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| 1 | Calcium signaling and T-type calcium channels in cancer cell cycling显示文摘Regulation of intracellular calcium is an important signaling mechanism for cell proliferation in both normal and cancerous cells. In normal epithelial cells, free calcium concentration is essential for cells to enter and accomplish the S phase and the M phase of the cell cycle. In contrast, cancerous cells can pass these phases of the cell cycle with much lower cytoplasmic free calcium concentrations, indicating an alternative mechanism has developed for fulfilling the intracellular calcium requirement for an increased rate of DNA synthesis and mitosis of fast replicating cancerous cells. The detailed mechanism underlying the altered calcium loading pathway remains unclear; however, there is a growing body of evidence that suggests the T-type Ca2+ channel is abnormally expressed in cancerous cells and that blockade of these channels may reduce cell proliferation in addition to inducing apoptosis. Recent studies also show that the expression of T-type Ca2+ channels in breast cancer cells is proliferation state dependent, i.e. the channels are expressed at higher levels during the fast-replication period, and once the cells are in a non-proliferation state, expression of this channel isminimal. Therefore, selectively blocking calcium entry into cancerous cells may be a valuable approach for preventing tumor growth. Since T-type Ca2+ channels are not expressed in epithelial cells, selective T-type Ca2+ channel blockers may be useful in the treatment of certain types of cancers. | James T Taylor Xiang-Bin Zeng Jonathan E Pottle Kevin Lee Alun R Wang Stephenie G Yi lennifer A S Scruggs Suresh S Sikka Ming Li | 2008 | World Journal of Gastroenterology2008，14，32： | 12 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | RAID: high-performance, reliable secondary storage 显示文摘 | Chen P M Lee E K Gibson G A | 1994 | ACM Computing Surveys1994，26，2： | 1 |
| 4 | Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells显示文摘 | KANG G Y LEE E R KIM J H | 2009 | Eur J Pharmacol2009，611，13： | 1 |
| 5 | The fate of human malignant melanoma cells transplanted into zebrafish embryos:assessment of migration and cell division in the absence of tumor formation显示文摘 | LEE L M J SEFTOR E A BONDE G | 2005 | Developmental Dynamics2005，233，4： | 1 |
| 6 | A study on the foaming behaviors of PP resins with talc as nucleating agent显示文摘 | Naguib H E Park G B Lee P C | 2006 | J Polym Eng2006，26，6： | 1 |
| 7 | Cloning of a cDNAencoding a human DNA-binding protein similar to ribosomalprotein S1显示文摘 | EKLUND E A LEE S W SKALNIK D G | 1995 | Gene1995，155，2： | 1 |
| 8 | ABA signaling:A messengers FIERY fate显示文摘 | Lee H Julie E G | 2001 | Curr Biol2001，11，： | 1 |
| 9 | Regulation of the Phospahorylation State and Microtubule-binding Activity of tau by Protein Phosphatase 2A显示文摘 | SONTAG E NUNBHAKDI-CRAIG V LEE G | 1996 | Neuron(S0896-6273)1996，17，6： | 1 |
| 10 | Comparison of AI-Cu-Fe quasierystalline particle reinforced AI composites fabricated by conventional casting and extrusion显示文摘 | Fleury E Lee S M Choi G Kim W T Kim D H | 2001 | J Mater Sci2001，36，： | 1 |
| 11 | Quantitation of soybean allergens using tandem mass spectromeey显示文摘 | HOUSTON N L LEE D G STEVENSON S E | 2011 | J Proteome Res2011，10，2： | 1 |
| 12 | Effect of floral nectar, water, and feeding frequency on Cotesia glomerata longevity 显示文摘 | Lee J C Heimpel G E | 2008 | BioControl2008，53，： | 1 |
| 13 | Effects of diet,packaging,and irradiation on protein oxidation,lipid oxidation,and color of raw broiler thigh meat during refrigerated storage显示文摘 | XIAO S ZHANG W G LEE E J | 2004 | Journal of Food Science2004，76，： | 1 |
| 14 | Microwave dielectric properties of Bi(Nb1-xTax)O4 ceramics with Cu2V2O7显示文摘 | KIM E S KIM J H LEE K G | | 0，，01： | 1 |
| 15 | High diversity andwidespread occurrence of mitotic spore mats in ectomycorrhizalPezizales显示文摘 | Healy R A Smith M E Bonito G M Pfister D H Ge Z W Guevara G G ’ Williams G Stafford K Kumar L Lee T HobartC Trappe J Vilgalys R McLaughlin D J | 2013 | Molecular Ecology2013，22，： | 1 |
| 16 | A role for glutamate decarboxylase during tomato ripening:the eharaeterisation of a cDNA encoding a putative glutamate decarboxylase with a calmodulin binding site 显示文摘 | PEDRO P G LEE W STEVE P DON G JULIE E G | 1995 | Plant Molecular Biology1995，27，6： | 1 |
| 17 | Comparison of AlCu-Fe quasicrystalline particle reinforced Al composites fabricated by conventional casting and extrusion显示文摘 | Lee S M Choi G | 2001 | J Mater Sci2001，36，： | 1 |
| 18 | Effective Preconditioning Through Ordering Interleaved with Incomplete Factorization显示文摘 | Lee I Raghavan P Ng E G | 2006 | SIAM Journal on Matrix Analysis and Applications2006，27，4： | 1 |
| 19 | Develop mere of a model of complete heart block in rats显示文摘 | Lee R J Sievers R E Gallinghouse G J Ursell P C | 1998 | J Appl Physiol1998，85，： | 1 |
| 20 | How does foreign direct investment affect economic growth? 显示文摘 | Borensztein E Lee G | 1998 | Journal of Interna- tional Economics1998，45，： | 1 |
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