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| 1 | Water quality criteria research and progress显示文摘Water quality criteria (WQC) are threshold limits for pollutants or other hazard factors in the ambient water environment, which are based on scientific experiments and extrapolations. Until now, there is limited information available regarding the study of water quality criteria in China. It is imperative to launch national-level systematic WQC studies that focus on the regional characteristics of China and provide scientific support for the enactment or revision of water quality standards and environmental management. This article reviews the concept of WQC and discusses the methodology and global progress of WQC research. The article also summarizes the key scientific issues in WQC research, including species sensitivity distribution, toxicological endpoint selection, and models selection. Furthermore, we can adopt the derivation method used in the USA and divide WQC into acute and chronic criteria. Finally, considering the current status of WQC research in China, we point out important directions for future national studies, including the selection of native species and the comprehensive use of models. | FENG ChengLian WU FengChang ZHAO XiaoLi LI HuiXian CHANG Hong | 2012 | Science China Earth Sciences2012，55，6： | 18 |
| 2 | Derivation of water quality criteria for representative water-body pollutants in China显示文摘In this study, toxicological data for zinc (Zn), cadmium (Cd), hexavalent chromium (Cr (VI)), benzene, and nitrobenzene were collected from various databases and publications, screened and then constructed into species sensitivity distribution (SSD) curves. Then water quality criteria (WQC) were derived for protection of the freshwater aquatic life in China against five representative pollutants. The values derived in this study were compared with those issued by the US Environmental Protection Agency and the Chinese national environmental standard for surface water to identify factors underlying the differences. The results showed that the SSD curves for the five pollutants differed significantly, with the examined aquatic species being generally more sensitive to Zn, Cd, and Cr (VI) than benzene and nitrobenzene. The acute WQC were: 48.43 μg L 1 for Zn, 0.4218 μg L 1 for Cd, 45.79 μg L 1 for Cr (VI), 2651 μg L 1 for benzene, and 1426 μg L 1 for nitrobenzene. The chronic WQC were: 20.01 μg L 1 for Zn, 0.2428 μg L 1 for Cd, 14.22 μg L 1 for Cr (VI), 530.2 μg L 1 for benzene, and 286.2 μg L 1 for nitrobenzene. The results of this comparative study of representative pollutants may offer guideline values for future WQC studies for China. | WU FengChang FENG ChengLian ZHANG RuiQing LI YuShuang DU DongYang | 2012 | Science China Earth Sciences2012，55，6： | 16 |
| 3 | Distribution characteristics and ecological risk assessment of PAHs in surface waters of China显示文摘The concentrations of PAHs in the surface waters from seven river basins in China were summarized from literature published from 2000-2010. Subsequently, the risks from individual PAHs and ∑PAHs in the surface waters of China were quantified by comparing the overlap between the probability distributions of exposure concentrations with the probability distributions of toxicity data. The results show that the concentrations of 15 PAHs in the surface waters ranged from 3.09 to 38139.00 ng L-1, with a geometric mean of 474.93 ng L-1. The significantly higher concentrations of the 15 PAHs occurred in the surface waters from northern China when compared with those from southern China. The concentrations of the 15 PAHs in Chinese surface waters were higher than those in other waters worldwide. The MOS10 (margin of safety) values were calculated at 90th percentile values of exposure concentrations and 10th percentile values of toxicity data, with 5.75, 0.17, 2.33, 0.30, 0.57, 1.74, 1.05, and 0.11 for Ace, Ant, Flu, BaP, Flua, Nap, Phe, and Pyr, respectively. The probabilities of the individual PAH concentrations exceeding the 10th percentile value of the toxicity data were 6.06%, 2.07%, 9.51%, and 2.07% for Nap, Ace, Phe, and Flu, respectively, suggesting minimal risk to aquatic organisms; however, the probabilities of BaP, Ant, Flua, and Pyr exceeding this value were 19.49%, 25.46%, 15.15%, and 30.50%, respectively, indicating potential risks. Among the individual PAHs, the ecological risk from Pyr was the highest, followed by, in descending order of risk, Ant, Bap, Flua, Phe, Nap, Flu, and Ace. Additionally, the combined ecological risk of ∑PAH8 in Chinese surface waters was significantly higher than any that of individual PAHs alone. The MOS10 values in the river basins were < 1, except for the Haihe River Basin, suggesting a potential combined risk from ∑PAH8 in the other six river basins. The probabilities calculation indicate that low to high ecological risk from ∑PAH8 for all aquatic species was reported in the Liaohe River Basin (65.58%), Huaihe River Basin (57.15%), Songhua River Basin (46.49%), Pearl River Basin (38.41%), Yangtze River Basin (25.98%), Yellow River Basin (15.92%), and Haihe River Basin (5.22%). | GUO GuangHui WU FengChang HE HongPing ZHANG RuiQing LI HuiXian FENG ChengLian | 2012 | Science China Earth Sciences2012，55，6： | 14 |
| 4 | Debrominated and methoxylated polybrominated diphenyl ether metabolites in rainbow trout(Oncorhynchus mykiss) after exposure to decabromodiphenyl ether显示文摘Decabromodiphenyl ether(BDE209) is the primary component in a commonly used flame retardant.Previous studies had proved that BDE209 itself was not toxic,while its metabolites including debrominated diphenyl ethers(De-BDEs) and methoxylated brominated diphenyl ethers(MeO-BDEs) posed a potential threat to organisms.Many studies had indicated that BDE209 could metabolize quickly in mammals,but lacking in the basic data about the metabolism of BDE209 in fish.In the present study,two replicate treatment groups of rainbow trout(Oncorhynchus mykiss) were exposed to BDE209 via a single intraperitoneal injection approximately 100 and 500 ng/g,respectively.Muscle,liver and blood samples were collected to analyze the specific metabolites on day 1 and day 28 post injection.The highest concentration of BDE209 was detected in muscle tissues,from 796.1 ng/g wet weight(day 1) to 687.1 ng/g wet weight(day 28) in high dose group,suggesting that BDE209 could accumulate slightly in muscle tissues.However,BDE209 was not detected in the blood for all treatments.Most congeners of De-BDEs were found in muscle and liver tissues,with the highest concentration in the liver.The main De-BDEs were nona-,octa-,hepta-and penta-De-BDEs.A total of seven MeO-BDE metabolites were observed among different fish tissues.Blood had the highest contribution of the MeO-BDE metabolites.Each MeO-BDE congener increased over the 28 days.These results in contrast to other studies suggested possible species-specific differences in metabolic abilities. | Chenglian Feng,Yiping Xu,Yue He,Qian Luo,Jinmiao Zha,Zijian Wang State Key Laboratory of Environmental Aquatic Chemistry,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China. | 2010 | Journal of Environmental Sciences2010，22，9： | 4 |
| 5 | Distribution and sources of polycyclic aromatic hydrocarbons in Wuhan section of the Yangtze River, China显示文摘 | Chenglian Feng Xinghui Xia Zhenyao Shen Zhui Zhou | 2007 | Environmental Monitoring and Assessment (-)2007，，1： | 2 |
| 6 | Organophosphate esters cause thyroid dysfunction via multiple signaling pathways in zebrafish brain显示文摘Organophosphate esters(OPEs)are widespread in various environmental media,and can disrupt thyroid endocrine signaling pathways.Mechanisms by which OPEs disrupt thyroid hormone(TH)signal transduction are not fully understood.Here,we present in vivo-in vitro-in silico evidence establishing OPEs as environmental THs competitively entering the brain to inhibit growth of zebrafish via multiple signaling pathways.OPEs can bind to transthyretin(TTR)and thyroxine-binding globulin,thereby affecting the transport of TH in the blood,and to the brain by TTR through the blood-brain barrier.When GH3 cells were exposed to OPEs,cell proliferation was significantly inhibited given that OPEs are competitive inhibitors of TH.Cresyl diphenyl phosphate was shown to be an effective antagonist of TH.Chronic exposure to OPEs significantly inhibited the growth of zebrafish by interfering with thyroperoxidase and thyroglobulin to inhibit TH synthesis.Based on comparisons of modulations of gene expression with the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases,signaling pathways related to thyroid endocrine functions,such as receptor-ligand binding and regulation of hormone levels,were identified as being affected by exposure to OPEs.Effects were also associated with the biosynthesis and metabolism of lipids,and neuroactive ligand-receptor interactions.These findings provide a comprehensive understanding of the mechanisms by which OPEs disrupt thyroid pathways in zebrafish. | Zhenfei Yan Chenglian Feng Xiaowei Jin Fangkun Wang Cong Liu Na Li Yu Qiao Yingchen Bai Fengchang Wu John P.Giesy | 2022 | Environmental Science and Ecotechnology2022，，4： | 2 |
| 7 | Toxicity mechanisms and bioavailability of copper to fish based on an adverse outcome pathway analysis显示文摘Copper(Cu)exists in a variety of forms in different aquatic environments,and affects their bioavailability.In this study we provide a systematic review on toxicity of Cu which focuses on identifying evidence in the mechanisms of Cu toxicity,and apply an adverse outcome pathway(AOP)analysis to identify multiple potential mechanisms and their interactions of Cu toxicity to fish.This analysis process included the mechanisms of behavior toxicant,oxidative toxicant,ion regulation disruption toxicity,as well as endocrine disruption toxicity.It was found that at low levels of Cu exposure,swimming,avoid predators,locating prey and other sensory functions will be impaired,and the organism will suffer from metabolic alkalosis and respiratory acidosis following the inhibition of the carbonic anhydrase active.The main pathway of acute toxicity of Cu to fish is the inhibition of the Na^(+)/K^(+)-ATPase enzyme,and lead to reduced intracellular sodium absorption,as well as Cu-induced increased cell permeability,in turn resulting in increased sodium ion loss,leading to cardiovascular collapse and respiratory insufficiency.The endocrine disruption toxicity of Cu to fish caused growth inhibition and reproductive reduction.In addition,there are several key pathways of Cu toxicity that are affected by hardness(e.g.,Ca^(2+))and intracellular DOC concentrations,including inhibiting Cu-induction,improving branchial gas exchange,altering membrane transport functions,decreasing Na+loss,and increasing Na+uptake.The results of the AOP analysis will provide a robust framework for future directed research on the mechanisms of Cu toxicity. | Wei Liao Ziwei Zhu Chenglian Feng Zhenfei Yan Yajun Hong Daqing Liu Xiaowei Jin | 2023 | Journal of Environmental Sciences2023，，5： | 1 |
| 8 | Distribution and sources of polycyclic aromatic hydrocarbons in Wuhan section of the Yangtze River, China 显示文摘 | FENG Chenglian XIA Xinghui SHEN Zhenyao | 2007 | Environmental Monitoring and Assessment2007，133，123： | 1 |
| 9 | Toxicokinetics and the related metabolites in rainbow trout(Oncorhynchus mykiss) after exposure to decabromodiphenyl ether显示文摘Decabromodiphenyl ether(BDE209) is poorly absorbed by mammals,and little information is available on the toxicokinetics of BDE209 and its metabolites in fish.In the present study,rainbow trout(Oncorhynchus mykiss) were administered to 100 ng/g and 500 ng/g body wet weight of BDE209 via a single intraperitoneal injection and parent BDE209 and its metabolites were sequentially monitored for 28 days.The results showed that toxicokinetic profiles of BDE209 could be described by the one-compartment model.In the higher dose group(500 ng/g wet weight),the calculated half-life(t1/2) and elimination rate(ke) were 17.7 d and 0.039/d in the liver,and 100.3 d and 0.007/d in the muscle,respectively.Three major methoxylated brominated diphenyl ethers(MeO-BDEs) were detected with 2,2',4,4'-tetrabromo-5-methoxydiphenyl ether(5-MeO-BDE47) being detected in all tissue samples.There was no significant temporal change of 5-MeO-BDE47 concentration in the muscle,whereas an exponential increase was observed in the liver.Therefore,the metabolism rate of BDE209 depended on the administered dose.BDE209 was hardly accumulated in the muscle of rainbow trout,while the liver was a primary metabolic organ.MeO-BDEs were formed via metabolism of BDE209,which probably played a significant role in fish toxicology as a potential indicator. | FENG ChengLian,XU YiPing,ZHA JinMiao,LUO Qian,SHAN XiaoQuan & WANG ZiJian State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China | 2010 | Science China Chemistry2010，53，11： | 1 |
| 10 | Relationship between BDE 209 metabolites and thyroid hormone levels in rainbow trout ( Oncorhynchus mykiss ) 显示文摘 | FENG Chenglian XU Yiping ZHAO Gaofeng | 2012 | Aquat Toxicol2012，，122123： | 1 |
| 11 | Distribution and sources of polycyclic aromatic hydrocarbons in Wuhan section of the Yangtze River, China显示文摘 | Chenglian Feng Xinghui Xia Zhenyao Shen Zhui Zhou | 2007 | Environmental Monitoring and Assessment (-)2007，，1： | 1 |
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