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| 1 | Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review显示文摘The inflammatory process plays a central role in the development and progression of numerous pathological situations,such as inflammatory bowel disease(IBD),autoimmune and neurodegenerative diseases,metabolic syndrome,and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease(CD) and ulcerative colitis(UC). Both pathological situations usually involve recurring or bloody diarrhea,pain,fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However,surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants,including vegetables and fruits which are the major dietary sources of these compounds for humans,together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids,evidencing a remarkable free-radical scavenging capacity. However,accumulating evidence suggests that flavonoids have many other biological properties,including anti-inflammatory,antiviral,anticancer,and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs. | Ali Salaritabar Behrad Darvishi Farzaneh Hadjiakhoondi Azadeh Manayi Antoni Sureda Seyed Fazel Nabavi Leo R Fitzpatrick Seyed Mohammad Nabavi Anupam Bishayee | 2017 | World Journal of Gastroenterology2017，23，28： | 10 |
| 2 | Probiotics for the treatment of Clostridium difficile associated disease显示文摘The purpose of this review paper is to update the current and potential future role of probiotics for Clostridium difficile-associated disease (CDAD). Included in this review, is an update on the testing of newer probiotics (e.g. , Bacillus coagulans GBI-30, 6086) in animal models of CDAD. There is a focus on the modulation of signal transduction pathways (i.e. , transcription factors like cAMP response element-binding, activator protein 1, and nuclear factor kappa B), as well as the inhibition of certain kinases (e.g. , p38 mitogen activated protein kinases) by probiotics. Inhibition of signal transduction by probiotics, such as Saccharomyces boulardii , result in multiple effects on intestinal fluid secretion, neutrophil influx into the colon, inflammation, and colonocyte apoptosis that may positively impact CDAD. Recent clinical approaches with probiotics, for the prevention of primary and recurrent CDAD, are also summarized in this review paper. Future directions for the treatment of CDAD by probiotics are also mentioned in this review. In particular, the use of multi-strain probiotic formulations such as Ecologic AAD and VSL #3 may represent a rationale pharmacological approach, particularly as adjunctive therapies for CDAD. Understanding the mechanistic basis of CDAD, and how probiotics interfere at ceratin steps in the pathogenic process, may also present the opportunity to design other multi-strain probiotics that could have a future impact on CDAD. | Leo R Fitzpatrick | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，3： | 7 |
| 3 | Harmonic Vibrational Frequencies: an Evaluation of Hartree-Fock, Moller-Plesset, Quadratic Configuration Interaction, Density Function Theory, and Semiempirical Scale Factors显示文摘 | Anthony P Leo R | 1996 | J Phys Chem1996，100，16： | 1 |
| 4 | Nailsalvage using the eponychia l flap显示文摘 | Adan R Leo G Tarallo L | 2006 | Tech Extrem Surg2006，10，4： | 1 |
| 5 | Vascular endothelial growth factor and interleukin-6 in paracrinetumor-stromal cell interac- tions in multiple myeloma显示文摘 | Dankbar B Padro T Leo R | 2000 | Blood2000，95，： | 1 |
| 6 | Dynamic dial- ysis for the drug release evaluation from doxorubicin-gelatin nanoparticle conjugates 显示文摘 | Leo E Cameroni R Forni F | 1999 | International journal ofpharmaceutics1999，180，1： | 1 |
| 7 | Fault detection in industrial:Processes using canonical varitae analysis and dynamic principal component analysis显示文摘 | Evan L R Leo H | 2000 | Chemo mettles and Intelligent:Laboratory Systems2000，51，8： | 1 |
| 8 | An outlook on ovarian cancer and borderline ovarian tumors:focus on genomic and proteomic findings显示文摘 | Tinelli A Vergara D Martignago R Leo G Pisanò M Malvasi A | | 0，，： | 1 |
| 9 | Vascular endothelial growthfactor and Interleukin-6 in paracrine tumor-stromal cell interac- tions inmultiple myeloma 显示文摘 | Dankbar B Padro T Leo R | 2000 | Blood2000，95，8： | 1 |
| 10 | Doxorubicin-loaded gelatin nanoparticles stabilized by glutaraldehyde: Involvement of the drug in the cross-linking process 显示文摘 | Leo E Angela Vandelli M Cameroni R | 1997 | In- ternational journal of Pharmaceutics1997，155，1： | 1 |
| 11 | Nail salvage using the eponychial flap显示文摘 | Adani R Leo G Tarallo L | | 0，，04： | 1 |
| 12 | Tumor regression incancer patients by very low doses of a T cell-engaging antibody显示文摘 | Bargou R Leo E Zugmaier G | 2008 | Science2008，321，5891： | 1 |
| 13 | Outbreak of Nipah-virus infection among abattoir workers in Singapore 显示文摘 | Paton N I Leo Y S Zaki S R | 1999 | Lancet1999，354，： | 1 |
| 14 | P CR2based identification of Microcystin 2p roding genotypes of dfferent cyan obalferin genera显示文摘 | Michael H Guntram C Leo R | 2003 | Archives of Microbiology2003，180，40： | 1 |
| 15 | Field verification of 2-D suspended sediment models显示文摘 | VAN R LEO C | 1990 | Journal of Hydraulic Engineering1990，116，10： | 1 |
| 16 | Triterpenoids saponins from Pteleopsis suberosa stem bark 显示文摘 | Leo M D Tommasi N D Sanogo R | 2006 | Phytochemistry2006，67，： | 1 |
| 17 | Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and than reoxygenated显示文摘 | Leo R Pratico D Iuliano L | 1997 | Circulation1997，95，4： | 1 |
| 18 | Equations of the reaction-diffusion type with a loop algebra structure显示文摘 | ALFINITO E GRASSI V LEO R A | 1998 | Inverse Problems1998，14，： | 1 |
| 19 | Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and than reoxygenated显示文摘 | Leo R Pratieo D Iuliano L | 1997 | Circulation1997，95，5： | 1 |
| 20 | Biochar Incorporation into Pasture Soil Suppresses in situ Nitrous Oxide Emissions from Ruminant Urine Patches显示文摘 | Taghizadeh-Toosi Arezoo Clough Tim J Condron Leo M Sherlock Robert R Anderson Craig R Craigie Robin A | 2011 | EN2011，，2： | 1 |
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