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209篇 您的检索式：作者名="LEOPOLD J"

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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	No-reflow during coronary intervention :observations and implications 显示文摘	Leopold JA Berger C J Cupples LA	2000	Circulation2000，102，：	2
3	Lignin geochemistry of a Late Quaternary core from Lake Washington显示文摘	Hedges J I Ertel J R Leopold E B	1982	Geochimica Cosmochimica Acta1982，46，：	1
4	New developments in fast 3D-surface quality control显示文摘	LEOPOLD J GUNTHER H LEOPOLD R		0，，02：	1
5	Host innate im- munite responses to sepsis显示文摘	Wiersanga W J Leopold S J Cranendonk D R	2014	Virulence2014，5，1：	1
6	Phytochelatins and heavy metal tolerance 显示文摘	Leopold I Schmidt J Neumarm D	1999	Phytochemistry1999，50，：	1
7	Acute and long-term toxicities associated with gemtuzumab ozogamicin (mylotarg(r)) therapy of acute myeloid leukemia显示文摘	Leopold L H Berger M S Feingold J	2002	Clin Lymphoma2002，1，：	1
8	Vasoactive sub- stances: nitric oxide and endothelial dysfunction in ath- erosclerosis 显示文摘	Russo G Leopold JA Loscalzo J	2002	Vasc Pharmacol2002，38，：	1
9	Noreflow during coronary intervention: observations and implications显示文摘	Leopold J A Berger C J Cupples L A	2000	Circulation2000，102，：	1
10	Vascular calcification:pathobiological mechanisms and clinical implications显示文摘	Johnson RC Leopold JA Loscalzo J		0，，10：	1
11	Vascular calcification: pathobiological mechanisms and clinical implications 显示文摘	Johnson RC Leopold JA Loscalzo J	2006	Circ Res2006，99，10：	1
12	Text categorization with support vector machines:how to represent texts in input space? 显示文摘	LEOPOLD E KINDERMANN J	2002	Machine Learning2002，46，123：	1
13	On the mechanism of aging in soybean seeds显示文摘	PARRISH D J LEOPOLD A C	1978	Plant Physiol1978，61，3：	1
14	Composition quality control and antmicrobial activity of the essential oil of long-time Dill seeds from Bulgaria显示文摘	LEOPOLD J GERHARD B ALBERA S	2003	Chemistry of Natural Compounds2003，51，：	1
15	Experimental Modification of Plant Senescence 显示文摘	Leopold A C Niedergang-Kamien E Janick J	1959	Plant Physiology1959，34，5：	1
16	Use of habitat guilds of fish to determine instream flow requirements显示文摘	LEOPOLD L B ORTH D J	1998	North Am J Fish Manage1998，8，：	1
17	On the mechanism of aging in Soy- bean seeds显示文摘	Parrish D J Leopold A C		0，，：	1
18	Phenological Changes Re-flect Climate Change in Wisconsin显示文摘	Bradley N L Leopold A C Ross J	1999	Proceedings of the Na-tional Academy of Science1999，96，：	1
19	Oxidative Enzymopathies and Vascular Disease 显示文摘	Leopold JA Loscalzo J	2005	Arterioscler Thromb Vasc Biol2005，25，7：	1
20	The reliability and predictive volume of an amniotic fluid scoring system in severe second trimester oligohydramnios 显示文摘	Moore TR Longo J Leopold G	1989	Obstet Gynecol1989，73，：	1

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