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| 1 | Magnetostratigraphy and paleoenvironmental record of Tertiary deposits of Lanzhou Basin显示文摘The Tertiary deposits of the Yongdeng section, the Lanzhou Basin were studied by means of magnetostrati-graphy. The magnetostratigraphic sequences from Paleocene to Miocene were established, and the time scale for the corresponding stratigraphy and mammalian faunas was also established by referring to their correlation to the GPTS of BKSA95 (The geomagnetic polarity time scale which was thoroughly revised and updated by Berggreen et al. in 1995). In the end the paleoenvironmental records and their relationship with the uplifting of the Tibetan Plateau were discussed. The results are as follows. The top boundary of the Xiliugou Formation is dated to be 51 Ma, i.e. Eocene. TheYehucheng Formation covers the time span of 51-31.5 Ma, i.e. from late Early Eocene to early Early Oligocene. The Xianshuihe Formation covers the time span of 31.5-15 Ma, i.e. from Early Oligocene to Middle Miocene. The lower member of the Xianshuihe Formation spans from 31.5 to 20.0 Ma, i.e. from Early Oligocene to early Early | YUE Leping F.Heller QIU Zhanxiang ZHANG Li XIE Guangpu QIU Zhuding ZHANG Yunxiang | 2001 | Chinese Science Bulletin2001，46，9： | 28 |
| 2 | Homology-mediated end joining-based targeted integration using CRISPR/Cas9显示文摘 | Yao, Xuan Wang, Xing Hu, Xinde Liu, Zhen Liu, Junlai Zhou, Haibo Shen, Xiaowen Wei, Yu Huang, Zijian Ying, Wenqin Wang, Yan Nie, Yan-Hong Zhang, Chen-Chen Li, Sanlan Cheng, Leping Wang, Qifang Wu, Yan Huang, Pengyu Sun, Qiang Shi, Linyu Yang, Hui | 2017 | Cell Research2017，27，6： | 28 |
| 3 | Assessment on heavy metals pollution of agricultural soil in Guanzhong District显示文摘The monitored soil samples were collected from Heihui irrigated area, Jiaokou irrigated area, Qianhe river valley and Jinghe river valley (hereafter Heihui, Jiaokou, Qianhe and Jinghe for short respectively) of Guanzhong District. According to the Environment Quality Standard for Soil (GB15618-1995II), we evaluated the pollution status of heavy metals (Cd, As, Cr and Pb) that could seriously endanger soil environment and human health by using single-factor index and synthetic pollution index methods. The results indicate that the synthetic pollution indices P of soil heavy metals are less than 0.7 in Heihui, Jiaokou, Qianhe and Jinghe of Guanzhong, the single-factor indices Pi of soil heavy metals of most soil samples are less than 0.7, so the soil environmental quality is in a good condition in Guanzhong on the whole; the enrichment degree of soil heavy metals is in the order of Heihui, Jinghe, Qianhe and Jiaokou; the contaminated degree of soil heavy metals has the feature of Cd > As > Cr > Pb; heavy metals contents in the cultivated horizon soil are generally higher than those in its underlayer soil, heavy metals contents of soil have the characteristic of enriching towards the cultivated horizon; Cd exceeds standard in the soil samples HS07a, b and HS08a, b at the Yangtao orchard in Heihui and in the soil sample QHS01a at the suburban vegetable plot in Qianhe, which was mainly caused by the long-term irrational use of chemical fertilizer and pesticide. | ZHENG Guozhang YUE Leping LI Zhipei CHEN Chao | 2006 | Journal of Geographical Sciences2006，16，1： | 21 |
| 4 | Hypoxia-inducible factor-lαand semaphorin4D genes involved with tumor-associated macrophage-induced metastatic behavior and clinical significance in colon cancer显示文摘 | Mu Linjun Wang Jinshen Chen Yuezhi Li Leping Guo Xiaobo Zheng Sheng Jing Changqing | 2014 | Chinese Medical Journal2014，，20： | 15 |
| 5 | Preparation and characterization of microcapsule containing epoxy resin and its self-healing performance of anticorrosion covering material显示文摘Microencapsulated healing agents that possess adequate strength,long shelf-life,and excellent bonding to the host material are required for self-healing materials. The in situ encapsulation method is demonstrated over an order of magnitude size reduction for the preparation of urea-formaldehyde(UF) capsules filled with a healing agent,a mixture epoxy resin of the epoxy 711 and E-51. Capsules with diameters as small as about 100 μm are achieved under the agitation rate of 800 r min-1. The capsules possess a uniform UF shell wall(4 μm average thickness) . By using the analysis of scanning electronic microscope(SEM) ,thermal analysis(TG-DTA) and FTIR,the characteristics of the microcapsules were investigated respectively. Successful self-healing has been demonstrated for anticorrosion covering materials with microcapsules. | LIAO LePing ZHANG Wei XIN Yi WANG HongMei ZHAO Yang LI WuJun | 2011 | Chinese Science Bulletin2011，56，4： | 8 |
| 6 | Evolution of the Ordos Plateau and environmental effects显示文摘Based on the analysis of temporary-spatial distribution, geomorphic position, contact relationship with underlying strata and grain size of red clay, we studied the formation and environmental background of red clay. During late Miocene-Pliocene, the Ordos Block finished the transformation from the basin to the plateau, which had an obvious environmental effect on the topography, indicated by the formation of highland undergoing wind erosion and lowland receiving red clay deposits. The red clay materials were sourced from dusts carried by wind energy and covered on the initial topography. Unlike Quaternary loess dust covering the overall the Loess Plateau, red clay deposited on the highland would be transported to the lowlands by wind and fluvial process. As a result, there was no continuous 'Red Clay Plateau' in the Ordos region and red clay was only preserved in former lowlands. However, red clay was discontinuously distributed through the Loess Plateau and to some extent modified the initial topography. The differential uplift in interior plateau is indicated by the uplift of northern Baiyushan, central Ziwuling and southern Weibeibeishan. The Weibeibeishan Depression formed earlier and became the sedimentary center of red clay resulting in the thicker red clay deposits in Chaona, Lingtai and Xunyi. Since Quaternary the aridity in the northern plateau enhanced and accelerated loess accumulation caused the formation of the Loess Plateau. During the late Pleistocene the rapid uplift led to the enhancement of erosion. Especially after the cut-through of Sanme Lake by the Yellow River, the decline of base level caused the falling of ground water level and at the same time the increase of drainage density resulting in the enhancement of evaporation capacity, which enhanced the aridity tendency of aridity in the Loess Plateau region. | YUE LePing LI JianXing ZHENG GuoZhang LI ZhiPei | 2007 | Science China Earth Sciences2007，50，z2： | 8 |
| 7 | Function of Ca^(2+)-/calmodulin-dependent protein kinase Ⅳ in Ca^(2+)-stimulated neuronal signaling and behavior显示文摘The activity of Ca2+/calmodulin-dependent protein kinase IV(Ca MKIV) is sensitive to activity-dependent changes in the level of intracellular Ca2+.Following neuronal stimulation,the activation of Ca MKIV may trigger synaptic modifications and transcriptional responses,both of which are involved in regulating cognitive and emotional behavior.Here,we used Ca MKIV knockout(KO) neurons and mice to examine the function of Ca MKIV in Ca2+-stimulated intracellular signaling and animal behavior,respectively.Following NMDA receptor activation or membrane depolarization,the up-regulation of CREB(c AMP responsive element binding protein) and its target gene Bdnf(brain-derived neurotrophic factor) was intact in cortical neurons obtained from Ca MKIV KO mice.Ca MKIV KO mice displayed severe impairment in contextual fear memory but normal locomotor activity and anxiety level in the contextual training chamber.Although Ca MKIV KO mice showed normal memory in the standard passive avoidance task,they were defective in learning the temporal dissociative passive avoidance task.As indicated by the light/dark test and marble-burying test data,Ca MKIV KO mice showed less anxiety and normal perseveration.In the voluntary wheel-running test,Ca MKIV KO mice showed normal running time and distance but higher maximal running speed.Our results demonstrate the function of Ca MKIV in regulating different forms of fear memory,anxiety,and certain aspect of motor function. | SONG ZiXiang CHEN Qi DING Qi ZHENG Fei LI ChengWei XU LePing WANG HongBing | 2015 | Science China(Life Sciences)2015，58，1： | 6 |
| 8 | Environmental change since mid-Pleistocene recorded in Shangshan achaeological site of Zhejiang显示文摘在迟了的时期的大约 173 ka BP 中间 -- 更新世,河的第二个平台被形成了由于因为气候,海水平变化和构造行动,高举发生在 Shangshan 区域。在 173 75 ka BP 之间。 | MAO Longjiang MO Duowen JIANG Leping JIA Yaofeng LIU Xiaoyan LI Minglin ZHOU Kunshu SHI Chenxi | 2008 | Journal of Geographical Sciences2008，18，2： | 6 |
| 9 | Magnetic characteristics and their paleoclimatic significance of Fengzhou loess in the Qinling Mountains of China显示文摘The Fengzhou loess section is very typical in the Qinling Mountains. The section, about 82 m thick and underlain by the Neogene red clay, consists of 33 layers of loess and 33 layers of paleosol. The section covers Brunhes normal polarity zone and Matuyama reversed polarity zone, and the B/M boundary is located in the middle of L\-8. Matuyama reversed polarity zone records Jaramillo, Olduvai and Reunion normal polarity subchrons. The boundary between Matuyama reversed polarity zone and Gauss normal polarity zone (M/Ga) appears in the lithological boundary between loess and the Neogene red clay. Loess accumulation in Fengzhou started before 2.48 Ma. The magnetic susceptibility curve indicates 33 cold_dry and humid_warm cycles of paleoclimatic variation in the Qinling Mountains during the last 2.48 Ma. The above climatic fluctuation may be well compared with that of the oxygen isotopic records from deep_sea deposits. | Xiangyi Lei Leping Yue Jianqi Wang Li Zhang | 1998 | Chinese Science Bulletin1998，43，18： | 3 |
| 10 | A statistical study on the brightening propagation of post-flare loops显示文摘After examining the data observed by TRACE 171 and 195 from May 1998 to December 2006, we choose as our sample 190 (39 X-class and 151 M-class) flare events which display post-flare loops (PFLs). We investigate the brightening propagation of these PFLs of the events in the sample along the magnetic neutral lines. In most of the cases, the length of the flare ribbons (FRs) ranges from 20 to 170 Mm. The propagating duration of the brightening lasts 10-60 min. The velocities of the propagation associated with the flare strength and the length of the FRs, range from 5 to 35 km·s-1. Furthermore, a greater propagating velocity corresponds to a greater deceleration (or acceleration). These PFLs display three types of propagating patterns: (1) the brightening begins at the middle part of a set of PFLs, and propagates bi-directionally towards its both ends; (2) the brightening first appears at one end of a set of PFLs, and then propagates to the other; (3) the initial brightening takes place at two (or more than two) positions on two (or more than two) sets of PFLs, and each brightening propagates bi-directionally along the magnetic neutral line. | LI LePing DUAN HongYu ZHANG Jun | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，11： | 2 |
| 11 | Stable carbon isotopic composition of soil organic carbon in karst area in Central Guizhou, China显示文摘THE stable carbon isotopic composition of soil organic carbon is a powerful tool for discussing the source ofsoil CO2 and the relationship of CO2 source and sink between soil CO2 and atmosphere CO2 and has beenwidely studied. However, few similar researches have been done in karst area which comprises 15%global terrestrial area. Preliminary research results about the stable carbon isotopic composition of soil organic carbon in karst area are reported here. In April and August 1998, the samples were collected continuously at 5-cm intervals from 0 to -45cm depth in meadow soil profile described by Zheng and located in the Hongfong Lake area in the central Guizhou Plateau which lies in the central East-Asia karst area. CO2 for δ13 C analysis was prepared | ZHENG Leping~(1,2), LI Tingyu~2, WAN Guojiang~2, WANG Shijie~2 and OUYANG Ziyuan~2 1. Department of Environmental Science and Engineering, Shanghai University, Shanghai 200072, China 2. State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China | 1999 | Chinese Science Bulletin1999，44，S2： | 2 |
| 12 | The seasonal and daily CO_2 concentration variance in karst meadow soil profile with depth in Central Guizhou, China显示文摘THE seasonal variance of soil CO2 concentration with depth in soil profile was widely studied. Few similarresearches on this topic have been done in karst area which comprises 15% global terrestrial area. In thisnote, the research results about the seasonal and daily soil CO2 concentration variance in karst area arereported. The soil gases were collected respectively by the sampling device at 200, 5,0, -5, -10,-15, -25, -35 and -45 cm from the land surface in meadow soil profile described by Zheng andlocated in the Hongfeng lake area in the central Guizhou Plateau which lies in the central East-Asia karstarea. Sampling time is in the morning, midday and at night in April, August and November, 1998 aswell as in January, 1999, respectively. Concentrations (volume percent) of CO2 in soil gas samples | ZHENG Leping~(1,2), LI Tingyu~2, WAN Guojiang~2, WANG Shijie~2 and OUYANG Ziyuan~2 1. Department of Environmental Science and Engineering, Shanghai University, Shanghai 200072, China 2. State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China | 1999 | Chinese Science Bulletin1999，44，S2： | 2 |
| 13 | Effects of Formulation Parameters and Process Variables on the Properties of Granules Obtained by Reactive Granulation显示文摘In this work, granulation between dodecyl-benzenesulfonic acid and sodium carbonate was investigated in a laboratory-scale high shear mixer. The effects offormulation parameters and process variables, including primary carbonate size, binder content, impeller speed, and operating temperature, were correlated to the properties ofthe product granules. Design ofexperiment and analysis ofvariance were combined to analyze the experimentaldata, and results showed that larger granule sizes with fewer fine particles can be obtained by employing higher binder contents and larger sodium carbonate sizes. The shear force ofthe impeller can extensively break oversized granules. The binder content exerted a contrasting effect on the flowability ofgranules formed with two kinds ofsodium carbonate, likely because ofdifferences in the liquid saturation ofthe solids. The dissolution rate determined by in-line size analysis showed that high binder contents were beneficialto dissolution performance, and the relationships between Hunter color and tested parameters were evaluated. The results ofthis work can be used as a reliable guidance for process controland optimization in powder detergent manufacturing. | Leping Dang Xiaojun Lang Xu Li Hongyuan Wei | 2018 | Transactions of Tianjin University2018，24，3： | 2 |
| 14 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 15 | Culture medium optimization for pigment production with RSM method显示文摘Response surface methodology was used to optimize a medium for a red-pigmented marine bacterium S-9801 strain (Flavobacterium sp.). In the first optimization step the influence of yeast extract, peptone, glucose and sodium chloride on pigment production was evaluated using a fractional factorial design. Pigment production was positively influenced by glucose and sodium chloride while other components had no significant effect. In the second step the path of steepest ascent was used to approach the optimal region of the medium composition. In the third step the optimal concentration of glucose and sodium chloride was determined by a central composite design and response analysis. The optimized medium allowed pigment production (A 535~650) to be increased from 0.137 to0.559, being 320% higher than the original medium. | WU Hongqing TIAN Li ZHANG Jiuming SUN Zhaobin HUANG Leping | 2005 | Acta Oceanologica Sinica2005，24，5： | 2 |
| 16 | CXCL12-induced upregulation of FOXM1 expression promotes human glioblastoma cell invasion显示文摘 | Shengwen Wang Shanyi Zhang Junliang Li Xinke Xu Yinlun Weng Meiguang Zheng Leping Ouyang Fangcheng Li | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 17 | Applications of the GA/KNN Method to SELDI Proteomics Data显示文摘 | Li Leping Umbach D M Terry P | 2004 | Bioinformatics2004，20，10： | 1 |
| 18 | Gene selection for sample classification based on gene expression data:study of sensitivity to choice of parameters of the GA/KNN method显示文摘 | Li Leping Weinberg Clarice R Darden Thomas A | 2001 | Bioinformatics2001，17，12： | 1 |
| 19 | Bubble circling phenomena in subcooled nucleate pool boiling on microwires显示文摘 | Leping Zhou Longting Wei Yuanyuan Li Xiaoze Du Buxuan Wang | 2013 | International Journal of Heat and Mass Transfer2013，，： | 1 |
| 20 | Applications of the GA/KNN Method to SELDI Proteomics Data显示文摘 | Li Leping Umbach D M Terry P | 2004 | Bioinformatics2004，20，10： | 1 |
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