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| 1 | 肺炎链球菌耐药性和血清型分布及隐匿性耐药克隆株的研究显示文摘目的 了解儿童肺炎链球菌携带者耐药菌株的流行情况 ,比较携带者菌株血清型与肺炎链球菌结合疫苗血清型的符合率 ,寻找单个患儿同时携带敏感和耐药菌株的可能性。方法 (1)对1997年 11月~ 12月在北京儿童医院普通门诊登记的 3个月~ 5岁儿童进行问卷调查 ;(2 )采集鼻咽拭子和尿标本 ,培养、分离和鉴定肺炎链球菌 ,并测定尿标本中的抗生素活性 ;(3)根据NCCLS方法使用微量稀释法测定肺炎链球菌对青霉素、头孢呋新、头孢噻肟、复方新诺明、红霉素和氯霉素的敏感性 ;(4 )从最初发现的青霉素、红霉素敏感株中寻找“隐匿性耐药克隆株”。结果 (1) 5 0 2例受试儿童中 ,分离出 190株肺炎链球菌 ,携带率为 37.8% (190 / 5 0 2 ) ,对青霉素的敏感率为 91.1% ;(2 )只有33 .9%的菌株血清型与建议使用的肺炎链球菌结合疫苗血清型相符 ;(3) 4 2例含青霉素和红霉素敏感菌株鼻咽拭子中发现 6株 (14% )“隐匿性耐药克隆株”。结论 在携带者中 ,肺炎链球菌对 β 内酰胺类耐药还不常见 ,但对红霉素和复方新诺明耐药却非常严重 ;建议使用的结合疫苗血清型不能覆盖大部分携带菌株 ;耐药菌株的小部分隐匿在敏感菌株中 。 | 俞桑洁 王槿芳 李洁 李艳 王雪莲 Whitney CG Levine OS Dowell SF 杨永弘 | 2000 | 中华儿科杂志2000，38，7： | 40 |
| 2 | The pneunomia etiology research for child health project: a 21st century child- hood pneumonia etiology study 显示文摘 | Levin OS O'Brien KL Deloria-Knoll M | 2012 | Clin Infect Dis2012，54，2： | 1 |
| 3 | The Pneumonia Etiology Research for Child Health Project: A 21st Century Childhood Pneumonia Etiology Study 显示文摘 | Levine OS O'Bden KL Deloria-Knoll M | 2012 | Clinical Infectious Diseases2012，54，2： | 1 |
| 4 | Risk factors for pediatric invasive group A streptococcal disease显示文摘 | FACTOR SH LEVINE OS HARRISON LH | 2005 | Emerg Infect Dis2005，11，7： | 1 |
| 5 | The pneumonia etiology research for child health project:a 21st century childhood pneumonia e- tiology study显示文摘 | Levine OS O'Brien KL Deloria-Knoll M | 2012 | Clin Infect Dis2012，54，2： | 1 |
| 6 | Systematic evalu-ation of serotypes causing invasive pneumococcal disease amongchildren under five; the pneumococcal global serotype project显示文摘 | Johnson HL Deloria-Knoll M Levine OS | 2010 | PLoS Med2010，7，00： | 1 |
| 7 | Pneumococcal vaccination in developing countries 显示文摘 | Levine OS O Brien KL | 2006 | Lancet2006，367，9526： | 1 |
| 8 | Development evalua tion and implementation of Haemophilus influenzae type vaccines for young children in developing countries: eurrer status and priority actions 显示文摘 | Levine OS Schwartz B Pierce N | 1998 | Pediatr Infect Dis J1998，17，9： | 1 |
| 9 | Early results of right ventricular pulmonary artery conduits in patients under 1 year of age显示文摘 | Levine AJ Miller PA Stumper OS | 2001 | Eur J Cardiot Horac Surg2001，19，2： | 1 |
| 10 | Early results of right ventricular pulmonary artery conduits in patients under 1 year of age 显示文摘 | Levine A J Miller PA Stumper OS | 2001 | Eur J Cardiothorac Surg2001，19，2： | 1 |
| 11 | Houseflies(Musca domestica)as mechanical vectors of shigellosis显示文摘 | Levine OS Levine MM | 1991 | Review of Infectious Diseases1991，13，4： | 1 |
| 12 | Haemophilus influenzae type b and Streptococcus pneumoniae as causes of pneumonia among children in Beijing, China显示文摘 | Levine OS Liu G Garman RL | 2000 | Emerg Infect Dis2000，6，2： | 1 |
| 13 | A literature review and survey of childhood pneumonia etiology studies: 2000- 2010显示文摘 | Gilani Z Kwong YD Levine OS | 2012 | Clin Infect Dis2012，54，2： | 1 |
| 14 | The Pneumonia Etiology Research for Child Health Project: a 21st century childhood pneumonia eti-ology study显示文摘 | Levine OS O'Brien KL Deloria - Knoll M | 2012 | Clin Infect Dis2012，54，2： | 1 |
| 15 | Cerebral mi- erobleeds in cerebrovascular and neurodegenerative dis- eases 显示文摘 | Arablinskii AV Makotrova TA Levin OS | 2013 | Zh Nevrol Psikhiat''r Im S S Korsakova2013，113，72： | 1 |
| 16 | Defining the burden of pneumonia in children preventable by vaccination against Hae- mophilus influenzae type b 显示文摘 | Levine OS Lagos R Mufioz A | 1999 | Pediatr Infect Dis J1999，18，12： | 1 |
| 17 | Toward elimination of Haemophilus influenzae type B carriage and disease among high-risk American Indian children 显示文摘 | Millar EV O'Brien KL Levine OS | 2000 | American Journal of Public Health2000，90，10： | 1 |
| 18 | Early results of right ventricular-pulmonary artery conduits in patients under 1 year of age显示文摘 | Levine AJ Miller PA Stumper OS | 2001 | Eur J Cardiothorac Surg2001，19，2： | 1 |
| 19 | Defining the burden of Hib disease in India显示文摘 | Wenger JD | 2002 | Indian Pediatr2002，39，1： | 1 |
| 20 | Houseflies (Musca domestica) as me- chanical vectors of shigeilosis显示文摘 | Levine OS Levine MM | 1991 | Rev Infect Dis1991，13，4： | 1 |
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