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| 1 | DNA G-quadruplex and its potential as anticancer drug target显示文摘G-quadruplex secondary structures are four-stranded globular nucleic acid structures form in the specific DNA and RNA G-rich sequences with biological significance such as human telomeres,oncogene-promoter regions,replication initiation sites,and 5′and 3′-untranslated(UTR)regions.The non-canonical G-quadruplex secondary structures can readily form under physiologically relevant ionic conditions and are considered to be new molecular target for cancer therapeutics.This review discusses the essential progress in our lab related to the structures and functions of biologically relevant DNA G-quadruplexes in human gene promoters and telomeres,and the opportunities presented for the development of G-quadruplex-targeted smallmolecule drugs. | ONEL Buket LIN Clement YANG Dan Zhou | 2014 | Science China Chemistry2014，57，12： | 3 |
| 2 | Spatial patterns and effects of air pollution and meteorological factors on hospitalization for chronic lung diseases in Beijing, China显示文摘Chronic obstructive pulmonary disease(COPD), lung cancer(LC) and tuberculosis(TB) are common chronic lung diseases that generate a large disease burden and significant health care resource use in China. The aim of this study was to quantify spatial patterns and effects of air pollution and meteorological factors on hospitalization of COPD, LC and TB in Beijing. Daily counts of hospitalization for 2010 were obtained from the Beijing Urban Employees Basic Medical Insurance(UEBMI) system.Bayesian hierarchical Poisson regression models were applied to identify spatial patterns of hospitalization for COPD, LC and TB at the district level and explore associations with inhalable particulate matter(aerodynamic diameter <10 μm, PM10), sulfur dioxide(SO2), nitrogen dioxide(NO2), mean temperature and relative humidity. There were 18,882, 14,295 and 2,940 counts of hospitalizations for COPD, LC and TB respectively, in Beijing in 2010. Clusters of high relative risk were in different locations for the three diseases. The effect of relative humidity on COPD hospitalization was most significant with a relative risk(RR) of 1.070(95%CI: 1.054, 1.086) per one percent increase. For lung cancer hospitalization, exposure to ambient SO2 was associated with a RR of 1.034(95%CI: 1.011, 1.058) per μg m–3 increase. For tuberculosis, the effect of mean temperature was significant with a RR of 1.107(95%CI: 1.038, 1.180) per °C increase. Risk factors and spatial patterns were different for hospitalization of non-infectious and infectious chronic lung disease in Beijing. Even over a short time period(one year), associations were apparent with air pollution and meteorological factors. | Lin Tian Chuan Yang Zijun Zhou Ziting Wu Xiaochuan Pan Archie C. A. Clements | 2019 | Science China(Life Sciences)2019，62，10： | 3 |
| 3 | The influence of chemical composition and microstructure of API linepipe steels on hydrogen induced cracking and sulfide stress corrosion cracking显示文摘 | Rogério Augusto Carneiro Rajindra Clement Ratnapuli Vanessa de Freitas Cunha Lins | 2003 | Materials Science & Engineering A2003，，1： | 2 |
| 4 | CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence显示文摘 | Petrie EJ Clements CS Lin J | 2008 | J Exp Meal2008，205，3： | 1 |
| 5 | Monte Carlo treatment planning and high-resolution alpha-track autoradiography for neutron capture therapy显示文摘 | Clement S Lin K | 1989 | Strahlenther Onkol1989，165，： | 1 |
| 6 | Current status of ablative techniques for small renal masses显示文摘 | Clements T Lin YK Raman JD | 2011 | Expert Rev Anticancer Ther2011，11，6： | 1 |
| 7 | Activity of the Arabidopsis RD29A and RD29B promoter elements in soybean under water stress 显示文摘 | Bihmidine S Lin J Stone J Awada T Specht J Clemente T | 2013 | Planta2013，237，1： | 1 |
| 8 | Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats 显示文摘 | Jiang ZY Lin YW Clement A | 1999 | J Clin Invest1999，104，4： | 1 |
| 9 | Palmitic Acid -Modified Poly-L-Lysinc for Non-Viral Delivery of Plasmid DNA to Skin Fibroblasts显示文摘 | Meysam Abbasi Hasan Uludag Vanessa lncani Cori Olson Xiaoyue Lin Bastiak Aetian Clements Dorothy Rutkowski Aziz Ghahary Michael Weinfeld | 2007 | Biomacromolecules2007，8，4： | 1 |
| 10 | Rare case of perforated giant gastric ulcer with concurrent thyroid storm:A case report显示文摘BACKGROUND Thyroid storm is an uncommon condition manifesting in severe thyrotoxicosis with a high mortality rate.The concurrence of peptic ulcer disease and hyperthyroidism is rare due to concurrent activation of both the sympathetic and parasympathetic pathways.We present a case of perforated giant gastric ulcer with concurrent thyroid storm who underwent damage control surgery with emergency patch repair with falciform ligament and recovered well.CASE SUMMARY A 53-year-old male chronic smoker,with no previous medical history,presented with severe generalized abdominal pain and vomiting for one day duration.Further history revealed weight loss,diarrhea,and anxiety over the past three months.On clinical examination,patient was febrile with temperature of 38.6 Degrees Celsius and tachycardic at 130-140 beats per minute,his blood pressure was low at 90/50mmHg.His abdomen was tender with generalized peritonism.In view of his clinical history,a thyroid screen was ordered which showed raised thyroxine(T4)levels of 90.3 pmol/L and low thyroxine stimulating hormone(TSH)levels of 0.005μU/mL.Chest X-ray showed no sub-diaphragmatic free air,but contrasted CT scan revealed pneumoperitoneum with large amount of intraabdominal free fluid.The working diagnosis was perforated peptic ulcer complicated by thyroid storm.An urgent endocrinologist consult was made,and patient was started on beta blocker and intravenous steroids pre-operatively.The patient underwent emergency laparotomy with washout and patch repair of the perforated gastric ulcer.Patient was monitored post-operatively in intensive care unit and required IV hydrocortisone and Lugol’s iodine.Histology of the ulcer edges showed no malignancy.On post-operative day seven,T4 decreased to 20.4 pmol/L,TSH was 0.005 mLU/L.His thyroid function test subsequently normalized 3 mo post-operatively with T418.1 pmol/L,TSH 1.91 mLU/L.Patient’s recovery was otherwise uneventful.Thyroid receptor antibody subsequently was positive,and patient was managed for Grave’s disease by the endocrinologist.CONCLUSION This case highlights the rare but life-threatening clinical emergency of peptic ulcer perforation complicated by thyroid storm.Multidisciplinary perioperative management is crucial to optimize patient for surgery and damage control principles should be taken for an acute surgical patient with concurrent endocrine crisis. | Jasper Xiangwei Wang Lin Seong Soh Dinesh Carl Junis Mahendran Chang Yi Woon Clement Luck Khng Chia | 2022 | World Journal of Surgical Procedures2022，12，1： | 0 |
| 11 | Recent Advances in Printed Thin-Film Batteries显示文摘The rapidly increasing demand for wearable electronic devices has motivated research in low-cost and flexible printed batteries with diverse form factors and architectures.In the past,technological achieve-ments in the field have been emphasized,overlooking the industrial and market requirements.However,different applications require different battery chemistries and formats,that greatly impacts the manu-facturing process and competition landscape.These chemistries and formats should therefore be selected carefully to maximize the chances for commercial success.As some of these technologies are starting to be marketed for portable electronics,there is a pressing need to evaluate different printing technologies and compare them in terms of the processing constraints and product requirements of specific electronic devices.By evaluating the intrinsic strengths and current limitations of printed battery technologies,development pathways can be prioritized,and potential bottlenecks can be overcome to accelerate the path to market. | Benoit Clement Miaoqiang Lyu Eeshan Sandeep Kulkarni Tongen Lin Yuxiang Hu Vera Lockett Chris Greig Lianzhou Wang | 2022 | Engineering2022，8，6： | 0 |
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