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| 1 | Structural and molecular basis for foot-andmouth disease virus neutralization by two potent protective antibodies显示文摘Dear Editor,Foot-and-mouth disease(FMD)is an economically devastating and highly contagious viral disease of cloven-hoofed animals with a global distribution.The causative agent,FMD virus(FMDV)is a small non-enveloped RNA virus,belonging to the Aphthoviruses genus within Picornaviridae family(Tuthill et al.,2010).Control of FMD has been largely reliant on vaccinations with inactivated virus vaccines.However,significant antigenic diversity within FMDV serotypes and inability of the vaccines to induce immune protection for a long duration of time impinge on the efficacy of available vaccines.The roles of neutralizing antibodies(NAbs)as the principal protective components of the immune responses to FMDV vaccination or infection have been well established(Pay and Hingley,1987;Juleff et al.,2009).Passive immunization of NAbs has also been demonstrated to be effective in curing FMD and many viral diseases(Harmsen et al.,2007;Qiu et al.,2018).A deep understanding of the molecular basis for viral neutralization by antibodies and the identification of key viral epitopes would aid in the development of potent rationally designed broad-spectrum vaccine. | Hu Dong Pan Liu Manyuan Bai Kang Wang Rui Feng Dandan Zhu Yao Sun Suyu Mu Haozhou Li Michiel Harmsen Shiqi Sun Xiangxi Wang Huichen Guo | 2022 | Protein & Cell2022，13，6： | 3 |
| 2 | Topological evolution of coexpression networks by new gene integration maintains the hierarchical and modular structures in human ancestors显示文摘We analyze the global structure and evolution of human gene coexpression networks driven by new gene integration. When the Pearson correlation coefficient is greater than or equal to 0.5, we find that the coexpression network consists of 334 small components and one 'giant' connected subnet comprising of 6317 interacting genes. This network shows the properties of power-law degree distribution and small-world. The average clustering coefficient of younger genes is larger than that of the elderly genes(0.6685 vs. 0.5762). Particularly, we find that the younger genes with a larger degree also show a property of hierarchical architecture. The younger genes play an important role in the overall pivotability of the network and this network contains few redundant duplicate genes. Moreover, we find that gene duplication and orphan genes are two dominant evolutionary forces in shaping this network. Both the duplicate genes and orphan genes develop new links through a 'rich-gets-richer'mechanism. With the gradual integration of new genes into the ancestral network, most of the topological structure features of the network would gradually increase. However, the exponent of degree distribution and modularity coefficient of the whole network do not change significantly, which implies that the evolution of coexpression networks maintains the hierarchical and modular structures in human ancestors. | Jian Zu Yuexi Gu Yu Li Chentong Li Wenyu Zhang Yong E.Zhang UnJin Lee Li Zhang Manyuan Long | 2019 | Science China(Life Sciences)2019，62，4： | 3 |
| 3 | 显示文摘 | Li Manyuan Knystautas E J | 2001 | Surface & Coatings Technology2001，138，： | 1 |
| 4 | Enhanced microhardness of four modern steels following nitrogen ion implantation显示文摘 | Li Manyuan Knystautas E mile J and Krishnadev Madhavarao | 2001 | Surface and Coatings Technology2001，138，： | 1 |
| 5 | Significant divergence of sex-related non-coding RNA expression patterns among closely related species in Drosophila显示文摘Whether or not non-coding RNA genes play a significant role in reproductive biology and evolution of sex determination systems is an important problem. We report identification of sex-related non-coding RNA (ncRNA) genes and an analysis of ncRNAs expression patterns among Drosophila species. We detected 12 candidate ncRNAs that are expressed in the gonads of D. melanogaster by an integrative approach of RT-PCR and computational analysis of sequence conservation across species. We ex-perimentally analyzed these ncRNA gene transcripts in head, ovary and testis of closely related species D. simulans, D. yakuba,D. pseudoobscura and D. virilis. We observed that the occurrence and extent of expression of most ncRNA fragments among closely related species show significant divergence. | YANG YongFei LI Zheng FAN QiChang LONG ManYuan ZHANG WenXia | 2007 | Chinese Science Bulletin2007，52，6： | 1 |
| 6 | GPDCCL: Cross-Domain Named Entity Recognition with Span-Based Domain Confusion Contrastive Learning显示文摘The goal of cross-domain named entity recognition is to transfer mod-els learned from labelled source domain data to unlabelled or lightly labelled target domain datasets.This paper discusses how to adapt a cross-domain sen-timent analysis model to thefield of named entity recognition,as the sentiment analysis model is more relevant to the tasks and data characteristics of named entity recognition.Most previous classification methods were based on a token-wise approach,and this paper introduces entity boundary information to prevent the model from being affected by a large number of nonentity labels.Specifically,adversarial training is used to enable the model to learn domain-confusing knowl-edge,and contrastive learning is used to reduce domain shift problems.The entity boundary information is transformed into a global boundary matrix representing sentence-level target labels,enabling the model to learn explicit span boundary information.Experimental results demonstrate that this method achieves good per-formance compared to multiple cross-domain named entity recognition models on the SciTech dataset.Ablation experiments reveal that the method of introducing entity boundary information significantly improves KL divergence and contrastive learning. | Ye Wang Chenxiao Shi Lijie Li Manyuan Guo | 2023 | 国际计算机前沿大会会议论文集2023，，2： | 0 |
| 7 | The Practice Strategy of Construction of Ecological Garden City in China: A Case Study of Action of “Xuchang Being Full of Green” in Xuchang City显示文摘Starting from the purpose and current situation of the implementation of action of 'Xuchang being full of green',this study analyzed the problems existing in the implementation of action of 'Xuchang being full of green' and discussed the implementation plan of action of 'Xuchang being full of green' from two aspects of macro strategy and node promotion strategy,hoping to promote the construction of ecological garden cities in Xuchang and other cities in China. | LI Manyuan YANG Kailiang ZHAI Xiaohui LI Yanke YANG Tao | 2020 | Journal of Landscape Research2020，12，1： | 0 |
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