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| 1 | Abnormal subchondral bone remodeling and its association with articular cartilage degradation in knees of type 2 diabetes patients显示文摘Type 2 diabetes(T2 D) is associated with systemic abnormal bone remodeling and bone loss. Meanwhile,abnormal subchondral bone remodeling induces cartilage degradation, resulting in osteoarthritis(OA).Accordingly, we investigated alterations in subchondral bone remodeling, microstructure and strength in knees from T2 D patients and their association with cartilage degradation. Tibial plateaus were collected from knee OA patients undergoing total knee arthroplasty and divided into non-diabetic(n = 70) and diabetes(n = 51) groups. Tibial plateaus were also collected from cadaver donors(n = 20) and used as controls.Subchondral bone microstructure was assessed using micro-computed tomography. Bone strength was evaluated by micro-finite-element analysis. Cartilage degradation was estimated using histology. The expression of tartrate-resistant acidic phosphatase(TRAP), osterix, and osteocalcin were calculated using immunohistochemistry. Osteoarthritis Research Society International(OARSI) scores of lateral tibial plateau did not differ between non-diabetic and diabetes groups, while higher OARSI scores on medial side were detected in diabetes group. Lower bone volume fraction and trabecular number and higher structure model index were found on both sides in diabetes group. These microstructural alterations translated into lower elastic modulus in diabetes group. Moreover, diabetes group had a larger number of TRAP^+ osteoclasts and lower number of Osterix^+ osteoprogenitors and Osteocalcin^+ osteoblasts. T2 D knees are characterized by abnormal subchondral bone remodeling and microstructural and mechanical impairments, which were associated with exacerbated cartilage degradation. In regions with intact cartilage the underlying bone still had abnormal remodeling in diabetes group, suggesting that abnormal bone remodeling may contribute to the early pathogenesis of T2 D-associated knee OA. | Yan Chen Yong-Can Huang Chun Hoi Yan Kwong Yuen Chiu Qingjun Wei Jingmin Zhao X Edward Guo Frankie Leung William W Lu | 2017 | Bone Research2017，5，4： | 10 |
| 2 | Indigenous Chinese personality constructs: Is the five factor model complete? 显示文摘 | CHEUNG F M LEUNG K ZI-IANG J X | 2001 | J Cross Cultural Psychol2001，32，40： | 1 |
| 3 | Performance evaluation of digital beamforming strategies for satellite communications显示文摘 | Li W Huang X Leung H | 2004 | IEEE Transactions on Aerospace and Electronic Systems2004，40，1： | 1 |
| 4 | Mesenchymal stem cell-based repair of articular cartilage with polyglycolic acid-hydroxyapatite biphasic scaffold显示文摘 | Zhou X Z Leung V Y Dong Q R | 2008 | Int J Artif Organs2008，31，6： | 1 |
| 5 | Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy显示文摘 | Sun X Kanwar JR Leung E | 2001 | Gene Ther2001，8，8： | 1 |
| 6 | Gene transfer of antisense hypoxia inducible factor-1 α enhances the therapeutic efficacy of cancer immunotherapy显示文摘 | Sun X Kanwar JR Leung E | | 0，，： | 1 |
| 7 | A social network analysis of overseas tourist movement patterns in Beijing: The impact of the Olympic games 显示文摘 | Leung X Y Wang F Wu B H Stahura K A Xie Z H | 2012 | International Journal of Tourism Research2012，14，5： | 1 |
| 8 | Large-eddy simulation of flow and pollutant dispersion in high-aspect-ratio urban street canyons with wall model显示文摘 | LI X X LIU C H LEUNG D Y C | 2008 | Bound-Layer Meteor2008，129，2： | 1 |
| 9 | Genome scanning for resistance -gene analogs in rice, barley, and wheat by high -resolution electrophoresis 显示文摘 | Chen X M Line R F Leung H | 1998 | Theor Appl Genet1998，97，： | 1 |
| 10 | Optimization of biodiesel production from camelina oil using orthogonal experiment显示文摘 | Wu X Leung D Y C | 2011 | Appl Energ2011，88，11： | 1 |
| 11 | Gene transfer of antisense hypoxia-inducible factor-1 enhances the therapeutic efficacy of cancer immunotherapy显示文摘 | Sun X Kanwar JR Leung E | 2001 | Gene Therapy2001，8，8： | 1 |
| 12 | A review on biodiesel production using catalyzed transesterification显示文摘 | Leung D Y C Wu X Leung M K H | 2010 | Applied Energy2010，87，： | 1 |
| 13 | Towards real-time community detection in large networks 显示文摘 | Leung I X Hui P Lio P | 2009 | Physical Review E2009，79，06： | 1 |
| 14 | Gene transfer of antisense hypoxia inducible factor 1 alpha enhances the therapeutic efficacy of cancer immunotherapy显示文摘 | Sun X Kanwar JR Leung E | 2001 | Gene Ther2001，8，8： | 1 |
| 15 | A review on the development andcommercialization of biomass gasification technologies in China显示文摘 | LEUNG D Y C YIN X L WU C Z | 2004 | Re-newable and Sustainable Energy Reviews2004，8，： | 1 |
| 16 | Genetic diversity of Chinese native chicken breeds based on protein polymorphism, randomly amplified polymorphic DNA, and microsatellite polymorphism显示文摘 | Zhang X Leung F C Chan D K O | 2002 | Poultry Science2002，81，： | 1 |
| 17 | Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis显示文摘 | X ZHU I LEAV Y LEUNG | 2004 | Am J Pathol2004，164，： | 1 |
| 18 | Parameter estimation in chaotic noise 显示文摘 | Leung H Huang X P | 1996 | IEEE Trans Sig Proc1996，44，： | 1 |
| 19 | Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation显示文摘 | Chan YC Leung FP Wong WT Tian XY Yung LM Lau CW Tsang SY Yao X Chen ZY Huang Y | | 0，，： | 1 |
| 20 | A monte carlo study of the effects of common method variance on significance testing and parameter bias in hierarchical linear modeling显示文摘 | Lai X Li F Leung K | | 0，，： | 1 |
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