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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Efficient synthesis of unsymmetrical bolaamphiphiles for spontaneous formation of vesicles and disks with a transmembrane organization显示文摘 | Guilbot J Benvegau T Legros N | 2001 | Langnuir2001，17，3： | 1 |
| 3 | Iron-catalyzed Reactions in Organic Synthesis显示文摘 | Bolm C Legros J Paih J L | 2004 | Chem Rev2004，104，12： | 1 |
| 4 | High-dose chemonthrapy with hematopoietic rescue in patients with stage Ⅲ to Ⅳ ovarian cancer: long-term results显示文摘 | Dqulplat J Fleury J | 1997 | J Clin Oncol1997，15，4： | 1 |
| 5 | Polycystic ovary syndrome 显示文摘 | Norman R J Dewailly D Legro RS | 2007 | Lancet2007，370，9588： | 1 |
| 6 | Iron-Catalyzed Reactions in Organic Synthesis显示文摘 | Bolm C Legros J Paiti J L | 2004 | Chem Rev2004，104，： | 1 |
| 7 | Characterization of acute and chronic myocardial infarcts by multidetector computed tomography:comparison with contrast-enhanced magnetic resonance显示文摘 | Gerber BL Belge B Legros G J | | Circulation0，，： | 1 |
| 8 | Polycystic ovary syndrome显示文摘 | Norman R J Dewailly D Legro R S | 2007 | Lancet2007，，370： | 1 |
| 9 | Interferon decreases VEGF levels in patients with chronic myeloid leukemia treated with imatinib显示文摘 | Legros L Guilhot J Huault S | 2014 | Leuk Res2014，38，6： | 1 |
| 10 | Applications of cata- lytic asymmetric sulfide oxidations to the syntheses of bi- ologically active sulfoxides显示文摘 | LEGROS J DEHLI J R BOLM C | 2005 | Adv Synth Catal2005，347，1： | 1 |
| 11 | Iron-catalyzed reactions in organic synthesis显示文摘 | Bolm C Legros J Paih J L | | 0，，： | 1 |
| 12 | Prolonged treatment with recombined growth hormone improves bone measures:study of body composition in 21 deficient adults on treatment显示文摘 | Beckers V Milet J Legros J J | | 0，，06： | 1 |
| 13 | Iron-catalyzed reaction in organic synthe- sis显示文摘 | Bolm C Legros J Paih J | 2004 | Chemical Reviews2004，104，12： | 1 |
| 14 | Structural study and electrical conductivity of salts based on functional- ized TI'F containing peripheral selenium atoms 显示文摘 | Kaboub L Legros J P Donnadieu B | 2004 | J Mater Chem2004，14，： | 1 |
| 15 | Polycystic ovary syndrome显示文摘 | Norman R J Dewailly D Legro R S | 2007 | Lancet2007，370，9588： | 1 |
| 16 | Reactive Compatibilization of Polyester/Vinyl Acetate Copolymer Blends: Rheological, Morphological and Mechanical Proper-ties显示文摘 | Legros A Carreau P J Favis B D Michd A | 1994 | Polymer1994，35，4： | 1 |
| 17 | Fabrication of pure YBaCuO powders with controlled microstructure显示文摘 | C Legros C Haut L Ponsonnet-Mora and J Ayache | 1999 | Journal of the European Ceramic Society1999，19，： | 1 |
| 18 | Polycystic ovary syndrome显示文摘 | Robert J Norman Didier Dewailly Richard S Legro Theresa E Hickey | 2007 | 2007 (9588)2007，，9588： | 1 |
| 19 | Scandinavian Journal of Clinical&Laboratory Investigation显示文摘 | Pequeux C Hendrick J C Hagelstein M T Geenen V Legros J J | 2001 | 61(5):4072001，61，5： | 1 |
| 20 | Cancer Research显示文摘 | Pequeux C Breton C Hendrick J C Hagelstein M T Martens H Winkler R Geenen V Legros J J | 2002 | 62(16):46232002，62，16： | 1 |
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