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| 1 | DOG1是一种敏感和特异性的胃肠道间质瘤的标记物显示文摘 | Espinosa I Lee C H Kim M K 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，3： | 117 |
| 2 | Estimating liver weight of adults by body weight and gender显示文摘瞄准:为了为估计接枝的足够估计标准肝重量,为癌症在主要肝切除术在实时施主肝移植和残余肝缩放。方法:在这研究,体重和身高的人体测量的数据在 159 个实时的肝施主为与肝重量的关联被测试包括中间的肝的静脉经历了施主权利肝切除术。肝重量从在背表格获得的正确脑叶接枝重量被计算,在计算断层摄影术上由正确脑叶的比例划分了。结果:这些题目,所有汉语,有 35.8+/-10.5 年,和女性的吝啬的年龄到 118:41 的男比率。正确脑叶的吝啬的体积是 710.14+/-131.46 mL 并且在计算断层摄影术上占据了整个肝的 64.55%+/-4.47% 。正确脑叶称了 598.90+/-117.39 g,估计的肝重量是 927.54+/-168.78 g。当体重和身高受到多重逐步的线性回归分析时,身高被发现不足道。一样的体重的女性有稍微更低的肝重量。一个公式基于体重和性被导出:估计的标准肝重量(g)= 218 + BW (kg ) x 12.3 + 性 x 51 (R2 = 0.48 )( 女 = 0,男 = 1 ) 。基于这 159 个题目,的人体测量的数据肝重量用在白种人,日语,朝鲜语,和汉语上从研究导出的以前出版的公式被计算。所有公式与这个公式相比过高估计肝重量。日本公式为成年人过高估计估计的标准肝重量(ESLW ) 不到 60 kg。结论:对中国男性和女性适用的一个公式是可得到的。为单个赛跑的一个公式显得必要。 | See Ching Chan Chi Leung Liu Chung Mau Lo Banny K Lam Evelyn W Lee Yik Wong Sheung Tat Fan | 2006 | World Journal of Gastroenterology2006，12，14： | 22 |
| 3 | Autoimmune pancreatitis in the context of IgG4-related disease:Review of imaging findings显示文摘Current understanding of autoimmune pancreatitis(AIP) recognizes a histopathological subtype of the disease to fall within the spectrum of IgG4-related disease.Along with clinical,laboratory,and histopathological data,imaging plays an important role in the diagnosis and management of AIP,and more broadly,within the spectrum of IgG4-related disease.In addition to the defined role of imaging in consensus diagnostic protocols,an array of imaging modalities can provide complementary data to address specific clinical concerns.These include contrast-enhanced computed tomography(CT) and magnetic resonance(MR) imaging for pancreatic parenchymal lesion localization and characterization,endoscopic retrograde and magnetic resonance cholangiopancreatography(ERCP and MRCP) to assess for duct involvement,and more recently,positron emission tomography(PET) imaging to assess for extra-pancreatic sites of involvement.While the imaging appearance of AIP varies widely,certain imaging features are more likely to represent AIP than alternate diagnoses,such as pancreatic cancer.While nonspecific,imaging findings which favor a diagnosis of AIP rather than pancreatic cancer include:delayed enhancement of affected pancreas,mild dilatation of the main pancreatic duct over a long segment,the 'capsule' and 'penetrating duct' signs,and responsiveness to corticosteroid therapy.Systemic,extra-pancreatic sites of involvement are also often seen in AIP and IgG4-related disease,and typically respond to corticosteroid therapy.Imaging by CT,MR,and PET also play a role in the diagnosis and monitoring after treatment of involved sites. | Leslie K Lee Dushyant V Sahani | 2014 | World Journal of Gastroenterology2014，20，41： | 23 |
| 4 | Generalized megaviscera of lupus:Refractory intestinal pseudo-obstruction,ureterohydronephrosis and megacholedochus显示文摘Dilated dysfunction involving multiple visceral organs has been reported in patients with systemic lupus erythematosus(SLE).Chronic intestinal pseudo-obstruction(CIPO) resulting from intestinal smooth muscle damage has presented in conjunction with ureterohydronephrosis and, more rarely, biliary dilatation(megacholedochus).While the molecular pathogenesis is largely unknown, observed histo-pathologic features include widespread myositis, myocyte necrosis in the intestinal muscularis propria with subsequent atrophy and fibrosis, preserved myenteric innervations and little vasculitis.High dose immunosuppression usually results in resolution of symptoms with recovery of smooth muscle function, indicative of an autoimmune etiology.We report a patient with SLE who presented with intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus, and present images that illustrate megaviscera simultaneously involving all 3 visceral organs.Since the co-manifestation of all 3 is unusual and has been reported only once previously, wehave termed this rare clinical syndrome generalized megaviscera of lupus(GML).Although the SLE disease-activity parameters responded to aggressive immunomodulative therapy in our patient, clinical evidence of peristaltic dysfunction persisted in all involved viscera.This is a variation from the favorable outcomes reported previously in SLE patients with GML and we attribute this poor clinical outcome to disease severity and, most importantly, delayed clinical presentation.Since inflammation followed by atrophy and fibrosis are key aspects in the pathogenesis and natural history of GML, the poor response in our patient who presented late in the clinical course may be the result of ‘burnt out' inflammation with irreversible end-stage flbrosis.Thus, early recognition and timely initiation of treatment may be the key to recover visceral peristaltic function in patients with GML. | Frederick D Park Jeffrey K Lee Ganga D Madduri Pradipta Ghosh | 2009 | World Journal of Gastroenterology2009，15，28： | 20 |
| 5 | Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor显示文摘因为早察觉和治疗为病人的医药管理是批评的,为早前列腺癌症诊断的新奇简历标记的鉴定是高度重要的。在基础房间层和地下室膜的连续性的混乱为高级职业人员静电干扰 intraepithelial 瘤形成(HGPIN ) 的前进是必要的到在人的前列腺的侵略腺癌。涉及变换到侵略显型的分子是强烈审查的题目。我们以前报导了矩阵 metalloproteinase-26 (MMP-26 ) 经由地下室膜蛋白质并且由激活 MMP-9 的酶原形式的劈开支持人的前列腺癌症房间的侵略。而且,我们发现了 metalloproteinases-4 (TIMP-4 ) 的那个织物禁止者是大多数有势力 MMP-26 的内长的禁止者。这里,我们更高示威(p<0.0001 ) 在 HGPIN 和癌症的 MMP-26 和 TIMP-4 表示,与非肿瘤的 acini 相比。他们的表示层次在 HGPIN 是最高的,但是在一样的纸巾在侵略癌症(为各个的 p<0.001 ) 衰退。连续前列腺癌症织物节染色的 Immunohistochemical 建议 MMP-26 和 TIMP-4 的 colocalization。现在的学习显示 MMP-26 和 TIMP-4 可以在 HGPIN 的变换期间起一个不可分的作用到侵略癌症并且可以也为早前列腺癌症诊断用作标记。房间研究(2006 ) 16:750-758。做 i:10.1038/sj .cr.7310089;出版联机 2006 年 8 月 29 日。 | Seakwoo Lee Kevin K Desai Kenneth A Iczkowski Robert G Newcomer Kevin J WU Yun-Ge Zhao Winston W Tan Mark D Roycik Qing-Xiang Amy Sang | 2006 | Cell Research2006，16，9： | 18 |
| 6 | Endoscopy and polyps-diagnostic and therapeutic advances in management显示文摘Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The goal remains to identify and remove benign neoplastic polyps prior to becoming invasive cancers. Polypoid lesions of the colon vary widely from hyperplastic, hamartomatous and inflammatory to neoplastic adenomatous growths. Although these lesions are all benign, they are common, with up to one-quarter of patients over 60 years old will develop pre-malignant adenomatous polyps. Colonoscopy is the most effective screening tool to detect polyps and colon cancer, although several studies have demonstrated missed polyp rates from 6%-29%, largely due to variations in polyp size. This number can be as high as 40%, even with advanced (> 1 cm) adenomas. Other factors including sub-optimal bowel preparation, experience of the endoscopist, and patient anatomical variations all affect the detection rate. Additional challenges in decision-making exist when dealing with more advanced, and typically larger, polyps that have traditionally required formal resection. In this brief review, we will explore the recent advances in polyp detection and therapeutic options. | Scott R Steele Eric K Johnson Bradley Champagne Brad Davis Sang Lee David Rivadeneira Howard Ross Dana A Hayden Justin A Maykel | 2013 | World Journal of Gastroenterology2013，19，27： | 16 |
| 7 | 加拿大新生儿重症监护室院内感染及其变化趋势对胎龄<33周早产儿预后的影响(英文)显示文摘败血症是新生儿重症监护室(NICU)的危重病症及造成新生儿死亡的重要原因之一,根据其发病时间,可分为早发(生后2 d内)和晚发(生后2 d后)。其中晚发的新生儿败血症,一般考虑为院内感染(NI)。胎龄越小,出生体重越低,NI的发生率越高。NI的发生率在加拿大各NICU之间差别较大,与各中心医护人员的相关诊疗行为密切相关。在国家卫生研究院"基于循证医学的医疗质量改进项目"的推动下,2003~2009年间加拿大全国NICU总的NI率明显下降,但不同中心各自感染率的变化趋势仍极为不同。本研究纳入了加拿大全国共24家NICU在2008~2012年间所有收入院的胎龄〈33周的早产儿共18 961名,探讨NI率的变化趋势以及其与早产儿预后的关系。 | Caitlin Jantzen Abhay Lodha Mirea Lucia Shoo K Lee Xiang Y Ye Koravangattu Sankaran 姚跃 | 2015 | 中国当代儿科杂志2015，17，10： | 13 |
| 8 | 基因表达分析表明p63是骨巨细胞瘤的一种诊断用标记显示文摘 | Lee C H Espinosa I Jensen K C 饶秋(摘译) | 2008 | 临床与实验病理学杂志2008，24，4： | 13 |
| 9 | 新生儿呼吸机相关性肺炎的病原菌分布及耐药性变迁显示文摘目的探讨新生儿呼吸机相关性肺炎(ventilator—associated pneumonia,VAP)的病原菌分布和耐药性变迁,以指导临床防治。方法收集复旦大学附属儿科医院新生儿重症监护病房(neonatal intensive care unit,NICU)采取综合感染防治措施前后3个不同阶段(2006年2月1日至2007年1月31日为第一阶段,2008年8月1日至2009年7月31日为第二阶段,2010年1月1日至2010年12月31日为第三阶段)使用气管插管机械通气≥48h,并在NICU住院≥5d的患儿的相关临床及实验室检查资料,对发生VAP患儿的下呼吸道分泌物标本进行病原菌检测,用琼脂扩散敏感试验法测定病原菌耐药性。采用两独立样本t检验、单因素方差分析或X^2检验进行统计学分析。结果3个阶段共纳入491例患儿,其中发生VAP共92例,VAP发生率为27.3/1000个呼吸机使用日。采取综合感染防治措施后新生儿VAP发生率逐渐下降,3个阶段VAP发生例数分别为38、22、32例,VAP发生率分别为48.8/1000个呼吸机使用日、25.7/1000个呼吸机使用日和18.5/1000个呼吸机使用日(X^2=26.19,P=0.000)。VAP病原菌以革兰阴性杆菌为主,占95.5%(63/66)。其中鲍曼不动杆菌是VAP最主要的致病菌,占65.2%(43/66);其次是肺炎克雷伯菌,占15.2%(10/66);大肠埃希菌及铜绿假单胞菌,各占6.1Voo(4/66)。3个阶段相比,第一阶段致VAP鲍曼不动杆菌对第三代头孢菌素全部耐药,对碳青霉烯类抗生素敏感率为57.9%,有8株多重耐药菌株;第二阶段分离到的病原菌对第三代头孢菌素敏感率上升至75.0%(X^2=16.39,P=0.000),且无耐碳青霉烯类菌株及多重耐药菌株;与第二阶段相比,第三阶段病原菌对头孢菌素及碳青霉烯类药物的敏感率分别下降至5.0%(X^2=11.76,P=0.001)和20.0%(X^2=6.72,P=0.01),出现10株多重耐种类逐年变迁。定期监测和分析NICU患儿VAP病原菌分布及其耐药性变迁,对临床合理使用抗菌药物及控制VAP发生具有重要指导意义。 | 周琦 曹云 蔡小狄 陈超 胡晓静 王传清 LEE Shoo K | 2012 | 中华围产医学杂志2012，15，8： | 12 |
| 10 | 父母参与NICU患儿护理的优势与挑战显示文摘在围产期护理发展之前,新生儿都是在家庭出生并由其父母和助产士进行护理。自20世纪初期,医院开始为新生儿、早产儿提供医疗服务和专业护理,取代了父母的家庭护理。1979年护士出现短缺,爱沙尼亚塔林儿童医院新生儿病房开展了一个新的护理模式,该项目规定:新生儿全天24 h由父母看护,必要的时候医护人员给予帮助;尽可能的提倡母乳喂养;尽量减少医疗技术使用。 | 李变 张欣 Warre R O'Brien K Lee SK | 2015 | 中国新生儿科杂志2015，30，6： | 12 |
| 11 | Treatment responses in Asians and Caucasians with chronic hepatitis C infection显示文摘AIM:To conduct a multicentre retrospective review of virological response rates in Asians infected with genotype 1 chronic hepatitis C(CHC) treated with combination interferon and ribavirin and then to compare their responses to that among Caucasians.METHODS:Asian patients infected with genotype 1 CHC treated at 4 Australian centres between 2001 to 2005 were identified through hospital databases.Baseline demographic characteristics,biochemical,virological and histological data and details of treatment were collected.Sustained virological responses(SVR) in this cohort were then compared to that in Caucasian subjects,matched by genotype,age,gender and the stage of hepatic fibrosis.RESULTS:A total of 108 Asians with genotype 1 CHC were identified.The end of treatment response(ETR) for the cohort was 79% while the SVR was 67%.Due to the relatively advanced age of the Asian cohort,only sixty-four subjects could be matched with Caucasians.The ETR among matched Asians and Caucasians was 81% and 56% respectively(P=0.003),while the SVR rates were 73% and 36%(P <0.001) respectively.This difference remained significant after adjusting for other predictive variables. | Kenneth K Yan Marianne Guirgis Amany Zekry Thuy Dinh Anouk Dev Jacob George Alice Lee | 2008 | World Journal of Gastroenterology2008，14，21： | 12 |
| 12 | 推荐以“EBV相关肺癌”术语替代和扩展肺淋巴上皮瘤样癌的组织学谱系显示文摘肺淋巴上皮瘤样癌(LELC)是一种罕见的EBV相关性癌,其组织学特征为癌细胞呈合体细胞样生长,伴显著的淋巴细胞浸润,组织学上与未分化型鼻咽癌难以区分。研究发现LELC亦可显示非经典组织学形态且缺乏显著的淋巴细胞浸润。作者选取61例肺LELC病例进行全面临床病理分析,并使用免疫组化分析软件对浸润淋巴细胞进行自动定量分析,发现肺LELC形态学上存在连续性谱系,呈现从富于淋巴细胞浸润的经典型未分化LELC至极少淋巴细胞浸润的非经典型组织学形态。 | Yeh Y C Kao H L Lee K L | 2019 | 临床与实验病理学杂志2019，35，5： | 12 |
| 13 | 婴儿和儿童睾丸卵黄囊瘤33例并临床病理特征分析显示文摘作者收集1918~2014年诊断的发生于5~71个月(平均20.7个月)的男孩睾丸纯卵黄囊瘤33例。除1例外所有患者均接受睾丸切除,18例同时行淋巴结清扫术(全部阴性);21例接受化疗,12例接受放疗。 | Cornejo K M Frazier L Lee R S 魏建国 许春伟 | 2015 | 临床与实验病理学杂志2015，31，9： | 11 |
| 14 | Treatment of diffuse intrinsic brainstem gliomas: failed approaches and future strategies显示文摘 | Frazier JL Lee J Thomale UW Noggle JC Cohen K J Jallo GI | 2009 | 中国神经肿瘤杂志2009，7，3： | 10 |
| 15 | 柑桔黄龙病的鉴定和柯赫氏定理(英文)显示文摘黄龙(梢)病被认为是世界柑橘生产上的毁灭性病害已超过一个世纪,但该病害的病原学至今还没有清晰地建立起来。根据16S rRNA基因序列分析,一组被称为'Candidatus Liberibacter species'的难培养细菌被认为与黄龙病相关。然而,要确定'Ca.Liberibacter spp.'是黄龙病病原的柯赫氏定理并没有真正完成。令我们担忧的是,近年来有些文献频频指出'Ca.Liberibacter spp.'是黄龙病的病原,其实该细菌与柑橘寄主的直接病理反应还没有完全确定。我们建议,在黄龙病病原学清楚之前,文献报道在这方面需要有准确的阐述。 | Chen J Deng X Civerolo E L Lee R F Jones J B Zhou C Hartung J S Manjunath K L Brlansky R H | 2011 | 植物病理学报2011，41，2： | 10 |
| 16 | Screening for gastric cancer in Asia: current evidence and practice显示文摘 | Wai K Leung Ming-shiang Wu Yasuo Kakugawa Jae J Kim Khay-guan Yeoh Khean Lee Goh Kai-chun Wu Deng-chyang Wu Jose Sollano Udom Kachintorn Takuji Gotoda Jaw-town Lin Wei-cheng You Enders KW Ng Joseph JY Sung | 2008 | Lancet Oncology2008，，3： | 7 |
| 17 | Experimental and modeling study of de novo formation of PCDD/PCDF on MSW fly ash显示文摘polychlorinateddibenzo-p-dioxins ( PCDD )和 polychlorinated dibenzo呋喃( PCDF )的形成上的硫二氧化物( SO2 )的效果在模仿的浪费燃烧 conditions.A chlorinationmodel basedon 下面在anentrained流动反应堆( EFR )被学习了有条件的概率被采用评估 PCDD andPCDFs.Results revealedthat 的相当或相同事物模式 SO2 的存在尽管 SO2suppressed PCDD/F formation.The 预言模型 ofPCDF 显示出好 ag 。 | LI Xiao-dong ZHANG Ji YAN Jian-hua CEN Ke-fa RYAN Shawn P GULLETT Brian K LEE Chunwai | 2007 | Journal of Environmental Sciences2007，19，1： | 6 |
| 18 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 19 | Patterns of in-hospital mortality and bleeding complications following PCI for very elderly patients: insights from the Dartmouth Dynamic Registry显示文摘BackgroundVery 老病人(年龄 85 年) 是人口的一个很快增加的片断。作为一个组,他们经历跟随经皮的冠的干预(一种总线标准) 的在里面医院死亡和流血复杂并发症的高率。然而,在流血和死亡在之间的关系老 unknown.MethodsRetrospective 评论在 Dartmouth-Hitchcock 从 2000 ~ 2015 在 17,378 连续一种总线标准过程上被执行医学中心。在索引一种总线标准承认期间流血的发生(流血要求的输送,存取地点 hematoma > 5 厘米, pseudoaneurysm,和 retroperitoneal 流血)? 并且在里面医院死亡为四个年龄组被报导(< 65 年, 65-74 年, 75-84 年,和 85 年) 。承受了谁的流血复杂并发症和那些的病人的死亡被计算, multivariate 分析为在里面医院被执行死亡。最后,知道流血的预言者在病人年龄之间被比较 < 85 年和年龄 17,378 个病人学习了的 85 years.ResultsOf,(5.9%) 1019 经历了流血,(2.1%) 369 死了在里面医院追随者一种总线标准。流血和在里面医院死亡的发生与增加年龄 monotonically 增加了(死亡:0.94% , 2.27% , 4.24% 和 4.58% ;流血:3.96% , 6.62% , 10.68% 和 13.99% 好久 < 65, 65-74, 75-84 和 85 年,分别地) 。除了病人年龄 85 年,在 multivariate 分析上,流血为所有年龄组与增加的死亡被联系[机会比率(95% CI ) :变老 < 65 年, 3.65 (1.99-6.74 ) ;年龄 65-74 年, 2.83 (1.62-4.94 ) ;年龄 75-84 年, 3.86 (2.56-5.82 ) ,年龄 85 年:1.39 (0.49-3.95 )] 有增加的 .ConclusionsBleeding 和死亡追随者一种总线标准增加变老。为老尽管有流血的高率,流血在里面医院死亡追随者一种总线标准不再是预兆的。 | Shawn X Li Hannah I Chaudry Jiyong Lee Theodore B Curran Vishesh Kumar Kendrew K Wong Bruce W Andrus James T DeVries | 2018 | Journal of Geriatric Cardiology2018，15，2： | 6 |
| 20 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
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