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| 1 | Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease:An observation on non-absorbable antibiotics显示文摘AIM: To estimate the prevalence of small intestine bacterial overgrowth (SIBO) among patients with an earlier diagnosis of irritable bowel disease (IBS) in our geographical area, and to collect information on the use of locally acting non-absorbable antibiotics in the management of SIBO. METHODS: A non-interventional study was conducted in 73 consecutive patients with a symptom-based diagnosis.. RESULTS: When the patients underwent a 'breath test', 33 (45.2%) showed the presence of a SIBO. After treatment with rifaximin 1200 mg/d for seven days in 32 patients, 19 (59.4%) showed a negative 'breath test' one week later as well as a significant reduction of symptoms, thus confirming the relationship between SIBO and many of the symptoms claimed by patients. In the other 13 patients, 'breath test' remained positive, and a further cycle of treatment with ciprofloxacin 500 mg/d was given for 7 additional days, resulting in a negative 'breath test' in one patient only. CONCLUSION: (1) about half of the patients with a symptomatic diagnosis of IBS have actually SIBO, which is responsible for most of the symptoms attributed to IBS; (2) only a 'breath test' with lactulose (or with glucose in subjects with an intolerance to lactose) can provide a differential diagnosis between IBS and SIBO, with almost identical symptoms; and (3) the use of non-absorbable antibiotics may be useful to reduce the degree of SIBO and related symptoms; it must be accompanied, however, by the correction of the wrong alimentary habits underlying SIBO. | I Esposito A de Leone G Di Gregorio S Giaquinto L de Magistris A Ferrieri G Riegler | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Shape tuning in fully free-from deformation features 显示文摘 | Pernot J P Guillet S Leon J C | 2005 | Journal of Computing and Information Seienee Engineering2005，5，2： | 1 |
| 4 | Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico显示文摘 | Perez-Padilla R de la Rosa Zamboni D Ponce de Leon S | 2009 | N Engl J Med2009，361，7： | 1 |
| 5 | Pneumonia and respiratory failure from swine-origin influenza A ( H1N1 ) in Mexico显示文摘 | Perez-Padilla R De la Rosa-Zamboni D Ponice de Leon S | 2009 | N Engl J Med2009，361，7： | 1 |
| 6 | A Pilot Study on Prevention of Catheter-related Urinary Tract Infections with Fluoroquinolones显示文摘 | Esposito S Noviello S Leone S | 2006 | J Chemother2006，18，5： | 1 |
| 7 | Robustness measures and robust scheduling for job shops 显示文摘 | V J Leon S D Wu H Storer | 1993 | IIE Transactions1993，26，5： | 1 |
| 8 | Free DNA in the serum of cancer patients and the effect of therapy显示文摘 | Leon S A Shapiro B Sklaroff D M | 1977 | Cancer Res1977，37，： | 1 |
| 9 | Free DNA in the serum of cancer patients and the effect of therapy显示文摘 | LEON S A SHAPIRO B SKLAROFF D M | 1997 | Cancer Res1997，37，3： | 1 |
| 10 | From ideas to action: Creating a learning organization 显示文摘 | Wick C W Leon L S | 1995 | Human Resource Management1995，34，2： | 1 |
| 11 | Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic bcl-2-family proteins显示文摘 | M Leone D Zhai S Sareth et d | 2003 | Cancer Research2003，63，： | 1 |
| 12 | Cancer prevention by tea polyphenols is linked to the irdirect inhibition of a tiapoptotic Bcl-2-family protein显示文摘 | Leone M Zhai D Sareth S | 2003 | Cancer Res2003，63，： | 1 |
| 13 | Empirical tests of budget ratcheting and its effect on managers' discretionary accrual choices显示文摘 | Leone A.J Rock S | | 0，，： | 1 |
| 14 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 15 | Genome-wide atlas of transcription through maize development显示文摘 | Sekhon R S Lin H Childs K L Hirsch C N Buell C R de Leon N Kaeppler S M | 2011 | The Plant Journal2011，66，4： | 1 |
| 16 | Probview: A flexible probabilistic database system 显示文摘 | Lakshmanan L V S Leone N Ross R | 1997 | ACM Transactions on Database Systems1997，22，3： | 1 |
| 17 | Pneumonia and respiratory failure from swine-origin influenza A (H1N1)in mexico显示文摘 | Peres-Padilla R de la Rosa-Zamboni D Ponce de Leon S | 2009 | N Engl J Med2009，361，7： | 1 |
| 18 | Pneumonia and respiratory failure from swine-origin influenza a (H1N1) in Mexico显示文摘 | Perez-Padilla R de la Rosa-Zamboni D Ponce de Leon S | 2009 | N Engl J Med2009，361，7： | 1 |
| 19 | 显示文摘 | CONTINI A LEONE S MENICHETFE S | 2006 | J Org Chem2006，71，15： | 1 |
| 20 | The Effect of a Psychosocial Intervention and Quality of Life after Acute Myocardial Infarction: The Enhancing Recovery in Coronary Heart Disease (ENRICHD) Clinical Trial显示文摘 | Mendes de Leon C F Czajkowski S M | 2006 | J Cardiopulm Rehabil2006，26，1： | 1 |
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