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| 1 | Vascular invasion in pancreatic cancer:Imaging modalities,preoperative diagnosis and surgical management显示文摘Pancreatic cancer is associated with a poor prognosis,and surgical resection remains the only chance for curative therapy.In the absence of metastatic disease,which would preclude resection,assessment of vascular invasion is an important parameter for determining resectability of pancreatic cancer.A frequent error is to misdiagnose an involved major vessel.Obviously,surgical exploration with pathological examination remains the'gold standard'in terms of evaluation of resectability,especially from the point of view of vascular involvement.However,current imaging modalities have improved and allow detection of vascular invasion with more accuracy.A venous resection in pancreatic cancer is a feasible technique and relatively reliable.Nevertheless,a survival benefit is not achieved by curative resection in patients with pancreatic cancer and vascular invasion.Although the discovery of an arterial invasion during the operation might require an aggressive management,discovery before the operation should be considered as a contraindication.Detection of vascular invasion remains one of the most important challenges in pancreatic surgery.The aim of this article is to provide a complete review of the different imaging modalities in the detection of vascular invasion in pancreatic cancer. | Nicolas C Buchs Michael Chilcott Pierre-Alexandre Poletti Leo H Buhler Philippe Morel | 2010 | World Journal of Gastroenterology2010，16，7： | 29 |
| 2 | 变荷载下饱和软黏土一维大应变固结解析理论显示文摘基于软黏土一维非线性大应变固结基本理论,建立了能考虑荷载变化、土层自重等因素影响的拉格朗日坐标下以超静孔压u为变量的一维大应变固结控制方程,并通过对土体压缩性和渗透性的假定获得了方程的解析解。基于此解,分析了单级等速加荷条件下软黏土一维大应变固结性状。从中可见,大应变固结过程中土体变形的发展要快于超静孔压的消散;荷载增大,超静孔压消散趋慢;加荷速率越大,土体固结越快;考虑土层自重影响时孔隙比的分布更为合理。此外,本文的解析解也可用于验证各种大应变固结数值解法的正确性。 | 谢康和 郑辉 C J Leo | 2003 | 水利学报2003，34，10： | 19 |
| 3 | New fecal test for non-invasive Helicobacter pylori detection:A diagnostic accuracy study显示文摘AIM To assess the diagnostic accuracy of a new fecal test for detecting Helicobacter pylori(H. pylori), using ^(13)Curea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS We conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of H. pylori infection, referred for dyspepsia between February and October 2017. At enrollment, all participants underwent 13 C-urea breath test. Participants aged over 50 years were scheduled to undergo upper endoscopy with histology. Participants collected stool samples 1-3 d after enrollment for a new fecal investigation(THD fecal test). The detection of bacterial 23 S rRNA subunit gene indicated H. pylori infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive(PPV) and negative(NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio(LR), together with 95% confidence intervals(CI).RESULTS We enrolled 294 consecutive participants(age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninetyfive(32.3%) participants had a positive ^(13)C-urea breath test. Twenty-three(7.8%) participants underwent upper endoscopy with histology, with a full concordance between ^(13)C-urea breath test and histology in detecting H. pylori infection. Four(1.4%) out of the 294 participants withdrew from the study after the enrollment visit and did not undergo THD fecal testing. In the 290 participants who completed the study, the THD fecal test sensitivity was 90.2%(CI: 84.2%-96.3%), specificity 98.5%(CI:96.8%-100%), PPV 96.5%(CI: 92.6%-100%), NPV 95.6%(CI: 92.8%-98.4%), accuracy 95.9%(CI: 93.6%-98.2%), positive LR 59.5(CI: 19.3-183.4), negative LR 0.10(CI: 0.05-0.18). Out of 83 infected participants identified with the THD fecal test, 34(41.0%) had bacterial genotypic changes consistent with antibiotic-resistant H. pylori infection. Of these, 27(32.5%) had bacterial strains resistant to clarithromycin, 3(3.6%) to levofloxacin, and 4(4.8%) to both antibiotics. CONCLUSION The THD fecal test has high performance for the non-invasive diagnosis of H. pylori infection while additionally enabling the assessment of bacterial antibiotic resistances. | Andrea Iannone Floriana Giorgio Francesco Russo Giuseppe Riezzo Bruna Girardi Maria Pricci Suetonia C Palmer Michele Barone Mariabeatrice Principi Giovanni FM Strippoli Alfredo Di Leo Enzo Ierardi | 2018 | World Journal of Gastroenterology2018，24，27： | 5 |
| 4 | Protein immobilization in crosslinked alginate microparticles 显示文摘 | Coppi C Iannuccelli V Leo E | 2002 | J Microencapsul2002，19，1： | 2 |
| 5 | Partition coefficients and their uses显示文摘 | LEO A HANSCHA C ELKINS D | 1971 | Chem Rev1971，71，6： | 1 |
| 6 | 3 ' ,4' -dihydroxyflavonol re- duces superoxide and improves nitric oxide function in diabetic rat mesenteric arteries显示文摘 | Leo C H Hart J L Woodman 0 L | 2011 | PLoS One2011，6，20： | 1 |
| 7 | Experience of endoscopic ultrasound in staging adenocarcinoma of the cardia显示文摘 | De Manzoni G Pedrazzoni C Di Leo A | 1999 | Eur J Surg Oncol1999，25，： | 1 |
| 8 | Bandwidth characterization in the micro positioning of ionic polymer actuators显示文摘 | Kothfar C S Leo DJ | 2005 | J Intelligent Mater Syst2005，16，1： | 1 |
| 9 | Effect of ethanol level in the perception of aroma attributes and the detection of volatile compounds in red wine显示文摘 | GOLDNER M C ZAMORA M DI LEO LIRA P | 2009 | J Sens Stud2009，24，2： | 1 |
| 10 | The role of IL-113 and TNF-ct signaling in the genesis of cancer treatment related symptoms(CTRS):a study using cytokine receptor--deficient mice显示文摘 | SMITH L B LEO M C ANDERSON C | 2014 | Brain Behavior and Immunity2014，，38： | 1 |
| 11 | A feasibility investigation on ultraflltration of palm oil and oleic acid removal from glycerin solutions: flux decline, fouling pattern, rejection and membrane characterizations显示文摘 | MAH S LEO C P WU T Y | 2012 | Journal of Membrane Science2012，389，： | 1 |
| 12 | Hypoxia and expression of the proapoptotic regulator BNIP3 in cervical cancer显示文摘 | HORN L C | 2006 | Int J Gynecol Cancer2006，16，： | 1 |
| 13 | Novel controlled - release lemna -derived IFN -2b (Loctemn) : pharmacokinetics, pharmacodynamics, and tolerability in a phase I clinical Trial显示文摘 | Leo GJ John EH Anna C | 2008 | J Interferon Cytokine Res2008，28，： | 1 |
| 14 | A new algorithm for ball recognition using circle Hough transform and neural classifier显示文摘 | 'ORAZIO T D GUARAGNELLA C LEO M | 2004 | Pattern Recognition2004，37，： | 1 |
| 15 | Biochar and the nitrogen cycle:Introduction显示文摘 | Tim J C Leo M C | 2010 | Journal of Environmental Quality2010，39，4： | 1 |
| 16 | P CR2based identification of Microcystin 2p roding genotypes of dfferent cyan obalferin genera显示文摘 | Michael H Guntram C Leo R | 2003 | Archives of Microbiology2003，180，40： | 1 |
| 17 | Field verification of 2-D suspended sediment models显示文摘 | VAN R LEO C | 1990 | Journal of Hydraulic Engineering1990，116，10： | 1 |
| 18 | Immune evaluations in cancer patients after colorectal resection 显示文摘 | Losacco T De Leo G Punzo C | 1994 | G Chir1994，15，10： | 1 |
| 19 | Management of triple negative breast cancer显示文摘 | Oakman C Viale G Leo AD | 2010 | Breast2010，19，5： | 1 |
| 20 | Metastases to the paraaortic lymph nodes in adenocarcinoma of the cardia 显示文摘 | De Manzoni G Pedrazzani C Di Leo A | 2001 | Eur J Surg2001，167，6： | 1 |
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