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| 1 | Colorectal cancer tumour markers and biomarkers:Recenttherapeutic advances显示文摘Colorectal cancer(CRC) is the second most commonly diagnosed cancer among females and third among males worldwide. It also contributes significantly to cancer-related deaths, despite the continuous progress in diagnostic and therapeutic methods. Biomarkers currently play an important role in the detection and treatment of patients with colorectal cancer. Risk stratification for screening might be augmented by finding new biomarkers which alone or as a complement of existing tests might recognize either the predisposition or early stage of the disease. Biomarkers have also the potential to change diagnostic and treatment algorithms by selecting the proper chemotherapeutic drugs across a broad spectrum of patients. There are attempts to personalise chemotherapy based on presence or absence of specific biomarkers. In this review, we update review published last year and describe our understanding of tumour markers and biomarkers role in CRC screening, diagnosis, treatment and follow-up. Goal of future research is to identify those biomarkers that could allow a non-invasive and cost-effective diagnosis, as well as to recognise the best prognostic panel and define the predictive biomarkers for available treatments. | Gustaw Lech Robert Słotwiński Maciej Słodkowski Ireneusz Wojciech Krasnodębski | 2016 | World Journal of Gastroenterology2016，22，5： | 33 |
| 2 | Serum concentration of sFas and sFasL in healthy HBsAg carriers,chronic viral hepatitis B and C patients显示文摘AIM: To estimate the amount of apoptosis among healthy HBsAg carriers, patients with chronic HBV infection treated with lamivudine and patients with chronic HCV infedJon treated with interferon alpha and ribavirin. Activity of apoptosis was evaluated by serum sFas/sFasL concentration measurement.Moreover dependence between apoptosis and HBV-DNA or HCV-RNA levels was studied.METHODS: Eighty-six persons were included into study: 34 healthy HBsAg carriers, 33 patients with chronic HBV infection and 19 patients with chronic HCV infection. Serum levels of sFas/sFasL were measured by ELISA assay. HBV-DNA and HCV-RNA were measured by RT-PCR assay. Levels of sFas/sFasL were determined before and 2 and 12 wk after therapy in patients with chronic hepatitis B and C infection.HBV-DNA or HCV-RNA was detected before treatment and 6 mo after treatment.RFSULTS: Twenty-four (71%) healthy HBsAg carriers showed HBV-DNA over 10^5/mL, which was comparable to the patients with chronic hepatitis B. Independently from HBV-DNA levels,the concentration of sFas among healthy HBsAg carriers was comparable to healthy persons. Among patients with chronic hepatitis B and C, the concentration of sFas was significantly higher in comparison to healthy HBsAg carriers and healthy persons. In chronic hepatitis B patients the concentration of sFas was decreased during lamivudine treatment. Among chronic hepatitis C patients the concentration of sFas was increased during IFN alpha and ribavirin treatment, sFasL was not detected in control group. Furthermore sFasL oo:urred more frequently in chronic hepatitis C patients in comparison to chronic hepatitis B patients.CONCLUSION: There are no correlations between apoptosis and HBV-DNA levels. However ther is an association between apoptosis and activity of inflammation in patients with chronic HBV infection. Apoptosis can be increased in patients with chronic hepatitis C by effective treatment which may be a result of apoptosis stimulation by IFN-α. | Tadeusz Wojciech Lapinski Oksana Kowalczuk Danuta Prokopowicz Lech Chyczewski | 2004 | World Journal of Gastroenterology2004，10，24： | 7 |
| 3 | 汽油和柴油混合燃料均质压燃(HCCI)的试验研究显示文摘汽油和柴油这两种不同特性的燃料被用作HCCI发动机的燃料。汽油具有高挥发性、易雾化和易于形成混合气的特性,被用来形成均质混合气;柴油具有良好的着火性和可燃性,被用来控制自燃和限制爆震燃烧。期望这两种特性不同而又相互补充的燃料混合后能够达到一个折衷的HCCI的燃烧性能。试验在一个专用于HCCI研究的单缸发动机上实施,采用两种中等的压缩比(10.4和15)和两种HCCI模式(进气加热和负气门叠开),试验结果证实了这种期望。结果是:随着混合燃料中柴油比例的增加,对于进气加热模式,HC- CI能稳定工作所需要的进气温度有所降低,对于负气门叠开模式,缸内平均指示压力和过量空气系数的范围有所扩展,并且两种方式下HC和NOx的排放均有所减少。 | 钟绍华 张永红 金国栋 Miroslaw Lech Wyszynski Xu Hongming | 2007 | 内燃机学报2007，25，1： | 7 |
| 4 | Liver fibrosis markers in alcoholic liver disease显示文摘Alcohol is one of the main factors of liver damage. The evaluation of the degree of liver fibrosis is of great value for therapeutic decision making in patients with alcoholic liver disease(ALD). Staging of liver fibrosis is essential to define prognosis and management of the disease. Liver biopsy is a gold standard as it has high sensitivity and specificity in fibrosis diagnostics. Taking into account the limitations of liver biopsy, there is an exigency to introduce non-invasive serum markers for fibrosis that would be able to replace liver biopsy. Ideal serum markers should be specific for the liver, easy to perform and independent to inflammation and fibrosis in other organs. Serum markers of hepatic fibrosis are divided into direct and indirect. Indirect markers reflect alterations in hepatic function, direct markers reflect extracellular matrix turnover. These markers should correlate with dynamic changes in fibrogenesis and fibrosis resolution. The assessment of the degree of liver fibrosis in alcoholic liver disease has diagnostic and prognostic implications, therefore noninvasive assessment of fibrosis remains important. There are only a few studies evaluating the diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with ALD. Several noninvasive laboratory tests have beenused to assess liver fibrosis in patients with alcoholic liver disease, including the hyaluronic acid, FibroTest, FibrometerA, Hepascore, Forns and APRI indexes, FIB4, an algorithm combining Prothrombin index(PI), α-2 macroglobulin and hyaluronic acid. Among these tests, Fibrotest, FibrometerA and Hepascore demonstrated excellent diagnostic accuracy in identifying advanced fibrosis and cirrhosis, and additionally, Fibrotest was independently associated with survival. Therefore, the use of biomarkers may reduce the need for liver biopsy and permit an earlier treatment of alcoholic patients. | Lech Chrostek Anatol Panasiuk | 2014 | World Journal of Gastroenterology2014，20，25： | 6 |
| 5 | Integrated photonics in the 21st century显示文摘We review the emergence and development of integrated photonics and its status today.The treatise is focused on information and communications technology(ICT)applications,but the technology is generically employable for a wealth of other applications,such as sensors.General properties of the waveguides that form the basis of integrated photonics are reviewed,and several examples of integrated photonics based on silicon and plasmonics are presented.The all-important development of integrated low-power nanophotonics is discussed and current challenges and prospects of the field are elucidated.The treatment is focused on the photonic fabric between source and detector. | Lars Thylén Lech Wosinski | 2014 | Photonics Research2014，2，2： | 6 |
| 6 | Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis显示文摘One to six percent of patients with microscopic colitis are refractory to medical treatment. The effect of faecal microbiota transplantation(FMT) in active collagenous colitis(CC) has, to the best of our knowledge, never been reported before. Here, we report the effect of repeated FMT in a patient with CC. The patient presented with severe symptoms including profuse diarrhea and profound weight loss. Although she responded to budesonide in the beginning, she became gradually refractory to medical treatment, and was therefore treated with FMT. The patient remained in remission for 11 mo after the third faecal transplantation. The immunomodulatory effect of the therapy was evaluated using flow cytometry, which showed alterations in the profile of intraepithelial and lamina propria lymphocyte subsets after the second transplantation. Our observations indicate that FMT can have an effect in CC, which support the hypothesis that luminal factors, influencing the intestinal microbiota, are involved in the pathogenesis of CC. | Sezin Günaltay Lech Rademacher Elisabeth Hultgren Hornquist Johan Bohr | 2017 | World Journal of Gastroenterology2017，23，7： | 4 |
| 7 | 均质压燃(HCCI)单区和多区燃烧模型的比较显示文摘利用耦合化学动力学软件包CHEMKIN建立了汽油HCCI发动机的单区和多区燃烧模型。与试验数据的对比表明:虽然单区模型在参数化研究中能较准确地预测混合气的自燃定时,但其准确性在很大程度上取决于缸内的均匀性;包含缝隙区、淬熄区、质量交换区和绝热核心区的九区燃烧模型通过设置特定的功能分区能更好地模拟HCCI的燃烧过程,它在对自燃定时的预测和对热量释放过程和排放物的形成机理的模拟等方面都有很好的性能。 | 钟绍华 孔斌 Miroslaw Lech Wyszynski Xu Hongming | 2007 | 内燃机工程2007，28，3： | 2 |
| 8 | Iron deficiency in chronic heart failure: An international pooled analysis显示文摘 | IJsbrand T. Klip Josep Comin-Colet Adriaan A. Voors Piotr Ponikowski Cristina Enjuanes Waldemar Banasiak Dirk J. Lok Piotr Rosentryt Ainhoa Torrens Lech Polonski Dirk J. van Veldhuisen Peter van der Meer Ewa A. Jankowska | 2013 | American Heart Journal2013，，： | 2 |
| 9 | A behavioral screening assay for Daphnia magna:a method to assess the effects of xenobiotics on special orientation显示文摘 | Goodrich M S Lech J J | 1990 | Environ Toxicol Chem1990，，9： | 1 |
| 10 | Fluorometric and NMR studies of the naproxen-cyclodextrin inclusion complexes in aqueous solutions显示文摘 | Nina Sadlej-Sosnowska Lech Kozerski Elzbieta Bed-narek | 2000 | Journal of Inclusion Phenomena and Macrocyclic Chemistry2000，37，： | 1 |
| 11 | Alteration of serum interleukin-1 receptor antagonist and interleukin-6 levels after surgical injury显示文摘 | Slotwinski R Lech G Gomula J | 2003 | Pol Merkur Lekarski2003，15，87： | 1 |
| 12 | Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced lupus nephritis 显示文摘 | Lech M Skuginna V Kulkarni O P | 2010 | J Pathol2010，220，5： | 1 |
| 13 | LDL/HDL changes in subclinical hypothyroidism:possible risk factors for coronary heart disease 显示文摘 | STAUB J J RYFF-DD LECHE A | 1988 | Clin Endocrinol (oxf)1988，28，2： | 1 |
| 14 | Technical and economic aspects of autothermal thermophilic aerobic digestion exemplified by sewage treatment plant in Gizycko显示文摘 | Izabela B Lech D | 2007 | Environment Protection Engineering2007，33，2： | 1 |
| 15 | The mRNA expression of pro- and anti-inflammatory cytokines in T regulatory cells in children with type 1 diabetes显示文摘 | Luczynski Wlodzimierz Stasiak-Barmuta Anna Juchniewicz Agnieszka Wawrusiewicz-Kurylonek Natalia Ilendo Elzbieta Kos Justyna Kretowski Adam Górska Maria Chyczewski Lech Bossowski Artur | 2010 | Folia Histochemica et Cytobiologica2010，，1： | 1 |
| 16 | Value of chosen immunologic parameters in assessment of surgical trama extent显示文摘 | Gomula J Slotwinski R Lech G | 2000 | Pol Merkurirsz Lek2000，9，： | 1 |
| 17 | The effect of igneous intrusive bodies on sedimentary thermal maturity 显示文摘 | Wang X Leche L Walters C | 1989 | Organic Geochemistry1989，64，6： | 1 |
| 18 | Analysis of Heparan Sulfate Oligosaceharides with Ion Pair-Reverse Phase Capil lary High Performace Liquid Chromatography-Microeleetro- spray Ionization Time of-Flight Mass Spectrometry 显示文摘 | Kuberan B Lech M Zhang L J | 2002 | Journal of American Chemical Society2002，124，29： | 1 |
| 19 | Estimation of the dynamic size of fractal aggregates 显示文摘 | Lech Gmaehowski | 2000 | Colloids and Surfaces A: Physicoehemieal and Engineering Aspects2000，170，23： | 1 |
| 20 | Study of empirical mode decomposition and spectral analysis for stress and emotion classification in natural speech显示文摘 | He L Lech M Maddage N C | | 0，，： | 1 |
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