| 1 | Topological evolution of coexpression networks by new gene integration maintains the hierarchical and modular structures in human ancestors显示文摘We analyze the global structure and evolution of human gene coexpression networks driven by new gene integration. When the Pearson correlation coefficient is greater than or equal to 0.5, we find that the coexpression network consists of 334 small components and one 'giant' connected subnet comprising of 6317 interacting genes. This network shows the properties of power-law degree distribution and small-world. The average clustering coefficient of younger genes is larger than that of the elderly genes(0.6685 vs. 0.5762). Particularly, we find that the younger genes with a larger degree also show a property of hierarchical architecture. The younger genes play an important role in the overall pivotability of the network and this network contains few redundant duplicate genes. Moreover, we find that gene duplication and orphan genes are two dominant evolutionary forces in shaping this network. Both the duplicate genes and orphan genes develop new links through a 'rich-gets-richer'mechanism. With the gradual integration of new genes into the ancestral network, most of the topological structure features of the network would gradually increase. However, the exponent of degree distribution and modularity coefficient of the whole network do not change significantly, which implies that the evolution of coexpression networks maintains the hierarchical and modular structures in human ancestors. | Jian Zu Yuexi Gu Yu Li Chentong Li Wenyu Zhang Yong E.Zhang UnJin Lee Li Zhang Manyuan Long | 2019 | Science China(Life Sciences)2019，62，4： | 3 |
| 2 | Expanding luminal epitheliums as cells of origin for prostate cancer显示文摘Despite tremendous progress made in human prostate biology over the past few decades,a full picture of prostate lineage hierarchy and its connection to cancer initiation remain to be delineated.Two recent studies published in Nat Genet.[1]and in Science[2]have profiled subpopulations of prostate cells at the single-cell level.Complementary analyses of data from the studies demonstrate self-renewal and differentiation capacities of different luminal epithelial cells,which can serve as cells of origin for prostate cancer.The system of lineage hierarchy controls cell differentiation and tissue formation from stem and progenitor cells,which may initiate cancer development if the process goes awry[3].Therefore,it is of great interest to identify cells with stemness or progenitor properties and delineate their lineage hierarchy in order to pinpoint the cells of origin for cancer when cellular genetics are altered[4]. | Yuexi Gu Gong-Hong Wei | 2021 | Asian Journal of Urology2021，8，2： | 0 |
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