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| 1 | Recent status of fluidized bed technologies for producing iron input materials for steelmaking显示文摘Today steel is produced by two steelmaking processes, the basic oxygen furnace and the electric arc furnace. Three types of iron input materials for both processes are liquid hot metal or in solidified form as pig iron, direct reduced iron (DRI) and hot briquetted iron (HBI) as well as steel scrap. Hot metal, pig iron, DRI and HBI are virgin iron materials, which have to be produced from iron ore by the so-called ironmaking technologies. New ironmaking processes based on fluidized bed technology have been developed in the last two decades. The main advantage of these technologies is that fine ore can be directly used in the processes and prior treatment such as sintering or pelletizing can be avoided which is required for the established processes. Theoretical aspects for reduction of fine iron oxides in a fluidized bed reactor system will be explained. The fluidized bed reducing technologies utilized in the most advanced new ironmaking processes for direct use of fine ore, FINMET , Circored , FINEX and HIsmelt will be compared. | Johannes Leopold Schenk | 2011 | Particuology2011，9，1： | 16 |
| 2 | Improvement on straightness of metal bar based on straightening stroke-deflection model显示文摘The straightening technics is one of important means to improve the straightness of metal bar. A nove way of predicting the straightening stroke is proposed based on mathematical methods and bending experimental and numerical simulation. The experimental and numerical simulation is conducted by following the mathematical load-stroke model of press straightening process under the elastic-plastic theory. For the linear guide rails, as an example, the stroke-deflection model focusing on the straight-ening stroke prediction can be achieved by contrasting and integrating the bending experimental results and finite element methods (FEM) simulation data. And then the formula for predicting the straightening stroke is presented based on the precise straightening stroke-deflection model. The stroke prediction formula with high precision can be applied to the straightening stroke prediction in the high straightness metal bar manufacturing process and automatic straightening machine conveniently. | LEOPOLD Juergen | 2009 | Science China(Technological Sciences)2009，52，7： | 9 |
| 3 | Optical coherence tomography angiography for the anterior segment显示文摘Optical coherence tomography angiography(OCTA)is a rapid and non-invasive technique for imaging vasculature in the eye.As OCTA can produce high-resolution cross-sectional images and allow depth-resolved analysis for accurate localization of pathology of interest,it has become a promising method for anterior segment imaging.Furthermore,OCTA offers a more patient-friendly alternative to the conventional invasive dye-based fluorescent angiography.However,conventional OCTA systems are typically designed and optimized for the posterior segment of the eye,and thus using OCTA for anterior segment imaging can present several difficulties and limitations.In this review,we summarized the recent developments and clinical applications in anterior segment OCTA(AS-OCTA)imaging,such as for the cornea,iris,sclera and conjunctiva.We also compared commercially available OCTA systems,discussed the limitations of adapting current OCTA technology for the anterior segment imaging,and proposed possible future directions for AS-OCTA systems.AS-OCTA provides potential for future clinical applications such as diagnosis of corneal and iris pathologies,pre-operative surgical planning,assessment of new antiangiogenic therapeutics or evaluation of limbal stem cell deficiency.With further development,OCTA for anterior segment imaging in the clinics may become common in the near future. | Wen Di Lee Kavya Devarajan Jacqueline Chua Leopold Schmetterer Jodhbir S.Mehta Marcus Ang | 2019 | Eye and Vision2019，6，1： | 9 |
| 4 | Optical coherence tomography angiography in diabetic retinopathy: a review of current applications显示文摘Background:Diabetic retinopathy(DR)is a leading cause of vision loss in adults.Currently,the standard imaging technique to monitor and prognosticate DR and diabetic maculopathy is dye-based angiography.With the introduction of optical coherence tomography angiography(OCTA),it may serve as a potential rapid,non-invasive imaging modality as an adjunct.Main text:Recent studies on the role of OCTA in DR include the use of vascular parameters e.g.,vessel density,intercapillary spacing,vessel diameter index,length of vessels based on skeletonised OCTA,the total length of vessels,vascular architecture and area of the foveal avascular zone.These quantitative measures may be able to detect changes with the severity and progress of DR for clinical research.OCTA may also serve as a non-invasive imaging method to detect diabetic macula ischemia,which may help predict visual prognosis.However,there are many limitations of OCTA in DR,such as difficulty in segmentation between superficial and deep capillary plexus;and its use in diabetic macula edema where the presence of cystic spaces may affect image results.Future applications of OCTA in the anterior segment include detection of anterior segment ischemia and iris neovascularisation associated with proliferative DR and risk of neovascular glaucoma.Conclusion:OCTA may potentially serve as a useful non-invasive imaging tool in the diagnosis and monitoring of diabetic retinopathy and maculopathy in the future.Future studies may demonstrate how quantitative OCTA measures may have a role in detecting early retinal changes in patients with diabetes. | Kai Yuan Tey Kelvin Teo Anna C.S.Tan Kavya Devarajan Bingyao Tan Jacqueline Tan Leopold Schmetterer Marcus Ang | 2019 | Eye and Vision2019，6，1： | 6 |
| 5 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 6 | Prevalence and correlates of depressive symptoms in adult patients with pulmonary tuberculosis in the Southwest Region of Cameroon显示文摘Background:Tuberculosis(TB)remains a global health challenge and depression is a significant contributor to the global burden of disease.Current evidence suggests that there is an association between depressive symptoms and TB,lower adherence to treatment,and increased morbidity and mortality.However,there is paucity of data regarding these associations in Cameroon.This study aimed to determine the prevalence and correlates of depression in adult patients with pulmonary TB(PTB)in the Southwest Region of Cameroon.Methods:A hospital-based cross-sectional study involving 265 patients with PTB was conducted from 2nd January to 31st March 2015 in the Limbe Regional Hospital and the Kumba District Hospital.Depression was diagnosed using the standard nine-item Patient Health Questionnaire,and classified as none,mild or moderate.Logistic regressions were used to investigate correlates of depression in these patients.Results:Of the 265 patients(mean age 36.9±10 years)studied,136(51.3%)were female.The prevalence of depression was 61.1%(95%CI:55.1–66.8),with a significant proportion(36.6%)having mild depression.Multivariable logistic regression analysis showed that being female(aOR=3.0,95%CI(1.7–5.5),P<0.001),having a family history of mental illness(aOR=2.5,95%CI:1.3–5.4,P>0.05),being on retreatment for TB(aOR=11.2,95%CI:5.2–31.1,P<0.001),having discontinued treatment(aOR=8.2,95%CI:1.1–23.3,P<0.05)and having a HIV/TB co-infection(aOR=2.5,95%CI:1.2–6.5,P<0.001)were factors associated with having a higher chance of being depressed.Conclusion:Our study suggests that there is a high prevalence of depression among PTB patients,with more than one in two patients affected.Multidisciplinary care for TB patients involving mental health practitioners is highly encouraged,especially for high-risk groups. | Jules Kehbila Cyril Jabea Ekabe Leopold Ndemnge Aminde Jean Jacques NNoubiap Peter Nde Fon Gottlieb Lobe Monekosso | 2016 | Infectious Diseases of Poverty2016，5，1： | 3 |
| 7 | INTERIM RESULTS FROM A NATIONAL MULTICENTER PHASE II TRIAL OF COMBINATION BACILLUS CALMETTE-GUERIN PLUS INTERFERON ALFA-2B FOR SUPERFICIAL BLADDER CANCER显示文摘 | MICHAEL A. O’DONNELL KATHLEEN LILLI CHRISTINA LEOPOLD | 2004 | The Journal of Urology2004，，3： | 2 |
| 8 | Modelling and simulation of fixtures during grinding显示文摘The complex workpiece-fixture behaviour during machining is an essential component of the fixture development process.In detail,the forces acting on fixture components have to be analysed.A method for the prediction of the reaction forces due to process and clamping loads is presented in this article.At the beginning,detailed information about the workpiece-fixture behaviour during the process is determined by a complex finite element model.Secondly,the reduction of the number of elements leads to a smaller model with less computation time,validated and used for the variation of process parameters.Finally,an analytical description is developed based on the combination of both results.With the help of the empiric equation it is possible to predict the reaction forces and the dependency on several process parameters.This method has been validated by modelling shape grinding of a nozzle guide vane. | Matthias KLAERNER Juergen LEOPOLD Lothar KROLL | 2009 | Science China(Technological Sciences)2009，52，7： | 2 |
| 9 | No-reflow during coronary intervention :observations and implications 显示文摘 | Leopold JA Berger C J Cupples LA | 2000 | Circulation2000，102，： | 2 |
| 10 | Deferral of leaf senescence of detached cucumber cotyledons显示文摘 | Poovaiah B W Leopold A C | 1973 | Plant Physiology1973，52，： | 1 |
| 11 | Lignin geochemistry of a Late Quaternary core from Lake Washington显示文摘 | Hedges J I Ertel J R Leopold E B | 1982 | Geochimica Cosmochimica Acta1982，46，： | 1 |
| 12 | No-reflow during coronary intervetion: observations and implications 显示文摘 | Leopold JA Berger CJ Cupples LA | | Circulation0，102，： | 1 |
| 13 | Heavy metal tol-erance of Silene vulgaris 显示文摘 | BRINGEZU K LICHTENBERGER O LEOPOLD I | 1999 | Journal of Plant Physiology1999，154，4： | 1 |
| 14 | River channel patterns:brai-ded,meandering and straight显示文摘 | Leopold L B Wolman M G | 1957 | US Geological SurveyProfessional Paper1957，282，： | 1 |
| 15 | Seasonal variation in methane fluxes from sedimentary basins to the atmosphere: Results from chamber measurements and modeling of transport from deep sources 显示文摘 | Klusman R W Leopold M E LeRoy M P | 2000 | Journal of Geophysical Research2000，105，24： | 1 |
| 16 | The Amino-Acid Sequence of Bovine Glutathione Peroxidase显示文摘 | Wolfgang A. GüNZLER Gerd J. STEFFENS Adelbert GROSSMANN Sung-Man A. KIM Fritz ?TTING Albrecht WENDEL Leopold FLOHé | 2009 | Hoppe-Seyler′s Zeitschrift für physiologische Chemie2009，，1： | 1 |
| 17 | The interrelations of migraine,vertigo and migrainous vertigo显示文摘 | Neuhauser H Leopold M v Brevern M | | 0，，： | 1 |
| 18 | New developments in fast 3D-surface quality control显示文摘 | LEOPOLD J GUNTHER H LEOPOLD R | | 0，，02： | 1 |
| 19 | Tocopherol and organicfree radical levels in soybean seeds during natural and acceler-ated aging显示文摘 | Priestley D A McBride M B Leopold C | 1980 | Plant Physiology1980，66，4： | 1 |
| 20 | Classifications in briehSchatzker classification of tibial plateau fractures 显示文摘 | Zehser DW Leopold SS | 2013 | Clin Orthop Relat Res2013，471，2： | 1 |
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