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| 1 | Gasdermin D is an executor of pyroptosis and required for interleukin-lp secretion显示文摘 | Wan-ting He Haoqiang Wan Lichen Hu Pengda Chen Xin Wang Zhe Huang Zhang-Hua Yang Chuan-Qi Zhong Jiahuai Han | 2015 | Cell Research2015，25，12： | 195 |
| 2 | Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis显示文摘Necroptosis 和 pyroptosis 是有血浆膜破裂的一个普通特征的规划房间死亡的二种形式。这里,我们与 necroptosis 比较学习了 pyroptosis 的形态学和机制。与 necroptosis 不同, pyroptosis 经历膜 blebbing 并且生产 apoptotic 在血浆膜以前的像身体的房间伸出(称为的 pyroptotic 身体) 破裂。在 necroptosis 的破裂是像爆炸的,而在 pyroptosis 它导致房间变平。necroptosis 的实行被混合的系 kinase 调停,这被知道像域(MLKL ) 在血浆膜的 oligomers,而 gasdermin-D (GSDMD ) 调停在它由 caspase-1 或 caspase-11 的劈开以后的 pyroptosis。我们显示出那 N 终端碎片 caspase 劈开产生的 GSDMD (GSDMD-N ) 也形成 oligomer 并且移居到血浆膜杀死房间。MLKL 和 GSDMD-N 是脂性的,两蛋白质的 N 终端序列为他们的 oligomerization 和血浆膜 translocation 是重要的。不同于在血浆膜上形成隧道的 MLKL,那导致渗透地胀大的选择离子的流入冲破的房间, GSDMD-N 形成非选择的毛孔并且不依靠增加的 osmolarity 破坏房间。我们的学习表明 GSDMD 的形成毛孔的活动和 MLKL 的形成隧道的活动在 pyroptosis 和 necroptosis 决定血浆膜破裂的不同方法。 | Xin Chen Wan-ting He Lichen Hu Jingxian Li Yuan Fang Xin Wang Xiaozheng Xu Zhuo Wang Kai Huang Jiahuai Han | 2016 | Cell Research2016，26，9： | 110 |
| 3 | Successive inverse and normal magnetocaloric effects in the Mn-vacancy compound Mn0.95Co0.75Cu0.25Ge显示文摘Ferromagnetic-structural transformation has been studied widely in MnCoGe-based materials. However, the magnetostructural transition(MST) from antiferromagnetic(AFM) orthorhombic phase to ferromagnetic(FM) hexagonal phase, which may lead to a large inverse magnetocaloric effect(MCE), has rarely been reported. Here, the introduction of Mn vacancy lowers the structural transition temperature while retains the AFM state in the orthorhombic phase, thus successfully realizing the AFM-FM MST in Mn0.95Co0.75Cu0.25Ge. Moreover, successive inverse and normal MCEs are observed around the first-order AFM-FM MST and the second-order FM-paramagnetic(PM) transition, respectively. A thermostat is proposed based on this special feature, which could release heat above the critical temperature while absorb heat below the critical temperature by simply applying the same magnetization/demagnetization cycles. This thermostat can be very useful in many applications where a constant temperature is required, such as cryostats and incubators. | FengXia Liu Hu Zhang He Zhou DaoYong Cong RongJin Huang LiChen Wang Yi Long | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，7： | 9 |
| 4 | Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment显示文摘Polymeric micelles have demonstrated wide utility for chemodrug delivery,which however,still suffer from shortcomings such as undesired drug loading,disassembly upon dilution,pre-leakage of drug cargoes during systemic circulation,and lack of cancer-selective drug release.Herein,a poly(ethylene glycol)(PEG)-polyphosphoester-based,reactive oxygen species (ROS)-responsive,core-cross-linked (CCL) micellar system was developed to encapsulate both chemodrug (doxorubicin,Dox) and photosensitizer (chlorin e6,Ce6).The hydrophobic core of the micelles was cross-linked via a thioketal (TK)-containing linker,which notably enhanced the drug loading and micelle stability.In tumor cells,far-red light irradiation of Ce6 generated ROS to cleave the TK linkers and disrupt the micelle cores.As such,micelles were destabilized and Dox release was promoted,which thereafter imparted synergistic anti-cancer effect with ROS-mediated photodynamic therapy.This study provides an effective approach to realize the precise control over drug loading,formulation stability,and cancer-selective drug release using polymeric micelles,and would render promising utilities for the programmed anti-cancer combination therapy. | Yongjuan Li Jian Hu Xun Liu Yong Liu Shixian Lv Juanjuan Dang Yong Ji Jinlin He Lichen Yin | 2019 | Nano Research2019，12，5： | 5 |
| 5 | Serum Vitamin A Nutritional Status of Children and Adolescents Aged 6−17 Years—China,2016−2017显示文摘Summary What is already known on this topic?Vitamin A deficiency(VAD)in children is still a global public health problem,which needs continuous monitoring and timely intervention.What is added by this report?Using surveillance data from China Nutrition and Health Surveillance of Children and Lactating Mothers in 2016−2017,the prevalence of VAD and marginal deficiency was 0.96%and 14.71%,respectively. | Rui Wang Huidi Zhang Yi-chun Hu Jing Chen Zhenyu Yang Liyun Zhao Lichen Yang | 2021 | China CDC weekly2021，3，9： | 2 |
| 6 | A Multi-Agent Based Equipment Bidding System on the Web显示文摘This paper puts forward a new framework of multi-agent based equipment bidding system on the Web(MAEBSW). The purpose of the paper is to make the process of enterprise equipment bidding, especially the decisionprocess of enterprise equipment bidding, more intelligent. The system discussed in this paper is an efficient method forthe enterprises doing business electronically. We also present our opinion of the approaches to defining agents. We em-phasize the importance of agent being able to provide explanation about its behavior for the user or other agents. Based onthis opinion we design a new common architecture of most agents in MAEBSW. | Hu Lichen, Liu Li, Dong Yu & Ding Yuzhan(University of Science and Technology, Beijing 100083, P. R. China China North Vehicle Institute, Beijing 100072, P. R. China) | 2002 | Journal of Systems Engineering and Electronics2002，13，4： | 1 |
| 7 | Titanium alloy production technology market prospects and industry develop- ment 显示文摘 | Cui Chunxiang Hu Baomin Zhao Lichen | 2011 | Materials and Design2011，32，： | 1 |
| 8 | Revision of P-wave Velocity and Thickness of Hydrate Layer in Shenhu Area, South China Sea显示文摘To revise P-wave velocity and thickness of the hydrate layer in the Shenhu area of the South China Sea, acoustic and resistivity logging curves are reanalyzed. The waterlogging phenomenon is found in the shallow sediments of five drilling wells, which causes P-wave velocity to approximate the propagation velocity of sea water(about 1500 m s-1). This also affects the identification of the hydrate layer and results in the underestimate of its thickness. In addition, because there could be about a 5 m thick velocity ramp above or below the hydrate layer as interpreted by acoustic and resistivity logging curves, the recalibrated thickness of this layer is less than the original estimated thickness. The recalibrated P-wave velocity of the hydrate layer is also higher than the original estimated velocity. For the drilling well with a relatively thin hydrate layer, the velocity ramp plays a more important role in identifying and determining the thickness of the layer. | GONG Jianming ZHANG Xunhua ZOU Changchun CHEN Qiang WANG Lichen YUAN Chunfang HU Gaowei JIANG Yubo | 2014 | Journal of Ocean University of China2014，13，5： | 1 |
| 9 | Giant low-field magnetocaloric effect in ferromagnetically ordered Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds显示文摘Magnetocaloric material is the key working substance for magnetic refrigerant technology,for which the low-field and low-temperature magnetocaloric effect(MCE)performance is of great importance for practical applications at low temperatures.Here,a giant low-field magnetocaloric effect in ferromagnetically ordered Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds was reported,and the magnetic structure was characterized based on low-temperature neutron powder diffraction.With increasing Tm content from 0 to 1,the Curie temperature of Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds decreases from 16.0 K to 3.6 K.For Er_(0.7)Tm_(0.3)Al_(2) compound,it showed the largest low-field magnetic entropy change(–SM)with the peak value of 17.2 and 25.7 J/(kg K)for 0–1 T and 0–2 T,respectively.The(–SM)max up to 17.2 J/(kg K)of Er0.7Tm0.3Al2 compound for 0–1 T is the largest among the intermetallic magnetocaloric materials ever reported at temperatures below 20 K.The peak value of adiabatic temperature change(Tad)max was determined as 4.13 K and 6.87 K for 0–1 T and 0–2 T,respectively.The characteristic of second-order magnetic transitions was confirmed on basis of Arrott plots,the quantitative criterion of exponent n,rescaled universal curves,and the mean-field theory criterion.The outstanding low-field MCE performance with low working temperatures indicates that Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds are promising candidates for magnetic cooling materials at liquid hydrogen and liquid helium temperatures. | Shuxian Yang Xinqi Zheng Dingsong Wang Juping Xu Wen Yin Lei Xi Chaofan Liu Jun Liu Jiawang Xu Hu Zhang Zhiyi Xu Lichen Wang Yihong Yao Maosen Zhang Yichi Zhang Jianxin Shen Shouguo Wang Baogen Shen | 2023 | Journal of Materials Science & Technology2023，，15： | 0 |
| 10 | Classification and Prediction of Skyrmion Material Based on Machine Learning显示文摘The discovery and study of skyrmion materials play an important role in basic frontier physics research and future information technology.The database of 196 materials,including 64 skyrmions,was established and predicted based on machine learning.A variety of intrinsic features are classified to optimize the model,and more than a dozen methods had been used to estimate the existence of skyrmion in magnetic materials,such as support vector machines,k-nearest neighbor,and ensembles of trees.It is found that magnetic materials can be more accurately divided into skyrmion and non-skyrmion classes by using the classification of electronic layer.Note that the rare earths are the key elements affecting the production of skyrmion.The accuracy and reliability of random undersampling bagged trees were 87.5%and 0.89,respectively,which have the potential to build a reliable machine learning model from small data.The existence of skyrmions in LaBaMnO is predicted by the trained model and verified by micromagnetic theory and experiments. | Dan Liu Zhixin Liu JinE Zhang Yinong Yin Jianfeng Xi Lichen Wang JieFu Xiong Ming Zhang Tongyun Zhao Jiaying Jin Fengxia Hu Jirong Sun Jun Shen Baogen Shen | 2023 | Research2023，，4： | 0 |
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