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| 1 | Cryptosporidiosis-an overview显示文摘Apicomplexan protozoan parasites of the genus Cryptosporidium infect the gastrointestinal tract and lungs of a wide variety of animals, including humans. The majority of human infections are due to either Cryptosporidium hominis (C. hominis) and/or Cryptosporidium parvum (C. parvum). The parasite has a complex life cycle that includes both asexual and sexual stages. While there are invasive free living stages, proliferation and differentiation take place within a unique parasitrophorous vacuole under the host cell brush border but outside the host cell cytoplasm. Infection is spread by environmentally resistant spores that primarily contaminate drinking water and occasionally food sources, which may cause significant outbreaks of diarrhea that generally lasts less than 2 w in immunocompetent individuals. In immunodeficient or immunosuppressed individuals, diarrhea may be copious and can result in significant morbidity and mortality, particularly in AIDS patients. Although diagnosis is relatively simple, effective drug treatment, particulary for infections in immunodeficient patients, has not been uniformly successful. This overview summarizes the species known to infect humans, aspects of the parasite life cycle, sources of infection, the pathophysiology of cryptosporidiosis, the immune response to infection, diagnosis, treatment and some aspects of cryptosporidiosis in China. | Gordon J Leitch | 2011 | The Journal of Biomedical Research2011，25，1： | 2 |
| 2 | Polyploidy in angiosperms显示文摘 | Leitch I J Bennett M D | 1997 | Trends Plant Sci1997，2，12： | 2 |
| 3 | Genome size evolu- tion in relation to leaf strategy and metabolic rates revisited 显示文摘 | Beaulieu J M Leitch I J Knight C A | 2007 | Annals of Botany2007，99，： | 1 |
| 4 | The importance of the left atrioventricular interval during atrioventricular sequential pacing显示文摘 | CHEVALIER S BASTA M LEITCH J W | 1997 | PACE1997，20，： | 1 |
| 5 | Arginine-derived nitric oxide reduces facal oocyst shedding in nude mice infected with Cryptosporidium parvum显示文摘 | Leitch G J Qing H E | 1994 | Infection and Immunity1994，62，11： | 1 |
| 6 | Genome size is a strong predictor of cell size and stomatal density in angio- sperms 显示文摘 | Beaulieu J M Leitch I J Patel S | 2008 | New Phytologist2008，179，： | 1 |
| 7 | Evolution of DNA a- mounts across land plants ( Embryophyta ) 显示文摘 | Leitch I J Soltis D E Sohis P S | 2005 | Annals of Botany2005，95，： | 1 |
| 8 | Evolution of rDNA in Nicotiana allopolyploids: a potential link between rDNA homogenization and epigenetics 显示文摘 | Kovarik A Dadejova M Lim Y K Chase M W Clarkson J J Knapp S Leitch A R | 2008 | Ann Bot (Lond)2008，101，6： | 1 |
| 9 | 显示文摘 | Bekker J Alberts V Leitch A W R | 2003 | Thin Solid Films2003，431，： | 1 |
| 10 | Genome size diver- sity in orchids-consequences and evolution 显示文摘 | Leitch I J Kahandawala I Suda J | 2009 | Annals of Botany2009，104，： | 1 |
| 11 | Rapid concerted e- volution of nuclear ribosomal DNA in two tragopogon allo- polyploids of recent and recurrent origin 显示文摘 | Kovarik A Pires J C Leitch A R | 2005 | Genetics2005，169，： | 1 |
| 12 | Genome size evolution in relation to leaf strategy and metabolic rates revisited显示文摘 | Beaulieu J M Leitch I J Knight C A | 2007 | Ann Bot2007，99，3： | 1 |
| 13 | Magnetic resonance imaging of shear wave propagation in excised tissue显示文摘 | Bishop J Poole G Leitch M | 1998 | Magn Res Imag1998，8，6： | 1 |
| 14 | Genome size is a strong predictor of cell size and stomatal density in angiosperms显示文摘 | Beaulieu J M Leitch I J Patel S | 2008 | New Phytol2008，179，4： | 1 |
| 15 | Nuclear DNA amounts in angiosperms 显示文摘 | BENNE3'I' M D LEITCH I J | 1995 | Annals of Botany1995，76，2： | 1 |
| 16 | The uhrastructure of the tegument of adult Schistosoma haematobium显示文摘 | Leitch B Probert A J Runham NW | 1984 | Parasitology1984，89，1： | 1 |
| 17 | Impacts of land use change on freshwater runoff into the near-coastal zone,Holetown Watershed,Barbados:Comparisons of long-term to single-storm effects显示文摘 | Leitch C Harbor J | 1999 | Journal of Soil and Water Conservation1999，3，： | 1 |
| 18 | Phylogenetic analysis of DNA C-values provides evidence for a small ancestral genome size in flowering plants 显示文摘 | Leitch I J Chase M W Bennett M D | 1998 | Annals of Botany1998，，： | 1 |
| 19 | Genome size is a strong predictor of cell size and stomatal density in angiosperms显示文摘 | Beaulieu J M Leitch I J Patel S Pendharkar A Knight C A | | 0，，04： | 1 |
| 20 | Long chain n-3polyunsaturated fatty acid incorporation into human atrium following fish oil supplementation显示文摘 | GARG M L LEITCH J BLAKE R J | 2006 | Lipid2006，41，： | 1 |
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