|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Morphology and surface electronic structure of MBE grown InN 显示文摘 | Himmerlich M Krischok S Lebedev V | 2007 | J Cryst Growth2007，306，： | 1 |
| 3 | Pt/GaN Schottky diodes for hydrogen gas sensors显示文摘 | Ali M Cimalla V Lebedev V | 2006 | Sensors and Actuators B2006，113，： | 1 |
| 4 | Transesterification of rapeseed oil under fiow conditions catalyzed by basic solids: M - AI(La) -O (M =Sr, Ba), M-Mg-O (M=Y, La) 显示文摘 | SHERSTYUK O V IVANOVA A S LEBEDEV M Y | 2012 | Appl Catal A- Gen2012，，： | 1 |
| 5 | Biochemical and structural studies of a L-haloacid dehalogenase from the thermophilic archaeon Sulfolobus tokodaii显示文摘 | Rye C A Isupov M N Lebedev A A | 2009 | Extremophiles2009，13，1： | 1 |
| 6 | Characteristics and scaling of tungsten-wire array Z pinch implosion dynamics at 20 MA显示文摘 | Cuneo M E Waisman E M Lebedev S V | 2005 | Physical Review E2005，71，04： | 1 |
| 7 | Brainmachine interfaces: past, present and future显示文摘 | LEBEDEV M NICOLELIS M | 2006 | Trends in Neuroscience2006，29，9： | 1 |
| 8 | Substrate heating effects on hardness of an α-Al2O3 thick film formed by aerosol deposition method显示文摘 | Lebedev M Akedo J Ito T | 2005 | J Crystal Growth2005，275，： | 1 |
| 9 | Optical absorption spectroscopy of synthetic tourmalines 显示文摘 | TARAN M N LEBEDEV A S PLATONOV A N | 1993 | Phys Chem Miner1993，20，3： | 1 |
| 10 | Learning to control a brain-machine interface for reaching and grasping by primates显示文摘 | Carmena J M Lebedev M A Crist R E | 2003 | PLoS Biology2003，1，2： | 1 |
| 11 | GC- MS comparison of the behavior of chlorine and sodium hy- pochlorite towards organic compounds dissolved in water 显示文摘 | Lebedev A T Shaydullina G M Sinikova N A | 2004 | Water Res2004，38，17： | 1 |
| 12 | Biochemical and structural studies of a haloacid dehalogenase from the thermophilic archaeon Sulfolobus tokodaii显示文摘 | Rye C Isupov M Lebedev A | | 0，，： | 1 |
| 13 | Brain - machine interface : pase,present and future 显示文摘 | Lebedev M A Nicolelis M A L | 2006 | Trends in Neurosciences2006，29，9： | 1 |
| 14 | GC-MS comparison of the behavior of chlorine and sodium hypochlorite towards organic compounds dissolved in water显示文摘 | Albert T Lebedev Gulnara M Shaydullina Nstalia A Sinikova | 2004 | Water Research2004，38，17： | 1 |
| 15 | Filamentous carbon templated SiO2-NiO aerogel: structure and catalytic properties for direct oxidation of hydrogen sulfide into sulfur显示文摘 | Ermakova M A Ermakov D Y Lebedev M Y | 2000 | Catalysis Letters2000，70，2： | 1 |
| 16 | Characteristics and scaling of tungsten-wire-array Z-pinch implosion dynamics at 20 MA 显示文摘 | Cuneo M E Waisman E M Lebedev S V | 2005 | Physical Review E2005，71，04： | 1 |
| 17 | Characteristics and scaling of tungsten-wire-array Z-pinch implosion dynamics at 20 MA显示文摘 | Cuneo M E Waisman E M Lebedev S V | | 0，，04： | 1 |
| 18 | Secondary electronic processes and the structure of X-ray photoelectron spectra of lanthanides in oxygen-containing compounds显示文摘 | Teterin Y A Lebedev A M Ivanov K E | 2004 | J Electron Spectrosc Relat Phenom2004，，： | 1 |
| 19 | Characteristics and scaling of tungsten-wire-array Z-pinch implosion dynamics at 20 MA显示文摘 | Cuneo M E Waisman E M Lebedev S V | 2005 | Physical Review2005，71，4： | 1 |
| 20 | SANS study of the precipitates microstructure evolution in A1 4032 car engine pistons显示文摘 | ROGANTE M LEBEDEV V T NICOLAIE F | 2005 | Physica B: Condensed Matter2005，258，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员