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| 1 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 2 | Characterization of the Yeast Transcriptome显示文摘 | Victor E Velculescu Lin Zhang Wei Zhou Jacob Vogelstein Munira A Basrai Douglas E Bassett Phil Hieter Bert Vogelstein Kenneth W Kinzler | 1997 | Cell1997，，2： | 4 |
| 3 | Quantum tunneling and chaos in a driven enharmonic oscillator 显示文摘 | Lin W A Balletine L E | 1990 | Physical Review Letters1990，65，： | 2 |
| 4 | Isolation and characterization of collagens from the skin, scale and bone of deep-sea redfish (Sebastes mentella)显示文摘 | LIN W XINXIN A FANGMEI Y | 2008 | Food Chemistry2008，108，： | 1 |
| 5 | The electrochemical polishing behaviour of P/M high-speed steel (ASP 23) in perchloric-acetic mixed acids显示文摘 | HUANG C A LIN W LIN S C | 2003 | Corrosion Science2003，45，11： | 1 |
| 6 | The role of the surgeon in the evolution of flexible endoscopy显示文摘 | Morgenthal C B Richards W O Dunkin B J Forde K A Vitale G Lin E | 2007 | Surg Endosc2007，21，6： | 1 |
| 7 | Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia显示文摘 | Hou H A Chou W C Lin L I | 2008 | Leuk Res2008，32，6： | 1 |
| 8 | Intermediate band photovoltaic solar cell based on ZnTe∶O显示文摘 | WANG W M LIN A S PHILLIPS J D | 2009 | Applied Phy-sics Letters2009，95，1： | 1 |
| 9 | A homochiral porous metal-organic framework for highly enantioselective heterogeneous asymmetric catalysis显示文摘 | Wu C D Hu A Zhang L Lin W | | 0，，： | 1 |
| 10 | A role for XRCC2gene polymorphisms in breast cancer risk and survival显示文摘 | Lin W Y Camp N J Cannon-Albright L A | 2011 | J Med Genet2011，48，7： | 1 |
| 11 | Coalbed methane liquefaction adopting a nitrogen expansion process with propane pre -cool- ing显示文摘 | Gao T Lin W S Gu A Z | 2010 | Applied Energy2010，87，7： | 1 |
| 12 | The oxazolidinone eperezolid binds to the 50s ribosomal subunit and competes with binding of chloramphenicol and lincomycin 显示文摘 | LIN A H MURRAY R W VIDMAR T J | 1997 | Antimicrob Agents Chemother1997，41，10： | 1 |
| 13 | HIV increases HCV replication in a TGF-β1-Dependent manner 显示文摘 | Lin W Y Weinberg E M Tai A W | 2008 | Gastroenterrology2008，134，： | 1 |
| 14 | Developmental potential of Gcn5^-/- embryonic stem cells in vivo and in vitro 显示文摘 | Lin W Srajer G Evrard Y A | 2007 | Dev Dyn2007，236，6： | 1 |
| 15 | Agency Costs and Ownership Structure显示文摘 | Cole R A Lin J W | 2000 | Journal of Finance2000，55，1： | 1 |
| 16 | Strategy,choice of performance measures, and performance 显示文摘 | Van der Stede W A Chow C W and Lin T W | 2006 | Bebavioral Research in Accounting2006，18，： | 1 |
| 17 | Agency Costs and Ownership Structure 显示文摘 | Ang J S Cole R A Lin J W | 2000 | Journal of Finance2000，55，1： | 1 |
| 18 | Zeolite-catalyzed isomerization of oleicacid to branched-chain isomers显示文摘 | Ngo H L Nunez A Lin W | 2007 | European Journal of Lipid Scienceand Technology2007，109，3： | 1 |
| 19 | A simple and fast secondary structure prediction method using hidden neural networks 显示文摘 | LIN Kuang SIMOSSIS A V TAYLOR W R HERINGA J | 2005 | Bioinformatics2005，21，2： | 1 |
| 20 | Agency Costs and Ownership Structure 显示文摘 | Ang J S Cole R A Lin J W | 2000 | Journal of Finance2000，55，1： | 1 |
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