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| 1 | Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment显示文摘AIM: To assess the antioxidant and antifibrotic effects of long-term Ginkgo biloba administration on liver fibrosis induced by biliary obstruction in rats.METHODS: Liver fibrosis was induced in male Wistar albino rats by bile duct ligation and scission (BDL). Ginkgo administered for 28 d. At the end of the treatment period,all rats were killed. Serum aspartate aminotransferase (AST),alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined to assess liver functions and tissue damage, respectively. Tumor necrosis factor-α (TNF-α) was also assayed in serum samples. Liver tissues were taken for determination of the hepatic malondialdehyde (MDA) and glutathione (GSH) levels,myeloperoxidase (MPO) activity and collagen content.Production of reactive oxidants was monitored by chemiluminescence (CL) assay. Serum AST, ALT, LDH, and TNF-α levels were elevated in the BDL group as compared to control group and were significantly decreased by EGb treatment.RESULTS: Hepatic GSH level, depressed by BDL, was elevated back to control level in EGb-treated BDL group.Increase in tissue MDA level, MPO activity and collagen content due to BDL were also attenuated by EGb treatment.Furthermore, luminol and lucigenin CL values in BDL group increased dramatically compared to control and reduced by EGb treatment.CONCLUSION: Our results suggest that Ginkgo biloba protects the liver from oxidative damage following BDL in rats. This effect possibly involves the inhibition of neutrophil infiltration and lipid peroxidation; thus, restoration of oxidant and antioxidant status in the tissue. | Gksel pener Levent Kabasakal Meral Yüksel Nursal Gedik Ynci Alican | 2005 | World Journal of Gastroenterology2005，11，35： | 7 |
| 2 | Prevalence of microscopic colitis in patients with diarrhea of unknown etiology in Turkey显示文摘AIM: To investigate the prevalence and demography of microscopic colitis in patients with diarrhea of unknown etiology and normal colonoscopy in Turkey. METHODS: Between March, 1998 to July, 2005, 129 patients with chronic non-bloody diarrhea of unexplained etiology who had undergone full colonoscopy with no obvious abnormalities were included in the study. Two biopsies were obtained from all colonic segments and terminal ileum for diagnosis of microscopic colitis. On histopathologic examination, criteria for lymphocytic colitis (intraepithelial lymphocyte ≥ 20 per 100 intercryptal epithelial cells, change in surface epithelium, mononuclear infiltration of the lamina propria) and collagenous colitis (subepithelial collagen band thickness ≥ 10 μm) were explored. RESULTS: Lymphocytic colitis was diagnosed in 12 (9%) patients (Female/Male: 7/5, mean age: 45 year, range: 27-63) and collagenous colitis was diagnosed in only 3 (2.5%) patients (all female, mean age: 60 years, range: 54-65).CONCLUSION: Biopsy of Turkish patients with the diagnosis of chronic non-bloody diarrhea of unexplained etiology and normal colonoscopic findings will reveal microscopic colitis in approximately 10% of the patients. Lymphocytic colitis is 4 times more frequent than collagenous colitis in these patients. | Levent Erdem Sadιk Yιldιrιm Nihat Akbayιr Banu Yιlmaz Necati Yenice Orhan Sami Gültekin nder Peker | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 3 | Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus显示文摘 | Büyükafsar K Levent A | 2003 | Biochem Biophys Res Commun2003，303，3： | 1 |
| 4 | Transformation of a simple plastic into a superhydrophobic surface显示文摘 | Yildirim E H Levent D A Avci Y | 2003 | Science2003，299，2： | 1 |
| 5 | Intrapleural hyperthermic perfusion chemotherapy in subjects with metastatic pleural malignancies显示文摘 | Ahmet Feridun I??k Maruf ?anl? Miray Y?lmaz Fatih Metero?lu ?ner Dikensoy Alper Sevin? Celaletdin Camc? Bülent Tun??zgür Levent Elbeyli | 2013 | Respiratory Medicine2013，，： | 1 |
| 6 | A comparative study: Assessment of the antioxidant system in the invasive green alga Caulerpa racemosa and some macrophytes from the Mediterranean显示文摘 | Levent C T Kadir Y | 2005 | Journal of Experimental Marine Biology and Ecology2005，321，： | 1 |
| 7 | Recombinant human erythropoietin administration in cardiac surgery显示文摘 | LEVENT Y SADIK E MUSTAFA S | 2001 | J Thorac Cardiovasc Surg2001，122，： | 1 |
| 8 | Electrochemical performance of boron- doped diamond electrode in surfactant-containing media for 517-526 显示文摘 | Levent A Yardim Y Senturk Z | 2014 | Sensor & Actuat B Chem2014，203，21： | 1 |
| 9 | Distal tibial reconstruction with use of a circular external fixator and an in- tramedullary nail 显示文摘 | LEVENT E MEHMET K NAZRIMOHD Y | 2007 | The Journal of Bone and Joint Surgery (Am)2007，89，： | 1 |
| 10 | Bentonite and sepiolite as supporting media: Immobilization of cata- lase显示文摘 | SEVILAY C LEVENT C KADIR Y | 2012 | Applied Clay Science2012，，6566： | 1 |
| 11 | Preparation of rapeseed protein isolate by sodium hexametaphosphate extraction, ultrafiltration, diafiltration, and ion-exchange显示文摘 | TZENG Y LEVENTE L D RUBIN L J | 1988 | Journal of Food Science1988，53，5： | 1 |
| 12 | Fascin and EMMPRIN ex- pression in primary mucinous tumors of ovary : a tissue microar- ray study显示文摘 | Omer A Mehmet K Levent Y | 2014 | Pathol Res Pract2014，210，12： | 1 |
| 13 | Quantitive analysis of the drainage after neck dissection 显示文摘 | Levent E Gonca Y Atilla M | 2000 | Otolaryngol Head Neck Surg2000，123，3： | 1 |
| 14 | Effects of soybean biodiesel on a DI diesel engine performnce,emission and combustion characteristics显示文摘 | Orkun O Levent Y Alp T E | 2014 | Fuel2014，，115： | 1 |
| 15 | Transformation of a Simple Plastic into a Superhydrophobic Surface 显示文摘 | Yidirim E H Levent D A Avci Y | 2003 | Science2003，299，5611： | 1 |
| 16 | Central venous stenosis in haemodialysis patients without a previous history of catheter placement显示文摘 | Levent O Tercan F Sedat Y | | 0，，： | 1 |
| 17 | Recombinant human erythropoietin administration in cardiac surgery显示文摘 | Levent Y Sadik E Mustafa S | 2001 | J Thorac Cardiovasc Surg2001，122，： | 1 |
| 18 | Smooth Second Order Sliding Mode Control: Missile Guidance Application 显示文摘 | Shtessel Y B Shkolnikov I A Levent A | 2007 | Automatica2007，43，： | 1 |
| 19 | Guidance and Control of Missile Interceptor Using Second-Order Sliding Modes 显示文摘 | Shtessel Y B Shkolnikov I A Levent A | 2009 | IEEE Transactions on Aerospace and Electronic Systems2009，45，1： | 1 |
| 20 | Spare parts inventory man agement with demand lead times and rationing显示文摘 | LEVENT KOCA GA Y SENA | 2007 | IIE Transactions2007，39，9： | 1 |
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