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| 1 | Gasdermin D is an executor of pyroptosis and required for interleukin-lp secretion显示文摘 | Wan-ting He Haoqiang Wan Lichen Hu Pengda Chen Xin Wang Zhe Huang Zhang-Hua Yang Chuan-Qi Zhong Jiahuai Han | 2015 | Cell Research2015，25，12： | 195 |
| 2 | Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis显示文摘Necroptosis 和 pyroptosis 是有血浆膜破裂的一个普通特征的规划房间死亡的二种形式。这里,我们与 necroptosis 比较学习了 pyroptosis 的形态学和机制。与 necroptosis 不同, pyroptosis 经历膜 blebbing 并且生产 apoptotic 在血浆膜以前的像身体的房间伸出(称为的 pyroptotic 身体) 破裂。在 necroptosis 的破裂是像爆炸的,而在 pyroptosis 它导致房间变平。necroptosis 的实行被混合的系 kinase 调停,这被知道像域(MLKL ) 在血浆膜的 oligomers,而 gasdermin-D (GSDMD ) 调停在它由 caspase-1 或 caspase-11 的劈开以后的 pyroptosis。我们显示出那 N 终端碎片 caspase 劈开产生的 GSDMD (GSDMD-N ) 也形成 oligomer 并且移居到血浆膜杀死房间。MLKL 和 GSDMD-N 是脂性的,两蛋白质的 N 终端序列为他们的 oligomerization 和血浆膜 translocation 是重要的。不同于在血浆膜上形成隧道的 MLKL,那导致渗透地胀大的选择离子的流入冲破的房间, GSDMD-N 形成非选择的毛孔并且不依靠增加的 osmolarity 破坏房间。我们的学习表明 GSDMD 的形成毛孔的活动和 MLKL 的形成隧道的活动在 pyroptosis 和 necroptosis 决定血浆膜破裂的不同方法。 | Xin Chen Wan-ting He Lichen Hu Jingxian Li Yuan Fang Xin Wang Xiaozheng Xu Zhuo Wang Kai Huang Jiahuai Han | 2016 | Cell Research2016，26，9： | 110 |
| 3 | Different approaches to caudate lobectomy with“curettage and aspiration”technique using a special instrument PMOD:A Report of 76 cases显示文摘AIM: To study different approaches to caudate lobectomy with 'curettage and aspiration' technique using Peng's multifunctional operative dissector (PMOD). The surgical procedure of isolated complete caudate lobectomy was specially discussed.METHODS: In 76 cases of various types of caudate lobectomy, three approaches were used including left side approach, right side approach, and anterior approach.Among the 76 cases, isolated complete caudate lobectomy was carried out in 6 cases with transhepatic anterior approach. The surgical procedure consisted of mobilization of the total liver, ligation and separation of the short hepatic veins, splitting the liver parenchyma through the Cantlie's plane, ligation and division of the caudate portal triads from the hilum, dissection of the root of major hepatic veins,detachment of the caudate lobe from liver parenchyma.RESULTS: The mean operative time was 285±51 min,the mean blood loss was 1 600 mi. No severe complications were observed. Among the 6 cases receiving isolated complete caudate lobectomy with transhepatic anterior approach, one case died 17 months after operation due to disease recurrence and liver failure, the other 5 cases have been alive without recurrence, with one longest survival of 49 months.CONCLUSION: The choice of approach is essential to the success of caudate lobectomy. As PMOD and 'curettage and aspiration' technique can delineate intrahepatic or extrahepatic vessels clearly, caudate lobe resection has become safer, easier and faster. | Shu—YouPeng Jiang—TaoLi Yi-PingMou Ying-BinLiu Yu-LianWu He-QingFang Li-PingCao LiChen Xiu-JunCai Cheng-HongPeng | 2003 | World Journal of Gastroenterology2003，9，10： | 29 |
| 4 | Different contributions of STAT3, ERK1/2, and PI3-K signaling to cardiomyocyte hypertrophy by cardiotrophin-1显示文摘AIM: To assess the contribution of signal transducer and activator of transcription 3(JAK-STAT3) pathway, extracellular signal-regulated kinases1/2 (ERK1/2) pathway, and phosphatidylinositol 3-kinase (PI3-K) pathway to cardiomyocytes hypertrophy induced by cardiotrophin-1 (CT-1), a new member of interleukin-6 (IL-6) family of cytokines. METHODS: STAT3, ERK1/2, and PI3-K were assessed by Western blot analysis. Activity of ERK1/2 was also confirmed by in-gel kinase assay. Hypertrophy of cardiomyocyte was evaluated by [^3H]leucine incorporation and cellular protein-to-DNA ratio. RESULTS: CT-1 simultaneously activated phosphorylation of STAT3, ERK1/2, and PI3-K in rat cardiomyocytes. Parthenolide, an inhibitor of STAT, suppressed CT-1-induced [^3H]leucine incorporation by 88.3% and protein-to-DNA ratio by 75.0%. U0126, an MEK1/2 inhibitor, increased CT-1-induced the phosphorylation of STAT3 in a dose-dependent manner and, consistently, augmented CT-1-induced increase in [^3H]leucine incorporation and cellular protein-to-DNA ratio by 17.6% and 16.3%, respectively. Wortmannin, a PI3-K inhibitor, did not influence CT-1-induced [^3H]leucine incorporation and cellular protein-to-DNA ratio. CONCLUSION: The hypertrophic effect of CT-1 was essentially mediated by STAT3, independent of PI3-K, and negatively regulated by ERK1/2 via inhibiting the phosphorylation of STAT3. The interaction between STAT3 and ERK1/2 in CT-1-induced signaling contributes to development of cardiac hypertrophy. | Ze-junTIAN WeiCUI Yong-junLI Yu-mingHAO JunDU FanLIU HuiZHANG Xiu-guangZU Su-yunLIU LiCHEN WeiAN | 2004 | Acta Pharmacologica Sinica2004，25，9： | 16 |
| 5 | QTL mapping of the root traits and their correlation analysis with drought resis-tance using DH lines from paddy and upland rice cross显示文摘A Double Haploid (DH) population, 116 plants, derived from the cross between Japonica upland rice IRAT109 and paddy rice Yuefu, planted in PVC pipe under upland ecosystem in 2001 and 2002, was used in this study. Seven root traits, including basal root thickness (BRT), total root number (RN), maximum root length (MRL), root fresh weight (RFW), root dry weight (RDW), ratio of root fresh weight to shoot fresh weight (RFW/SFW) and ratio of root dry weight to shoot dry weight (RDW/SDW), were studied. Using index of drought resistance (IDR), the ratio of yield under upland ecosystem to yield under lowland ecosystem of DH lines, as the criteria of drought resistance, and correla-tion analysis between root traits and IDR, showed that BRT, MRL and RN were significantly correlated with IDR. High IDR lines had thicker BRT, longer MRL and less RN than low IDR lines. A molecular linkage map with 94 RFLP markers and 71 SSR markers covering 1535.1 cM was pro-duced. QTLs and G譋 interactions for BRT, RN, MRL, RFW, RDW, RFW/SFW and RDW/SDW were obtained based on the constructed molecular linkage map and soft-ware QTLmapper version 1.0. A total of 18 additive QTLs and 18 pairs of epistatic QTLs associated with root traits were detected. There were nine additive QTLs and two pairs of epistatic QTLs performed significant interactions with environment. Some QTLs with high general contribution and no G譋 interaction were obtained. Two pairs of epistatic QTLs mrl3 and mrl8, brt3 and brt11a controlling MRL and BRT had high general contributions of 21.51% and 13.03% respectively. An additive QTL and a pair of epistatic QTLs controlling RFW and RDW had high general contributions of 13.50% and 25.64% respectively. Marker assisted selec-tion (MAS) for rice drought resistance based on QTL with high general contribution, low G譋 interaction and tightly linkage with IDR were also discussed. | MUPing LIZichao LIChunping ZHANGHongliang WUChangming LIChen WANGXiangkun | 2003 | Chinese Science Bulletin2003，48，24： | 15 |
| 6 | Improved complex filter applied in enhancing EFT/B immunity at a coal mine monitoring substation显示文摘A monitoring system is an important guarantee of safety in a production mine. However, not all monitoring substations pass the electrical fast transient/burst (EFT/B) immunity test and the explosion-proof test simultaneously. To enhance the immunity, the values of capacitance and inductance should be increased, which are actually limited by coal mine explosion-proof standards. Hence, for the first time, an active filter was applied in an electromagnetic interference (EMI) output filter. As a result, the interference within 30 MHz clearly weakened, but the frequency spectrum had a wide range. An EMI input filter and ferrite beads were adopted to restrain higher frequency interference. An output interference spectrogram of the substation was obtained with an analyzer. The results indicate that the improved complex filtering markedly help to control interference. With the support of improved complex filtering and other enhancing immunity means about I/O ports, the substation managed to pass both the EFT/B immunity test and the explosion-proof test synchronously. We conclude that improved complex filtering is of vital importance in enhancing the electromagnetic compatibility (EMC) of the coal mine monitoring system. | SUN Ji-ping MA Feng-ying LIChen | 2008 | Journal of China University of Mining and Technology2008，18，1： | 13 |
| 7 | Catalysis of Manganese(II) on Chromium(VI) Reduction by Citrate显示文摘The catalysis of manganese(II) (Mn2+) on chromium(VI) (Cr6+) reduction by citrate was studied through batch experiments with the concentration of citrate greatly in excess of Cr6+ at 25℃and in pH ranges of 4.0 to 5.0. Results showed that at pH 4.5 within 22 h direct reduction of Cr6+ by citrate was not observed, but for the same time when Mn2+ (50 to 200μmol L-1) was added, nearly all Cr6+ was reduced, with the higher initial Mn2+ concentration having faster Cr6+ reduction. In the initial stage of the reaction, the Cr6+ reduction could be described with a pseudo-first-order kinetics equation. In the later stage of the reaction, plots of lnc(Cr6+) versus t, where c(Cr6+) is the Cr6+ concentration in the reaction and t is the reaction time, deviated from the initial linear trend. The deviations suggested that the pseudo-first-order kinetics did not apply to the whole experimental period and that some reaction intermediates could have greatly accelerated Cr6+ reduction by citrate. The catalysis of the intermediates increased with the reaction time and gradually reached stability. Then, the plot of lnc(Cr6+) versus t in the presence of Mn2+ was linear again, with the rate constant increasing by 102 times compared with the absence of Mn2+. Complexation between Mn2+ and citrate was likely a prerequisite for the catalysis of Mn2+ on the reaction. Additional experiments showed that introducing ethylenediaminetetraacetic acid (EDTA) into the reaction system strongly suppressed the catalysis of Mn2+. | LIChen LAN Ye-Qing DENG Bao-Lin | 2007 | Pedosphere2007，17，3： | 12 |
| 8 | Successive inverse and normal magnetocaloric effects in the Mn-vacancy compound Mn0.95Co0.75Cu0.25Ge显示文摘Ferromagnetic-structural transformation has been studied widely in MnCoGe-based materials. However, the magnetostructural transition(MST) from antiferromagnetic(AFM) orthorhombic phase to ferromagnetic(FM) hexagonal phase, which may lead to a large inverse magnetocaloric effect(MCE), has rarely been reported. Here, the introduction of Mn vacancy lowers the structural transition temperature while retains the AFM state in the orthorhombic phase, thus successfully realizing the AFM-FM MST in Mn0.95Co0.75Cu0.25Ge. Moreover, successive inverse and normal MCEs are observed around the first-order AFM-FM MST and the second-order FM-paramagnetic(PM) transition, respectively. A thermostat is proposed based on this special feature, which could release heat above the critical temperature while absorb heat below the critical temperature by simply applying the same magnetization/demagnetization cycles. This thermostat can be very useful in many applications where a constant temperature is required, such as cryostats and incubators. | FengXia Liu Hu Zhang He Zhou DaoYong Cong RongJin Huang LiChen Wang Yi Long | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，7： | 9 |
| 9 | A Pulse Immunization Model for Inhibiting Malware Propagation in Mobile Wireless Sensor Networks显示文摘Mobile wireless sensor networks(MWSNs)may be under attack due to their large-scale characteristics. One of the main threats is to inject malware into some nodes. To prevent malware from spreading in a largescale MWSN, an effective measure is to immunize susceptible nodes by disseminating and installing security patches. This work suggests a novel modeling framework and some mathematical models based on the pulse differential equation and the epidemic theory, in which the immunization operations are implemented on susceptible nodes in a pulse way. The maximum immunization period of time is derived to minimine the number of immunization operations while ensuring malware extinct over time in the MWSN. The theoretical results are confirmed by extensive simulations. | WANG Xiaoming HE Zaobo ZHANG Lichen | 2014 | Chinese Journal of Electronics2014，23，4： | 8 |
| 10 | China Nutrition and Health Surveys(1982−2017)显示文摘The status of nutrition and health among residents is one of the important indicators reflecting the developing level in a country or a region.China’s government initiated the first China National Nutrition Survey in 1959.The Second National Nutrition Survey and the Third National Nutrition Survey were then conducted in 1982 and 1992,respectively(1-2).The China National Nutrition and Health Survey(2002)combined the nutrition and chronic diseases survey and became the fourth survey(3). | Dongmei Yu Liyun Zhao Jian Zhang Zhenyu Yang Lichen Yang Jian Huang Hongyun Fang Qiya Guo Xiaoli Xu Lahong Ju Gangqiang Ding | 2021 | China CDC weekly2021，3，9： | 6 |
| 11 | Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment显示文摘Polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemic circulation,and lack of cancer-selective drug release.Herein,a poly(ethylene glycol)(PEG)-polyphosphoester-based,reactive oxygen species (ROS)-responsive,core-cross-linked (CCL) micellar system was developed to encapsulate both chemodrug (doxorubicin,Dox) and photosensitizer (chlorin e6,Ce6).The hydrophobic core of the micelles was cross-linked via a thioketal (TK)-containing linker,which notably enhanced the drug loading and micelle stability.In tumor cells,far-red light irradiation of Ce6 generated ROS to cleave the TK linkers and disrupt the micelle cores.As such,micelles were destabilized and Dox release was promoted,which thereafter imparted synergistic anti-cancer effect with ROS-mediated photodynamic therapy.This study provides an effective approach to realize the precise control over drug loading,formulation stability,and cancer-selective drug release using polymeric micelles,and would render promising utilities for the programmed anti-cancer combination therapy. | Yongjuan Li Jian Hu Xun Liu Yong Liu Shixian Lv Juanjuan Dang Yong Ji Jinlin He Lichen Yin | 2019 | Nano Research2019，12，5： | 5 |
| 12 | Timescale Analysis of Spectral Lags显示文摘A technique for timescale analysis of spectral lags performed directly in the time domain is developed. Simulation studies are made to compare the time domain technique with the Fourier frequency analysis for spectral time lags. The time domain technique is applied to studying rapid variabilities of X-ray binaries and γ-ray bursts. The results indicate that in comparison with the Fourier analysis the timescale analysis technique is more powerful for the study of spectral lags in rapid variabilities on short time scales and short duration flaring phenomena. | Ti-PeiLi Jin-LuQu HuaFeng Li-MingSong Guo-QiangDing LiChen | 2004 | Chinese Journal of Astronomy and Astrophysics2004，4，6： | 4 |
| 13 | Experimental investigation on flow characteristics in circular tube inserted with rotor-assembled strand using PIV显示文摘Rotor-assembled strand works as a typical tube insert to achieve heat transfer augmentation and scale inhibition in a heat exchanger.In this work, the PIV experiment regarding the flow fields in a circular tube inserted with rotor-assembled strand was conducted and the flow characteristics on transverse section and longitudinal section were analyzed.The results showed that swirling flow was produced in the tube inserted with rotors and it was particularly strong within the swing diameter of the rotor on the section that contains the rotor;the average turbulence intensity and the radial velocity were improved notably; the velocity vectors on the longitudinal section remained along the direction of a straight line; both the swirling flow and average turbulence intensity were higher for the rotor with three blades than for the rotor with two blades except that the radial velocity was approximate, but they were all reduced by enlarging the lead of the rotor.Characterization of the flow patterns in a circular tube contributes to understanding the heat transfer efficiency and scale inhibition performance of the rotor-assembled strand and provides guidance for its application. | Lichen He Weimin Yang Changfeng Guan Hua Yan Lin Zheng Xiahua Zuo | 2019 | Chinese Journal of Chemical Engineering2019，27，1： | 3 |
| 14 | Energy Efficient Forwarding Algorithm in Opportunistic Networks显示文摘In opportunistic networks, a successful message transmission between node pairs depends on the message size, the transmission speed and the connection duration time. This paper proposes a new message forwarding algorithm to improve the message delivery ratio and reduce the energy consumption. Previous encounter characteristics between nodes are used to estimate future connection duration time using a three point estimation method. Furthermore, the buffer utilization of nodes is used as a weight for the likelihoods to meet destinations according to the hop count of messages stored in the buffer.The simulation results show that the proposed forwarding algorithm achieves higher delivery ratio and less overhead ratio than the other four popular routing protocols.In addition, the proposed algorithm gains a better average residual energy performance among all the compared protocols. | ZHANG Feng | 2016 | Chinese Journal of Electronics2016，25，5： | 3 |
| 15 | Morbidity and risk factors for surgical site infection following cesarean section in Guangdong Province, China显示文摘 | Shi‐PengGong Hong‐XiaGuo Hong‐ZhenZhou LiChen Yan‐HongYu | 2012 | Journal of Obstetrics and Gynaecology Research2012，，3： | 3 |
| 16 | Preparation of TiO2/MCM-41 by plasma enhanced chemical vapor deposition method and its photocatalytic activity显示文摘 | Shenghung WANG Kuohua WANG Jihmirn JEHNG Lichen LIU | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 3 |
| 17 | A Novel and Efficient Catalytic System for Aerobic Oxidative Coupling of 2-Naphthol Derivatives显示文摘The paper reported a novel and efficient aerobic oxidative coupling reaction of 2-naphthol derivatives catalyzed by CuCu (Ⅰ or Ⅱ)N-alkylimidazole complexes in excellent yields. The crystal structure of CuCu(Ⅱ)N-methylimidazole complex to be determined by X-Ray. | LiCHEN JingBoLAN ZhiHuaMAO XiaoQiYU RuGangXIE | 2004 | Chinese Chemical Letters2004，15，8： | 2 |
| 18 | Cardiomyocyte-targeted anti-inflammatory nanotherapeutics against myocardial ischemia reperfusion (IR) injury显示文摘Myocardial ischemia reperfusion(IR)injury is closely related to the overwhelming inflammation in the myocardium.Herein,cardiomyocyte-targeted nanotherapeutics were developed for the reactive oxygen species(ROS)-ultrasensitive co-delivery of dexamethasone(Dex)and RAGE small interfering RNA(siRAGE)to attenuate myocardial inflammation.PPTP,a ROSdegradable polycation based on PGE2-modified,PEGylated,ditellurium-crosslinked polyethylenimine(PEI)was developed to surface-decorate the Dex-encapsulated mesoporous silica nanoparticles(MSNs),which simultaneously condensed siRAGE and gated the MSNs to prevent the Dex pre-leakage.Upon intravenous injection to IR-injured rats,the nanotherapeutics could be efficiently transported into the inflamed cardiomyocytes via PGE2-assisted recognition of over-expressed E-series of prostaglandin(EP)receptors on the cell membranes.Intracellularly,the over-produced ROS degraded PPTP into small segments,promoting the release of siRAGE and Dex to mediate effective RAGE silencing(72%)and cooperative antiinflammatory effect.As a consequence,the nanotherapeutics notably suppressed the myocardial fibrosis and apoptosis,ultimately recovering the systolic function.Therefore,the current nanotherapeutics represent an effective example for the codelivery and on-demand release of nucleic acid and chemodrug payloads,and might find promising utilities toward the synergistic management of myocardial inflammation. | Min Lan Mengying Hou Jing Yan Qiurong Deng Ziyin Zhao Shixian Lv Juanjuan Dang Mengyuan Yin Yong Ji Lichen Yin | 2022 | Nano Research2022，15，10： | 2 |
| 19 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 20 | Reaction-Diffusion Equation Based Image Denoising Algorithm显示文摘 | ZHAO Xueqing WANG Xiaoming ZHANG Lichen | 2012 | Chinese Journal of Electronics2012，21，3： | 2 |
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