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| 1 | Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis显示文摘AIM: To study the safety of epidural anesthesia(EA),its effect on pancreatic perfusion and the outcome of patients with acute pancreatitis(AP).METHODS: From 2005 to August 2010,patients with predicted severe AP [Ranson score ≥ 2,C-reactive protein > 100 or necrosis on computed tomography(CT)] were prospectively randomized to either a group receiving EA or a control group treated by patientcontrolled intravenous analgesia. Pain management was evaluated in the two groups every eight hours using the visual analog pain scale(VAS). Parameters for clinical severity such as length of hospital stay,use of antibiotics,admission to the intensive care unit,radiological/clinical complications and the need for surgical necrosectomy including biochemical data were recorded. A CT scan using a perfusion protocol was performed on admission and at 72 h to evaluate pancreatic blood flow. A significant variation in blood flow was defined as a 20% difference in pancreatic perfusion between admission and 72 h and was measured in the head,body and tail of the pancreas.RESULTS: We enrolled 35 patients. Thirteen were randomized to the EA group and 22 to the control group. There were no differences in demographic characteristics between the two groups. The Balthazar radiological severity score on admission was higher in the EA group than in the control group(mean score 4.15 ± 2.54 vs 3.38 ± 1.75,respectively,P = 0.347) and the median Ranson scores were 3.4 and 2.7 respectively(P = NS). The median duration of EA was 5.7 d,and no complications of the epidural procedure were reported. An improvement in perfusion of the pancreas was observed in 13/30(43%) of measurements in the EA group vs 2/27(7%) in the control group(P = 0.0025). Necrosectomy was performed in 1/13 patients in the EA group vs 4/22 patients in the control group(P = 0.63). The VAS improved during the first ten days in the EA group compared to the control group(0.2 vs 2.33,P = 0.034 at 10 d). Length of stay and mortality were not statistically different between the 2 groups(26 d vs 30 d,P = 0.65,and 0% for both respectively).CONCLUSION: Our study demonstrates that EA increases arterial perfusion of the pancreas and improves the clinical outcome of patients with AP. | Samira M Sadowski Axel Andres Philippe Morel Eduardo Schiffer Jean-Louis Frossard Alexandra Platon Pierre-Alexandre Poletti Leo Bühler | 2015 | World Journal of Gastroenterology2015，21，43： | 21 |
| 2 | Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers显示文摘In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cy-clinD1 accelerated the progression of cell cycle. | SONG Xin1, TAO Yongguang1, ZENG Liang1, YANG Jing1, TANG Faqing1, Leo M. Lee2, GONG Jianping3, WU Qiao4 & CAO Ya1 1. Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, China 2. Laboratory of Molecular Technology SAIC-Frederick, National Cancer Institute P.O. Box B, Frederick, MD 21702, USA 3. Molecular Medical Center, Tongji Hospital, Tongji Medical University, Wuhan 430030, China 4. Key Laboratory of the Ministry of Education for Cell Biology, and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China | 2005 | Science China(Life Sciences)2005，48，4： | 4 |
| 3 | Vascular endothelial growth factor and interleukin-6 in paracrinetumor-stromal cell interac- tions in multiple myeloma显示文摘 | Dankbar B Padro T Leo R | 2000 | Blood2000，95，： | 1 |
| 4 | The role of IL-113 and TNF-ct signaling in the genesis of cancer treatment related symptoms(CTRS):a study using cytokine receptor--deficient mice显示文摘 | SMITH L B LEO M C ANDERSON C | 2014 | Brain Behavior and Immunity2014，，38： | 1 |
| 5 | Vascular endothelial growthfactor and Interleukin-6 in paracrine tumor-stromal cell interac- tions inmultiple myeloma 显示文摘 | Dankbar B Padro T Leo R | 2000 | Blood2000，95，8： | 1 |
| 6 | A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol 显示文摘 | Fasano T Cefalu A B Di Leo E | 2007 | Arterioscler Thromb Vasc Biol2007，27，3： | 1 |
| 7 | Random Forests显示文摘 | Leo B | 2001 | Machine Learning2001，45，1： | 1 |
| 8 | Efficacy of chlorhexidine-and calcium hydroxide-containing medicaments against Enterococcus faecalis in vitro显示文摘 | Leo T Santos JM | 2003 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2003，96，： | 1 |
| 9 | High glucose induces adipogenic differentiation of muscle-derived stem cells显示文摘 | Aguiari P Leo S Zavan B | 2008 | Proc Natl Acad Sci2008，105，4： | 1 |
| 10 | All life cycle engineering and design显示文摘 | Leo A Jens B L | 1995 | Annals of the CIPR1995，44，2： | 1 |
| 11 | Involvenent of vascular endothelial growth factor receptor-3 in maintenance of integrity of endothelial cell lining during tumor angiogenesis显示文摘 | Padro T Leo R | 2000 | Blood2000，96，2： | 1 |
| 12 | Lithium conducting glass ceramic with Nasicon structure 显示文摘 | Leo C J Chowdari B V R Subba G V | 2002 | Mater Res Bull2002，，37： | 1 |
| 13 | Current status of HER2 testing显示文摘 | Di Leo A Dowsett M Horten B | 2002 | Oncology2002，63，： | 1 |
| 14 | Anaerobic treatment of pulp and paper mill effluents: an overview of applications 显示文摘 | Willie J B M Leo H A Erik | 2007 | Appita Jour- nal2007，60，2： | 1 |
| 15 | Collagen and proteoglycan abnormalities in the gdf-5-deficient mice and molecular changes when treating disk cells with recombinant growth factor显示文摘 | LEO B M BS G B | 2004 | Spine2004，29，20： | 1 |
| 16 | Vascular endothelial groth factor and interleukin-6 in paracrine tumor-stromal cell inter actions in multiple myeloma显示文摘 | Dankbar B Padro J Leo K | 2000 | Blood2000，95，8： | 1 |
| 17 | Computational microstructure analyzing technique for quantitative characterization of shrinkage and gas pores in pressure die cast AZ91 magnesium alloy 显示文摘 | LEO PRAKASH D G PRASANNA B REGENER D | 2005 | Computational Materials Science2005，，32： | 1 |
| 18 | Random forests显示文摘 | LEO B | 2001 | Machine Learning2001，45，： | 1 |
| 19 | Computational micmstructure analyzing lechnique for quantitative characterization of shrinkage and gas pores in pressure die cast AZ91 Magnesium alloy显示文摘 | LEO PRAKASH D G PRASANNA B REGENER D | 2005 | Computational Materials Science2005，，32： | 1 |
| 20 | The future of shipboard noise predictions 显示文摘 | RAYMOND F LEO B | 2000 | SNAME2000，，5： | 1 |
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