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| 1 | Outcome of transarterial chemoembolization in patients with inoperable hepatocellular carcinoma eligible for radiofrequency ablation显示文摘AIM: To evaluate the outcome of transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma (HCC) <5 cm in diameter eligible for radiofrequency ablation (RFA).METHODS: The treatment-related mortality, morbidity,long-term survival, and prognostic factors of HCC patients who had TACE and fulfilled the present inclusion criteria for RFA were evaluated.RESULTS: Of the 748 patients treated with TACE between January 1990 and December 2002, 114 patients were also eligible for RFA. The treatment-related mortality and morbidity were 1% and 19%, respectively. Survival at 1, 3, and 5 years was 80%, 43%, and 23%, respectively. Older age and a high albumin level were associated with a better survival, whereas a high α-fetoprotein level (AFP) and the size of the largest tumor >3 cm in diameter were adverse prognostic factors in multivariate analysis.CONCLUSION: The morbidity, mortality, and survival data after TACE for small HCCs eligible for RFA are comparable to those reported after RFA in the literature. Our data suggest the need for a randomized comparison of the two treatment modalities for small HCCs. | Mike SL Liem Ronnie TP Poon Chung Mau Lo Wai Kuen Tso Sheung Tat Fan | 2005 | World Journal of Gastroenterology2005，11，29： | 15 |
| 2 | Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies显示文摘Cancer cells are well documented to rewire their metabolism and energy production networks to support and enable rapid proliferation, continuous growth, survival in harsh conditions, invasion, metastasis, and resistance to cancer treatments. Since Dr. Otto Warburg's discovery about altered cancer cell metabolism in 1930, thousands of studies have shed light on various aspects of cancer metabolism with a common goal to find new ways for effectively eliminating tumor cells by targeting their energy metabolism. This review highlights the importance of the main features of cancer metabolism, summarizes recent remarkable advances in this field, and points out the potentials to translate these scientific findings into life-saving diagnosis and therapies to help cancer patients. | Liem Minh Phan Sai-Ching Jim Yeung Mong-Hong Lee | 2014 | Cancer Biology & Medicine2014，11，1： | 11 |
| 3 | A MUCLTI-PARAMETER SPLITTING EXTRAPOLATION AND A PARALLEL ALGORITHM显示文摘The finite element solutions of elliptic equations are shown to have a multiparameter asymptotic error expansion. Based on this expansion and a multi-parametersplitting extrapolation technique, a parallel algorithm for solving multi-dimensional equations with high order accuracy is introduced. | ZHOU Aihui(Institute of Systems Science, Academia Sinica, Beijing 100080, China)Liem Chin-ho Shih Tsi-min(Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong)LU Tao(Institute of Chengdu Computer Application, Academia Sinica, Ch | 1997 | Systems Science and Mathematical Sciences1997，10，3： | 8 |
| 4 | Expression of β-catenin in hepatocellular carcinoma显示文摘AIM: The β-catenin has been recognized as a critical member of the Wnt signaling pathway and plays an important role in the generation/differentiation of many tissues. Inappropriate activation of this pathway has been implicated in carcinogenesis. The mechanism underlying the development as well as its prognosis of hepatocellular carcinoma (HCC) has remained unclear. The purpose of this study is to analyze the expression of β-catenin in HCC in relation to histological grades and viral hepatitis backgrounds.METHODS: Thirty-two sections were selected at random from autopsy and surgical cases of HCC. Immuohistologically,the location and positivity of β-catenin expression in HCC was examined.RESULTS: Normal hepatocytes did not express β-catenin.In 78% of HCC β-catenin was expressed at the membrane of the cells, with or without cytoplasmic and/or nuclear expression. The tumor cells with well- and moderatelydifferentiated grades expressed frequently at the membrane and cytoplasm compared with poorly-differentiated type.Nuclear expression of β-catenin was prone to occur in the tumor cells of poorly-differentiated grade. There were 15% of hepatitis C virus (HCV) backgrounds with nuclear expression. In contrast, there was 38% with nuclear expression in hepatitis B virus (HBV) backgrounds. In nonBnonC hepatitis, no case expressed nuclear β-catenin.CONCLUSION: The β-catenin expression in HCC cells was heterogenous among types of hepatitis viral infection.Wnt signaling pathway might be deeply involved in less-differentiated HCC and HBV background. | Liem Thanh Tien Masahiro Ito Mikiko Nakao Daisuke Niino Meirmanov Serik Masahiro Nakashima Chun-Yang Wen Hiroshi Yatsuhashi Hiromi Ishibashi | 2005 | World Journal of Gastroenterology2005，11，16： | 8 |
| 5 | Stem cell-based therapy for human diseases显示文摘Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated.Stem cell-based therapy,including human pluripotent stem cells(hPsCs)and multipotent mesenchymal stem cells(MSCs),has recently emerged as a key player in regenerative medicine.hPSCs are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body,including three germ layers.MsCs are multipotent progenitor cells possessing self-renewal ability(limited in vitro)and differentiation potential into mesenchymal lineages,according to the International Society for Cell and Gene Therapy(ISCT).This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow(BM),adipose tissue(AT),or the umbilical cord(UC)for the treatment of human diseases,including neurological disorders,pulmonary dysfunctions,metabolic/endocrine-related diseases,reproductive disorders,skin burns,and cardiovascular conditions.Moreover,we discuss our own clinical trial experiences on targeted therapies using MsCs in a clinical setting,and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications,with the ultimate objective of facilitating translational research in regenerative medicine into clinical applications.The mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment,AT-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration,and UC-MsCs are potentially good candidates for pulmonary disease and acute respiratory distress svndrometreatment. | Duc M.Hoang Phuong T.Pham Trung Q.Bach Anh T.L.Ngo Quyen T.Nguyen Trang T.K.Phan Giang H.Nguyen Phuong T.T.Le Van T.Hoang Nicholas R.Forsyth Michael Heke Liem Thanh Nguyen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 7 |
| 6 | 基于三维动力学模型的重型卡车动态参数对平顺性的影响显示文摘为了研究重型卡车动态参数对驾驶员舒适性的影响,以路面随机不平度为激扰,以驾驶室座椅垂向、驾驶室的俯仰角和侧倾角的加权加速度均方根值为目标函数,建立了13自由度的三维动力学模型.采用Matlab/Simulink软件对整车模型进行仿真计算,分析了不同系统参数,如悬架、轮胎、驾驶室悬架和驾驶员座椅悬架的参数对驾驶员座椅垂向振动、驾驶室前后和左右晃动的影响.研究结果表明:悬架系统中刚度和阻尼参数的最佳匹配对车辆平顺性的影响非常明显;随着悬架系统和轮胎刚度的增加,车辆平顺性从优向劣转变,而随着悬架系统阻尼的增加,车辆平顺性呈现从劣转优现象.该研究为重型卡车悬架系统设计提供相应的理论依据. | Le Van Quynh 张建润 王园 孙小娟 Nguyen Van Liem | 2013 | 东南大学学报(自然科学版)2013，43，4： | 6 |
| 7 | Impact of diabetes on promoting the growth of breast cancer显示文摘Background:Type Ⅱ diabetes mellitus(DM2)is a significant risk factor for cancers,including breast cancer.However,a proper diabetic breast cancer mouse model is notwell-established for treatment strategy design.Additionally,the precise diabetic signaling pathways that regulate cancer growth remain unresolved.In the present study,we established a suitable mouse model and demonstrated the pathogenic role of diabetes on breast cancer progression.Methods:We successfully generated a transgenic mouse model of human epidermal growth factor receptor 2 positive(Her2^(+) or ERBB2)breast cancer with DM2 by crossing leptin receptor mutant(Lepr^(db/+))mice with (MMTV-ErbB2/neu)mice.Themousemodelswere administrated with antidiabetic drugs to assess the impacts of controlling DM2 in affecting tumor growth.Magnetic resonance spectroscopic imaging was employed to analyze the tumor metabolism.Results:Treatment with metformin/rosiglitazone in MMTV-ErbB2/Lepr^(db/db) mousemodel reduced serum insulin levels,prolonged overall survival,decreased cumulative tumor incidence,and inhibited tumor progression.Anti-insulin resistance medications also inhibited glycolytic metabolism in tumors in vivo as indicated by the reduced metabolic flux of hyperpolarized ^(13)C pyruvate-to-lactate reaction.The tumor cells from MMTV-ErbB2/Lepr^(db/db) transgenic mice treated with metformin had reprogrammed metabolism by reducing levels of both oxygen consumption and lactate production.Metformin decreased the expression of Myc and pyruvate kinase isozyme 2(PKM2),leading to metabolism reprogramming.Moreover,metformin attenuated the mTOR/AKT signaling pathway and altered adipokine profiles.Conclusions:MMTV-ErbB2/Lepr^(db/db) mouse model was able to recapitulate diabetic HER2^(+) human breast cancer.Additionally,our results defined the signaling pathways deregulated in HER2^(+) breast cancer under diabetic condition,which can be intervened by anti-insulin resistance therapy. | Ping-Chieh Chou Hyun Ho Choi Yizhi Huang Enrique Fuentes-Mattei Guermarie Velazquez-Torres Fanmao Zhang Liem Phan Jaehyuk Lee Yanxia Shi James A.Bankson Yun Wu Huamin Wang Ruiying Zhao Sai-Ching Jim Yeung Mong-Hong Lee | 2021 | Cancer Communications2021，41，5： | 4 |
| 8 | On the invalidity of fuzzifying numerical judgments in the Analytic Hierarchy Process显示文摘 | Thomas L. Saaty Liem T. Tran | 2007 | Mathematical and Computer Modelling2007，，7： | 3 |
| 9 | Morpho-Physiological Changes in Roots of Rice Seedling upon Submergence显示文摘Submergence is a serious environmental condition that causes large loss in rice production in rain fed lowland and flood affected area. This study evaluated morphological and physiological responses of rice roots to submergence using two tolerant rice genotypes FR13A and Swarna-Sub 1 and two sensitive ones Swarna and IR42. The tolerant genotypes had higher survival rate and less shoot elongation but greater root elongation during submergence than the sensitive ones. After submergence,the tolerant genotypes also had higher root dry weight and more active roots than the sensitive ones.Tolerant genotypes exhibited less root injury, with less malondialdehyde production and slower electrolyte leakage after submergence. Tolerant genotypes also maintained higher concentrations of soluble sugar and starch in roots and shoots and higher chlorophyll retention after submergence than the sensitive ones.Our data showed that root traits such as root activity and root growth are associated with survival rate after submergence. This is probably accomplished through higher energy supply, and membrane integrity is necessary to preserve root function and reduce injury during submergence. These root traits are important for submergence tolerance in rice. | Liem T.BUI Evangelina S.ELLA Maribel L.DIONISIO-SESE Abdelbagi M.ISMAIL | 2019 | Rice science2019，26，3： | 3 |
| 10 | Vorolanib,an oral VEGFR/PDGFR dual tyrosine kinase inhibitor for treatment of patients with advanced solid tumors:An open-label,phaseⅠdose escalation and dose expansion trial显示文摘Objective:This study evaluated the safety and preliminary efficacy of vorolanib,a novel tyrosine kinase inhibitor,for treatment of patients with advanced solid tumors.Methods:During dose escalation,patients received increasing doses of oral vorolanib(50-250 mg once daily)in cycles of four weeks for up to one year.During dose expansion,patients received recommended doses(100 and 200 mg)in 4-week cycles.The primary endpoint was to determine the safety and maximum tolerated dose and/or the recommended phase II dose(RP2 D).The severity and type of adverse drug reactions(ADRs)were assessed using the Common Terminology Criteria for Adverse Events version 4.0.The second endpoint was preliminary efficacy in terms of objective response and progression-free survival(PFS).Results:No dose-limiting toxicity occurred during dose escalation(50-250 mg).Five(26.3%)patients in the escalation cohort(n=19)and 12(48.0%)in the expansion cohort(n=25)experienced grade 3 ADRs.The most common ADRs were hair color changes,fatigue,portal hypertension,hypertriglyceridemia,and proteinuria.During dose expansion,the patients treated with 200 mg and 100 mg(once daily)showed an objective response rate of 22.2%and 5.9%,respectively;the disease control rate was 88.9%and 73.3%,respectively;the median PFS was9.9[95%confidence interval(95%CI):7.4-not reached]months and 3.8(95%CI:1.9-not reached)months,respectively.Conclusions:Oral vorolanib at a dose of 200 mg(once daily)exhibited an acceptable safety profile and favorable clinical benefit for patients with advanced solid tumors.The RP2 D for vorolanib was determined to be 200 mg as a daily regimen. | Yan Song Jinwan Wang Xiubao Ren Jie Jin Li Mao Chris Liang Lieming Ding Lin Yang | 2021 | Chinese Journal of Cancer Research2021，33，1： | 2 |
| 11 | Limitation of myocardial infarct size after primary angioplasty:Is a higher patency the only mechanism?显示文摘 | OTTERVANGER J P LIEM A De BOER M J | 1999 | Am Heart J1999，137，3： | 2 |
| 12 | Radiofrequency Lesion Adjacent to the Dorsal Root Ganglion for Cervicobrachial Pain: A Prospective Double Blind Randomized Study显示文摘 | Maarten van Kleef Leon Liem Richel Lousberg Gerard Barendse Fons Kessels Menno E. Sluijter | 1996 | Neurosurgery1996，，6： | 2 |
| 13 | Angiographic Assessment of Myocardial Reperfusion in Patients Treated With Primary Angioplasty for Acute Myocardial Infarction: Myocardial Blush Grade显示文摘 | Arnoud W.J. van ’t Hof Aylee Liem Harry Suryapranata Jan C.A. Hoorntje Menko-Jan de Boer Felix Zijlstra | 1998 | Circulation1998，，23： | 2 |
| 14 | The meaning of complementary, alternative and traditional medicine among the Indonesian psychology community: a pilot study显示文摘OBJECTIVE: Complementary, alternative and traditional medicine(CATM) is a new field, as well as a promising area of study and practice in psychology. It is important to research the cultural context and meaning of CATM, including its definitions and examples, among different communities of psychology because CATM's use is dependent on how it is understood by the members. The aim of this pilot study is to provide an interpretation of the Indonesian psychology community's understanding of CATM through a qualitative approach.METHODS: Online interviews with open-ended questions and purposive sampling were used.Participants were dominantly psychologists or lecturers in clinical psychology area. Ten males and 12 females with an average age of 28.0 ± 2.5 years voluntarily participated in this study. Interviews were audio-recorded, transcribed verbatim, and reviewed and analysed by the two authors to ensure accuracy of interpretation.RESULTS: It was found that there was no single meaning of CATM among the Indonesian community of psychology. Participants were not familiar enough with the terms and tended to use them with overlap.It can be suggested that 'complementary medicine' and 'alternative medicine' or 'complementaryalternative medicine' combined provides more suitable terminology for use among Indonesian psychology community when communicating with other health care professionals.CONCLUSION: The understanding of the terms and examples of CATM were diverse and were often used interchangeably in the projects/interviews. It was also found that Indonesian psychologists required more education regarding CATM. In addition, future studies with more participants from various aspects of the psychology community should be conducted to capture a more representative sample. | Andrian Liem Kuncoro Dewi Rahmawati | 2017 | Journal of Integrative Medicine2017，15，4： | 2 |
| 15 | GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene 显示文摘 | Gallagher P G Liem R I Wong E | 2005 | J Biol Chem2005，280，39： | 1 |
| 16 | Adrenal insufficiency meningococcal sepsis: hioavailable eortisol levels and impact of Interleukin 6 levels and intubation with etomidate on adrenal function and mortality显示文摘 | Brinker M Joosten KF Liem O | 2005 | Clin Endocrinol Metab2005，90，9： | 1 |
| 17 | Accuracy of ultrasonography for the diagnosis of intussusception in infants in Vietnam显示文摘 | Justice FA De Campo M Liem NT | 2007 | Pediatr Radiol2007，37，2： | 1 |
| 18 | Elevated serum HLA calss Ⅰ levels coincide with acute and chronic graft-versus-host disease 显示文摘 | Liem LM Koelman CA Doxiadis Ⅱ | 1997 | Bone Marrow Transplant1997，20，3： | 1 |
| 19 | Levels of certain metals,organochlorine pesticides and dioxins in cord blood, maternal blood,human milk and some commonly used nutrients in the surroundings of the Aral Sea (Karakalpakstan, Repubic of Uzbekistan) 显示文摘 | Ataniyazova OA Baumann RA Liem AK | 2001 | Acts Paediatr2001，90，7： | 1 |
| 20 | Suppression by antisense mRNA demonstrate a requirement for the glial fibrillary acidic protein in the formation of stable astrocytic process in response to neurons显示文摘 | WINSTEIN D E SHELANSKI M L LIEM R K H | 1991 | J Cell Biol1991，112，6： | 1 |
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