 1 |
| 12 | Analog VLSI implementations of auditory wavelet transforms using switched-capacitor circuits 显示文摘 | LIN J KI W H EDWARDS T | 1994 | IEEE Trans Circ Syst I: Fundam Theo & Applic1994，41，9： | 1 |
| 13 | Blimp-1-dependent repression of pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells 显示文摘 | Lin KI Angelin Duclos C Kuo TC | 2002 | Mol Cell Biol2002，22，13： | 1 |
| 14 | Ng, Fast Inversion of Triangular Toeplitz Matrices 显示文摘 | Lin Fu - Rong Ching Wai - Ki Michael K | 2004 | Theoretical Computer Science2004，315，： | 1 |
| 15 | Evaporator model for operation with dry,wet,and frosted finned surfaces显示文摘 | Oskarsson SP Krakow KI Lin S | 1990 | ASHRAE Trans1990，96，1： | 1 |
| 16 | Blimp-1, orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program 显示文摘 | Shaffer AL Lin KI Kuo TC | 2002 | Immunity2002，17，1： | 1 |
| 17 | Blimp-1 is required for the formation of immunoglobulin se- creting plasma cells and pre-plasma memory B cells显示文摘 | Shapiro-Shelef M Lin KI McHeyzer-Williams LJ | | Immunity0，19，4： | 1 |
| 18 | Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells 显示文摘 | Shapiro Shelef M Lin KI McHeyzer Williams LJ | 2003 | Immunity2003，19，4： | 1 |
| 19 | Blimp-1 is required for the formation of immunoglohulin secreting plasma ceils and pre-plasma memory B cells 显示文摘 | Shapiro-Shelef M Lin KI McHeyzer-Williams LJ | 2003 | Immunity2003，19，4： | 1 |
| 20 | Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated in- duction of transcription factor Blimp-1 显示文摘 | Lin KI Kao YY Kuo HK | 2006 | J Biol Chem2006，281，24： | 1 |
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