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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Genetic polymorphisms of cytokine genes and risk for trichloroethylene-induced severe generalized dermatitis: a case-control study 显示文摘 | DAI Y LENG S LI L | 2004 | Biomarkers2004，9，6： | 1 |
| 3 | Heteropolyanion basedionic liquids:reaction-induced self-separation catalystsfor esterification显示文摘 | Leng Y Wang J Zhu D R | 2009 | Angew Chem Int Ed2009，48，1： | 1 |
| 4 | 显示文摘 | Leng Y X Sun H Yang P | 2001 | Thin Solid Films2001，，： | 1 |
| 5 | Study of the zinc electroplating process using electrochemical noise technique 显示文摘 | ZHANG Z LENG W H CAI Q Y CAO F H ZHANG J Q | 2005 | Journal of Electroanalytical Chemistry2005，578，： | 1 |
| 6 | 显示文摘 | Leng Y J Chan S H Khor K A | 2004 | International Journal of Hydrogen Energy2004，，29： | 1 |
| 7 | Cloning of Beauveria bassiana chitinase gene Bbchitl and its application to improve fungal strain virulence显示文摘 | Fang W G Leng B Xiao Y H | 2005 | Appl Environ Microbiol2005，71，： | 1 |
| 8 | Neurotrophins protect against cytosine arabinoside-induced apoptosis of immature rat cerebellar neurons显示文摘 | LEEDS P LENG Y CHALECKA-FRANASZEK E | 2005 | J Neurochem Int2005，46，1： | 1 |
| 9 | The microstructure and mechanical properities of TiN and TiO2/TiN duplex films synthesized synthesized by plasma immersion ion implantlon and deposition on artificial valve 显示文摘 | Leng Y X Chen J Y Yang P | 2006 | Surface & Coating Technology2006，201，： | 1 |
| 10 | Role for macrophage migration in- hibitory factor in asthma显示文摘 | Mizue Y Ghani S Leng L | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
| 11 | Electrochemical Micromachining of Titanium Surfaces tor Biomedical Applications 显示文摘 | l u X Leng Y | 2005 | Journal of Materials Processing Technology2005，169，2： | 1 |
| 12 | Heteropolyanion-based i- onic hybrid solid:A green bulk-type catalyst for hydroxyl- ation of benzene with hydrogen peroxide 显示文摘 | Leng Y Wang J Zhu D R | 2011 | Chem Eng J2011，173，2： | 1 |
| 13 | A method for constructing trivariate nonseparable compactly supported orthogonal wavelets显示文摘 | LENG J S HUANG T Z FU Y D | 2009 | Inter J Comput Math2009，86，7： | 1 |
| 14 | TLR3signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71infection显示文摘 | Zhu K Yang J Luo K Yang C Zhang N Xu R Chen J Jin M Xu B Guo N Wang J Chen Z Cui Y Zhao H Wang Y Deng C Bai L Ge B Qin C F Shen H Yang C F Leng Q | 2015 | PLoS Pathog2015，11，10： | 1 |
| 15 | Reductive debromination of polybrominated diphenyl ethers in anaerobic sediment and a biomimetic system显示文摘 | TOKARZ Ⅲ J A AHN M Y LENG J | 2008 | Environmental Science & Technology2008，42，4： | 1 |
| 16 | MIF signal transduction initiated by binding to CD74显示文摘 | Leng L Metz CN Fang Y | 2003 | J Exp Med2003，197，11： | 1 |
| 17 | Anti-heat shock protein 70 autoantibody epitope changes and BD091 promotes atherosclerosis in rats显示文摘 | Leng X Zhan R Wang Y | | 0，，： | 1 |
| 18 | Stick-slip friction and energy dissipation in boundary lubrication显示文摘 | Lei Y J Leng Y S | 2011 | Physical Review Letters2011，107，14： | 1 |
| 19 | Kinetic modeling of electro-Fenton reaction in aqueous solution显示文摘 | H Liu X Z Li Y J Leng | 2007 | Water Research2007，41，： | 1 |
| 20 | Role of macrophage migration inhibitory factor in asthma显示文摘 | Mizue Y Ghani S Leng L | 2005 | Proc Natl Acad Sci USA2005，102，14： | 1 |
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