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| 1 | Nearshore Wave Field Analysis Using SAR Images显示文摘Satellite remote sensing technique offers a wide range of information, and is one of the tools for ocean wave observation. This paper discusses the limitations of Synthetic Aperture Radar (SAR) images in wave field analysis. It is found that the wave field analysis is affected by the gray value distribution of image and the relationship between satellite travel and wave propagation directions. Since human activities and coastal engineering are performed in nearshore areas, some issues are discussed for nearshore SAR image analysis. Several case studies show that the wave parameters estimated from nearshore SAR images are quite different from in situ measurements, suggesting that the wave information derived from nearshore SAR images cannot appropriately represent the wave characteristics. One of the reasons is that the wave field is non homogeneous in the nearshore area. | DOONG Dongjiing KAO Chiachuen CHUANG Zsuhsin LIN Hongpeng | 2003 | 海洋工程:英文版2003，17，1： | 2 |
| 2 | A spike-trimer protein-based tetravalent COVID-19 vaccine elicits enhanced breadth of neutralization against SARS-CoV-2 Omicron subvariants and other variants显示文摘Multivalent vaccines combining crucial mutations from phylogenetically divergent variants could be an effective approach to defend against existing and future SARS-Co V-2 variants.In this study,we developed a tetravalent COVID-19 vaccine SCTV01E,based on the trimeric Spike protein of SARS-Co V-2 variants Alpha,Beta,Delta,and Omicron BA.1,with a squalenebased oil-in-water adjuvant SCT-VA02B.In the immunogenicity studies in na?ve BALB/c and C57BL/6J mice,SCTV01E exhibited the most favorable immunogenic characteristics to induce balanced and broad-spectrum neutralizing potencies against pre-Omicron variants(D614G,Alpha,Beta,and Delta)and newly emerging Omicron subvariants(BA.1,BA.1.1,BA.2,BA.3,and BA.4/5).Booster studies in C57BL/6J mice previously immunized with D614G monovalent vaccine demonstrated superior neutralizing capacities of SCTV01E against Omicron subvariants,compared with the D614G booster regimen.Furthermore,SCTV01E vaccination elicited na?ve and central memory T cell responses to SARS-Co V-2 ancestral strain and Omicron spike peptides.Together,our comprehensive immunogenicity evaluation results indicate that SCTV01E could become an important COVID-19 vaccine platform to combat surging infections caused by the highly immune evasive BA.4/5 variants.SCTV01E is currently being studied in a head-to-head immunogenicity comparison phase 3 clinical study with inactivated and m RNA vaccines(NCT05323461). | Rui Wang Hongpeng Huang Chulin Yu Chunyun Sun Juan Ma Desheng Kong Yalong Lin Dandan Zhao Shaozheng Zhou Jianbo Lu Sai Cao Yanjing Zhang Chunxia Luo Xuefeng Li Yang Wang Liangzhi Xie | 2023 | Science China(Life Sciences)2023，66，8： | 1 |
| 3 | DNMT3A inhibits E2F1-induced arterial marker expression and impairs angiogenesis in human umbilical artery endothelial cells显示文摘Arterial marker genes EphrinB2 and HEY2 are essential for cardiovascular development and post-natal neovascularization.Our previous study confirmed.that E2F1 could activate the transcription of EphrinB2 and HEY2 in human mesenchymal stem cells;however,the detailed mechanism has not been resolved yet.In this study,we focused on the interaction between E2F1 and DNMT3A,a de novo DNA methyltransferase,on regulating the expression of EphrinB2 and HEY2,and explored the potential mechanisms.Gain-and loss-of-function experiments implicated the positive effect of E2F1 on the expression of EphrinB2 and HEY2 and tube formation in human umbilical artery endothelial cells.Accumulation of DNMT3A decreased the levels of EphrinB2 and HEY2,and impaired tube formation induced by E2F1,while inhibiting DNMT3A by RNA interference aug-mented their expression and angiogenesis in E2F 1-trasfected cells.We then asked whether the low expressions of EphrinB2 and HEY2 induced by DNMT3A are related to the methylation status of their promoters.Surprisingly,the methylation status of the CpG islands in the promoter region was not significantly affected by overexpression of exogenous DNMT3A.Furthermore,the inter-action between E2F1 and DNMT3A was confirmed by co-immunoprecipitation.DNMT3A could inhibit the transcription of EphrinB2 and HEY2 promoters by affecting the binding of E2F1 to its recognition sequences as revealed by luciferase reporter assay and chromatin immunoprecipita-tion.These results identified a novel mechanism underlying the cooperation of DNMT3A with E2F1 on regulating target gene expression,and revealed their roles in the angiogenic process. | Kaiyue Su Ningning Lin Shouqiang Xie Yabo Han Zaiming Yang Hongmin Zhang Hongpeng He Sa Zhou Wenjian Ma Tongcun Zhang Nan Wang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 1 |
| 4 | A Novel Product Remaining Useful Life Prediction Approach Considering Fault Effects显示文摘In this paper,a novel remaining useful life prediction approach considering fault effects is proposed.The Wiener process is used to construct the degradation process of single performance characteristic with the fault effects.The first passage time based remaining useful life distribution is calculated by assuming fault occurrence moment is a random variable and follows a certain distribution.Expectation maximization algorithm is employed to estimate model parameters,where the fault occurrence moment is considered as a missing data.Finally,a Copula function is used to describe the dependence between the multiple performance characteristics and derive joint remaining useful life(RUL)distribution of product with the fault effects.The effectiveness of the proposed approach is verified by the experiments of turbofan engines. | Jingdong Lin Zheng Lin Guobo Liao Hongpeng Yin | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，11： | 0 |
| 5 | NEW STORIES IN BEIJING'S CULTURAL PARKS显示文摘There are many approaches to assessing the cultural development of a city.The construction and development of cultural and creative industry parks can serve as one barometer for measuring cultural development.During the China International Fair for Trade in Services 2021 from September 2 to 7 in Beijing,10 cultural and creative industry parks,including Zhongguancun Software Park,768 Creative Industry Park and Jiacheng Hutong Creative Workshop,along with 80 companies located in the parks,were present to display the latest developments in the capital city. | Zhang Hongpeng(Translated) Brad Green Jin Jianhui(Photos) Wu Yibin(Photos) | 2021 | Beijing2021，，38： | 0 |
| 6 | Mechanisms of Myocardial Stunning in Stress-Induced Cardiomyopathy显示文摘Stress-induced cardiomyopathy,in contrast to acute myocardial infarction,is a type of acute heart failure characterized by reversible left ventricular dysfunction.Cardiac imaging primarily reveals left ventricle myocardial stunning,81.7%of which is apical type.Emotional or psychological stress usually precedes the onset of stress-induced cardiomyopathy,which is increasingly being recognized as a unique neurogenic myocardial stunning disease.To distinguish between acute myocardial infarction and acute viral or auto-immune myocarditis,this review summarizes specific mechanisms of myocardial stunning in stress-induced cardiomyopathy,such as calcium disorders,metabolic alterations,anatomical and histological variations in different parts of the left ventricle,and microvascular dysfunction. | Quanwei Pei Nadine Mbabazi Lina Zou Junpei Zhang Hongpeng Yin Bin Li Jiaxin Wang Weifa Wang Pengqi Lin Junjie Yang Dechun Yin | 2022 | Cardiovascular Innovations and Applications2022，7，3： | 0 |
| 7 | The Role of Sleep Deprivation in Arrhythmias显示文摘Sleep is essential to the normal psychological and physiological activities of the human body.Increasing evidence indicates that sleep deprivation is associated with the occurrence,development,and poor treatment effects of various arrhythmias.Sleep deprivation affects not only the peripheral nervous system but also the central nervous system,which regulates the occurrence of arrhythmias.In addition,sleep deprivation is associated with apoptotic pathways,mitochondrial energy metabolism disorders,and immune system dysfunction.Although studies increasingly suggest that pathological sleep patterns are associated with various atrial and ventricular arrhythmias,further research is needed to identify specific mechanisms and recommend therapeutic interventions.This review summarizes the findings of sleep deprivation in animal experiments and clinical studies,current challenges,and future research directions in the field of arrhythmias. | Wenlong Wang Hongpeng Yin Ge Sun Junpei Zhang Jingmei Sun Nadine Mbabazi Lina Zou Bin Li Pengqi Lin Quanwei Pei Xin Wang Penghe Wang Xuanrui Ji Xiufen Qu Dechun Yin | 2022 | Cardiovascular Innovations and Applications2022，7，3： | 0 |
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