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| 1 | Precise orbit determination of Beidou Satellites with precise positioning显示文摘Chinese Beidou satellite navigation system constellation currently consists of eight Beidou satellites and can provide preliminary service of navigation and positioning in the Asia-Pacific Region.Based on the self-developed software Position And Navigation Data Analysis(PANDA) and Beidou Experimental Tracking Stations (BETS),which are built by Wuhan University,the study of Beidou precise orbit determination,static precise point positioning (PPP),and high precision relative positioning,and differential positioning are carried out comprehensively.Results show that the radial precision of the Beidou satellite orbit determination is better than 10 centimeters.The RMS of static PPP can reach several centimeters to even millimeters for baseline relative positioning.The precision of kinematic pseudo-range differential positioning and RTK mode positioning are 2-4 m and 5-10 cm respectively,which are close to the level of GPS precise positioning.Research in this paper verifies that,with support of ground reference station network,Beidou satellite navigation system can provide precise positioning from several decimeters to meters in the wide area and several centimeters in the regional area.These promising results would be helpful for the implementation and applications of Beidou satellite navigation system. | SHI Chuang ZHAO QiLe LI Min TANG WeiMing HU ZhiGang LOU YiDong ZHANG HongPing NIU XiaoJi LIU JingNan | 2012 | Science China Earth Sciences2012，55，7： | 61 |
| 2 | Contrasting Effects of Ethylene Biosynthesis on Induced Plant Resistance against a Chewing and a Piercing-Sucking Herbivore in Rice显示文摘乙烯是有在草食动物抵抗上对比效果的压力荷尔蒙。然而,这些差别是否植物特定或草食动物特定,仍然保持未知。我们克隆米饭 1-aminocyclopropane-1-carboxylic 酸(ACC ) synthase 基因, OsACS2,其抄本响应由二个重要害虫的机械伤害和群袭是很快起来调整的:有斑纹的茎 borer (SSB ) Chilo suppressalis 和棕色的 planthopper (BPH ) Nilaparvata lugens。OsACS2 (当交流) 的 Antisense 表示减少了得到的乙烯排放,得到 SSB 的胰岛素朊酶禁止者(TrypPI ) 活动,导致 SSB 的不稳定的版本,和 SSB 抵抗。ACC 的外长的申请恢复了 TrypPI 活动和 SSB 抵抗。与 SSB 相对照, BPH 群袭在当交流线增加了不稳定的排放。因此, BPH 喜欢喂并且在上产卵野类型(WT ) 能被归因于二讨厌的 volatiles, 2-heptanone 和 2-heptanol 的 plantsan 效果,那被当交流植物在更高的数量射出。BPH 蜜露排泄被减少,生来的敌人吸引力在当交流线被提高,导致到 BPH 的更高全面的抵抗。这些结果证明发信号的乙烯对咀嚼和一只穿透吸昆虫在米饭防卫回答和电阻上有形成对照的、草食动物特定的效果,并且可以调停在不同的喂的草食动物之间的抵抗交易在米饭的行业协会。 | Jing Lu Jiancai Li Hongping Ju Xiaoli Liu Matthias Erb Xia Wang Yonggen Lou | 2014 | Molecular Plant2014，7，11： | 15 |
| 3 | Distribution characteristics and ecological risk assessment of PAHs in surface waters of China显示文摘The concentrations of PAHs in the surface waters from seven river basins in China were summarized from literature published from 2000-2010. Subsequently, the risks from individual PAHs and ∑PAHs in the surface waters of China were quantified by comparing the overlap between the probability distributions of exposure concentrations with the probability distributions of toxicity data. The results show that the concentrations of 15 PAHs in the surface waters ranged from 3.09 to 38139.00 ng L-1, with a geometric mean of 474.93 ng L-1. The significantly higher concentrations of the 15 PAHs occurred in the surface waters from northern China when compared with those from southern China. The concentrations of the 15 PAHs in Chinese surface waters were higher than those in other waters worldwide. The MOS10 (margin of safety) values were calculated at 90th percentile values of exposure concentrations and 10th percentile values of toxicity data, with 5.75, 0.17, 2.33, 0.30, 0.57, 1.74, 1.05, and 0.11 for Ace, Ant, Flu, BaP, Flua, Nap, Phe, and Pyr, respectively. The probabilities of the individual PAH concentrations exceeding the 10th percentile value of the toxicity data were 6.06%, 2.07%, 9.51%, and 2.07% for Nap, Ace, Phe, and Flu, respectively, suggesting minimal risk to aquatic organisms; however, the probabilities of BaP, Ant, Flua, and Pyr exceeding this value were 19.49%, 25.46%, 15.15%, and 30.50%, respectively, indicating potential risks. Among the individual PAHs, the ecological risk from Pyr was the highest, followed by, in descending order of risk, Ant, Bap, Flua, Phe, Nap, Flu, and Ace. Additionally, the combined ecological risk of ∑PAH8 in Chinese surface waters was significantly higher than any that of individual PAHs alone. The MOS10 values in the river basins were < 1, except for the Haihe River Basin, suggesting a potential combined risk from ∑PAH8 in the other six river basins. The probabilities calculation indicate that low to high ecological risk from ∑PAH8 for all aquatic species was reported in the Liaohe River Basin (65.58%), Huaihe River Basin (57.15%), Songhua River Basin (46.49%), Pearl River Basin (38.41%), Yangtze River Basin (25.98%), Yellow River Basin (15.92%), and Haihe River Basin (5.22%). | GUO GuangHui WU FengChang HE HongPing ZHANG RuiQing LI HuiXian FENG ChengLian | 2012 | Science China Earth Sciences2012，55，6： | 14 |
| 4 | A modified Kelvin impact model for pounding simulation of base-isolated building with adjacent structures显示文摘基础隔离能有效地在一座上层建筑上减少地震力量,在特别地低 -- 到中等上升的大楼。在强壮的近差错的地面运动下面,然而跳可以发生在在孤立底的大楼(围嘴) 和它的包围挡土墙之间的隔离水平。为了有效地调查在估计通常使用的一些以后,与邻近的结构跳的 BIB 的行为,影响当模特儿,一个修改凯尔文影响模型在这篇论文被建议。在修改凯尔文模型的相关参数理论上通过一个简单的跳案例被导出并且数字地验证了。同时,孤立的上层建筑的无弹力被介绍以便精确地评估潜在的损坏到与邻近的结构跳 BIB 引起的上层建筑。修改凯尔文影响模型的可靠性与另外的影响模型一起通过数字比较被验证。然而,从各种各样的影响的数字结果之间的差别分析模型不是重要的。围嘴的许多数字模拟被进行调查各种各样的设计参数的影响并且在跳期间在山峰上调节内部故事的飘移和地板加速。跳能实质地增加地板加速,这被显示出,特别在影响发生的一楼。颤动的更高的模式在跳期间是激动的,增加而不是保留上层建筑的一个将近僵硬身体的运动的内部故事的飘移。而且,更高的韧性要求能在上层建筑的更低的地板上被强加。而且,影响僵硬似乎在隔离水平和上层建筑的更低的地板的内部故事的飘移在加速反应起一个重要作用。最后,数字结果证明隔离系统的过多的灵活性过去常最小化加速可以引起 BIB 更产生在有限地震差距下面跳的地板。 | Ye Kun Li Li Zhu Hongping | 2009 | Earthquake Engineering and Engineering Vibration2009，8，3： | 13 |
| 5 | Purification and Characterization of a New Ribosome Inactivating Protein from Cinchonaglycoside C-treated Tobacco Leaves显示文摘A new ribosome-inactivating protein(RIP)with a molecular weight of 31 kDa induced by Cinchonaglycoside C(1)designatedCLP31,was isolated from tobacco leaves.Analysis of this protein sequence indicated that it belongs to the RIP family and itwas distinct from the other plant RIPs reported previously at its N-terminal amino acid sequence.CIP31 can directly impairsynthesis of coat protein(CP)of tobacco mosaic virus(TMV),which resulted in inhibition of TMV long distance movementand multiplication in tobacco plants at concentrations of ng/mL.Furthermore,no toxicity was shown to the growth andfertility of the plants.CIP31 was synthesized only in the presence of Cinchonaglycoside C(1)and was independent of thesalicylic acid(SA)signal pathway.We provided evidence for the SA-independent biological induction of resistance. | Yanmei Li Yantao Jia Zhongkai Zhang Xiaoying Chen Hongping He Rongxiang Fang Xiaojiang Hao | 2007 | Journal of Integrative Plant Biology2007，49，9： | 8 |
| 6 | Polyoxometalate-based silica-supported ionic liquids for heterogeneous oxidative desulfurization in fuels显示文摘With the aim of deep desulfurization, silica-supported polyoxometalate-based ionic liquids were successfully prepared by a one-pot hydrothermal process and employed in heterogeneous oxidative desulfurization of various sulfur compounds. The compositions and structures of the hybrid samples were characterized by various methods such as FT-IR, XPS, Raman,UV–Vis, wide-angle XRD and N_2 adsorption–desorption. The experimental results indicated that the hybrid materials presented a high dispersion of tungsten species and excellent catalytic activity for the removal of 4,6-dimethyldibenzothiophene without any organic solvent as extractant, and the sulfur removal could reach 100.0% under mild conditions.The catalytic performance on various substrates was also investigated in detail. After cycling seven cycles, the sulfur removal of the heterogeneous system still reached 93.0%. The GC-MS analysis results demonstrated that the sulfur compound was first adsorbed by the catalyst and subsequently oxidized to its corresponding sulfone. | Ming Zhang Miao Wang Jiapeng Yang Hongping Li Jiaqi Liu Xiao Chen Wenshuai Zhu Huaming Li | 2018 | Petroleum Science2018，15，4： | 5 |
| 7 | Global modeling 2^(nd)-order ionospheric delay and its effects on GNSS precise positioning显示文摘Ionospheric delay is one of the major error sources in GNSS navigation and positioning.Nowadays,the dual-frequency technique is the most widely used in ionospheric refraction correction.However,dual-frequency measurements can only eliminate the first-order term of ionospheric delay,while the effect of the second-order term on GNSS observations may be several centimeters.In this paper,two models,the International Reference Ionosphere (IRI) 2007 and International Geomagnetic Reference Field (IGRF) 11 are used to estimate the second-order term through the integral calculation method.Besides,the simplified single layer ionosphere model in a dipole moment approximation for the earth magnetic field is used.Since the traditional integral calculation method requires large calculation load and takes much time,it is not convenient for practical use.Additionally,although the simplified single layer ionosphere model is simple to implement,it results in larger errors.In this study,second-order term ionospheric correction formula proposed by Hoque (2007) is improved for estimating the second-order term at a global scale.Thus,it is more practicable to estimate the second-order term.More importantly,its results have a higher precision of the sub-millimeter level for a global scale in normal conditions.Compared with Hoque's original regional correction model,which calculates coefficients through polynomial fitting of elevation and latitudes,this study proposes a piece-wise look-up table and interpolation technique to modify Hoque model.Through utilizing a table file,the modified Hoque model can be conveniently implemented in an engineering software package,like as PANDA in this study.Through applying the proposed scheme for the second-order ionospheric correction into GNSS precise positioning in both PPP daily and epoch solutions,the results have shown south-shift characteristics in daily solution at a global scale and periodic change with VTEC daily variation in epoch positioning solution. | ZHANG HongPing LV HaiXia LI Min SHI Chuang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 5 |
| 8 | Retrieve Sea Surface Salinity Using Principal Component Regression Model Based on SMOS Satellite Data显示文摘The sea surface salinity(SSS) is a key parameter in monitoring ocean states. Observing SSS can promote the understanding of global water cycle. This paper provides a new approach for retrieving sea surface salinity from Soil Moisture and Ocean Salinity(SMOS) satellite data. Based on the principal component regression(PCR) model, SSS can also be retrieved from the brightness temperature data of SMOS L2 measurements and Auxiliary data. 26 pair matchup data is used in model validation for the South China Sea(in the area of 4?–25?N, 105?–125?E). The RMSE value of PCR model retrieved SSS reaches 0.37 psu(practical salinity units) and the RMSE of SMOS SSS1 is 1.65 psu when compared with in-situ SSS. The corresponding Argo daily salinity data during April to June 2013 is also used in our validation with RMSE value 0.46 psu compared to 1.82 psu for daily averaged SMOS L2 products. This indicates that the PCR model is valid and may provide us with a good approach for retrieving SSS from SMOS satellite data. | ZHAO Hong LI Changjun LI Hongping LV Kebo ZHAO Qinghui | 2016 | Journal of Ocean University of China2016，15，3： | 5 |
| 9 | Thermochemical Sulfate Reduction in the Tazhong District,Tarim Basin,Northeast China:Evidence from Formation Water and Natural Gas Geochemistry显示文摘形成水和天然气地球化学在的系统的分析中央在迟了的阶段的煤气的侵略被天然气的 H2S 和 CO2 的内容的增加伴随的 Tarim 盆( CUTB )表演高举,由形成高全部的溶解固体形成流水,由 HCO 的内容的增加? 3 ,相对 Cl ?,由第二家庭离子的增加(Ca2+,Mg2+,Sr2+和Ba2+)并且由 SO2 的内容的减少? 4 ,相对 Cl ?。上述现象能仅仅由 thermochemical 硫酸盐减小(TSR ) 的方法被解释。TSR 经常发生在油和水的转变地区并且经常在下列反应公式被描述:CH+CaSO4+H-2OH2S+CO2+CaCO3。(1 ) 溶解了 SO2 ? 当 H2S 和 CO2 被产生时, 4 在上述反应在形成水里被消费,导致 SO2 的减少 ? 4 在形成水和在天然气的 H2S 和 CO2 的增加里。如果形成水存在,产生 CO2 将继续与碳酸盐反应形成酸式碳酸盐,它能在形成水里被溶解,因此导致 Ca2+ 和 HCO 的丰富 ? 3。上述反应能被下列方程描述:CO2+H2O+CaCO3Ca2++2HCO ? 3。在 CUTB 的寒武纪、更低的奥陶纪的 stratigraphic 温度超过了 120 整瑣湯捩栠獩潴祲漠?桚橥慩杮?畆楪湡?湡?楊湡硧?牰癯湩散?景猠畯桴?楨慮椠?浩潰瑲湡?潦?湵敤獲慴摮湩?桴?整瑣湯捩攠潶畬楴湯漠?潓瑵?桃湩?畢?瑩?慭浧瑡捩愠瑣癩瑩?瀠瑥潲敧敮楳?猠牴瑡杩慲桰捩猠煥敵据?景琠敨?浡慩獮慨?片畯?獩猠楴汬猠牴湯汧?潣瑮潲敶獲慩??牥?敷瀠敲敳瑮渠睥猠湥楳楴敶栠杩?敲潳畬楴湯椠湯洠捩潲瀭潲敢???偍??A稠物潣?敧'覡睖珱K杯捩污搠瑡?潦?桴?慍業湡桳湡?潲灵愠摮瀠瑥潲牧灡楨慣?慤慴琠?潣獮牴楡?桴?...桴? | XIANG Caifu PANG Xiongqi WANG Jianzhong LI Qiming WANG Hongping ZHOU Changqian YANG Haijun | 2010 | Acta Geologica Sinica(English Edition)2010，84，2： | 4 |
| 10 | Simple synthesis of sandwich-like SnSe2/rGO as high initial coulombic efficiency and high stability anode for sodium-ion batteries显示文摘Metal selenides owing to their high theoretical capacity and good conductivity are considered as one of the potential candidates for the anode materials of sodium-ion batteries(SIBs).However,their practical applications are greatly restricted by the poor cycling performances and complicated synthesis methods.In this work,a sandwich-like Sn Se2/reduced graphene oxide(r GO)composite with a small amount of r GO(7.3%)is synthesized by a simple one-pot solvothermal technique.The as-synthesized Sn Se2/r GO shows improved initial coulombic efficiency(ICE)of 73.7%,high capacity of 402.0 m Ah g-1 after 150 cycles at 0.1 A g-1 with a retention of 86.2%and outstanding rate performances.The abundant Sn-O-C bonds of synthesized material not only accelerate the charge transfer at the interface but also enhance the mechanical strength to accommodate volume variation and prevent active material loss during cycling.Moreover,the compact structure leads to thin solid electrolyte interface(SEI)so that high initial coulombic efficiency was obtained.Furthermore,full cells are assembled to test its potential application.This work offers a simple method to synthesize Sn Se2/r GO as a candidate anode for SIBs. | Tingting Wang Kaiwei Yang Juan Shi Shangrui Zhou Liwei Mi Hongping Li Weihua Chen | 2020 | Journal of Energy Chemistry2020，29，7： | 4 |
| 11 | Numerical study of three-dimensional wave-induced longshore current's effects on sediment spreading of the Huanghe River mouth显示文摘A three-dimensional wave radiation stress is introduced into the hydrodynamic sediment coupled model COHERENS-SED,which has been developed through introducing wave-enhanced bottom shear stress,wave dependent surface drag coefficient,wave-induced surface mixing,SWAN,damping function of sediment on turbulence,sediment model and depth-dependent wave radiation stress to COHERENS.The COHERENS-SED is adopted to study the effects induced by wave-induced three-dimensional longshore current on suspended sediment spreading of the Huanghe River (Yellow River) mouth.Several different cases divided by setting different wave parameters of inputting boundary waves are carried out.The modeling results agree with measurement data.In terms of simulation results,it is easy to know that three-dimensional wave radiation stress plays an obvious role when inputting boundary wave height is stronger than 3 m.Moreover,wave direction also affects the sediment spreading rules of the mouth strongly too. | LIANG Bingchen ZHAO Hongping LI Huajun WU Guoxiang | 2012 | Acta Oceanologica Sinica2012，31，2： | 4 |
| 12 | Synergistic Effects of Chiral Morphology and Reconfiguration in Cattail Leaves显示文摘 | Zilong Zhao Weixi Huang Bingwei Li Kexing Chen Kuifu Chen Hongping Zhao Xiqiao Feng | 2015 | Journal of Bionic Engineering2015，12，4： | 3 |
| 13 | Amorphous TiO_2-supported Keggin-type ionic liquid catalyst catalytic oxidation of dibenzothiophene in diesel显示文摘Supported ionic liquid(IL) catalysts [C_nmim]_3PMo_(12)O_(40)/Am TiO_2(amorphous TiO_2) were synthesized through a one-step method for extraction coupled catalytic oxidative desulfurization(ECODS) system. Characterizations such as FTIR, DRS,wide-angle XRD, N_2 adsorption–desorption and XPS were applied to analyze the morphology and Keggin structure of the catalysts. In ECODS with hydrogen peroxide as the oxidant, it was found that ILs with longer alkyl chains in the cationic moiety had a better effect on the removal of dibenzothiophene. The desulfurization could reach 100% under optimal conditions, and GC–MS analysis was employed to detect the oxidized product after the reaction. Factors affecting the desulfurization efficiencies were discussed, and a possible mechanism was proposed. In addition, cyclic experiments were also conducted to investigate the recyclability of the supported catalyst. The catalytic activity of [C_(16)mim]_3 PMo_(12)O_(40)/Am TiO_2 only dropped from 100% to 92.9% after ten cycles, demonstrating the good recycling performance of the catalyst and its potential industrial application. | Zhendong Yu Donghui Wang Suhang Xun Minqiang He Ruliang Ma Wei Jiang Hongping Li Wenshuai Zhu Huaming Li | 2018 | Petroleum Science2018，15，4： | 3 |
| 14 | SDS-PAGE study on photooxidation damage of lysozyme induced by riboflavin显示文摘The photooxidation damage of lysozyme under 315-375 nm irradiation in the presence of riboflavin was studied by using sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE).Indica- tions showed that the mechanisms and products of oxidative damage were relative to the concentra- tion of riboflavin,the time of irradiation and the ambience.The type I process was examined in a nitrogen saturated solution,whereas both type I and type II were observed in an aerobic atmosphere and type II was the dominant process.The study also suggested that antioxidants,such as melatonin, can reduce the damage of lysozyme effectively. | ZHANG ZhaoXia ZHAO HongWei ZHU HongPing GE Min WANG WenFeng YAO SiDe LI WenXin | 2007 | Science China Chemistry2007，50，1： | 3 |
| 15 | Synthesis,photophysical properties and TD-DFT calculation of four two-photon absorbing triphenylamine derivatives显示文摘In this study,linear absorption,single-photon excited fluorescence,fluorescence quantum yields,fluorescence lifetime and two-photon excited fluorescence of a series of triphenylamine derivatives (L1,L2,L3 and L4) have been measured.L1 and L3 are D--A type dyes,while L2 and L4 are D--D--A type dyes (D=donor,A=acceptor).The investigated compounds consist of triphenylamine-bearing donor-substituted and/or systematically extended-conjugated length,which are designed to gain insight into the effect of the ethoxyl unit and-linkage length on the linear and nonlinear optical properties.The influence of solvent polarity on the photophysical properties was investigated.Employing time-dependent density functional theory (TD-DFT) calculations,the structure-property relationships are discussed. | KONG Lin YANG JiaXiang ZHOU HongPing LI ShengLi HAO FuYing ZHANG Qiong TU YuLong WU JieYing XUE ZhaoMing TIAN YuPeng | 2013 | Science China Chemistry2013，56，1： | 3 |
| 16 | A comparative study of the extractive desulfurization mechanism by Cu(Ⅱ)and Zn-based imidazolium ionic liquids显示文摘A comparative study of the extractive desulfurization(EDS) mechanism by Cu(Ⅱ) and Zn-based ILs([C_4mim]_2[MCl_4], M ? Cu(Ⅱ) or Zn)has been performed. It is found that the p–p interaction and C-H/p interaction play important roles in EDS for both Cu(Ⅱ) and Zn-based ILs,which is different from Al, Fe-based ILs. In the gas phase models, the interaction energy between Zn-based ILs and dibenzothiophene(DBT) is stronger than the interaction energy of Cu(Ⅱ)-based ILs. In order to consider the solvent effect, a generic ionic liquid of solvation model has been implemented, which is few considered in the previous calculations of EDS. It is interesting to find that the gap of interaction energies between Cu(Ⅱ), Zn-based ILs and DBT are reduced when the solvent effect is considered. In addition, by combined discussion of currently theoretical and experimental evidences for metal-based ILs with different compositions, we firstly propose that the EDS performance should be influenced by the balance of the contribution of cation, metal-based anion, metal chlorides and the viscosity. | Hongping Li Beibei Zhang Wei Jiang Wenshuai Zhu Ming Zhang Chao Wang Jingyu Pang Huaming Li | 2019 | Green Energy & Environment2019，4，1： | 2 |
| 17 | New evidence for microstructural evolution model of acid-activated montmorillonite显示文摘Ca-montmorillonite samples from Choushan treated at various acid concentrations were studied using chemical analysis, XRD, 29Si and 27A1 MAS NMR, to investigate the microstructure of the activated montmorillonites. With the increase of acid concentration and dissolution of cations of montmorillonite, the intensity of d(001) decreased obviously and significant changes of the microstructure of Si and Al occurred. There were two new types of structural units of Si atoms formed: (SiO)3SiOH units and Q4(0A1) units. For Al atoms, in the course of activation, the removal of one of a pair of octahedral aluminium atoms from montmorillonite removed two hydroxyl groups and left the other aluminum of the pair in the four-fold coordination. The 27A1 signal at 5 54.0 corresponding to AlIV arose from the four-coordinated Al in the octahedral sheet. This study first confirmed, by 29Si and 27A1 MAS NMR spectra, that the model of microstructural evolution for activated montmorillonite postulated by Thomas et al. (1950) | HE Hongping GUO Jiugao LIN Hongfu LI Liyun | 2002 | Chinese Science Bulletin2002，47，9： | 2 |
| 18 | Performance study on T-stub connected semi-rigid joint between rectangular tubular columns and H-shaped steel beams显示文摘This paper investigates the performance of T-stub connected semi-rigid joint of rectangular tubular columns and H-shaped steel beams.The finite element analysis software ABAQUS is used to analyze the nonlinear performance of the joint under monotonic loading.Meanwhile,the dimensions of T-stub,column and beam are considered as analytic parameters to discuss the performance of the joint.The analysis shows that the thickness and the length of T-stub webs,the height of beam section,bolt diameter,shear connector and the preloaded force affect the performance of the joint largely,and the thickness of the steel tube,the thickness and length of T-stub flange,bolt spacing have relatively little influences on the performance of the joint.The research results indicate that this joint is semi-rigid joint. | Guochang LI Hongping YU Chen FANG | 2013 | Frontiers of Structural and Civil Engineering2013，7，3： | 2 |
| 19 | Piezo1 regulates migration and invasion of breast cancer cells via modulating cell mechanobiological properties显示文摘Cell migration and invasion are two essential processes during cancer metastasis. Increasing evidence has shown that the Piezo1 channel is involved in mediating cell migration and invasion in some types of cancers. However, the role of Piezo1 in the breast cancer and its underlying mechanisms have not been clarified yet. Here, we show that Piezo1 is high-expressed in breast cancer cell (BCC) lines, despite its complex expression in clinical patient database. Piezo1 knockdown (Piezo1-KD) promotes unconfined BCC migration, but impedes confined cell migration. Piezo1 may mediate BCC migration through the balances of cell adhesion, cell stiffness, and contractility. Furthermore, Piezo1-KD inhibits BCC invasion by impairing the invadopodium formation and suppressing the expression of metalloproteinases (MMPs) as well. However, the proliferation and cell cycle of BCCs are not significantly affected by Piezo1. Our study highlights a crucial role of Piezo1 in regulating migration and invasion of BCCs, indicating Piezo1 channel might be a new prognostic and therapeutic target in BCCs. | Yang Yu Xiao’an Wu Sisi Liu Hongping Zhao Bo Li Hucheng Zhao Xiqiao Feng | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 2 |
| 20 | The oral microbiome of pregnant women facilitates gestational diabetes discrimination显示文摘The oral microbiota plays an important role in the development of various diseases,whereas its association with gestational diabetes mellitus (GDM) remains largely unclear.The aim of this study is to identify biomarkers from the oral microbiota of GDM patients by analyzing the microbiome of the saliva and dental plaque samples of 111 pregnant women.We find that the microbiota of both types of oral samples in GDM patients exhibits differences and significantly varies from that of patients with periodontitis or dental caries.Using bacterial biomarkers from the oral microbiota,GDM classification models based on support vector machine and random forest algorithms are constructed.The area under curve (AUC) value of the classification model constructed by combination of Lautropia and Neisseria in dental plaque and Streptococcus in saliva reaches 0.83,and the value achieves a maximum value of 0.89 by adding clinical features.These findings suggest that certain bacteria in either saliva or dental plaque can effectively distinguish women with GDM from healthy pregnant women,which provides evidence of oral microbiome as an informative source for developing noninvasive biomarkers of GDM. | Xiaoqing Li Jiayong Zheng Xiuling Ma Bing Zhang Jinyang Zhang Wenhuan Wang Congcong Sun Yeping Wang Jianqiong Zheng Haiying Chen Jiejing Tao Hai Wang Fengyi Zhang Jinfeng Wang Hongping Zhang | 2021 | Journal of Genetics and Genomics2021，48，1： | 2 |
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