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| 1 | Autologous fibroblasts induce fibrosis of the nucleus pulposus to maintain the stability of degenerative intervertebral discs显示文摘Lumbar degenerative disc diseases cause low back pain(LBP). The maintenance of the height and stability of the intervertebral disc(IVD) space is an effective treatment for LBP. The following study evaluated the effects of fibroblast injection on intervertebral disc degeneration(IDD) in a preclinical setting. Compared with the IDD group, the fibroblast treatment group demonstrated effective maintenance of IVD height, reduced endplate degeneration, and improved nuclear magnetic resonance signals and overall histological structure. In doing so, fibrotic IVDs maintained the stability and biomechanics of the vertebra. This finding is in agreement with clinical findings that human nucleus pulposus(NP) fibrosis is essential for the maintenance of IVD height and mechanical properties in patients following percutaneous endoscopic lumbar discectomy(PELD). Mechanistically, we demonstrated that injected fibroblasts not only proliferated but also induced NP cells to adopt a fibrotic phenotype via the secretion of TGF-β.Finally, to better mimic human conditions, the efficacy of autologous fibroblast injection in the treatment of IDD was further examined in a nonhuman primate cynomolgus monkey model due to their capacity for upright posture. We showed that the injection of fibroblasts could maintain the IVD height and rescue IVD signals in cynomolgus monkeys. Taken together, the results of our study reveal that autologous fibroblast injection can enhance the natural process of fibrosis during acute and subacute stages of stress-induced IDD. Fibrotic IVDs can maintain the stability, biological activity, and mechanical properties of the intervertebral space, thus providing a new direction for the treatment of intervertebral space-derived lumbar degenerative diseases. | Chen Chen Tangjun Zhou Xiaojiang Sun Chen Han Kai Zhang Changqing Zhao Xunlin Li Haijun Tian Xiao Yang Yifan Zhou Zhiqian Chen An Qin Jie Zhao | 2020 | Bone Research2020，8，1： | 3 |
| 2 | Suppression intra-channel four-wave mixing by strong dispersion management in 160 Gb/s OTDM RZ 100 km transmission显示文摘The effect of intra-channel four-wave mixing on the performance of a 160 Gb/s OTDM RZ 100 km transmission system is analyzed. Strong dispersion management to suppress the detrimental effects of intra-channel four-wave mixing is presented theoretically and verified experimentally. Results demonstrate that amplitude fluctuation and ghost pulses are well suppressed by strong dispersion management. Stable (>2 h) error-free (10-12 ) transmission over 100 km is achieved without forward-error correction, and the power penalty is ~3.6 dB. | JIA Nan LI TangJun ZHONG KangPing WANG MuGuang LI Jing | 2011 | Chinese Science Bulletin2011，56，25： | 2 |
| 3 | Design and fabrication of erbium doped photosensitive fibers显示文摘A kind of erbium doped photosensitive fiber(EDPF) was proposed and fabricated,whose core was made of double layers named photosensitive layer and erbium doped layer.The double-layer core de-sign can overcome difficulties in fabrication of EDPF with single core design,i.e.the conflict between the high consistency rare earth doping and high consistency germanium doping.A sample was fabri-cated through the modified chemical vapor deposition method combined with solution doping tech-nique.The peak absorption coefficient was 48.80 dB/m at 1.53 μm,the background loss was lower than 0.1 dB/m,and the reflectivity of the fiber Brag gratings(FBG) written directly on the sample fiber was up to 97.3% by UV-writing technology.Moreover,a C band tunable fiber laser was fabricated using the sample fiber,in which a uniform FBG was written directly on EDPFs as a reflector.A single wavelength lasing with a maximum wavelength tuning range of 1555.2―1558.0 nm was achieved experimentally.Within this tuning range,the full-width at half maximum(FWHM) of the laser output was smaller than 0.015 nm and the side mode suppression ratio(SMSR) was better than 50 dB. | LI Jian LIU Peng LU ShaoHua WANG Jing MAO XiangQiao WEI Huai FU YongJun ZHENG Kai NING TiGang LI TangJun JIAN ShuiSheng | 2009 | Science China(Technological Sciences)2009，52，5： | 1 |
| 4 | Multi- wavelength erbium-doped fiber ring lasers with overlap- written fiber Bragg gratings显示文摘 | Wei Daoping Li Tangjun Zhao Yucheng | 2000 | Optics Letters2000，25，16： | 1 |
| 5 | Study on a Multiplexer a 40 Gb/s OTDM System显示文摘In a 4×10Gb/s OTDM system (optical time-division-multiplication) system, multiplexing devices are key devices. The time interval of four channels of the 40Gb/s OTDM system is 25ps respectively. If the time intervals are no accurate, will induce the system performance to degeneration. In order to make out OTDM device and carry out a transmission experiment in a 40Gb/s OTDM system, a kind of OTDM device is researched. This scheme be used to fabricate multiplex device. Also the device have been used to a 4... | Li Tangjun Jiang Zhongao Cui Jie Gong Xiangfeng Diao Cao Institute of Lightwave Technology, Northern Jiaotong University, Beijing, China, 100044 | 2003 | 光学学报2003，23，S1： | 1 |
| 6 | Compensating Large PMD by Four Free degrees in an OTDM System显示文摘In this paper, by introducing a two-stages polarization mode dispersion (PMD) compensator after a optical fiber link with a large PMD, we compensated over 270ps first-order and 2000ps2 high-order PMD in a optical fiber link with super high PMD. Our experimental results shows that, the compensators based on the two-stages of compensator can be used to PMD compensation in a 20Gb/s OTDM system with 60 km high PMD fiber. Before compensation, 270ps DGD is became into max. 7ps after compensation. At simultane... | Li Tangjun Wang Muguang Cui Jie Luo Ri Jian Shuisheng Institute of Lightwave Technology, Northern Jiaotong University, Beijing, China, 100044 | 2003 | 光学学报2003，23，S1： | 0 |
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