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| 1 | What can imaging tell us about cognitive impairment and dementia?显示文摘Dementia is a contemporary global health issue with far reaching consequences, not only for affected individuals and their families, but for national and global socioeconomic conditions. The hallmark feature of dementia is that of irreversible cognitive decline, usually affecting memory, and impaired activities of daily living. Advances in healthcare worldwide have facilitated longer life spans, increasing the risks of developing cognitive decline and dementia in late life. Dementia remains a clinical diagnosis. The role of structural and molecular neuroimaging in patients with dementia is primarily supportive role rather than diagnostic, American and European guidelines recommending imaging to exclude treatable causes of dementia, such as tumor, hydrocephalus or intracranial haemorrhage, but also to distinguish between different dementia subtypes, the commonest of which is Alzheimer's disease. However, this depends on the availability of these imaging techniques at individual centres. Advanced magnetic resonance imaging(MRI) techniques, such as functional connectivity MRI, diffusion tensor imaging and magnetic resonance spectroscopy, and molecular imaging techniques, such as 18 F fluoro-deoxy glucose positron emission tomography(PET), amyloid PET, tau PET, are currently within the realm of dementia research but are available for clinical use. Increasingly the research focus is on earlier identification of at risk preclinical individuals, for example due to family history. Intervention at the preclinical stages before irreversible brain damage occurs is currently the best hope of reducing the impact of dementia. | Leela Narayanan Alison Dorothy Murray | 2016 | World Journal of Radiology2016，8，3： | 7 |
| 2 | 播散性浅表性光化性汗孔角化症MVK基因突变检测显示文摘目的:检测2个中国汉族播散性浅表性光化性汗孔角化症(DSAP)家系患者MVK基因突变。方法:提取2个DSAP家系及100名无亲缘关系的健康对照外周血DNA,采用PCR扩增患者MVK基因的全部外显子及其侧翼序列,用Sanger测序法对PCR扩增产物直接测序检测基因突变。结果:发现1个新的剪切位点突变(c.1040-2A>C)和1个已报道的错义突变(c.1094T>C)。结论:本研究进一步证实MVK基因突变与DSAP发病相关。 | Parimi Leela Rani 付希安 王真真 杨宝琦 施仲香 刘红 张福仁 | 2016 | 中国麻风皮肤病杂志2016，32，3： | 6 |
| 3 | Chemopreventive effect of apple and berry fruits against colon cancer显示文摘Colon cancer arises due to the conversion of precancerous polyps(benign)found in the inner lining of the colon.Prevention is better than cure,and this is very true with respect to colon cancer.Various epidemiologic studies have linked colorectal cancer with food intake.Apple and berry juices are widely consumed among various ethnicities because of their nutritious values.In this review article,chemopreventive effects of these fruit juices against colon cancer are discussed.Studies dealing with bioavailability,in vitro and in vivo effects of apple and berry juices are emphasized in this article.A thorough literature survey indicated that various phenolic phytochemicals present in these fruit juices have the innate potential to inhibit colon cancer cell lines.This review proposes the need for more preclinical evidence for the effects of fruit juices against different colon cancer cells,and also strives to facilitate clinical studies using these juices in humans in large trials.The conclusion of the review is that these apple and berry juices will be possible candidates in the campaign against colon cancer. | Saravana Kumar Jaganathan Muthu Vignesh Vellayappan Gayathri Narasimhan Eko Supriyanto Dyah Ekashanti Octorina Dewi Aqilah Leela T Narayanan Arunpandian Balaji Aruna Priyadarshini Subramanian Mustafa Yusof | 2014 | World Journal of Gastroenterology2014，20，45： | 3 |
| 4 | Antioxidant and free radical scavenging activities of polyphenol-enriched curry leaf ( Murraya koenigii L.) extracts显示文摘 | Mylarappa B. Ningappa Ramadas Dinesha Leela Srinivas | 2007 | Food Chemistry2007，，2： | 3 |
| 5 | Method of quasi-upper and lower solutions in abstract cones 显示文摘 | Lakshmikantham V Leela S Vatsala A S | 1982 | Nonlinear Anal1982，，6： | 1 |
| 6 | Bacterial decolorization and degradation of azo dyes 显示文摘 | Anjali E Poonam S Leela I | 2007 | International Biodeterioration and Biodegradation2007，59，2： | 1 |
| 7 | Method of quasi-upper and lower solutions in abstract cones显示文摘 | LAKSHM I V LEELA S VATSALA A S | 1982 | Nonlinear Anal1982，，6： | 1 |
| 8 | Removal of hexavalent chromium using a novel cross linked xanthated chitosan 显示文摘 | Nalini Awantika Dixit Leela Iyengar | 2006 | Bioresource Technology2006，97，18： | 1 |
| 9 | Constitutive Interferon-Inducible Protein 16-Inflammasome Activation during Epstein-Barr Virus Latency I, II, and III in B and Epithelial Cells显示文摘 | Mairaj Ahmed Ansari Vivek Vikram Singh Sujoy Dutta Mohanan Valiya Veettil Dipanjan Dutta Leela Chikoti Jie Lu David Everly Bala Chandran | 2013 | Journal of Virology2013，，15： | 1 |
| 10 | Nagumo-type uniqueness result for fractional differential equations 显示文摘 | Lakshmikantham V Leela S | 2009 | Nonlinear Anal2009，71，： | 1 |
| 11 | Somatic embryogenesis in peanut:Influence of growth regulators and sugars显示文摘 | Susan Eapen Leela George | 1993 | Plant Cell Tissue Organ Culture1993，35，2： | 1 |
| 12 | Isolation,identification and application of novel bacterial consortiumTJ-1 for the decolourization of structurally different azo dyes显示文摘 | Taruna J Leela I Karunakar S | 2008 | Bioresource Technology2008，99，15： | 1 |
| 13 | LiNi1/3Co1/3Mn1/3O2-graphene composite as a promising cathode for lithium-ion batteries显示文摘 | Venkateswara Rao C Leela Mohana Reddy A Ishikawa Y | 2011 | ACS Applied Materials & Interfaces2011，3，8： | 1 |
| 14 | LiNit/a CQ/s Mnt/a Oz-graphene composite as a promising cathode for lithium-ion batteries显示文摘 | Venkateswara Rao C Leela Mohana Reddy A Ishikowa Y | 2011 | ACS Applied Materials Inter{aces2011，3，8： | 1 |
| 15 | Krasnoselskii-Krein-type uniqueness result for fractional differential equations 显示文摘 | Iakshmikantham V Leela S A | 2009 | Nonlinear Anal2009，71，： | 1 |
| 16 | Double knockout pigs deficient in N ‐glycolylneuraminic acid and G alactose α‐1,3‐ G alactose reduce the humoral barrier to xenotransplantation显示文摘 | Andrew J. Lutz Ping Li Jose L. Estrada Richard A. Sidner Ray K. Chihara Susan M. Downey Christopher Burlak Zheng‐Yu Wang Luz M. Reyes Bess Ivary Fuqin Yin Ross L. Blankenship Leela L. Paris A. Joseph Tector | 2013 | Xenotransplantation2013，，1： | 1 |
| 17 | Another approach to the theory of differential inequalities relative to changes in the initial times显示文摘 | Lakshmikantham V Leela S Vasundharadevi J | 1999 | J of Inequal & Appl1999，4，2： | 1 |
| 18 | Periodic boundary value problem for differential equations with delay and monotone iterative method显示文摘 | Leela S Oguztoreli M N | 1987 | Journal of Mathematical Analysis and Applications1987，122，： | 1 |
| 19 | Removal of hexavalent chromium using a novel cross linked xanthated chitosan 显示文摘 | Nalini Sankararamakrishnan Awantika Dixit Leela Iyengar | 2006 | Bioresource Technology2006，97，18： | 1 |
| 20 | Cr(VI) Reduction by Bacillus coagulans Isolated from Contaminated Soils显示文摘 | Ligy Philip Leela Iyengar C. Venkobachar | 1998 | Journal of Environmental Engineering1998，，12： | 1 |
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